ES2956708T3 - Un dispositivo de administración de fármacos - Google Patents
Un dispositivo de administración de fármacos Download PDFInfo
- Publication number
- ES2956708T3 ES2956708T3 ES16821716T ES16821716T ES2956708T3 ES 2956708 T3 ES2956708 T3 ES 2956708T3 ES 16821716 T ES16821716 T ES 16821716T ES 16821716 T ES16821716 T ES 16821716T ES 2956708 T3 ES2956708 T3 ES 2956708T3
- Authority
- ES
- Spain
- Prior art keywords
- impregnated
- masses
- delivery device
- polymer
- approximately
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012377 drug delivery Methods 0.000 title description 21
- 238000003780 insertion Methods 0.000 claims abstract description 43
- 230000037431 insertion Effects 0.000 claims abstract description 43
- 239000012530 fluid Substances 0.000 claims abstract description 15
- 230000000717 retained effect Effects 0.000 claims abstract description 11
- 239000013543 active substance Substances 0.000 claims description 91
- -1 polyethylene Polymers 0.000 claims description 72
- 229920000642 polymer Polymers 0.000 claims description 51
- 229920001296 polysiloxane Polymers 0.000 claims description 23
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 230000014759 maintenance of location Effects 0.000 claims description 11
- 239000004677 Nylon Substances 0.000 claims description 10
- 229920001778 nylon Polymers 0.000 claims description 10
- 238000001746 injection moulding Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000004743 Polypropylene Substances 0.000 claims description 8
- 229920001155 polypropylene Polymers 0.000 claims description 8
- 238000001125 extrusion Methods 0.000 claims description 7
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 7
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 7
- 239000004700 high-density polyethylene Substances 0.000 claims description 6
- 229920001684 low density polyethylene Polymers 0.000 claims description 6
- 239000004702 low-density polyethylene Substances 0.000 claims description 6
- 239000004417 polycarbonate Substances 0.000 claims description 6
- 229920000515 polycarbonate Polymers 0.000 claims description 6
- 229920000954 Polyglycolide Polymers 0.000 claims description 5
- 238000000748 compression moulding Methods 0.000 claims description 5
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 5
- 229920001903 high density polyethylene Polymers 0.000 claims description 5
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 5
- 229920001610 polycaprolactone Polymers 0.000 claims description 5
- 239000004632 polycaprolactone Substances 0.000 claims description 5
- 239000004952 Polyamide Substances 0.000 claims description 4
- 239000005062 Polybutadiene Substances 0.000 claims description 4
- 239000004793 Polystyrene Substances 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims description 4
- 229920005669 high impact polystyrene Polymers 0.000 claims description 4
- 239000004797 high-impact polystyrene Substances 0.000 claims description 4
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 4
- 229920002492 poly(sulfone) Polymers 0.000 claims description 4
- 229920000070 poly-3-hydroxybutyrate Polymers 0.000 claims description 4
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229920006260 polyaryletherketone Polymers 0.000 claims description 4
- 229920002857 polybutadiene Polymers 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 239000004633 polyglycolic acid Substances 0.000 claims description 4
- 239000004626 polylactic acid Substances 0.000 claims description 4
- 229920000193 polymethacrylate Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- 229920000098 polyolefin Polymers 0.000 claims description 4
- 229920002223 polystyrene Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 229920002620 polyvinyl fluoride Polymers 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 229920001169 thermoplastic Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002988 biodegradable polymer Polymers 0.000 claims description 3
- 239000004621 biodegradable polymer Substances 0.000 claims description 3
- 238000005266 casting Methods 0.000 claims description 3
- 229910003460 diamond Inorganic materials 0.000 claims description 3
- 239000010432 diamond Substances 0.000 claims description 3
- 238000005304 joining Methods 0.000 claims description 3
- 229920002469 poly(p-dioxane) polymer Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920003048 styrene butadiene rubber Polymers 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 2
- 241000842962 Apoda limacodes Species 0.000 claims 1
- 244000043261 Hevea brasiliensis Species 0.000 claims 1
- 229920003052 natural elastomer Polymers 0.000 claims 1
- 229920001194 natural rubber Polymers 0.000 claims 1
- 241000124008 Mammalia Species 0.000 abstract description 19
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 172
- 239000000186 progesterone Substances 0.000 description 85
- 229960003387 progesterone Drugs 0.000 description 85
- 239000003814 drug Substances 0.000 description 31
- 229940079593 drug Drugs 0.000 description 31
- 241001465754 Metazoa Species 0.000 description 27
- 241000283690 Bos taurus Species 0.000 description 18
- 238000011068 loading method Methods 0.000 description 17
- 210000002381 plasma Anatomy 0.000 description 16
- 239000000126 substance Substances 0.000 description 15
- 229920003023 plastic Polymers 0.000 description 11
- 239000004033 plastic Substances 0.000 description 11
- 210000001215 vagina Anatomy 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 238000013461 design Methods 0.000 description 9
- 230000012173 estrus Effects 0.000 description 9
- 238000000605 extraction Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 229920002959 polymer blend Polymers 0.000 description 6
- 241000282887 Suidae Species 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
- 239000003688 hormone derivative Substances 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 235000010755 mineral Nutrition 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- 239000011782 vitamin Substances 0.000 description 5
- 235000013343 vitamin Nutrition 0.000 description 5
- 229940088594 vitamin Drugs 0.000 description 5
- 229930003231 vitamin Natural products 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 102000010907 Cyclooxygenase 2 Human genes 0.000 description 4
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 4
- 241001494479 Pecora Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000002141 anti-parasite Effects 0.000 description 4
- 229940121375 antifungal agent Drugs 0.000 description 4
- 239000003096 antiparasitic agent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000007952 growth promoter Substances 0.000 description 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
- 239000003607 modifier Substances 0.000 description 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 230000027758 ovulation cycle Effects 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- 230000000843 anti-fungal effect Effects 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- 210000004767 rumen Anatomy 0.000 description 3
- 241000894007 species Species 0.000 description 3
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 description 2
- GUHPRPJDBZHYCJ-SECBINFHSA-N (2s)-2-(5-benzoylthiophen-2-yl)propanoic acid Chemical compound S1C([C@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CC=C1 GUHPRPJDBZHYCJ-SECBINFHSA-N 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- 241000220438 Arachis Species 0.000 description 2
- 235000003911 Arachis Nutrition 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 description 2
- 241000282832 Camelidae Species 0.000 description 2
- 229930186147 Cephalosporin Natural products 0.000 description 2
- 241000282994 Cervidae Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 2
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 description 2
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 2
- 241000237503 Pectinidae Species 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- 241000282849 Ruminantia Species 0.000 description 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 229960004420 aceclofenac Drugs 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 229940126575 aminoglycoside Drugs 0.000 description 2
- 230000000507 anthelmentic effect Effects 0.000 description 2
- 239000000921 anthelmintic agent Substances 0.000 description 2
- 229940124339 anthelmintic agent Drugs 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 229940041011 carbapenems Drugs 0.000 description 2
- 229960000590 celecoxib Drugs 0.000 description 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 2
- 229940124587 cephalosporin Drugs 0.000 description 2
- 150000001780 cephalosporins Chemical class 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229940075894 denatured ethanol Drugs 0.000 description 2
- 229960003428 dexibuprofen Drugs 0.000 description 2
- HEFNNWSXXWATRW-JTQLQIEISA-N dexibuprofen Chemical compound CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-JTQLQIEISA-N 0.000 description 2
- 229960002783 dexketoprofen Drugs 0.000 description 2
- DKYWVDODHFEZIM-NSHDSACASA-N dexketoprofen Chemical compound OC(=O)[C@@H](C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-NSHDSACASA-N 0.000 description 2
- 229960001259 diclofenac Drugs 0.000 description 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 229930182833 estradiol Natural products 0.000 description 2
- 229960005293 etodolac Drugs 0.000 description 2
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 description 2
- 229960004945 etoricoxib Drugs 0.000 description 2
- MNJVRJDLRVPLFE-UHFFFAOYSA-N etoricoxib Chemical compound C1=NC(C)=CC=C1C1=NC=C(Cl)C=C1C1=CC=C(S(C)(=O)=O)C=C1 MNJVRJDLRVPLFE-UHFFFAOYSA-N 0.000 description 2
- 229960001419 fenoprofen Drugs 0.000 description 2
- 229940124307 fluoroquinolone Drugs 0.000 description 2
- 229960002390 flurbiprofen Drugs 0.000 description 2
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 2
- 229960001680 ibuprofen Drugs 0.000 description 2
- 238000005470 impregnation Methods 0.000 description 2
- 229960000905 indomethacin Drugs 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 2
- 229960000991 ketoprofen Drugs 0.000 description 2
- 230000006651 lactation Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 description 2
- 229940041033 macrolides Drugs 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 229960003987 melatonin Drugs 0.000 description 2
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 2
- 229960001929 meloxicam Drugs 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 229960002009 naproxen Drugs 0.000 description 2
- CMWTZPSULFXXJA-VIFPVBQESA-M naproxen(1-) Chemical compound C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-M 0.000 description 2
- 229920006173 natural rubber latex Polymers 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 description 2
- 229960004454 oxfendazole Drugs 0.000 description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 2
- 150000002960 penicillins Chemical class 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 2
- 229960000371 rofecoxib Drugs 0.000 description 2
- 235000020637 scallop Nutrition 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 150000003456 sulfonamides Chemical class 0.000 description 2
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 2
- 229960000894 sulindac Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- 229940040944 tetracyclines Drugs 0.000 description 2
- 229960001312 tiaprofenic acid Drugs 0.000 description 2
- 229960004089 tigecycline Drugs 0.000 description 2
- FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 description 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- WDPFQABQVGJEBZ-MAKOZQESSA-N Bothermon Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 WDPFQABQVGJEBZ-MAKOZQESSA-N 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125687 antiparasitic agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 229940124447 delivery agent Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960002418 ivermectin Drugs 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 229960001614 levamisole Drugs 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000003843 mucus production Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ70988215 | 2015-07-09 | ||
| PCT/NZ2016/050113 WO2017007342A1 (en) | 2015-07-09 | 2016-07-11 | A drug delivery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2956708T3 true ES2956708T3 (es) | 2023-12-26 |
Family
ID=57685921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16821716T Active ES2956708T3 (es) | 2015-07-09 | 2016-07-11 | Un dispositivo de administración de fármacos |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12097090B2 (enExample) |
| EP (2) | EP3319549B1 (enExample) |
| JP (2) | JP7255038B2 (enExample) |
| AR (1) | AR105308A1 (enExample) |
| AU (1) | AU2016291095B2 (enExample) |
| ES (1) | ES2956708T3 (enExample) |
| MX (2) | MX2018000355A (enExample) |
| WO (1) | WO2017007342A1 (enExample) |
| ZA (1) | ZA201800586B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4013348B1 (en) * | 2019-08-14 | 2023-12-20 | Elanco Tiergesundheit AG | New wing protector for winged capsule and method of using same |
| US20230049584A1 (en) * | 2020-02-07 | 2023-02-16 | Agilis International Limited | Device for insertion into a cavity |
| JP7741552B2 (ja) * | 2022-02-09 | 2025-09-18 | 国立研究開発法人農業・食品産業技術総合研究機構 | 腟内投与具、卵巣機能制御方法、及び製剤を家畜の腟内に投与するためのキット |
| AU2023243456A1 (en) * | 2022-03-31 | 2024-09-19 | Elanco Us Inc. | Winged capsule devices and methods |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US3854476A (en) * | 1973-04-05 | 1974-12-17 | R Dickinson | Intra-vaginal device and method |
| US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| NZ200564A (en) * | 1982-05-10 | 1987-03-06 | Ahi Operations Ltd | Device for slowly releasing chemicals into body cavities of animals |
| NZ207341A (en) | 1984-03-01 | 1988-02-29 | Harvey Alex Ind Ltd | Device containing chemical impregnants for insertion into a body cavity of an animal |
| DE3838815A1 (de) * | 1988-11-17 | 1990-05-23 | Hoechst Ag | Verfahren zum herstellen eines intravaginalen applikationssystems |
| NZ230023A (en) | 1989-07-21 | 1993-02-25 | Carter Holt Harvey Plastic Pro | Removable intra-vaginal retention device for veterinary use |
| NZ286492A (en) * | 1996-05-01 | 1998-02-26 | Dec International Nz Ltd Subst | Intra vaginal devices for synchronising oestrus of animals is made up of cured silicone rubber material with 5% by weight of progesterone |
| WO1998033452A1 (en) * | 1997-02-03 | 1998-08-06 | Dec International Nz Limited | Active delivery device and related procedures |
| WO1998053758A1 (en) | 1997-05-28 | 1998-12-03 | Dec International Nz Limited | Intra-vaginal device for pigs |
| NZ330596A (en) | 1998-06-05 | 2001-02-23 | Dec Res | Intravaginal devices allowing for increased uptake of active ingredients |
| WO1999040966A1 (en) | 1998-02-13 | 1999-08-19 | Graham Francois Duirs | Drug delivery system |
| NZ509894A (en) | 2001-02-09 | 2002-11-26 | Interag | A "T" or "Y" shaped intravaginal device suitable for delivery of pharmaceuticals such as progesterone |
| AU2003234231A1 (en) * | 2002-04-24 | 2003-11-10 | Rutgers | New polyarylates for drug delivery and tissue engineering |
| IL173762A0 (en) * | 2006-02-16 | 2006-07-05 | David Braver Dr | A device and method for the prolonged delivery of an active agent to a body cavity |
| US9333329B2 (en) | 2008-03-04 | 2016-05-10 | Elan Ziv | Vaginal carrier for the controlled release of substances |
| FI20085277A0 (fi) | 2008-04-02 | 2008-04-02 | Bayer Schering Pharma Oy | Kohdunsisäinen järjestelmä |
| US20110033519A1 (en) * | 2009-08-07 | 2011-02-10 | Leong Madeline | Device with Aromatase Inhibitor for the Treatment and Prevention of Uterine Fibroids and Method of Use |
| EP2708213A1 (en) * | 2012-09-13 | 2014-03-19 | PAT&Co bvba | Multipurpose ethylene vinyl acetate fibrous drug delivery systems for long-term implantation or insertion |
| NZ715344A (en) | 2013-05-20 | 2020-02-28 | St Reproductive Tech Llc | Sensor apparatus and associated systems and methods |
| WO2016056926A1 (en) * | 2014-10-09 | 2016-04-14 | Ulti Pharmaceuticals Limited | A substance delivery device |
-
2016
- 2016-07-11 US US15/742,751 patent/US12097090B2/en active Active
- 2016-07-11 AU AU2016291095A patent/AU2016291095B2/en active Active
- 2016-07-11 EP EP16821716.4A patent/EP3319549B1/en active Active
- 2016-07-11 AR ARP160102098A patent/AR105308A1/es active IP Right Grant
- 2016-07-11 MX MX2018000355A patent/MX2018000355A/es unknown
- 2016-07-11 EP EP23168114.9A patent/EP4230177A1/en active Pending
- 2016-07-11 WO PCT/NZ2016/050113 patent/WO2017007342A1/en not_active Ceased
- 2016-07-11 JP JP2018521171A patent/JP7255038B2/ja active Active
- 2016-07-11 ES ES16821716T patent/ES2956708T3/es active Active
-
2018
- 2018-01-09 MX MX2024011521A patent/MX2024011521A/es unknown
- 2018-01-29 ZA ZA2018/00586A patent/ZA201800586B/en unknown
-
2022
- 2022-02-07 JP JP2022017424A patent/JP2022066212A/ja not_active Withdrawn
-
2024
- 2024-08-23 US US18/813,520 patent/US20250090292A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3319549A4 (en) | 2019-02-27 |
| WO2017007342A1 (en) | 2017-01-12 |
| NZ739675A (en) | 2020-10-30 |
| ZA201800586B (en) | 2018-12-19 |
| EP4230177A1 (en) | 2023-08-23 |
| MX2018000355A (es) | 2018-08-16 |
| US20180200036A1 (en) | 2018-07-19 |
| AU2016291095A1 (en) | 2018-03-01 |
| AR105308A1 (es) | 2017-09-20 |
| CA2991017A1 (en) | 2017-01-12 |
| EP3319549A1 (en) | 2018-05-16 |
| AU2016291095B2 (en) | 2021-04-29 |
| US20250090292A1 (en) | 2025-03-20 |
| EP3319549B1 (en) | 2023-06-21 |
| BR112018000479A2 (pt) | 2018-09-18 |
| JP7255038B2 (ja) | 2023-04-11 |
| JP2018520829A (ja) | 2018-08-02 |
| JP2022066212A (ja) | 2022-04-28 |
| MX2024011521A (es) | 2024-09-25 |
| US12097090B2 (en) | 2024-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250090292A1 (en) | Drug delivery device | |
| US5840074A (en) | Method and apparatus for delivering first agent followed by second agent | |
| US6444224B1 (en) | Intra-vaginal device for pigs | |
| US6352524B1 (en) | Active delivery device with reduced passive delivery | |
| Thomasy et al. | Transdermal fentanyl combined with nonsteroidal anti‐inflammatory drugs for analgesia in horses | |
| ES2265181T3 (es) | Sistema de administracion de farmacos. | |
| PL84500B1 (enExample) | ||
| US20060051391A1 (en) | Device for the controlled administration of substances to be inserted in a body cavity | |
| KR0137261B1 (ko) | 소수성 부하물을 함유하는 지효성 전달 장치 | |
| CA2991017C (en) | A drug delivery device | |
| WO2016056926A1 (en) | A substance delivery device | |
| BR112018000479B1 (pt) | Dispositivo de entrega passível de inserção, retenção e retirada de uma cavidade de corpo de um mamífero-alvo não humano e método para fabricar um dispositivo de entrega para inserção em uma cavidade de corpo de um mamífero-alvo não humano | |
| NZ739675B2 (en) | A drug delivery device | |
| AU2021216966A1 (en) | Device for insertion into a cavity | |
| AU755686B2 (en) | Active delivery device with reduced passive delivery | |
| NZ521404A (en) | Method for maintaining progesterone plasma levels | |
| NZ314175A (en) | Intra-vaginal delivery device including a bladder of variable volume and gas generating means | |
| BUNT et al. | Design and development of controlled release intravaginal veterinary drug delivery | |
| NZ743450A (en) | Drug release device and use | |
| NZ329337A (en) | Automatic injection of liquid by delivery device system with reduced passive delivery | |
| NZ337350A (en) | Body implantable device comprising a reservoir and gas generating means for the delivery of progesterone |