AU2018297274B2 - Treatment of heart disease by inhibition of the action of muscle A-kinase anchoring protein (mAKAP) - Google Patents

Treatment of heart disease by inhibition of the action of muscle A-kinase anchoring protein (mAKAP) Download PDF

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AU2018297274B2
AU2018297274B2 AU2018297274A AU2018297274A AU2018297274B2 AU 2018297274 B2 AU2018297274 B2 AU 2018297274B2 AU 2018297274 A AU2018297274 A AU 2018297274A AU 2018297274 A AU2018297274 A AU 2018297274A AU 2018297274 B2 AU2018297274 B2 AU 2018297274B2
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rsk3
makap
mice
heart
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Michael S. Kapiloff
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AU2018297274A 2017-07-06 2018-07-05 Treatment of heart disease by inhibition of the action of muscle A-kinase anchoring protein (mAKAP) Active AU2018297274B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762529224P 2017-07-06 2017-07-06
US62/529,224 2017-07-06
PCT/US2018/040913 WO2019010301A1 (en) 2017-07-06 2018-07-05 TREATMENT OF CARDIOPATHIES BY INHIBITING THE ACTION OF PROTEINS FROM ANCHORING TO MUSCLE PROTEIN KINASES A (MAKAP)

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AU2018297274A1 AU2018297274A1 (en) 2020-01-23
AU2018297274B2 true AU2018297274B2 (en) 2023-05-18

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AU2018297274A Active AU2018297274B2 (en) 2017-07-06 2018-07-05 Treatment of heart disease by inhibition of the action of muscle A-kinase anchoring protein (mAKAP)

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US (1) US10907153B2 (https=)
EP (1) EP3658157B1 (https=)
JP (1) JP7193874B2 (https=)
AU (1) AU2018297274B2 (https=)
CA (1) CA3065816C (https=)
ES (1) ES2958662T3 (https=)
WO (1) WO2019010301A1 (https=)

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Publication number Priority date Publication date Assignee Title
US9132174B2 (en) 2013-03-15 2015-09-15 Anchored Rsk3 Inhibitors, Llc Treatment of heart disease by inhibition of the action of ribosomal S6 kinase 3 (RSK3)
WO2020051296A1 (en) * 2018-09-06 2020-03-12 Icahn School Of Medicine At Mount Sinai Compositions and methods for the treatment of heart disease
CA3139974A1 (en) * 2019-05-15 2020-11-19 University Of Miami Treatment of heart disease by disruption of the anchoring of pp2a
EP4103214B1 (en) 2020-02-13 2026-04-29 Tenaya Therapeutics, Inc. Gene therapy vectors for treating heart disease
JP2026505638A (ja) * 2023-02-13 2026-02-16 シーアールアイ バイオテック,インコーポレイテッド 心筋細胞における選択的発現のためのヒトトロポニンt遺伝子のプロモーター-エンハンサー配列

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US9217155B2 (en) * 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
US20160038568A1 (en) * 2013-03-15 2016-02-11 Anchored Rsk3 Inhibitors, Llc Treatment of heart disease by inhibition of the action of ribosomal s6 kinase 3 (rsk3)

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JP2007505158A (ja) * 2003-05-21 2007-03-08 ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム 心肥大および心不全の処置としてのプロテインキナーゼC−μ(PKD)の阻害
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US9217155B2 (en) * 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
US20130136729A1 (en) * 2011-11-11 2013-05-30 University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group Compositions and methods for targeting and treating diseases and injuries using adeno-associated virus vectors
US20160038568A1 (en) * 2013-03-15 2016-02-11 Anchored Rsk3 Inhibitors, Llc Treatment of heart disease by inhibition of the action of ribosomal s6 kinase 3 (rsk3)

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SAE-WON LEE, ET AL.: "AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin", SCIENTIFIC REPORTS, vol. 5, no. 1, 1 December 2015 (2015-12-01), pages 1 - 14, XP055565478, DOI: 10.1038/srep16523 *
SILVA J.M. ET AL.: "Second-generation shRNA libraries covering the mouse and human genomes", NATURE GENETICS, NATURE PUBLISHING GROUP US, NEW YORK, vol. 37, no. 11, 1 November 2005 (2005-11-01), New York, pages 1281 - 1288, XP002521542, ISSN: 1061-4036, DOI: 10.1038/ngl650 *

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EP3658157A4 (en) 2021-03-24
ES2958662T3 (es) 2024-02-13
WO2019010301A1 (en) 2019-01-10
AU2018297274A1 (en) 2020-01-23
CA3065816A1 (en) 2019-01-10
JP2020527167A (ja) 2020-09-03
WO2019010301A8 (en) 2020-05-22
JP7193874B2 (ja) 2022-12-21
CA3065816C (en) 2024-11-19
EP3658157A1 (en) 2020-06-03
EP3658157B1 (en) 2023-07-26
US20190010493A1 (en) 2019-01-10
US10907153B2 (en) 2021-02-02

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