ES274951A1 - Process for the production of water-soluble derivatives of tetracyclines - Google Patents
Process for the production of water-soluble derivatives of tetracyclinesInfo
- Publication number
- ES274951A1 ES274951A1 ES0274951A ES274951A ES274951A1 ES 274951 A1 ES274951 A1 ES 274951A1 ES 0274951 A ES0274951 A ES 0274951A ES 274951 A ES274951 A ES 274951A ES 274951 A1 ES274951 A1 ES 274951A1
- Authority
- ES
- Spain
- Prior art keywords
- water
- tetracycline
- tetracyclines
- production
- soluble derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A water-soluble derivative of a tetracycline is prepared by treating an aqueous suspension of a tetracycline with formaldehyde at a pH value between 5 and 9. The tetracycline may be tetracycline itself, chlorotetracycline, oxytetracycline or demethylchlorotetracycline. The formaldehyde may be added in aqueous solution, in gaseous form or as paraldehyde, and the soluble product may be separated by lyophilization or by precipitation with a mixture of water-miscible organic solvents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH365461A CH408908A (en) | 1961-03-27 | 1961-03-27 | Process for the preparation of water-soluble derivatives of tetracyclines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES274951A1 true ES274951A1 (en) | 1962-07-01 |
Family
ID=4260650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0274951A Expired ES274951A1 (en) | 1961-03-27 | 1962-02-24 | Process for the production of water-soluble derivatives of tetracyclines |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE615398A (en) |
| BR (1) | BR6237270D0 (en) |
| CH (1) | CH408908A (en) |
| ES (1) | ES274951A1 (en) |
| FR (2) | FR1558901A (en) |
| GB (1) | GB955902A (en) |
| SE (1) | SE311649B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3247250A (en) * | 1964-09-30 | 1966-04-19 | Eastman Kodak Co | Carboxamido nu-substituted tetracyclines |
-
1961
- 1961-03-27 CH CH365461A patent/CH408908A/en unknown
-
1962
- 1962-02-24 ES ES0274951A patent/ES274951A1/en not_active Expired
- 1962-03-19 GB GB10467/62A patent/GB955902A/en not_active Expired
- 1962-03-20 BR BR137270/62A patent/BR6237270D0/en unknown
- 1962-03-20 FR FR1558901D patent/FR1558901A/fr not_active Expired
- 1962-03-21 BE BE615398A patent/BE615398A/en unknown
- 1962-03-26 SE SE3352/62A patent/SE311649B/xx unknown
- 1962-06-19 FR FR901195A patent/FR2005M/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE615398A (en) | 1962-07-16 |
| GB955902A (en) | 1964-04-22 |
| BR6237270D0 (en) | 1973-05-24 |
| SE311649B (en) | 1969-06-23 |
| FR1558901A (en) | 1969-03-07 |
| FR2005M (en) | 1963-09-09 |
| CH408908A (en) | 1966-03-15 |
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