ES296783A1 - Procedure for obtaining steroid compounds (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for obtaining steroid compounds (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES296783A1
ES296783A1 ES296783A ES296783A ES296783A1 ES 296783 A1 ES296783 A1 ES 296783A1 ES 296783 A ES296783 A ES 296783A ES 296783 A ES296783 A ES 296783A ES 296783 A1 ES296783 A1 ES 296783A1
Authority
ES
Spain
Prior art keywords
steroid
acyl
translation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES296783A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US259373A external-priority patent/US3240777A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES296783A1 publication Critical patent/ES296783A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J17/00Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J75/00Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for obtaining steroid compounds, especially 16-glucuronides and 16-galacturonides of 11,17-bis-oxygen-20-ketopregnane with unsaturated ring A, and their salts, of the general formula ** (See formula) ** where Z is a radical of a 11,17-bis-oxygen-20-keto-16-hydroxy-steroid with unsaturated A ring, of the Pregnane series, in which a hydrogen at C-16 has been replaced by the glucuronide or galacturonide fraction, and M is hydrogen or a cation; characterized in that an 11,17-bis-oxygen-20-keto-16-hydroxyisosteroid is reacted with a (tri-0-acyl- α -D-glucopyran-silbromo) -uronate or (tri-0-acyl-) α -D-galactopyranosylbromo) -uronate alkyl, to form the corresponding (steroid-21-yl-tri-0-acyl- β -D-glucopyranoside) -uronate or (steroid-21-yltri-0-acyl- β -D-galactopyranoside) -alkyluronate, which is then hydrolysed with an alkaline hydrolyzate, to form a salt of the 16-glucuronide or 16-galacturonide steroid, and, if desired, the salt is converted to the free acid of the 16-glucuronide or 16-galacturonide steroid. (Machine-translation by Google Translate, not legally binding)
ES296783A 1963-02-18 1964-02-14 Procedure for obtaining steroid compounds (Machine-translation by Google Translate, not legally binding) Expired ES296783A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US259373A US3240777A (en) 1963-02-18 1963-02-18 Steroid 16alpha-glucuronide of the antiinflammatory pregnane series

Publications (1)

Publication Number Publication Date
ES296783A1 true ES296783A1 (en) 1964-05-01

Family

ID=22984672

Family Applications (1)

Application Number Title Priority Date Filing Date
ES296783A Expired ES296783A1 (en) 1963-02-18 1964-02-14 Procedure for obtaining steroid compounds (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
AT (1) AT253699B (en)
BE (1) BE643982A (en)
BR (1) BR6456897D0 (en)
CH (1) CH453350A (en)
ES (1) ES296783A1 (en)
FR (2) FR1552764A (en)
GB (1) GB1049113A (en)
NL (1) NL6401466A (en)

Also Published As

Publication number Publication date
GB1049113A (en) 1966-11-23
FR3624M (en) 1965-10-18
BE643982A (en) 1964-08-18
NL6401466A (en) 1964-08-19
FR1552764A (en) 1969-01-10
CH453350A (en) 1968-06-14
AT253699B (en) 1967-04-25
BR6456897D0 (en) 1973-08-14

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