ES2943252T3 - Fumarato de (+)-3-(2,3-difluorofenil)-3-metoxipirrolidina, un proceso para su preparación y sus usos - Google Patents

Fumarato de (+)-3-(2,3-difluorofenil)-3-metoxipirrolidina, un proceso para su preparación y sus usos Download PDF

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Publication number
ES2943252T3
ES2943252T3 ES18730980T ES18730980T ES2943252T3 ES 2943252 T3 ES2943252 T3 ES 2943252T3 ES 18730980 T ES18730980 T ES 18730980T ES 18730980 T ES18730980 T ES 18730980T ES 2943252 T3 ES2943252 T3 ES 2943252T3
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Spain
Prior art keywords
salt
formula
compound
disorder
formula iib
Prior art date
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Active
Application number
ES18730980T
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English (en)
Spanish (es)
Inventor
Clas Sonesson
Maija Buksa
Inese Reine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Integrative Res Laboratories Sweden AB
Integrative Research Laboratories Sweden AB
Original Assignee
Integrative Res Laboratories Sweden AB
Integrative Research Laboratories Sweden AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
ES18730980T 2017-05-19 2018-05-18 Fumarato de (+)-3-(2,3-difluorofenil)-3-metoxipirrolidina, un proceso para su preparación y sus usos Active ES2943252T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17171938 2017-05-19
EP17195451 2017-10-09
EP17207406 2017-12-14
EP18151428 2018-01-12
PCT/EP2018/063123 WO2018211080A1 (en) 2017-05-19 2018-05-18 (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine or pharmaceutically acceptable salts thereof, a process for preparation thereof and uses thereof

Publications (1)

Publication Number Publication Date
ES2943252T3 true ES2943252T3 (es) 2023-06-12

Family

ID=62599537

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18730980T Active ES2943252T3 (es) 2017-05-19 2018-05-18 Fumarato de (+)-3-(2,3-difluorofenil)-3-metoxipirrolidina, un proceso para su preparación y sus usos

Country Status (10)

Country Link
US (3) US11078158B2 (OSRAM)
EP (1) EP3625213B1 (OSRAM)
JP (1) JP7126522B2 (OSRAM)
CN (1) CN110621659B (OSRAM)
CA (1) CA3064136A1 (OSRAM)
DK (1) DK3625213T3 (OSRAM)
ES (1) ES2943252T3 (OSRAM)
FI (1) FI3625213T3 (OSRAM)
PL (1) PL3625213T3 (OSRAM)
WO (1) WO2018211080A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3976581B1 (en) * 2019-05-24 2023-11-22 Irl 790 AB Tartaric acid salts of [2-(3-fluoro-5-methane-sulfonylphenoxy)ethyl](propyl)amine
BR112022025065A2 (pt) * 2020-06-10 2022-12-27 Epics Therapeutics Síntese de ácido (2s,5r)-5-(2-clorofenil)-1-(2'-metoxi-[1,1'-bifenil]-4- carbonil)pirrolidina-2-carboxílico
WO2025003437A1 (en) 2023-06-28 2025-01-02 Integrative Research Laboratories Sweden Ab A pharmaceutical composition comprising a fumaric acid salt of (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586229A1 (en) 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
EP1582524B1 (en) 2004-04-02 2008-08-13 Ludwig Maximilians Universität Method of preparing organomagnesium compounds
KR20100038295A (ko) * 2007-06-05 2010-04-14 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘
KR101660936B1 (ko) * 2008-11-24 2016-10-05 인터그레이티브 리서치 래버러토리즈 스웨덴 에이비 피질 카테콜아민성 신경전달의 조절자로서의 ３-페닐-３-메톡시피롤리딘 유도체
CN106957252B (zh) * 2014-11-19 2019-11-19 连云港恒运药业有限公司 一种质子泵抑制剂中间体及其制备方法

Also Published As

Publication number Publication date
US20200024231A1 (en) 2020-01-23
EP3625213A1 (en) 2020-03-25
WO2018211080A1 (en) 2018-11-22
JP7126522B2 (ja) 2022-08-26
DK3625213T3 (da) 2023-04-24
US20240400505A1 (en) 2024-12-05
JP2020520936A (ja) 2020-07-16
CA3064136A1 (en) 2018-11-22
FI3625213T3 (fi) 2023-05-29
US20210317081A1 (en) 2021-10-14
US12091384B2 (en) 2024-09-17
CN110621659A (zh) 2019-12-27
EP3625213B1 (en) 2023-03-08
US11078158B2 (en) 2021-08-03
CN110621659B (zh) 2023-02-28
PL3625213T3 (pl) 2023-07-17

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