ES2861048T3 - Derivados de 7-azaindol - Google Patents

Derivados de 7-azaindol Download PDF

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Publication number
ES2861048T3
ES2861048T3 ES16002047T ES16002047T ES2861048T3 ES 2861048 T3 ES2861048 T3 ES 2861048T3 ES 16002047 T ES16002047 T ES 16002047T ES 16002047 T ES16002047 T ES 16002047T ES 2861048 T3 ES2861048 T3 ES 2861048T3
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ES
Spain
Prior art keywords
salts
atoms
well
formula
compound
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16002047T
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English (en)
Spanish (es)
Inventor
Dieter Dorsch
Christian Sirrenberg
Thomas J J Mueller
Eugen Merkul
Gnuni Amatunu Karapetyan
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Merck Patent GmbH
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Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of ES2861048T3 publication Critical patent/ES2861048T3/es
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES16002047T 2011-02-01 2012-01-09 Derivados de 7-azaindol Active ES2861048T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102011009961A DE102011009961A1 (de) 2011-02-01 2011-02-01 7-Azaindolderivate

Publications (1)

Publication Number Publication Date
ES2861048T3 true ES2861048T3 (es) 2021-10-05

Family

ID=45554609

Family Applications (3)

Application Number Title Priority Date Filing Date
ES12701437.1T Active ES2608317T3 (es) 2011-02-01 2012-01-09 Derivados de 7-Azaindol
ES16002047T Active ES2861048T3 (es) 2011-02-01 2012-01-09 Derivados de 7-azaindol
ES14000623.0T Active ES2634643T3 (es) 2011-02-01 2012-01-09 Derivados de 7-azaindol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES12701437.1T Active ES2608317T3 (es) 2011-02-01 2012-01-09 Derivados de 7-Azaindol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES14000623.0T Active ES2634643T3 (es) 2011-02-01 2012-01-09 Derivados de 7-azaindol

Country Status (18)

Country Link
US (3) US8981101B2 (OSRAM)
EP (3) EP2746281B1 (OSRAM)
JP (1) JP5891249B2 (OSRAM)
KR (1) KR20140014158A (OSRAM)
CN (3) CN105712991B (OSRAM)
AR (1) AR085110A1 (OSRAM)
AU (1) AU2012213775B2 (OSRAM)
BR (1) BR112013019028A2 (OSRAM)
CA (2) CA3082435A1 (OSRAM)
DE (1) DE102011009961A1 (OSRAM)
EA (1) EA201300873A1 (OSRAM)
ES (3) ES2608317T3 (OSRAM)
HK (1) HK1226394A1 (OSRAM)
IL (1) IL227689A0 (OSRAM)
MX (1) MX2013008212A (OSRAM)
SG (1) SG192133A1 (OSRAM)
WO (1) WO2012104007A2 (OSRAM)
ZA (1) ZA201306542B (OSRAM)

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DE102010053347A1 (de) * 2010-12-03 2012-06-06 Merck Patent Gmbh 3-Hetaryl-substituierte Pyrrolo[2,3-b] pyridin-derivative als PDK1-Inhibitoren
DE102011009961A1 (de) * 2011-02-01 2012-08-02 Merck Patent Gmbh 7-Azaindolderivate
WO2013124025A1 (en) * 2012-02-21 2013-08-29 Merck Patent Gmbh Furopyridine derivatives
DE102012019369A1 (de) 2012-10-02 2014-04-03 Merck Patent Gmbh 7-Azaindolderivat
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
GB201303109D0 (en) 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
WO2014145051A1 (en) 2013-03-15 2014-09-18 Jiazhong Zhang Heterocyclic compounds and uses thereof
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
JP6499282B2 (ja) 2014-09-26 2019-04-10 ギリアード サイエンシーズ, インコーポレイテッド Tank結合キナーゼ阻害剤化合物として有用なアミノトリアジン誘導体
CN107530302A (zh) * 2015-03-04 2018-01-02 丹娜法伯癌症研究院 Melk的水杨酸酯抑制剂和使用方法
WO2016164641A1 (en) * 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MX2017015357A (es) * 2015-06-29 2018-03-16 Merck Patent Gmbh Compuestos inhibidores de serina/treonina-proteina cinasa (tbk)/inhibidor de cinasa de factor nuclear kappa-b subunidad epsilon (ikk-epsilon) y usos de los mismos.
WO2017106556A1 (en) 2015-12-17 2017-06-22 Gilead Sciences, Inc. Tank-binding kinase inhibitor compounds
US10894784B2 (en) 2015-12-18 2021-01-19 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
CN105906608B (zh) * 2016-05-03 2018-10-19 中山大学 8-氨基喹啉-松果体素杂联体及其药物组合物
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
GB201702947D0 (en) 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
US11180495B2 (en) * 2017-06-19 2021-11-23 Abbisko Therapeutics Co., Ltd. Nitrogen heteroaryl derivative having CSF1R inhibitory activity, and preparation method therefor and application thereof
US10717735B2 (en) 2017-10-13 2020-07-21 Plexxikon Inc. Solid forms of a compound for modulating kinases
JP7478142B2 (ja) * 2018-06-07 2024-05-02 ディスアーム セラピューティクス, インコーポレイテッド Sarm1阻害剤
JP2021527125A (ja) * 2018-06-07 2021-10-11 ディサーム・セラピューティクス・インコーポレイテッドDisarm Therapeutics, Inc. Sarm1阻害剤
KR20200046680A (ko) * 2018-10-25 2020-05-07 한국과학기술원 Pdk1 저해제를 포함하는 역노화 유도용 조성물
WO2025016273A1 (zh) * 2023-07-14 2025-01-23 拜西欧斯(北京)生物技术有限公司 异喹啉衍生物、包含其的药物组合物以及它们的用途

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JP2003500397A (ja) 1999-05-19 2003-01-07 スミスクライン ビーチャム パブリック リミテッド カンパニー Mrs阻害剤としての2−nh−ピリドンおよびピリミドン
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DE102010053347A1 (de) 2010-12-03 2012-06-06 Merck Patent Gmbh 3-Hetaryl-substituierte Pyrrolo[2,3-b] pyridin-derivative als PDK1-Inhibitoren
DE102011009961A1 (de) * 2011-02-01 2012-08-02 Merck Patent Gmbh 7-Azaindolderivate

Also Published As

Publication number Publication date
CN105732617A (zh) 2016-07-06
CA2826051A1 (en) 2012-08-09
EA201300873A1 (ru) 2014-02-28
ES2608317T3 (es) 2017-04-07
HK1226394A1 (zh) 2017-09-29
US20130310391A1 (en) 2013-11-21
WO2012104007A2 (de) 2012-08-09
ZA201306542B (en) 2014-05-28
CN105712991A (zh) 2016-06-29
EP2746281B1 (de) 2017-04-26
WO2012104007A3 (de) 2013-10-17
US9266887B2 (en) 2016-02-23
CA3082435A1 (en) 2012-08-09
US9725446B2 (en) 2017-08-08
EP3133074A2 (de) 2017-02-22
EP2746281A3 (de) 2014-10-08
EP3133074B1 (de) 2020-12-09
US8981101B2 (en) 2015-03-17
AU2012213775A1 (en) 2013-09-19
DE102011009961A1 (de) 2012-08-02
EP2670748A2 (de) 2013-12-11
AR085110A1 (es) 2013-09-11
US20160130269A1 (en) 2016-05-12
AU2012213775A8 (en) 2013-10-24
EP3133074A3 (de) 2017-05-17
EP2746281A2 (de) 2014-06-25
BR112013019028A2 (pt) 2016-10-04
KR20140014158A (ko) 2014-02-05
EP2670748B1 (de) 2016-09-28
JP2014509313A (ja) 2014-04-17
SG192133A1 (en) 2013-08-30
CN105732617B (zh) 2017-12-01
CA2826051C (en) 2020-08-18
IL227689A0 (en) 2013-11-25
JP5891249B2 (ja) 2016-03-22
CN105712991B (zh) 2017-12-01
ES2634643T3 (es) 2017-09-28
US20150152104A1 (en) 2015-06-04
MX2013008212A (es) 2013-08-26
CN103502247A (zh) 2014-01-08
CN103502247B (zh) 2016-02-24
AU2012213775B2 (en) 2016-11-10

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