ES2959601T3 - Un polipéptido EphA4 modificado - Google Patents
Un polipéptido EphA4 modificado Download PDFInfo
- Publication number
- ES2959601T3 ES2959601T3 ES16858502T ES16858502T ES2959601T3 ES 2959601 T3 ES2959601 T3 ES 2959601T3 ES 16858502 T ES16858502 T ES 16858502T ES 16858502 T ES16858502 T ES 16858502T ES 2959601 T3 ES2959601 T3 ES 2959601T3
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- Prior art keywords
- epha4
- amino acid
- protein
- sequence
- eph
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
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| PCT/AU2016/051010 WO2017070738A1 (en) | 2015-10-27 | 2016-10-27 | A method of treatment and agents useful for same |
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| EP4308149A4 (en) * | 2021-03-18 | 2025-02-26 | Valery Krasnoperov | Use of sephb4-hsa fusion protein as a first-line therapy in cancer treatment |
| AU2022388189A1 (en) * | 2021-11-11 | 2024-05-02 | Eisai R&D Management Co., Ltd. | Anti-epha4 antibody |
| WO2023154948A1 (en) * | 2022-02-14 | 2023-08-17 | Vasgene Therapeutics Inc. | Ephrin type-b receptor 4 (ephb4) agents and production thereof |
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| WO1997012635A1 (en) | 1995-10-02 | 1997-04-10 | Cytotherapeutics, Inc. | Method for treating amyotrophic lateral sclerosis |
| AUPP674898A0 (en) * | 1998-10-27 | 1998-11-19 | Walter And Eliza Hall Institute Of Medical Research, The | A method of treatment |
| JP2007525203A (ja) * | 2004-02-27 | 2007-09-06 | オンコセラピー・サイエンス株式会社 | ＰＲＣおよびＰＤＡＣａの治療標的としてのＥｐｈＡ４ |
| US20080003210A1 (en) | 2006-03-13 | 2008-01-03 | Medimmune, Inc. | Non-human primate receptor tyrosine kinases |
| WO2008150010A1 (ja) * | 2007-06-08 | 2008-12-11 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法 |
| EP2223999B1 (en) * | 2007-11-30 | 2017-10-18 | Eisai R&D Management Co., Ltd. | Epha4 polypeptide having novel activity and use thereof |
| EP2260864A1 (en) * | 2009-06-10 | 2010-12-15 | University of Melbourne | Therapeutic applications |
| EP2653552B1 (en) * | 2010-12-17 | 2016-10-19 | Eisai R&D Management Co., Ltd. | SCREENING METHOD USING GELATINASE-MEDIATED EphA4 CLEAVAGE REACTION AS AN INDICATOR |
| MY199344A (en) | 2013-02-18 | 2023-10-24 | Vegenics Pty Ltd | Ligand binding molecules and uses thereof |
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- 2016-10-27 CN CN201680074679.6A patent/CN108884135B/zh active Active
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| US20180339020A1 (en) | 2018-11-29 |
| AU2016345063A2 (en) | 2018-07-19 |
| WO2017070738A1 (en) | 2017-05-04 |
| EP3368551A1 (en) | 2018-09-05 |
| EP3368551B1 (en) | 2023-07-12 |
| JP6877419B2 (ja) | 2021-05-26 |
| US10617738B2 (en) | 2020-04-14 |
| CN108884135B (zh) | 2024-03-26 |
| CA3003294A1 (en) | 2017-05-04 |
| CN108884135A (zh) | 2018-11-23 |
| AU2016345063B2 (en) | 2021-08-05 |
| JP2019501112A (ja) | 2019-01-17 |
| AU2016345063A1 (en) | 2018-05-17 |
| EP3368551A4 (en) | 2019-06-05 |
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