ES294436A1 - Un metodo de producir una sal de un derivado sulfometilico de polimixina b o e - Google Patents
Un metodo de producir una sal de un derivado sulfometilico de polimixina b o eInfo
- Publication number
- ES294436A1 ES294436A1 ES0294436A ES294436A ES294436A1 ES 294436 A1 ES294436 A1 ES 294436A1 ES 0294436 A ES0294436 A ES 0294436A ES 294436 A ES294436 A ES 294436A ES 294436 A1 ES294436 A1 ES 294436A1
- Authority
- ES
- Spain
- Prior art keywords
- solution
- salt
- polymyxin
- precipitate
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010078777 Colistin Proteins 0.000 title abstract 3
- 229960005266 polymyxin b Drugs 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- DETXZQGDWUJKMO-UHFFFAOYSA-N 2-hydroxymethanesulfonic acid Chemical compound OCS(O)(=O)=O DETXZQGDWUJKMO-UHFFFAOYSA-N 0.000 title 2
- LUBKKVGXMXTXOZ-QGZVFWFLSA-N (+)-geodin Chemical compound COC(=O)C1=CC(=O)C=C(OC)[C@@]11C(=O)C(C(O)=C(Cl)C(C)=C2Cl)=C2O1 LUBKKVGXMXTXOZ-QGZVFWFLSA-N 0.000 title 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- ZBJNZFQKYZCUJU-PAHFEQBRSA-N N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide Polymers CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O ZBJNZFQKYZCUJU-PAHFEQBRSA-N 0.000 title 1
- 239000007795 chemical reaction product Substances 0.000 title 1
- 229960003346 colistin Drugs 0.000 title 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 title 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 title 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 title 1
- 159000000001 potassium salts Chemical class 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 6
- 239000000243 solution Substances 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000002244 precipitate Substances 0.000 abstract 4
- -1 sulphomethyl Chemical class 0.000 abstract 4
- 241000699670 Mus sp. Species 0.000 abstract 2
- 108010093965 Polymyxin B Proteins 0.000 abstract 2
- 108010040201 Polymyxins Proteins 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 238000001990 intravenous administration Methods 0.000 abstract 2
- 229920000024 polymyxin B Polymers 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 108010001478 Bacitracin Proteins 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 229930193140 Neomycin Natural products 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003708 ampul Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 abstract 1
- 229960004927 neomycin Drugs 0.000 abstract 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940041153 polymyxins Drugs 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- UCRLQOPRDMGYOA-DFTDUNEMSA-L zinc;(4r)-4-[[(2s)-2-[[(4r)-2-[(1s,2s)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2s,3s)-1-[[(3s,6r,9s,12r,15s,18r,21s)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2s)-butan-2-yl]-6-(carbox Chemical compound [Zn+2].C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@H](CC([O-])=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 UCRLQOPRDMGYOA-DFTDUNEMSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB47190/62A GB1062895A (en) | 1962-12-13 | 1962-12-13 | Sulphomethyl derivatives of polymxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES294436A1 true ES294436A1 (es) | 1964-06-01 |
Family
ID=10444070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0294436A Expired ES294436A1 (es) | 1962-12-13 | 1963-12-12 | Un metodo de producir una sal de un derivado sulfometilico de polimixina b o e |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3317506A (OSRAM) |
| AT (1) | AT249266B (OSRAM) |
| BE (1) | BE641002A (OSRAM) |
| BR (1) | BR6355349D0 (OSRAM) |
| CH (1) | CH438579A (OSRAM) |
| DE (1) | DE1518440C3 (OSRAM) |
| DK (1) | DK107559C (OSRAM) |
| ES (1) | ES294436A1 (OSRAM) |
| FR (2) | FR1605453A (OSRAM) |
| GB (1) | GB1062895A (OSRAM) |
| LU (1) | LU44997A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3476738A (en) * | 1967-12-04 | 1969-11-04 | Upjohn Co | Pentakis(n-(sulfomethyl))circulin and salts thereof |
| US3622665A (en) * | 1969-07-02 | 1971-11-23 | Upjohn Co | Process for treating gram-negative bacterial diseases with pentakis {8 n-sulfomethyl{9 {0 circulin or salt thereof |
| US9724278B2 (en) | 2008-06-13 | 2017-08-08 | Colgate-Palmolive Company | Oral compositions and uses thereof |
| UA117673C2 (uk) | 2013-01-11 | 2018-09-10 | Кселлія Фармасьютікалз Апс | Поліміксини, композиція, спосіб одержання і спосіб застосування (варіанти) |
| BR112017000228A2 (pt) | 2014-07-09 | 2017-10-31 | Xellia Pharmaceuticals Aps | polimixinas de baixa substituição e suas composições. |
| RS58792B1 (sr) | 2014-10-03 | 2019-07-31 | Xellia Pharmaceuticals Aps | Inhalacioni uređaj |
| WO2016050928A1 (en) | 2014-10-03 | 2016-04-07 | Xellia Pharmaceuticals Aps | Compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2599950A (en) * | 1947-04-30 | 1952-06-10 | American Cyanamid Co | Method of preparing polymyxin |
| US3044934A (en) * | 1960-05-19 | 1962-07-17 | Burroughs Wellcome Co | Parenteral administration of methanesulphonate of polymyxin a, b or e |
| US3228836A (en) * | 1962-10-09 | 1966-01-11 | Warner Lambert Pharmaceutical | Aldehyde complexes of colistin and polymyxin antibiotics |
-
1962
- 1962-12-13 GB GB47190/62A patent/GB1062895A/en not_active Expired
-
1963
- 1963-12-04 CH CH1488163A patent/CH438579A/de unknown
- 1963-12-04 US US328049A patent/US3317506A/en not_active Expired - Lifetime
- 1963-12-09 BE BE641002A patent/BE641002A/xx unknown
- 1963-12-10 DE DE1518440A patent/DE1518440C3/de not_active Expired
- 1963-12-11 LU LU44997A patent/LU44997A1/xx unknown
- 1963-12-11 AT AT993063A patent/AT249266B/de active
- 1963-12-11 BR BR155349/63A patent/BR6355349D0/pt unknown
- 1963-12-12 ES ES0294436A patent/ES294436A1/es not_active Expired
- 1963-12-12 FR FR957003A patent/FR1605453A/fr not_active Expired
- 1963-12-12 DK DK580063AA patent/DK107559C/da active
-
1964
- 1964-03-10 FR FR966818A patent/FR3405M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3317506A (en) | 1967-05-02 |
| DE1518440C3 (de) | 1973-09-27 |
| LU44997A1 (OSRAM) | 1964-06-11 |
| BR6355349D0 (pt) | 1973-07-19 |
| DK107559C (da) | 1967-06-12 |
| GB1062895A (en) | 1967-03-22 |
| FR3405M (fr) | 1965-07-05 |
| AT249266B (de) | 1966-09-12 |
| DE1518440A1 (de) | 1969-06-12 |
| FR1605453A (en) | 1976-02-27 |
| BE641002A (OSRAM) | 1964-06-09 |
| CH438579A (de) | 1967-06-30 |
| DE1518440B2 (de) | 1973-03-01 |
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