ES2956849T3 - Composiciones farmacéuticas mucoadhesivas de corticosteroides - Google Patents

Composiciones farmacéuticas mucoadhesivas de corticosteroides Download PDF

Info

Publication number
ES2956849T3
ES2956849T3 ES19790866T ES19790866T ES2956849T3 ES 2956849 T3 ES2956849 T3 ES 2956849T3 ES 19790866 T ES19790866 T ES 19790866T ES 19790866 T ES19790866 T ES 19790866T ES 2956849 T3 ES2956849 T3 ES 2956849T3
Authority
ES
Spain
Prior art keywords
composition
minutes
amount
approximately
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES19790866T
Other languages
English (en)
Spanish (es)
Inventor
Arnaud Grenier
Dario Carrara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Ferring BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=68296606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2956849(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring BV filed Critical Ferring BV
Application granted granted Critical
Publication of ES2956849T3 publication Critical patent/ES2956849T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0031Rectum, anus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ES19790866T 2018-10-24 2019-10-23 Composiciones farmacéuticas mucoadhesivas de corticosteroides Active ES2956849T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862749878P 2018-10-24 2018-10-24
EP19150077 2019-01-02
PCT/IB2019/059079 WO2020084530A1 (en) 2018-10-24 2019-10-23 Mucoadhesive pharmaceutical compositions of corticosteroids

Publications (1)

Publication Number Publication Date
ES2956849T3 true ES2956849T3 (es) 2023-12-29

Family

ID=68296606

Family Applications (2)

Application Number Title Priority Date Filing Date
ES19790866T Active ES2956849T3 (es) 2018-10-24 2019-10-23 Composiciones farmacéuticas mucoadhesivas de corticosteroides
ES23181722T Active ES3043383T3 (en) 2018-10-24 2019-10-23 Mucoadhesive pharmaceutical compositions of corticosteroids

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES23181722T Active ES3043383T3 (en) 2018-10-24 2019-10-23 Mucoadhesive pharmaceutical compositions of corticosteroids

Country Status (16)

Country Link
US (1) US12539306B2 (https=)
EP (3) EP4233872B1 (https=)
JP (1) JP7479362B2 (https=)
KR (1) KR102862769B1 (https=)
CN (1) CN113271979A (https=)
AU (1) AU2019365253B2 (https=)
BR (1) BR112021007140A2 (https=)
CA (1) CA3116649A1 (https=)
CL (1) CL2021001046A1 (https=)
CO (1) CO2021005913A2 (https=)
DK (1) DK3870226T3 (https=)
ES (2) ES2956849T3 (https=)
FI (2) FI3870226T3 (https=)
MX (1) MX2021004537A (https=)
PL (2) PL3870226T3 (https=)
WO (1) WO2020084530A1 (https=)

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5458879A (en) 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US5554380A (en) 1994-08-04 1996-09-10 Kv Pharmaceutical Company Bioadhesive pharmaceutical delivery system
US6319513B1 (en) 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US20010016577A1 (en) 1998-08-24 2001-08-23 Douglas Joseph Dobrozsi Oral mucoadhesive compositions containing gastrointestinal actives
WO2001028515A1 (en) * 1999-10-22 2001-04-26 Líf-Hlaup ehf. Bio-Gels Pharmaceuticals Inc. Pharmaceutical composition for treatment of mucosal epithelial ulceration and/or erosion
PT1997478E (pt) 2001-02-15 2013-12-10 Access Pharma Inc Formulações líquidas para a prevenção e para o tratamento de doenças e distúrbios das mucosas
US7544348B2 (en) 2001-02-15 2009-06-09 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
EP1531837A4 (en) * 2001-06-07 2006-11-15 Chiou Consulting Inc COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND TREATMENT OF APHTEOUS ULCERS AND LESIONS DUE TO HERPES
US20030059446A1 (en) * 2001-09-18 2003-03-27 Kulkarni Arun B. Physically stable sprayable gel composition
US20060018937A1 (en) * 2002-10-25 2006-01-26 Foamix Ltd. Steroid kit and foamable composition and uses thereof
JP2007522077A (ja) * 2003-08-21 2007-08-09 アクセス ファーマシューティカルズ, インコーポレイテッド 粘膜の疾患および障害の予防および処置のための液体製剤
US8030003B2 (en) 2004-12-07 2011-10-04 Children's Hospital Medical Center Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
CL2007002214A1 (es) 2006-08-14 2008-03-07 Boehringer Ingelheim Int Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
US20090149433A1 (en) 2007-11-13 2009-06-11 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
CN101969956B (zh) * 2007-11-13 2014-03-05 梅里蒂奇制药公司 皮质类固醇组合物
US8865692B2 (en) 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
US20090264392A1 (en) 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
CA2723215A1 (en) 2008-05-01 2009-11-05 Revalesio Corporation Compositions and methods for treating digestive disorders
US8030297B2 (en) * 2008-05-14 2011-10-04 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of OTIC disorders
ES2358158T3 (es) 2008-07-21 2011-05-06 Dr. Falk Pharma Gmbh Formulación farmacéutica para el tratamiento del tracto digestivo superior.
HUE051538T2 (hu) 2008-08-20 2021-03-01 Univ California Kortikoszteroidok a gyomor-bél traktus gyulladásos betegségeinek kezelésére
AU2009322556A1 (en) 2008-12-01 2011-07-21 Children's Hospital Medical Center Methods of determining efficacy of glucocorticoid treatment of eosinophilic esophagitis
MX2011013061A (es) * 2009-06-05 2012-02-28 Aciex Therapeutics Inc Formulaciones oftalmicas de fluticasona y metodos de uso.
WO2010144865A2 (en) 2009-06-12 2010-12-16 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
JP5833007B2 (ja) 2009-08-31 2015-12-16 ドクター・レディーズ・ラボラトリーズ・リミテッド ステロイドを含む局所製剤
MX364947B (es) 2009-10-01 2019-05-15 Adare Pharmaceuticals Inc Composiciones de corticosteroides administradas oralmente.
EP3970726A1 (en) * 2010-06-24 2022-03-23 ViroPharma Biologics LLC Methods of treatment for esophageal inflammation
CN103974706A (zh) 2011-10-06 2014-08-06 N·V·努特里奇亚 嗜酸细胞性食管炎的治疗
WO2014074995A1 (en) * 2012-11-09 2014-05-15 Scidose, Llc Enema composition for treatment of ulcerative colitis having long term stability
EP2938327B1 (en) 2012-12-26 2017-12-06 Otic Pharma Ltd. Foamable otic pharmaceutical compositions
WO2014155397A1 (en) 2013-03-29 2014-10-02 Italchimici S.P.A. Oral suspension for treating eosinophilic esophagitis
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
PT2886108T (pt) 2013-12-23 2019-04-01 Dr Falk Pharma Gmbh Formulação farmacêutica otimizada para o tratamento de alterações inflamatórias do esófago
US20160184431A1 (en) 2014-03-11 2016-06-30 Promius Pharma Llc Topical compositions comprising a corticosteroid
CA2946373C (en) * 2014-05-01 2018-07-31 Integral Biosystems Llc Membrane-adherent self-assembled systems for treatment of ocular disorders
US11623008B2 (en) 2014-08-20 2023-04-11 Professional Compounding Centers Of America Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan
DE102014119576A1 (de) * 2014-12-23 2016-06-23 Ernst-Moritz-Arndt-Universität Greifswald Pharmazeutische Arzneimittelform zur Applikation auf Schleimhäuten
US20180140619A1 (en) * 2015-05-04 2018-05-24 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for delivering therapeutic agents into the colon
BR102018008324A2 (pt) 2018-04-25 2019-11-05 Laboratorios Ferring Ltda composição farmacêutica de uso tópico e processo de fabricação de composição farmacêutica de uso tópico

Also Published As

Publication number Publication date
CL2021001046A1 (es) 2022-01-07
JP2022505535A (ja) 2022-01-14
MX2021004537A (es) 2021-06-15
AU2019365253A1 (en) 2021-05-27
FI3870226T3 (fi) 2023-09-15
FI4233872T3 (fi) 2025-10-02
DK3870226T3 (da) 2023-09-18
CO2021005913A2 (es) 2021-05-20
ES3043383T3 (en) 2025-11-25
PL3870226T3 (pl) 2023-12-27
EP3870226B1 (en) 2023-06-28
US12539306B2 (en) 2026-02-03
CN113271979A (zh) 2021-08-17
JP7479362B2 (ja) 2024-05-08
CA3116649A1 (en) 2020-04-30
WO2020084530A1 (en) 2020-04-30
EP4233872A3 (en) 2023-10-11
EP4233872A2 (en) 2023-08-30
EP3870226A1 (en) 2021-09-01
EP4233872B1 (en) 2025-07-02
US20210379081A1 (en) 2021-12-09
EP4603097A3 (en) 2025-10-22
AU2019365253B2 (en) 2025-02-20
KR20210088547A (ko) 2021-07-14
EP4603097A2 (en) 2025-08-20
KR102862769B1 (ko) 2025-09-19
BR112021007140A2 (pt) 2021-07-20
PL4233872T3 (pl) 2025-11-24

Similar Documents

Publication Publication Date Title
US20220323463A1 (en) Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
ES2660141T3 (es) Composiciones para el tratamiento de la inflamación gastrointestinal
US10272037B2 (en) Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
ES2811051T3 (es) Corticosteroides para el tratamiento de enfermedades inflamatorias del tracto gastrointestinal
ES2956849T3 (es) Composiciones farmacéuticas mucoadhesivas de corticosteroides
RU2805936C1 (ru) Мукоадгезивные фармацевтические композиции на основе кортикостероидов
WO2018193423A1 (en) Oral pharmaceutical compositions of corticosteroids
HK40096558B (en) Mucoadhesive pharmaceutical compositions of corticosteroids
HK40096558A (en) Mucoadhesive pharmaceutical compositions of corticosteroids
HK40058424B (en) Mucoadhesive pharmaceutical compositions of corticosteroids
HK40058424A (en) Mucoadhesive pharmaceutical compositions of corticosteroids