ES2763184T3 - Dosificación terapéutica de una neurregulina en el tratamiento o profilaxis de la insuficiencia cardíaca - Google Patents

Dosificación terapéutica de una neurregulina en el tratamiento o profilaxis de la insuficiencia cardíaca Download PDF

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Publication number
ES2763184T3
ES2763184T3 ES17209369T ES17209369T ES2763184T3 ES 2763184 T3 ES2763184 T3 ES 2763184T3 ES 17209369 T ES17209369 T ES 17209369T ES 17209369 T ES17209369 T ES 17209369T ES 2763184 T3 ES2763184 T3 ES 2763184T3
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ES
Spain
Prior art keywords
peptide
neurregulin
days
nrg
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17209369T
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English (en)
Spanish (es)
Inventor
Anthony Caggiano
Anindita Ganguly
Jennifer Iaci
Tom Parry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acorda Therapeutics Inc
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Acorda Therapeutics Inc
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Publication of ES2763184T3 publication Critical patent/ES2763184T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES17209369T 2008-07-17 2009-07-17 Dosificación terapéutica de una neurregulina en el tratamiento o profilaxis de la insuficiencia cardíaca Active ES2763184T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13517108P 2008-07-17 2008-07-17

Publications (1)

Publication Number Publication Date
ES2763184T3 true ES2763184T3 (es) 2020-05-27

Family

ID=42005671

Family Applications (2)

Application Number Title Priority Date Filing Date
ES17209369T Active ES2763184T3 (es) 2008-07-17 2009-07-17 Dosificación terapéutica de una neurregulina en el tratamiento o profilaxis de la insuficiencia cardíaca
ES09813336.6T Active ES2664394T3 (es) 2008-07-17 2009-07-17 Dosificación terapéutica de una neuregulina o de una subsecuencia de la misma para el tratamiento o la profilaxis de la insuficiencia cardiaca

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES09813336.6T Active ES2664394T3 (es) 2008-07-17 2009-07-17 Dosificación terapéutica de una neuregulina o de una subsecuencia de la misma para el tratamiento o la profilaxis de la insuficiencia cardiaca

Country Status (13)

Country Link
US (5) US20110166068A1 (https=)
EP (3) EP3338791B1 (https=)
JP (5) JP5797112B2 (https=)
CN (3) CN107019794B (https=)
AU (3) AU2009292216B2 (https=)
BR (1) BRPI0916442A2 (https=)
CA (1) CA2731113A1 (https=)
DK (2) DK2320933T3 (https=)
ES (2) ES2763184T3 (https=)
MX (2) MX384378B (https=)
PL (2) PL3338791T3 (https=)
RU (4) RU2536938C2 (https=)
WO (1) WO2010030317A2 (https=)

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US20110166068A1 (en) * 2008-07-17 2011-07-07 Acorda Therapeutics, Inc. Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Pro-phylaxis of Heart Failure
EP3777878A1 (en) 2008-08-15 2021-02-17 Acorda Therapeutics, Inc. Compositions and methods for treatment during non-acute periods following cns neurological injury
EP2370458B1 (en) * 2008-11-28 2014-10-15 Zensun (Shanghai) Science and Technology Limited Neuregulin peptides and their use
NZ625673A (en) 2009-10-14 2015-11-27 Acorda Therapeutics Inc Use of a neuregulin to treat peripheral nerve injury
WO2013053076A1 (en) * 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
EP3842059A1 (en) * 2012-03-30 2021-06-30 Acorda Therapeutics, Inc. Ggf2 to treat surgical peripheral nerve injury or neuropathic pain therefrom
JP6542678B2 (ja) * 2013-03-06 2019-07-10 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはその断片の治療的投与の方法
EP3895724B1 (en) 2013-05-22 2025-06-25 Zensun (Shanghai) Science and Technology, Co., Ltd. Extended release of neuregulin for treating heart failure
CN110946993A (zh) 2014-01-03 2020-04-03 上海泽生科技开发股份有限公司 纽兰格林制剂的配方
CN111407882A (zh) * 2014-10-17 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
WO2017053794A1 (en) 2015-09-25 2017-03-30 Sawyer Douglas B Methods for treating cardiac injury
WO2017182500A1 (en) * 2016-04-19 2017-10-26 Leibniz-Institut Für Alternsforschung - Fritz-Lipmann-Institut E.V. (Fli) Neuregulin for the treatment and/or prevention of tumors of the nervous system
CN110835368A (zh) * 2018-08-15 2020-02-25 上海泽生科技开发股份有限公司 神经调节蛋白多肽片段及其用途
AR121035A1 (es) 2019-04-01 2022-04-13 Lilly Co Eli Compuestos de neuregulina-4 y métodos de uso
JP2022547335A (ja) * 2019-09-16 2022-11-11 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． 組換えヒトニューレグリン誘導体及びその使用
WO2023070078A1 (en) * 2021-10-22 2023-04-27 The Research Institute At Nationwide Children's Hospital Neuregulin for protection against respiratory viral infection and post-viral disease

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US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US6087323A (en) 1992-04-03 2000-07-11 Cambridge Neuroscience, Inc. Use of neuregulins as modulators of cellular communication
US7037888B1 (en) 1992-04-03 2006-05-02 Acorda Therapeutics, Inc. Methods for treating muscle diseases and disorders
US5811098A (en) * 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
US5912326A (en) 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors
US6136558A (en) * 1997-02-10 2000-10-24 Genentech, Inc. Heregulin variants
US6051401A (en) 1998-07-28 2000-04-18 Bayer Corporation Methods and constructs for protein expression
PL203689B1 (pl) 1998-09-25 2009-11-30 Cubist Pharmaceuticals Zastosowanie daptomycyny
AUPP785098A0 (en) * 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6635249B1 (en) * 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
CN1138785C (zh) * 1999-06-04 2004-02-18 周明东 生长因子神经调节蛋白及其类似物的新应用
JP2003527337A (ja) 1999-11-12 2003-09-16 エントレメッド インコーポレイテッド 抗血管新生スケジュールに基づく治療薬の投与方法
AU2001274947B2 (en) 2000-05-23 2006-08-17 Acorda Therapeutics, Inc. Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
CU23157A1 (es) * 2001-01-03 2006-07-18 Ct Ingenieria Genetica Biotech COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL
EP1569689A4 (en) 2002-01-18 2009-08-05 Novartis Vaccines & Diagnostic IL2 / ANTI-HER2-ANTIBODY COMBINATION THERAPY AGAINST CANCER, which is characterized by overexpression of the HER2-RECEPTOR PROTEIN
AU2002304965A1 (en) * 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
WO2006087420A2 (en) * 2005-02-18 2006-08-24 Orion Corporation A method for treating heart failure
JP2006265244A (ja) 2005-03-23 2006-10-05 Pfizer Prod Inc Ｃｔｌａ４抗体とホルモン治療を用いた前立腺癌の治療
US7776817B2 (en) 2005-09-02 2010-08-17 Morehouse School Of Medicine Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration
US20070213264A1 (en) * 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
ES2530526T3 (es) * 2005-12-30 2015-03-03 Zensun Shanghai Science And Technology Ltd Liberación extendida de neurregulina para mejorar la función cardíaca
WO2009108390A2 (en) 2008-02-29 2009-09-03 Acorda Therapeutics, Inc. Method for achieving desired glial growth factor 2 plasma levels
US20110166068A1 (en) 2008-07-17 2011-07-07 Acorda Therapeutics, Inc. Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Pro-phylaxis of Heart Failure
NZ625673A (en) 2009-10-14 2015-11-27 Acorda Therapeutics Inc Use of a neuregulin to treat peripheral nerve injury
EP2603221A4 (en) 2010-08-13 2014-02-26 Univ Georgetown GGF2 AND METHOD FOR ITS APPLICATION
EP3842059A1 (en) 2012-03-30 2021-06-30 Acorda Therapeutics, Inc. Ggf2 to treat surgical peripheral nerve injury or neuropathic pain therefrom

Also Published As

Publication number Publication date
US9198951B2 (en) 2015-12-01
AU2009292216B2 (en) 2015-03-05
AU2015202877B2 (en) 2017-03-09
CN102159236A (zh) 2011-08-17
DK2320933T3 (en) 2018-04-16
EP2320933A1 (en) 2011-05-18
ES2664394T3 (es) 2018-04-19
EP2320933B1 (en) 2017-12-27
RU2011105821A (ru) 2012-08-27
WO2010030317A2 (en) 2010-03-18
US20160113999A1 (en) 2016-04-28
AU2015202877A1 (en) 2015-06-18
RU2020111236A3 (https=) 2021-09-21
JP2015129137A (ja) 2015-07-16
EP3338791A1 (en) 2018-06-27
DK3338791T3 (da) 2019-12-16
EP3632459A1 (en) 2020-04-08
AU2009292216A1 (en) 2010-03-18
RU2020111236A (ru) 2021-09-21
CN107019794A (zh) 2017-08-08
BRPI0916442A2 (pt) 2018-06-19
CA2731113A1 (en) 2010-03-18
JP6189879B2 (ja) 2017-08-30
CN107019794B (zh) 2021-03-12
US11235031B2 (en) 2022-02-01
EP3338791B1 (en) 2019-09-18
RU2698090C2 (ru) 2019-08-22
JP2019196370A (ja) 2019-11-14
US20180280477A1 (en) 2018-10-04
US20110166068A1 (en) 2011-07-07
AU2017203528A1 (en) 2017-06-15
JP2022023208A (ja) 2022-02-07
JP2011528353A (ja) 2011-11-17
PL2320933T3 (pl) 2018-07-31
RU2719199C1 (ru) 2020-04-17
RU2014141514A (ru) 2016-05-10
MX384378B (es) 2025-03-14
PL3338791T3 (pl) 2020-04-30
US9956266B2 (en) 2018-05-01
RU2536938C2 (ru) 2014-12-27
HK1256637A1 (en) 2019-09-27
JP5797112B2 (ja) 2015-10-21
MX2011000696A (es) 2011-07-29
CN104623633A (zh) 2015-05-20
US20130324466A1 (en) 2013-12-05
US20200009228A1 (en) 2020-01-09
EP2320933A4 (en) 2013-02-27
JP2017200949A (ja) 2017-11-09

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