ES2910165T3 - Sales de fosforamidato de difosfato de nucleósidos como compuestos contra el cáncer - Google Patents
Sales de fosforamidato de difosfato de nucleósidos como compuestos contra el cáncer Download PDFInfo
- Publication number
- ES2910165T3 ES2910165T3 ES18819340T ES18819340T ES2910165T3 ES 2910165 T3 ES2910165 T3 ES 2910165T3 ES 18819340 T ES18819340 T ES 18819340T ES 18819340 T ES18819340 T ES 18819340T ES 2910165 T3 ES2910165 T3 ES 2910165T3
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- alkyl
- compound
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- cycloalkyl
- aryl
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Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1720279.7A GB201720279D0 (en) | 2017-12-05 | 2017-12-05 | Anticancer compounds |
| PCT/GB2018/053525 WO2019110991A1 (en) | 2017-12-05 | 2018-12-05 | Salts of diphosphate phosphoramidate of nucleosides as anticancer compounds |
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| ES2910165T3 true ES2910165T3 (es) | 2022-05-11 |
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| ES18819340T Active ES2910165T3 (es) | 2017-12-05 | 2018-12-05 | Sales de fosforamidato de difosfato de nucleósidos como compuestos contra el cáncer |
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| US (2) | US11560400B2 (https=) |
| EP (2) | EP3720864B1 (https=) |
| JP (1) | JP7268819B2 (https=) |
| KR (1) | KR20200092980A (https=) |
| CN (1) | CN111527098A (https=) |
| AU (1) | AU2018379713A1 (https=) |
| BR (1) | BR112020011221A2 (https=) |
| CA (1) | CA3082269A1 (https=) |
| CL (1) | CL2020001479A1 (https=) |
| DK (1) | DK3720864T3 (https=) |
| EA (1) | EA202091218A1 (https=) |
| ES (1) | ES2910165T3 (https=) |
| GB (1) | GB201720279D0 (https=) |
| HR (1) | HRP20220451T1 (https=) |
| IL (1) | IL274808B2 (https=) |
| MA (2) | MA51006A (https=) |
| MX (1) | MX2020005850A (https=) |
| PH (1) | PH12020550728A1 (https=) |
| PL (1) | PL3720864T3 (https=) |
| PT (1) | PT3720864T (https=) |
| SG (1) | SG11202004342TA (https=) |
| WO (1) | WO2019110991A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IL291927A (en) | 2014-11-28 | 2022-06-01 | NuCana plc | Oligonucleotides containing modified nucleosides |
| JP2020164521A (ja) * | 2019-03-29 | 2020-10-08 | 国立大学法人 長崎大学 | 抗ウィルス薬 |
| CN116768949B (zh) * | 2022-07-12 | 2026-03-03 | 南京工业大学 | 一种基于3’-脱氧腺苷经化学修饰改性的具有抗癌效应的化合物 |
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| GB0505781D0 (en) | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
| WO2010135520A1 (en) | 2009-05-20 | 2010-11-25 | Chimerix, Inc. | Compounds, compositions and methods for treating viral infection |
| GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| HUE029022T2 (en) | 2011-03-01 | 2017-02-28 | Nucana Biomed Ltd | Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer |
| WO2014124430A1 (en) * | 2013-02-11 | 2014-08-14 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| SI3043803T1 (sl) | 2013-09-11 | 2022-09-30 | Emory University | Nukleotidne in nukleozidne sestave in njihova uporaba |
| CN105646629A (zh) | 2014-11-25 | 2016-06-08 | 广州市恒诺康医药科技有限公司 | L-核苷类化合物及其应用 |
| IL291927A (en) | 2014-11-28 | 2022-06-01 | NuCana plc | Oligonucleotides containing modified nucleosides |
| SG10202013032YA (en) * | 2014-12-15 | 2021-02-25 | Univ Emory | Phosphoramidates for the treatment of hepatitis b virus |
| DK3236972T3 (en) | 2014-12-26 | 2021-10-04 | Univ Emory | Antivirale N4-hydroxycytidin-derivativer |
| WO2017106710A1 (en) | 2015-12-17 | 2017-06-22 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| US20190085013A1 (en) | 2016-03-07 | 2019-03-21 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| GB201609602D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Chemical compounds |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
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| JP2021505578A (ja) | 2021-02-18 |
| US20230192750A1 (en) | 2023-06-22 |
| CN111527098A (zh) | 2020-08-11 |
| PL3720864T3 (pl) | 2022-05-02 |
| CA3082269A1 (en) | 2019-06-13 |
| HRP20220451T1 (hr) | 2022-05-27 |
| PT3720864T (pt) | 2022-04-06 |
| IL274808A (en) | 2020-07-30 |
| MA51007A (fr) | 2020-10-14 |
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| PH12020550728A1 (en) | 2021-02-15 |
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| US11560400B2 (en) | 2023-01-24 |
| GB201720279D0 (en) | 2018-01-17 |
| EP4043471A1 (en) | 2022-08-17 |
| DK3720864T3 (da) | 2022-04-11 |
| AU2018379713A1 (en) | 2020-07-23 |
| WO2019110991A1 (en) | 2019-06-13 |
| EP3720864A1 (en) | 2020-10-14 |
| MA51006A (fr) | 2020-10-14 |
| SG11202004342TA (en) | 2020-06-29 |
| BR112020011221A2 (pt) | 2020-11-17 |
| US20210171566A1 (en) | 2021-06-10 |
| EP3720864B1 (en) | 2022-01-05 |
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