ES2781115T3 - Proceso y dispositivo para fraccionamiento suave de aislados funcionales derivados de granos y semillas oleaginosas - Google Patents
Proceso y dispositivo para fraccionamiento suave de aislados funcionales derivados de granos y semillas oleaginosas Download PDFInfo
- Publication number
- ES2781115T3 ES2781115T3 ES15839089T ES15839089T ES2781115T3 ES 2781115 T3 ES2781115 T3 ES 2781115T3 ES 15839089 T ES15839089 T ES 15839089T ES 15839089 T ES15839089 T ES 15839089T ES 2781115 T3 ES2781115 T3 ES 2781115T3
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- protein
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- aqueous solution
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Links
- 238000000034 method Methods 0.000 title claims abstract description 180
- 238000005194 fractionation Methods 0.000 title description 3
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- 102000004169 proteins and genes Human genes 0.000 claims abstract description 251
- 239000000284 extract Substances 0.000 claims abstract description 100
- 238000001914 filtration Methods 0.000 claims abstract description 74
- 239000007864 aqueous solution Substances 0.000 claims abstract description 64
- 239000002245 particle Substances 0.000 claims abstract description 61
- 235000013312 flour Nutrition 0.000 claims abstract description 37
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 235000019198 oils Nutrition 0.000 claims description 65
- 150000002632 lipids Chemical class 0.000 claims description 39
- 240000002791 Brassica napus Species 0.000 claims description 32
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims description 32
- 239000012466 permeate Substances 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 21
- 238000005119 centrifugation Methods 0.000 claims description 11
- 239000002244 precipitate Substances 0.000 claims description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 8
- 235000010469 Glycine max Nutrition 0.000 claims description 6
- 235000013339 cereals Nutrition 0.000 claims description 6
- 244000068988 Glycine max Species 0.000 claims description 5
- 244000020551 Helianthus annuus Species 0.000 claims description 5
- 235000003222 Helianthus annuus Nutrition 0.000 claims description 5
- 235000021374 legumes Nutrition 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims description 4
- 235000007164 Oryza sativa Nutrition 0.000 claims description 4
- 235000009566 rice Nutrition 0.000 claims description 4
- 240000004713 Pisum sativum Species 0.000 claims description 3
- 235000010582 Pisum sativum Nutrition 0.000 claims description 3
- 235000021307 Triticum Nutrition 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
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- 235000013162 Cocos nucifera Nutrition 0.000 claims description 2
- 235000004431 Linum usitatissimum Nutrition 0.000 claims description 2
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- 244000082988 Secale cereale Species 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
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- 150000002576 ketones Chemical class 0.000 claims description 2
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- 244000045232 Canavalia ensiformis Species 0.000 claims 1
- 235000010617 Phaseolus lunatus Nutrition 0.000 claims 1
- 244000098338 Triticum aestivum Species 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 230
- 239000003921 oil Substances 0.000 description 56
- 238000002474 experimental method Methods 0.000 description 55
- 238000000605 extraction Methods 0.000 description 50
- 239000000463 material Substances 0.000 description 48
- 239000003925 fat Substances 0.000 description 40
- 238000011084 recovery Methods 0.000 description 34
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 28
- 241000196324 Embryophyta Species 0.000 description 26
- 238000000751 protein extraction Methods 0.000 description 23
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- 108010064851 Plant Proteins Proteins 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
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- 235000004213 low-fat Nutrition 0.000 description 7
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- 238000002955 isolation Methods 0.000 description 5
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- 239000010935 stainless steel Substances 0.000 description 5
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- 238000013019 agitation Methods 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 238000010963 scalable process Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- 102000006395 Globulins Human genes 0.000 description 3
- 108010044091 Globulins Proteins 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 230000000433 anti-nutritional effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
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- 239000012153 distilled water Substances 0.000 description 3
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- 230000002572 peristaltic effect Effects 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 3
- -1 that is Proteins 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical class OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 235000019779 Rapeseed Meal Nutrition 0.000 description 2
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- 239000006227 byproduct Substances 0.000 description 2
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- 230000002349 favourable effect Effects 0.000 description 2
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- 238000011068 loading method Methods 0.000 description 2
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- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 235000002949 phytic acid Nutrition 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000006920 protein precipitation Effects 0.000 description 2
- 239000004456 rapeseed meal Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 238000007696 Kjeldahl method Methods 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
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- 239000006286 aqueous extract Substances 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
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- 238000002845 discoloration Methods 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 125000004383 glucosinolate group Chemical group 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000005431 greenhouse gas Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910017464 nitrogen compound Inorganic materials 0.000 description 1
- 150000002830 nitrogen compounds Chemical class 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000011165 process development Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical class COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000000956 solid--liquid extraction Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 239000013595 supernatant sample Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/12—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from cereals, wheat, bran, or molasses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/16—Vegetable proteins from soybean
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Edible Oils And Fats (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2013960 | 2014-12-11 | ||
| PCT/NL2015/050856 WO2016093698A2 (en) | 2014-12-11 | 2015-12-11 | Mild fractionation of functional isolates derived from grains and oilseeds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2781115T3 true ES2781115T3 (es) | 2020-08-28 |
Family
ID=55443296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15839089T Active ES2781115T3 (es) | 2014-12-11 | 2015-12-11 | Proceso y dispositivo para fraccionamiento suave de aislados funcionales derivados de granos y semillas oleaginosas |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10602756B2 (https=) |
| EP (1) | EP3229603B1 (https=) |
| JP (1) | JP6717828B2 (https=) |
| CN (1) | CN106998741B (https=) |
| AU (1) | AU2015361292B2 (https=) |
| CA (1) | CA2969971C (https=) |
| DK (1) | DK3229603T3 (https=) |
| ES (1) | ES2781115T3 (https=) |
| LT (1) | LT3229603T (https=) |
| PL (1) | PL3229603T3 (https=) |
| RU (1) | RU2724544C2 (https=) |
| UA (1) | UA123143C2 (https=) |
| WO (1) | WO2016093698A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10617133B2 (en) * | 2015-04-23 | 2020-04-14 | Nutriati, Inc. | Method and system for removing anti-nutritionals from a feed stock |
| PL422158A1 (pl) * | 2017-07-10 | 2019-01-14 | Napiferyn Biotech Spolka Z Ograniczona Odpowiedzialnoscia | Sposób izolacji białka z nasion roślin, izolat białkowy i zastosowanie izolatu białkowego |
| RU2019144058A (ru) | 2017-07-10 | 2021-08-10 | Напиферин Биотек Сп. Зо.О | Способ выделения белка из растительного материала |
| NL2021320B1 (en) * | 2018-07-17 | 2020-01-24 | Napiferyn Biotech Sp Z O O | Method for preparation protein-fibre concetrate from plant material |
| WO2021253135A1 (en) * | 2020-06-19 | 2021-12-23 | Botaneco Inc. | Protein compositions produced from sunflower plant materials |
| NL2028223B1 (en) | 2021-05-17 | 2022-12-02 | Napiferyn Biotech Sp Z O O | Improved method for preparation of protein-enriched products from plant material |
| NL2029591B1 (en) * | 2021-11-02 | 2023-06-01 | Cano Ela B V | Method for extracting a lipid-, a protein-, and/or a carbohydrate-containing composition from oil-rich seeds |
| US20250338868A1 (en) | 2022-05-11 | 2025-11-06 | Aarhus Universitet | Processing of whole oilseeds for manufacturing protein concentrates |
| CN115343142B (zh) * | 2022-07-28 | 2025-10-17 | 辽宁成大生物股份有限公司 | 药用卤化丁基橡胶塞表面的二甲硅油在人用狂犬病疫苗中迁移量的atr检测方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3018280A (en) * | 1958-07-08 | 1962-01-23 | Borden Co | Seedmeal protein composition |
| IE45808B1 (en) * | 1976-11-26 | 1982-12-01 | Taylor P Co Inc | Improvements in or relating to edible oilseed extracts |
| US4296026A (en) * | 1980-09-22 | 1981-10-20 | General Foods Inc. | Production of soybean protein isolate of improved purity |
| US5844086A (en) | 1996-01-31 | 1998-12-01 | Stilts Corporation | Oil seed protein extraction |
| CN1486143A (zh) * | 2000-11-21 | 2004-03-31 | μ | 改性油料种子物质 |
| CA2613103A1 (en) * | 2005-07-01 | 2007-01-11 | Burcon Nutrascience (Mb) Corp. | Production of canola protein |
| US20070207254A1 (en) * | 2006-03-03 | 2007-09-06 | Specialty Protein Producers, Inc. | Methods of separating fat from soy materials and compositions produced therefrom |
| UA113181C2 (xx) * | 2011-07-28 | 2016-12-26 | Виділення білка з олієвмісного насіння | |
| BR112015022443A2 (pt) * | 2013-03-18 | 2017-07-18 | Dsm Ip Assets Bv | método para a extração de proteínas a partir de sementes oleaginosas |
-
2015
- 2015-12-11 WO PCT/NL2015/050856 patent/WO2016093698A2/en not_active Ceased
- 2015-12-11 CN CN201580066643.9A patent/CN106998741B/zh active Active
- 2015-12-11 CA CA2969971A patent/CA2969971C/en active Active
- 2015-12-11 RU RU2017118514A patent/RU2724544C2/ru active
- 2015-12-11 AU AU2015361292A patent/AU2015361292B2/en active Active
- 2015-12-11 US US15/534,558 patent/US10602756B2/en active Active
- 2015-12-11 LT LTEP15839089.8T patent/LT3229603T/lt unknown
- 2015-12-11 DK DK15839089.8T patent/DK3229603T3/da active
- 2015-12-11 EP EP15839089.8A patent/EP3229603B1/en active Active
- 2015-12-11 UA UAA201704934A patent/UA123143C2/uk unknown
- 2015-12-11 PL PL15839089T patent/PL3229603T3/pl unknown
- 2015-12-11 ES ES15839089T patent/ES2781115T3/es active Active
- 2015-12-11 JP JP2017529835A patent/JP6717828B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017118514A3 (https=) | 2019-07-24 |
| EP3229603B1 (en) | 2020-01-15 |
| DK3229603T3 (da) | 2020-03-16 |
| PL3229603T3 (pl) | 2020-06-29 |
| CN106998741B (zh) | 2021-07-09 |
| RU2724544C2 (ru) | 2020-06-23 |
| WO2016093698A2 (en) | 2016-06-16 |
| UA123143C2 (uk) | 2021-02-24 |
| CA2969971C (en) | 2022-11-29 |
| EP3229603A2 (en) | 2017-10-18 |
| JP2018501785A (ja) | 2018-01-25 |
| AU2015361292B2 (en) | 2020-03-26 |
| RU2017118514A (ru) | 2019-01-11 |
| WO2016093698A9 (en) | 2016-08-25 |
| JP6717828B2 (ja) | 2020-07-08 |
| CN106998741A (zh) | 2017-08-01 |
| US10602756B2 (en) | 2020-03-31 |
| CA2969971A1 (en) | 2016-06-16 |
| AU2015361292A1 (en) | 2017-06-29 |
| US20170318834A1 (en) | 2017-11-09 |
| WO2016093698A3 (en) | 2016-08-04 |
| LT3229603T (lt) | 2020-02-25 |
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