ES2882126T3 - Inhibición de ornitina aminotransferasa con análogos de GABA para el tratamiento de carcinoma hepatocelular - Google Patents
Inhibición de ornitina aminotransferasa con análogos de GABA para el tratamiento de carcinoma hepatocelular Download PDFInfo
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- ES2882126T3 ES2882126T3 ES15856956T ES15856956T ES2882126T3 ES 2882126 T3 ES2882126 T3 ES 2882126T3 ES 15856956 T ES15856956 T ES 15856956T ES 15856956 T ES15856956 T ES 15856956T ES 2882126 T3 ES2882126 T3 ES 2882126T3
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076980P | 2014-11-07 | 2014-11-07 | |
| PCT/US2015/059738 WO2016073983A2 (en) | 2014-11-07 | 2015-11-09 | Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma |
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| Publication Number | Publication Date |
|---|---|
| ES2882126T3 true ES2882126T3 (es) | 2021-12-01 |
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| US (1) | US9603820B2 (en:Method) |
| EP (1) | EP3215144B1 (en:Method) |
| JP (1) | JP6867949B2 (en:Method) |
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| IL (1) | IL252042B (en:Method) |
| MX (1) | MX2017006022A (en:Method) |
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| US10822301B2 (en) | 2018-04-12 | 2020-11-03 | Northwestern University | 3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase |
| IL278932B2 (en) * | 2018-05-25 | 2024-03-01 | Univ Northwestern | PROCESS FOR THE SYNTHESIS OF (S)-3-AMINO-4-(DIFLUOROMETHYLENYL)CYCLOPENT-l-ENE-l-CARBOXYLIC ACID |
| EP3813816B1 (en) | 2018-06-07 | 2023-06-07 | Ovid Therapeutics Inc. | Use of (s)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid and related compounds, (1s,3s)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid in the treatment of fragile x syndrome or fragile x-associated tremor/ataxia syndrome |
| US11203596B2 (en) | 2019-02-25 | 2021-12-21 | Northwestern University | Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity |
| US11078153B2 (en) * | 2019-04-03 | 2021-08-03 | Northwestern University | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase |
| US11993569B2 (en) | 2020-01-23 | 2024-05-28 | Northwestern University | 3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases |
| EP4301724A4 (en) * | 2021-03-03 | 2025-05-28 | Northwestern University | (S)-3-AMINO-4,4-DIHALOCYCLOPENT-1-CARBOXYLIC ACID AS SELECTIVE INACTIVATORS OF HUMAN ORNITHINE AMINOTRANSFERASE |
| CN117203219A (zh) * | 2021-04-20 | 2023-12-08 | 拜斯科技术开发有限公司 | 特异性针对p-选择素的双环肽配体 |
| CN118401255A (zh) * | 2021-08-19 | 2024-07-26 | N1生命股份有限公司 | 紫杉醇缀合化合物、包含所述化合物的药物组合物及它们的使用方法 |
| WO2024196851A1 (en) * | 2023-03-17 | 2024-09-26 | Northwestern University | Bicyclic compounds as inactivators of oat and gaba-at |
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| US6794413B1 (en) * | 2002-07-19 | 2004-09-21 | Northwestern University | Compounds and related methods for inhibition of γ-aminobutyric acid aminotransferase |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| IL177609A (en) | 2006-08-21 | 2015-11-30 | Yaron Ilan | Use of gobacoline or its analogue to produce a drug to treat liver carcinoma |
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- 2015-11-09 US US14/936,153 patent/US9603820B2/en active Active
- 2015-11-09 AU AU2015342801A patent/AU2015342801A1/en not_active Abandoned
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Also Published As
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| JP6867949B2 (ja) | 2021-05-12 |
| US9603820B2 (en) | 2017-03-28 |
| JP2017533964A (ja) | 2017-11-16 |
| WO2016073983A2 (en) | 2016-05-12 |
| CA2966642A1 (en) | 2016-05-12 |
| IL252042B (en) | 2020-05-31 |
| EP3215144A2 (en) | 2017-09-13 |
| IL252042A0 (en) | 2017-06-29 |
| CA2966642C (en) | 2023-03-28 |
| WO2016073983A3 (en) | 2016-08-11 |
| US20160128958A1 (en) | 2016-05-12 |
| EP3215144A4 (en) | 2018-06-20 |
| EP3215144B1 (en) | 2021-04-28 |
| AU2015342801A1 (en) | 2017-05-18 |
| MX2017006022A (es) | 2017-11-17 |
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