ES2958662T3 - Tratamiento de cardiopatía por inhibición de la acción de la proteína de anclaje a la cinasa A del músculo (mAKAP) - Google Patents

Tratamiento de cardiopatía por inhibición de la acción de la proteína de anclaje a la cinasa A del músculo (mAKAP) Download PDF

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ES2958662T3
ES2958662T3 ES18827388T ES18827388T ES2958662T3 ES 2958662 T3 ES2958662 T3 ES 2958662T3 ES 18827388 T ES18827388 T ES 18827388T ES 18827388 T ES18827388 T ES 18827388T ES 2958662 T3 ES2958662 T3 ES 2958662T3
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rsk3
composition
makap
cardiac
mice
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Michael S Kapiloff
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A01K2217/00—Genetically modified animals
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
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ES18827388T 2017-07-06 2018-07-05 Tratamiento de cardiopatía por inhibición de la acción de la proteína de anclaje a la cinasa A del músculo (mAKAP) Active ES2958662T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762529224P 2017-07-06 2017-07-06
PCT/US2018/040913 WO2019010301A1 (en) 2017-07-06 2018-07-05 TREATMENT OF CARDIOPATHIES BY INHIBITING THE ACTION OF PROTEINS FROM ANCHORING TO MUSCLE PROTEIN KINASES A (MAKAP)

Publications (1)

Publication Number Publication Date
ES2958662T3 true ES2958662T3 (es) 2024-02-13

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ES18827388T Active ES2958662T3 (es) 2017-07-06 2018-07-05 Tratamiento de cardiopatía por inhibición de la acción de la proteína de anclaje a la cinasa A del músculo (mAKAP)

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Country Link
US (1) US10907153B2 (https=)
EP (1) EP3658157B1 (https=)
JP (1) JP7193874B2 (https=)
AU (1) AU2018297274B2 (https=)
CA (1) CA3065816C (https=)
ES (1) ES2958662T3 (https=)
WO (1) WO2019010301A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132174B2 (en) 2013-03-15 2015-09-15 Anchored Rsk3 Inhibitors, Llc Treatment of heart disease by inhibition of the action of ribosomal S6 kinase 3 (RSK3)
WO2020051296A1 (en) * 2018-09-06 2020-03-12 Icahn School Of Medicine At Mount Sinai Compositions and methods for the treatment of heart disease
CA3139974A1 (en) * 2019-05-15 2020-11-19 University Of Miami Treatment of heart disease by disruption of the anchoring of pp2a
EP4103214B1 (en) 2020-02-13 2026-04-29 Tenaya Therapeutics, Inc. Gene therapy vectors for treating heart disease
JP2026505638A (ja) * 2023-02-13 2026-02-16 シーアールアイ バイオテック，インコーポレイテッド 心筋細胞における選択的発現のためのヒトトロポニンｔ遺伝子のプロモーター－エンハンサー配列

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489125B1 (en) 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
AU2003295600A1 (en) * 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
JP2007505158A (ja) * 2003-05-21 2007-03-08 ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム 心肥大および心不全の処置としてのプロテインキナーゼＣ−μ（ＰＫＤ）の阻害
US9217155B2 (en) * 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
US8734809B2 (en) * 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
US20130136729A1 (en) 2011-11-11 2013-05-30 University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group Compositions and methods for targeting and treating diseases and injuries using adeno-associated virus vectors
US9132174B2 (en) * 2013-03-15 2015-09-15 Anchored Rsk3 Inhibitors, Llc Treatment of heart disease by inhibition of the action of ribosomal S6 kinase 3 (RSK3)

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EP3658157A4 (en) 2021-03-24
WO2019010301A1 (en) 2019-01-10
AU2018297274A1 (en) 2020-01-23
AU2018297274B2 (en) 2023-05-18
CA3065816A1 (en) 2019-01-10
JP2020527167A (ja) 2020-09-03
WO2019010301A8 (en) 2020-05-22
JP7193874B2 (ja) 2022-12-21
CA3065816C (en) 2024-11-19
EP3658157A1 (en) 2020-06-03
EP3658157B1 (en) 2023-07-26
US20190010493A1 (en) 2019-01-10
US10907153B2 (en) 2021-02-02

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