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Glaxo Laboratories Ltd
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Glaxo Laboratories Ltd
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Application filed by Glaxo Laboratories LtdfiledCriticalGlaxo Laboratories Ltd
Priority to ES0298061ApriorityCriticalpatent/ES298061A1/en
Publication of ES298061A1publicationCriticalpatent/ES298061A1/en
A process for the production of compounds of the general formula ** (See formula) ** wherein R1 is an alkoxy, alkylthio, acyloxy, acyl, carboxyalkyl, carbamoyl, alkyl, hydroxy, amino or substituted amino group or a hydrogen or a halogen atom; R 2 is a hydrogen atom or a halogen or an alkoxy, alkylthio, acyloxy, acyl, carboxyalkyl, carbamoyl, alkyl, hydroxy, amino or substituted amino group; R3 is a hydrogen atom, except when R1 is a hydrogen atom, or an alkyl, hydroxyalkyl, hydroxy-alkylcarbamoyl, or alkanoyloxy group containing said alkyl groups not more than four carbon atoms and x is 1 or 2, wherein a compound of the general formula ** (See formula) ** where R represents hydrogen or the group ** (See formula) ** wherein R1 and R2 have the meanings defined above, or a water-soluble salt thereof, is reacted in a strongly polar medium with a nucleophile of formula ** (See formula) ** where R3 and x have the meanings defined above, and the resulting compound, in which R represents hydrogen, is phenylacetylated with an appropriate derivative. (Machine-translation by Google Translate, not legally binding)
ES0298061A1964-03-261964-03-26A procedure for the production of antibiotic compounds (Machine-translation by Google Translate, not legally binding)
ExpiredES298061A1
(en)