ES284254A1 - A procedure for the production of an alpha-aminobencilopeniline (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the production of an alpha-aminobencilopeniline (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES284254A1
ES284254A1 ES284254A ES284254A ES284254A1 ES 284254 A1 ES284254 A1 ES 284254A1 ES 284254 A ES284254 A ES 284254A ES 284254 A ES284254 A ES 284254A ES 284254 A1 ES284254 A1 ES 284254A1
Authority
ES
Spain
Prior art keywords
translation
group
formula
production
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES284254A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES284254A1 publication Critical patent/ES284254A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Control Of Vending Devices And Auxiliary Devices For Vending Devices (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A process for the production of an α-aminobenzylpenicillin, which comprises the mixture of about 1.0 to 3.0 moles (per mole of 6-aminopenicillanic acid) of a 2-phenylglyclic chloride hydrochloride belonging to the group consisting of those compounds who have the formula ** (See formula) ** where R1, R2 and R3 are, each, elements belonging to the group consisting of hydrogen, nitro, di-lower alkyl, lower alkylamino, lower alkyl, fluorine, chlorine, bromine, iodine, alkoxy. lower), lower alkylthio, lower alkyl sulfonyl, sulfamyl, benzyl, phenethyl, cycloheptyl, cyclohexyl, cyclopentyl and trifluoromethyl and 6-aminopenicillanic acid in an aqueous medium maintained at about -50º C to + 20º C, a highly acidic pH value, to produce a solution of an α-aminobenzylpenicillin belonging to the group consisting of those compounds that have the formula ** (See formula) ** where R1, R2 and R3 have the same meaning as indicated above. (Machine-translation by Google Translate, not legally binding)
ES284254A 1962-01-29 1963-01-17 A procedure for the production of an alpha-aminobencilopeniline (Machine-translation by Google Translate, not legally binding) Expired ES284254A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16965762A 1962-01-29 1962-01-29

Publications (1)

Publication Number Publication Date
ES284254A1 true ES284254A1 (en) 1963-07-16

Family

ID=22616620

Family Applications (1)

Application Number Title Priority Date Filing Date
ES284254A Expired ES284254A1 (en) 1962-01-29 1963-01-17 A procedure for the production of an alpha-aminobencilopeniline (Machine-translation by Google Translate, not legally binding)

Country Status (12)

Country Link
AT (1) AT242863B (en)
BE (1) BE646913A (en)
BR (1) BR6346524D0 (en)
CH (1) CH464206A (en)
CY (1) CY411A (en)
DE (1) DE1296142B (en)
DK (1) DK133283C (en)
ES (1) ES284254A1 (en)
GB (1) GB962719A (en)
MY (1) MY6800018A (en)
NO (1) NO122925B (en)
SE (1) SE301981B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240960A (en) * 1979-03-19 1980-12-23 Bristol-Myers Company Trimethylsilyl substituted penicillins
US4278600A (en) 1979-03-19 1981-07-14 Bristol-Myers Company Production of penicillins
US4310458A (en) 1979-03-19 1982-01-12 Bristol-Myers Company Production of penicillins
US4351766A (en) * 1979-07-12 1982-09-28 Bristol-Myers Company Production of penicillins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE620519A (en) *
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
GB873049A (en) * 1958-10-06 1961-07-19 Beecham Res Lab Improvements in or relating to penicillin derivatives

Also Published As

Publication number Publication date
SE301981B (en) 1968-07-01
DK133283C (en) 1976-09-20
GB962719A (en) 1964-07-01
BR6346524D0 (en) 1973-06-14
NO122925B (en) 1971-09-06
AT242863B (en) 1965-10-11
CY411A (en) 1967-10-20
DK133283B (en) 1976-04-20
DE1296142B (en) 1969-05-29
CH464206A (en) 1968-10-31
MY6800018A (en) 1968-12-31
BE646913A (en) 1964-08-17

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