ES2753625T3 - Un método para predecir el riesgo de recaída del cáncer - Google Patents

Un método para predecir el riesgo de recaída del cáncer Download PDF

Info

Publication number
ES2753625T3
ES2753625T3 ES15778623T ES15778623T ES2753625T3 ES 2753625 T3 ES2753625 T3 ES 2753625T3 ES 15778623 T ES15778623 T ES 15778623T ES 15778623 T ES15778623 T ES 15778623T ES 2753625 T3 ES2753625 T3 ES 2753625T3
Authority
ES
Spain
Prior art keywords
genes
cancer
expression
proteins encoded
foxm1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES15778623T
Other languages
English (en)
Spanish (es)
Inventor
Adrian Bracken
Fiona Lanigan
William Gallagher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Dublin
College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
Original Assignee
University College Dublin
College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Dublin, College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin filed Critical University College Dublin
Application granted granted Critical
Publication of ES2753625T3 publication Critical patent/ES2753625T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES15778623T 2014-09-19 2015-09-18 Un método para predecir el riesgo de recaída del cáncer Active ES2753625T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14185673 2014-09-19
PCT/EP2015/071524 WO2016042164A1 (en) 2014-09-19 2015-09-18 A method of predicting risk of recurrence of cancer

Publications (1)

Publication Number Publication Date
ES2753625T3 true ES2753625T3 (es) 2020-04-13

Family

ID=51589137

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15778623T Active ES2753625T3 (es) 2014-09-19 2015-09-18 Un método para predecir el riesgo de recaída del cáncer

Country Status (9)

Country Link
US (3) US10557175B2 (de)
EP (1) EP3194621B1 (de)
JP (1) JP6730983B2 (de)
AU (1) AU2015316711B2 (de)
CA (1) CA2961725C (de)
ES (1) ES2753625T3 (de)
IL (1) IL251141B (de)
NZ (1) NZ730124A (de)
WO (1) WO2016042164A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3194621B1 (de) * 2014-09-19 2019-08-14 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Verfahren zur vorhersage des risikos des wiederauftretens von krebs
JP7131773B2 (ja) * 2016-04-29 2022-09-06 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ホルモン受容体に関連する転写活性の標的尺度
CN106039312B (zh) * 2016-05-25 2019-07-23 中山大学肿瘤防治中心 Znf367基因在制备治疗乳腺癌药物、诊断及预后评估试剂中的应用
GB201709417D0 (en) * 2017-06-14 2017-07-26 Inst Of Cancer Research: Royal Cancer Hospital Cyclin dependent kinase 4/6 inhibitors for use in methods of treating cancer
USD875753S1 (en) * 2018-03-06 2020-02-18 Ventana Medical Systems, Inc. Display screen or portion thereof with graphical user interface for biological slide scanning
EP4042161A4 (de) * 2019-10-09 2023-12-20 The University of North Carolina at Chapel Hill Dna-kopienzahlveränderungen (cnas) zum bestimmen von krebsphänotypen
EP4253567A1 (de) 2022-03-31 2023-10-04 OncoAssure Limited Verfahren zur vorhersage des risikos von aggressivem oder wiederkehrendem krebs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3470535B1 (de) 2003-06-24 2020-04-01 Genomic Health, Inc. Vorhersage der wahrscheinlichkeit eines wiederauftretens von krebs
US20080275652A1 (en) 2005-05-13 2008-11-06 Universite Libre De Bruxelles Gene-based algorithmic cancer prognosis
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
US9605319B2 (en) 2010-08-30 2017-03-28 Myriad Genetics, Inc. Gene signatures for cancer diagnosis and prognosis
EP2549399A1 (de) 2011-07-19 2013-01-23 Koninklijke Philips Electronics N.V. Beurteilung der Wnt-Weg-Aktivität mit probabilistischer Modellierung der Zielgenexpression
WO2014066796A2 (en) 2012-10-25 2014-05-01 Myriad Genetics, Inc. Breast cancer prognosis signatures
EP2958999A4 (de) 2013-02-21 2016-10-19 Myriad Genetics Inc Gensignaturen für lungenkrebsprognose und therapieauswahl
EP3194621B1 (de) * 2014-09-19 2019-08-14 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Verfahren zur vorhersage des risikos des wiederauftretens von krebs

Also Published As

Publication number Publication date
NZ730124A (en) 2023-05-26
IL251141A0 (en) 2017-04-30
JP2017536085A (ja) 2017-12-07
CA2961725C (en) 2023-04-04
EP3194621A1 (de) 2017-07-26
EP3194621B1 (de) 2019-08-14
JP6730983B2 (ja) 2020-07-29
US10557175B2 (en) 2020-02-11
IL251141B (en) 2019-09-26
US20180148788A1 (en) 2018-05-31
US20240002947A1 (en) 2024-01-04
US20200157643A1 (en) 2020-05-21
AU2015316711B2 (en) 2021-10-21
AU2015316711A1 (en) 2017-04-06
WO2016042164A1 (en) 2016-03-24
CA2961725A1 (en) 2016-03-24

Similar Documents

Publication Publication Date Title
ES2753625T3 (es) Un método para predecir el riesgo de recaída del cáncer
Jadaliha et al. Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer
Toraih et al. Pilot study of serum microRNA-21 as a diagnostic and prognostic biomarker in Egyptian breast cancer patients
Magnani et al. The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer
Liu et al. Keratin 17 activates AKT signalling and induces epithelial-mesenchymal transition in oesophageal squamous cell carcinoma
Zhang et al. Down-regulation of long non-coding RNA MEG3 serves as an unfavorable risk factor for survival of patients with breast cancer
US20170107577A1 (en) Determining Cancer Aggressiveness, Prognosis and Responsiveness to Treatment
Wu et al. The expression profiles of microRNAs in Kaposi’s sarcoma
US20140302042A1 (en) Methods of predicting prognosis in cancer
Fan et al. Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer
JP2011500071A (ja) 遺伝子に基づくアルゴリズム的ガン予後及び患者の臨床結果
Milioli et al. The discovery of novel biomarkers improves breast cancer intrinsic subtype prediction and reconciles the labels in the metabric data set
WO2015157772A1 (en) Hsf1 in tumor stroma
Tan et al. Long noncoding RNA VPS9D1-AS1 overexpression predicts a poor prognosis in non-small cell lung cancer
US11680298B2 (en) Method of identifying risk of cancer and therapeutic options
JP2016523527A (ja) 抗がん薬剤に対する感受性及び耐性を解析する、がん患者の予後を予測する及び個別化治療方法のためのアッセイ、方法及びキット
Li et al. Validation of ESM1 related to ovarian cancer and the biological function and prognostic significance
Zhang et al. Dysregulation of DNA methylation patterns may identify patients with breast cancer resistant to endocrine therapy: A predictive classifier based on differentially methylated regions
Ou-Yang et al. Identification of CHD4-β1 integrin axis as a prognostic marker in triple-negative breast cancer using next-generation sequencing and bioinformatics
US20150322533A1 (en) Prognosis of breast cancer patients by monitoring the expression of two genes
Yu et al. MicroRNA‑200a‑3p and GATA6 are abnormally expressed in patients with non‑small cell lung cancer and exhibit high clinical diagnostic efficacy
Cheng et al. A three-microRNA signature predicts clinical outcome in breast cancer patients.
Yan et al. Signaling networks of activated oncogenic and altered tumor suppressor genes in head and neck cancer
Dadiani et al. Tumor evolution inferred by patterns of microRNA expression through the course of disease, therapy, and recurrence in breast cancer
Gao et al. A tumor microenvironment-related mRNA–ncRNA signature for prediction early relapse and chemotherapeutic sensitivity in early-stage lung adenocarcinoma