ES289641A1 - Ergoline ó derivatives - Google Patents

Ergoline ó derivatives

Info

Publication number
ES289641A1
ES289641A1 ES0289641A ES289641A ES289641A1 ES 289641 A1 ES289641 A1 ES 289641A1 ES 0289641 A ES0289641 A ES 0289641A ES 289641 A ES289641 A ES 289641A ES 289641 A1 ES289641 A1 ES 289641A1
Authority
ES
Spain
Prior art keywords
methyl
acid
dihydrolysergol
general formula
ergoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0289641A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of ES289641A1 publication Critical patent/ES289641A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention comprises ergoline II derivatives of the general formula <FORM:1047164/C2/1> wherein R is a hydrogen atom or a methyl radical and R1 is an acyl radical of an alkanoic, carbamoic carboxylic acid having from 1-10 carbon atoms, or an unsubstituted aromatic or pyridine carboxylic acid and the preparation thereof by reduction of dihydrolysergic acid-2 or 1-methyl dihydrolysergic acid-2 to dihydrolysergol-2 or 1-methyl dihydrolysergol-2 and esterification of the resulting alcohol with the anhydride or chloride of the appropriate acid. Therapeutic compositions for oral or parenteral administration having oxytocic, antienteraminic, enteraminic, andrenolytic, hypotensive and sedative activity comprising a compound of the above general formula and an excipient or diluent. Reference has been directed by the Comptroller to Specification 1,008,466.
ES0289641A 1962-07-05 1963-07-04 Ergoline ó derivatives Expired ES289641A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1341062 1962-07-05

Publications (1)

Publication Number Publication Date
ES289641A1 true ES289641A1 (en) 1963-10-16

Family

ID=11144424

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0289641A Expired ES289641A1 (en) 1962-07-05 1963-07-04 Ergoline ó derivatives

Country Status (3)

Country Link
BE (1) BE634493A (en)
ES (1) ES289641A1 (en)
GB (1) GB1047164A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1048122B (en) * 1973-05-23 1980-11-20 Simes ERGOLINE CARBAMATES

Also Published As

Publication number Publication date
BE634493A (en) 1963-11-18
GB1047164A (en) 1966-11-02

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