ES2833580T3 - Método y aparato para cultivar células que utilizan movimiento ondulatorio - Google Patents
Método y aparato para cultivar células que utilizan movimiento ondulatorio Download PDFInfo
- Publication number
- ES2833580T3 ES2833580T3 ES06757812T ES06757812T ES2833580T3 ES 2833580 T3 ES2833580 T3 ES 2833580T3 ES 06757812 T ES06757812 T ES 06757812T ES 06757812 T ES06757812 T ES 06757812T ES 2833580 T3 ES2833580 T3 ES 2833580T3
- Authority
- ES
- Spain
- Prior art keywords
- container
- pivot axis
- bag
- tilting
- cell culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000033001 locomotion Effects 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 23
- 238000012258 culturing Methods 0.000 title claims abstract description 11
- 238000004113 cell culture Methods 0.000 claims abstract description 35
- 239000007788 liquid Substances 0.000 claims abstract description 33
- 239000007789 gas Substances 0.000 claims abstract description 26
- 238000012546 transfer Methods 0.000 claims abstract description 24
- 230000007246 mechanism Effects 0.000 claims abstract description 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 22
- 239000001301 oxygen Substances 0.000 claims abstract description 22
- 230000010261 cell growth Effects 0.000 claims abstract description 5
- 230000014759 maintenance of location Effects 0.000 claims abstract 6
- 229920003023 plastic Polymers 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 230000000717 retained effect Effects 0.000 claims description 3
- 230000002792 vascular Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 abstract description 5
- 210000004027 cell Anatomy 0.000 description 41
- 238000002474 experimental method Methods 0.000 description 20
- 239000002609 medium Substances 0.000 description 18
- 230000012010 growth Effects 0.000 description 13
- 230000000694 effects Effects 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 230000010355 oscillation Effects 0.000 description 6
- 239000013598 vector Substances 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000035899 viability Effects 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 229920002457 flexible plastic Polymers 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000012365 batch cultivation Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 238000012807 shake-flask culturing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 239000007160 ty medium Substances 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/25—Mixing the contents of independent containers, e.g. test tubes the containers being submitted to a combination of movements other than within a horizontal plane, e.g. rectilinear and pivoting movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Mechanical Engineering (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05076493A EP1739165A1 (fr) | 2005-06-29 | 2005-06-29 | Procédé et dispositif pour la culture de cellules utilisant un mouvement de vague |
| PCT/NL2006/000319 WO2007001173A2 (fr) | 2005-06-29 | 2006-06-27 | Procede et dispositif destines a cultiver des cellules au moyen d'un mouvement ondulatoire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2833580T3 true ES2833580T3 (es) | 2021-06-15 |
Family
ID=35520516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06757812T Active ES2833580T3 (es) | 2005-06-29 | 2006-06-27 | Método y aparato para cultivar células que utilizan movimiento ondulatorio |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8889406B2 (fr) |
| EP (2) | EP1739165A1 (fr) |
| DK (1) | DK1896564T3 (fr) |
| ES (1) | ES2833580T3 (fr) |
| PL (1) | PL1896564T3 (fr) |
| WO (1) | WO2007001173A2 (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE502007004216D1 (de) * | 2006-11-14 | 2010-08-05 | Marcel Roell | Schwingmischer |
| JP5023795B2 (ja) * | 2007-04-27 | 2012-09-12 | 東洋製罐株式会社 | 細胞培養方法、細胞培養システム、及び培地調整装置 |
| US9090398B2 (en) | 2007-05-04 | 2015-07-28 | Emd Millipore Corporation | Disposable processing bag with alignment feature |
| DE102008015386B4 (de) * | 2008-03-20 | 2015-10-01 | Sartorius Stedim Biotech Gmbh | Bioreaktor |
| US20110151552A1 (en) * | 2009-12-23 | 2011-06-23 | Ge Healthcare Bio-Sciences Corp. | Bioreactors |
| US20120156669A1 (en) | 2010-05-20 | 2012-06-21 | Pond Biofuels Inc. | Biomass Production |
| US8969067B2 (en) | 2010-05-20 | 2015-03-03 | Pond Biofuels Inc. | Process for growing biomass by modulating supply of gas to reaction zone |
| US8940520B2 (en) | 2010-05-20 | 2015-01-27 | Pond Biofuels Inc. | Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply |
| US8889400B2 (en) | 2010-05-20 | 2014-11-18 | Pond Biofuels Inc. | Diluting exhaust gas being supplied to bioreactor |
| US11512278B2 (en) | 2010-05-20 | 2022-11-29 | Pond Technologies Inc. | Biomass production |
| WO2012000502A1 (fr) | 2010-07-01 | 2012-01-05 | Stobbe Tech A/S | Dispositif d'agitation et bioréacteur |
| WO2012048276A2 (fr) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Procédés et systèmes configurables pour la culture et la récolte de cellules dans un système de bioréacteur à fibres creuses |
| US9738863B2 (en) | 2011-02-23 | 2017-08-22 | Ge Healthcare Bio-Sciences Ab | Bioreactor including a rocking device |
| US20120276633A1 (en) | 2011-04-27 | 2012-11-01 | Pond Biofuels Inc. | Supplying treated exhaust gases for effecting growth of phototrophic biomass |
| US9228166B2 (en) * | 2011-12-20 | 2016-01-05 | Pall Corporation | Rockable biocontainer |
| WO2013103293A1 (fr) | 2012-01-04 | 2013-07-11 | Cellution Biotech B.V. | Procédé et appareil pour la culture de cellules |
| EP3241607B1 (fr) * | 2012-06-15 | 2019-04-10 | Life Technologies Corporation | Système de mélange de fluides ayant un boîtier de support inclinable et procédé de drainage |
| US9534261B2 (en) | 2012-10-24 | 2017-01-03 | Pond Biofuels Inc. | Recovering off-gas from photobioreactor |
| FR2997703B1 (fr) * | 2012-11-07 | 2016-12-30 | Biomerieux Sa | Procede de traitement d'au moins un echantillon biologique |
| WO2014183066A2 (fr) | 2013-05-10 | 2014-11-13 | Whitehead Institute For Biomedical Research | Modification protéique de cellules vivantes à l'aide de sortase |
| WO2015073918A1 (fr) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expansion de cellules dans un bioréacteur |
| CN106029866A (zh) * | 2014-03-07 | 2016-10-12 | 东洋制罐集团控股株式会社 | 细胞培养方法以及细胞培养装置 |
| CN106232800B (zh) | 2014-03-25 | 2020-07-03 | 泰尔茂比司特公司 | 介质的被动替代 |
| CN106715676A (zh) | 2014-09-26 | 2017-05-24 | 泰尔茂比司特公司 | 按计划供养 |
| US10105664B2 (en) * | 2014-10-30 | 2018-10-23 | Omni International, Inc. | Reciprocating tube-shaking mechanisms for processing a material |
| CN104357324B (zh) * | 2014-11-21 | 2018-12-07 | 天津艾赛博生物技术有限公司 | 一种用于生物反应器的摇动平台 |
| DK3253863T3 (da) * | 2015-02-05 | 2019-08-19 | Gen Electric | Bioreaktorsystem til celledyrkning |
| WO2017004592A1 (fr) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Croissance cellulaire à l'aide de stimuli mécaniques |
| WO2017205667A1 (fr) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Expansion cellulaire |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| CA3036691A1 (fr) | 2016-09-14 | 2018-03-22 | Vbc Holdings Llc | Systemes, appareil et procedes de commande d'un mouvement d'une culture cellulaire pour optimiser la croissance cellulaire |
| US11525113B2 (en) * | 2016-10-31 | 2022-12-13 | Global Life Sciences Solutions Usa Llc | Bioreactor assembly |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| CN110612344B (zh) | 2017-03-31 | 2023-09-12 | 泰尔茂比司特公司 | 细胞扩增 |
| CN107380296B (zh) * | 2017-08-25 | 2023-12-26 | 湖南匡楚科技有限公司 | 基于爬行机器人的化工物料混合装置 |
| CN108246183A (zh) * | 2018-01-31 | 2018-07-06 | 黑龙江省地质矿产测试应用研究所 | 一种带有温度调节功能的矿产样品自动搅拌装置 |
| EP3856886A1 (fr) | 2018-09-27 | 2021-08-04 | Global Life Sciences Solutions USA LLC | Sac à compartiments multiples pour la culture de cellules |
| US20210199484A1 (en) * | 2019-12-31 | 2021-07-01 | Pall Corporation | Biocontainer assembly for bioprocessing system |
| US11299700B1 (en) | 2021-02-19 | 2022-04-12 | Acequia Biotechnology, Llc | Bioreactor containers and methods of growing hairy roots using the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2625208C3 (de) * | 1976-06-04 | 1980-02-21 | Behringwerke Ag, 3550 Marburg | Fermenter |
| US5017490A (en) * | 1989-03-10 | 1991-05-21 | Baxter International Inc. | Method for in vitro reproduction and growth of cells in culture medium |
| US5697701A (en) * | 1996-08-02 | 1997-12-16 | Fokos Designs, Ltd. | Fluid mixer providing gentle agitation |
| US6190913B1 (en) | 1997-08-12 | 2001-02-20 | Vijay Singh | Method for culturing cells using wave-induced agitation |
| US6753178B2 (en) * | 2000-03-01 | 2004-06-22 | Clemson University | Intermittent immersion vessel apparatus and process for plant propagation |
| US6544788B2 (en) | 2001-02-15 | 2003-04-08 | Vijay Singh | Disposable perfusion bioreactor for cell culture |
| AU2002367057B2 (en) * | 2001-12-21 | 2007-01-11 | Organogenesis Inc. | Chamber with adjustable volume for cell culture and organ assist |
| US7229820B2 (en) * | 2002-06-13 | 2007-06-12 | Wilson Wolf Manufacturing Corporation | Apparatus and method for culturing and preserving tissue constructs |
-
2005
- 2005-06-29 EP EP05076493A patent/EP1739165A1/fr not_active Withdrawn
-
2006
- 2006-06-27 EP EP06757812.0A patent/EP1896564B1/fr active Active
- 2006-06-27 WO PCT/NL2006/000319 patent/WO2007001173A2/fr active Application Filing
- 2006-06-27 PL PL06757812T patent/PL1896564T3/pl unknown
- 2006-06-27 DK DK06757812.0T patent/DK1896564T3/da active
- 2006-06-27 ES ES06757812T patent/ES2833580T3/es active Active
-
2007
- 2007-12-27 US US11/964,874 patent/US8889406B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8889406B2 (en) | 2014-11-18 |
| EP1739165A1 (fr) | 2007-01-03 |
| WO2007001173A3 (fr) | 2007-03-08 |
| EP1896564A2 (fr) | 2008-03-12 |
| EP1896564B1 (fr) | 2020-09-09 |
| PL1896564T3 (pl) | 2021-05-04 |
| WO2007001173A2 (fr) | 2007-01-04 |
| DK1896564T3 (da) | 2020-11-30 |
| US20080160597A1 (en) | 2008-07-03 |
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