ES2715204T3 - Tratamiento de la enfermedad de Dupuytren - Google Patents
Tratamiento de la enfermedad de Dupuytren Download PDFInfo
- Publication number
- ES2715204T3 ES2715204T3 ES11779628T ES11779628T ES2715204T3 ES 2715204 T3 ES2715204 T3 ES 2715204T3 ES 11779628 T ES11779628 T ES 11779628T ES 11779628 T ES11779628 T ES 11779628T ES 2715204 T3 ES2715204 T3 ES 2715204T3
- Authority
- ES
- Spain
- Prior art keywords
- disease
- tnf
- composition
- dupuytren
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 55
- 208000001708 Dupuytren contracture Diseases 0.000 title claims description 65
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 122
- 239000005557 antagonist Substances 0.000 claims abstract description 89
- 201000010099 disease Diseases 0.000 claims abstract description 80
- 239000000203 mixture Substances 0.000 claims abstract description 61
- 230000008602 contraction Effects 0.000 claims abstract description 57
- 230000000893 fibroproliferative effect Effects 0.000 claims abstract description 32
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 14
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 6
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 5
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract 4
- 102000029816 Collagenase Human genes 0.000 claims description 55
- 108060005980 Collagenase Proteins 0.000 claims description 55
- 229960002424 collagenase Drugs 0.000 claims description 53
- 210000002744 extracellular matrix Anatomy 0.000 claims description 34
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 33
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 33
- 210000001519 tissue Anatomy 0.000 claims description 33
- 239000003795 chemical substances by application Substances 0.000 claims description 32
- 230000015556 catabolic process Effects 0.000 claims description 28
- 238000006731 degradation reaction Methods 0.000 claims description 28
- 238000003776 cleavage reaction Methods 0.000 claims description 24
- 230000007017 scission Effects 0.000 claims description 24
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 14
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 14
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 206010016629 fibroma Diseases 0.000 claims description 12
- 206010049444 fibromatosis Diseases 0.000 claims description 12
- 206010034464 Periarthritis Diseases 0.000 claims description 11
- 208000024891 symptom Diseases 0.000 claims description 9
- 208000016272 Ledderhose disease Diseases 0.000 claims description 6
- 229960003115 certolizumab pegol Drugs 0.000 claims description 6
- 229960000598 infliximab Drugs 0.000 claims description 6
- 208000009975 plantar fibromatosis Diseases 0.000 claims description 6
- 208000004362 Penile Induration Diseases 0.000 claims description 5
- 208000020758 Peyronie disease Diseases 0.000 claims description 5
- 102100040247 Tumor necrosis factor Human genes 0.000 claims description 5
- 230000000699 topical effect Effects 0.000 claims description 5
- 108010008165 Etanercept Proteins 0.000 claims description 4
- 229960002964 adalimumab Drugs 0.000 claims description 4
- 229960000403 etanercept Drugs 0.000 claims description 4
- 229960001743 golimumab Drugs 0.000 claims description 4
- 210000002435 tendon Anatomy 0.000 claims description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 85
- 210000000651 myofibroblast Anatomy 0.000 description 63
- 210000002950 fibroblast Anatomy 0.000 description 45
- 230000000694 effects Effects 0.000 description 31
- 208000035475 disorder Diseases 0.000 description 30
- 102000005622 Receptor for Advanced Glycation End Products Human genes 0.000 description 24
- 108010045108 Receptor for Advanced Glycation End Products Proteins 0.000 description 24
- 238000000034 method Methods 0.000 description 21
- 230000002500 effect on skin Effects 0.000 description 19
- 238000004519 manufacturing process Methods 0.000 description 18
- 210000003491 skin Anatomy 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 16
- 238000010586 diagram Methods 0.000 description 15
- 239000011159 matrix material Substances 0.000 description 15
- 210000001616 monocyte Anatomy 0.000 description 14
- 102000008186 Collagen Human genes 0.000 description 13
- 108010035532 Collagen Proteins 0.000 description 13
- 229920001436 collagen Polymers 0.000 description 13
- 239000000512 collagen gel Substances 0.000 description 12
- 238000001356 surgical procedure Methods 0.000 description 12
- 239000012634 fragment Substances 0.000 description 11
- 210000001503 joint Anatomy 0.000 description 11
- 230000002255 enzymatic effect Effects 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- 230000009467 reduction Effects 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 description 9
- 108700010013 HMGB1 Proteins 0.000 description 9
- 101150021904 HMGB1 gene Proteins 0.000 description 9
- 102100037907 High mobility group protein B1 Human genes 0.000 description 9
- 102000005741 Metalloproteases Human genes 0.000 description 9
- 108010006035 Metalloproteases Proteins 0.000 description 9
- 210000004969 inflammatory cell Anatomy 0.000 description 9
- 239000003112 inhibitor Substances 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- KPKZJLCSROULON-QKGLWVMZSA-N Phalloidin Chemical compound N1C(=O)[C@@H]([C@@H](O)C)NC(=O)[C@H](C)NC(=O)[C@H](C[C@@](C)(O)CO)NC(=O)[C@H](C2)NC(=O)[C@H](C)NC(=O)[C@@H]3C[C@H](O)CN3C(=O)[C@@H]1CSC1=C2C2=CC=CC=C2N1 KPKZJLCSROULON-QKGLWVMZSA-N 0.000 description 8
- 102100032442 Protein S100-A8 Human genes 0.000 description 8
- 238000009826 distribution Methods 0.000 description 8
- 210000002540 macrophage Anatomy 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 206010061818 Disease progression Diseases 0.000 description 7
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 7
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 7
- 230000006399 behavior Effects 0.000 description 7
- 230000001588 bifunctional effect Effects 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000005750 disease progression Effects 0.000 description 7
- 239000000835 fiber Substances 0.000 description 7
- 230000001965 increasing effect Effects 0.000 description 7
- 230000004054 inflammatory process Effects 0.000 description 7
- 108020004999 messenger RNA Proteins 0.000 description 7
- 230000002265 prevention Effects 0.000 description 7
- 230000002035 prolonged effect Effects 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 6
- 230000001419 dependent effect Effects 0.000 description 6
- 230000004069 differentiation Effects 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 238000010166 immunofluorescence Methods 0.000 description 6
- 210000000811 metacarpophalangeal joint Anatomy 0.000 description 6
- 230000008506 pathogenesis Effects 0.000 description 6
- 239000013610 patient sample Substances 0.000 description 6
- 238000011477 surgical intervention Methods 0.000 description 6
- 102000007469 Actins Human genes 0.000 description 5
- 108010085238 Actins Proteins 0.000 description 5
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 description 5
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 5
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 5
- 102100025136 Macrosialin Human genes 0.000 description 5
- 241001529936 Murinae Species 0.000 description 5
- 102000001400 Tryptase Human genes 0.000 description 5
- 108060005989 Tryptase Proteins 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 231100000673 dose–response relationship Toxicity 0.000 description 5
- 230000036252 glycation Effects 0.000 description 5
- 210000003630 histaminocyte Anatomy 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 4
- 108010028275 Leukocyte Elastase Proteins 0.000 description 4
- 102000016799 Leukocyte elastase Human genes 0.000 description 4
- 108010009711 Phalloidine Proteins 0.000 description 4
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000003111 delayed effect Effects 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 210000003195 fascia Anatomy 0.000 description 4
- 230000003176 fibrotic effect Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 231100000241 scar Toxicity 0.000 description 4
- 210000002460 smooth muscle Anatomy 0.000 description 4
- 230000009897 systematic effect Effects 0.000 description 4
- 230000008733 trauma Effects 0.000 description 4
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 4
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 3
- 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 description 3
- 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 description 3
- 102100032420 Protein S100-A9 Human genes 0.000 description 3
- 210000002798 bone marrow cell Anatomy 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 210000002808 connective tissue Anatomy 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 230000002688 persistence Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000000770 proinflammatory effect Effects 0.000 description 3
- 230000002062 proliferating effect Effects 0.000 description 3
- 238000011321 prophylaxis Methods 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241001112695 Clostridiales Species 0.000 description 2
- 206010061819 Disease recurrence Diseases 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000004761 fibrosis Effects 0.000 description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
- 201000010603 frozen shoulder Diseases 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- -1 mast cells Proteins 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000000394 mitotic effect Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 210000003899 penis Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000001124 posttranscriptional effect Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 210000001626 skin fibroblast Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940022743 xiaflex Drugs 0.000 description 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 1
- OFNXOACBUMGOPC-HZYVHMACSA-N 5'-hydroxystreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](CO)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O OFNXOACBUMGOPC-HZYVHMACSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004266 Collagen Type IV Human genes 0.000 description 1
- 108010042086 Collagen Type IV Proteins 0.000 description 1
- 206010012559 Developmental delay Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010014954 Eosinophilic fasciitis Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 208000032912 Local swelling Diseases 0.000 description 1
- 101150053046 MYD88 gene Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 description 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 description 1
- 201000003687 Plantar fascial fibromatosis Diseases 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102100029812 Protein S100-A12 Human genes 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 102000003743 Relaxin Human genes 0.000 description 1
- 108090000103 Relaxin Proteins 0.000 description 1
- 108010081750 Reticulin Proteins 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 102000002689 Toll-like receptor Human genes 0.000 description 1
- 108020000411 Toll-like receptor Proteins 0.000 description 1
- 102100024333 Toll-like receptor 2 Human genes 0.000 description 1
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 description 1
- 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 description 1
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 description 1
- 102100038217 Vascular endothelial growth factor B Human genes 0.000 description 1
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 description 1
- 102000013127 Vimentin Human genes 0.000 description 1
- 108010065472 Vimentin Proteins 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 108010055267 advanced glycation end products-bovine serum albumin Proteins 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000037020 contractile activity Effects 0.000 description 1
- 238000011262 co‐therapy Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 210000001145 finger joint Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- OFNXOACBUMGOPC-UHFFFAOYSA-N hydroxystreptomycin Natural products CNC1C(O)C(O)C(CO)OC1OC1C(C=O)(O)C(CO)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O OFNXOACBUMGOPC-UHFFFAOYSA-N 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- OKPOKMCPHKVCPP-UHFFFAOYSA-N isoorientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(OC)=C(O)C=C3CCN2C)=C1 OKPOKMCPHKVCPP-UHFFFAOYSA-N 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000012148 non-surgical treatment Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 208000030346 palmar fibromatosis Diseases 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000009522 phase III clinical trial Methods 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229960005095 pioglitazone Drugs 0.000 description 1
- 235000017924 poor diet Nutrition 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000026447 protein localization Effects 0.000 description 1
- 208000019539 pyogenic bacterial infections due to MyD88 deficiency Diseases 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- JTQHYPFKHZLTSH-UHFFFAOYSA-N reticulin Natural products COC1CC(OC2C(CO)OC(OC3C(O)CC(OC4C(C)OC(CC4OC)OC5CCC6(C)C7CCC8(C)C(CCC8(O)C7CC=C6C5)C(C)O)OC3C)C(O)C2OC)OC(C)C1O JTQHYPFKHZLTSH-UHFFFAOYSA-N 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960003433 thalidomide Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 210000005048 vimentin Anatomy 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Marine Sciences & Fisheries (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1018325.9A GB201018325D0 (en) | 2010-10-30 | 2010-10-30 | Treatment for dupuytren's disease |
| GBGB1018362.2A GB201018362D0 (en) | 2010-11-01 | 2010-11-01 | Treatment of dupuytren's disease |
| GBGB1113718.9A GB201113718D0 (en) | 2011-08-10 | 2011-08-10 | Treatment of Dupuytren's Disease |
| PCT/EP2011/069147 WO2012056044A1 (en) | 2010-10-30 | 2011-10-31 | Treatment for dupuytren's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2715204T3 true ES2715204T3 (es) | 2019-06-03 |
Family
ID=44913268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11779628T Active ES2715204T3 (es) | 2010-10-30 | 2011-10-31 | Tratamiento de la enfermedad de Dupuytren |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9138458B2 (enExample) |
| EP (1) | EP2632446B1 (enExample) |
| JP (2) | JP6004494B2 (enExample) |
| AU (2) | AU2011322482B2 (enExample) |
| CA (1) | CA2847197C (enExample) |
| DK (1) | DK2632446T3 (enExample) |
| ES (1) | ES2715204T3 (enExample) |
| RU (1) | RU2013123796A (enExample) |
| WO (1) | WO2012056044A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012056044A1 (en) | 2010-10-30 | 2012-05-03 | Imperial Innovations Ltd | Treatment for dupuytren's disease |
| BR112014027347A2 (pt) | 2012-05-01 | 2017-06-27 | Proteolease Ltd | método para extrair um dente em um sujeito com essa necessidade, método para substituir um dente com um implante dentário e kit para extrair um dente |
| WO2013169382A1 (en) * | 2012-05-07 | 2013-11-14 | DePuy Synthes Products, LLC | Methods and devices for treating intervertebral disc disease |
| US20160158325A1 (en) * | 2013-07-11 | 2016-06-09 | 180 Therapeutics Lp | Method of treating fibroproliferative disorders including dupuytren's disease with one or more specific human matrix metalloproteinase and a tnf antagonist |
| AU2016226415B2 (en) * | 2015-03-02 | 2021-09-09 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using a TNF receptor 2 antagonist |
| US12344667B2 (en) * | 2016-04-08 | 2025-07-01 | 180 Therapeutics Lp | Method of treating early stage Dupuytren's disease |
| US20190202907A1 (en) * | 2016-09-02 | 2019-07-04 | 180 Therapeutics Lp | Method of treating systemic fibrotic disorders using an il-33/tnf bispecific antibody |
| WO2018045210A1 (en) * | 2016-09-02 | 2018-03-08 | Therapeutics Lp 180 | Method of treating localized fibrotic disorders using an il-33/tnf bispecific antibody |
| US11564963B2 (en) | 2017-11-22 | 2023-01-31 | Progeneron, Llc | Topical compositions, process of large-scale manufacture, and method of use |
| EP3980022B1 (en) | 2019-06-07 | 2025-01-15 | Dale Biotech, LLC | Treatment of dupuytren's disease, osteoarthritis, or adhesive capsulitis with rhamnolipids. |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0939121T4 (da) * | 1989-09-12 | 2008-02-04 | Ahp Mfg B V | TNF-bindende proteiner |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| GB9405076D0 (en) * | 1994-03-16 | 1994-04-27 | Inst Of Ophtalmology | A medical use of matrix metalloproteinase inhibitors |
| US6486140B2 (en) | 1994-07-19 | 2002-11-26 | Medicarb Ab | Agents, and methods employing them, for the prevention or reduction of tissue adhesion at a wound site |
| US5589171A (en) | 1994-08-22 | 1996-12-31 | Advance Biofactures Of Curacao | Treatment of Dupuytren's disease with collagenase |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| CN1083337C (zh) | 1996-03-26 | 2002-04-24 | 精工爱普生株式会社 | 打印装置及其控制方法 |
| US6086872A (en) | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
| US6031005A (en) * | 1998-08-03 | 2000-02-29 | Easterling; W. Jerry | Composition and method for treating Peyronie's disease and related connective tissue disorders |
| US6060474A (en) * | 1998-11-05 | 2000-05-09 | New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Method for preventing scar tissue formation |
| GB0105330D0 (en) | 2001-03-02 | 2001-04-18 | Renovo Ltd | Genetic testing |
| US7754217B2 (en) * | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
| WO2002087576A1 (en) * | 2001-04-30 | 2002-11-07 | Arachnova Therapeutics Ltd. | The treatment of scarring and related conditions using ppar-gamma activators |
| DE60327075D1 (de) | 2002-07-05 | 2009-05-20 | Univ Laval | Der entzündungsreaktionen |
| GB0306165D0 (en) | 2003-03-18 | 2003-04-23 | Delta G Ltd | Medical treatment |
| US20080025986A1 (en) * | 2003-06-06 | 2008-01-31 | Ozes Osman N | Methods of Treating Tnf-Mediated Disorders |
| JP2007519756A (ja) * | 2004-01-30 | 2007-07-19 | アンジオテック インターナショナル アーゲー | 拘縮を治療するための組成物および方法 |
| KR20090130158A (ko) * | 2005-01-21 | 2009-12-17 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 유착 관절낭염을 치료하는 방법 |
| US7431927B2 (en) * | 2005-03-24 | 2008-10-07 | Epitomics, Inc. | TNFα-neutralizing antibodies |
| AU2010221213B2 (en) | 2009-03-06 | 2014-10-23 | Kenneth William Gregg | Composition for controlling fish |
| WO2010102262A1 (en) | 2009-03-06 | 2010-09-10 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloprotease 1 und uses thereof |
| WO2012056044A1 (en) | 2010-10-30 | 2012-05-03 | Imperial Innovations Ltd | Treatment for dupuytren's disease |
-
2011
- 2011-10-31 WO PCT/EP2011/069147 patent/WO2012056044A1/en not_active Ceased
- 2011-10-31 AU AU2011322482A patent/AU2011322482B2/en active Active
- 2011-10-31 CA CA2847197A patent/CA2847197C/en active Active
- 2011-10-31 EP EP11779628.4A patent/EP2632446B1/en active Active
- 2011-10-31 ES ES11779628T patent/ES2715204T3/es active Active
- 2011-10-31 US US13/882,262 patent/US9138458B2/en active Active
- 2011-10-31 JP JP2013535462A patent/JP6004494B2/ja active Active
- 2011-10-31 RU RU2013123796/15A patent/RU2013123796A/ru not_active Application Discontinuation
- 2011-10-31 DK DK11779628.4T patent/DK2632446T3/en active
-
2015
- 2015-09-11 US US14/852,442 patent/US10273296B2/en active Active
-
2016
- 2016-08-29 JP JP2016166524A patent/JP2017014266A/ja active Pending
-
2017
- 2017-06-23 AU AU2017204267A patent/AU2017204267B2/en active Active
-
2019
- 2019-04-30 US US16/399,547 patent/US10669334B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10669334B2 (en) | 2020-06-02 |
| US9138458B2 (en) | 2015-09-22 |
| RU2013123796A (ru) | 2014-12-10 |
| EP2632446A1 (en) | 2013-09-04 |
| EP2632446B1 (en) | 2018-12-12 |
| AU2017204267A1 (en) | 2017-07-13 |
| WO2012056044A1 (en) | 2012-05-03 |
| US20130287760A1 (en) | 2013-10-31 |
| JP2013540803A (ja) | 2013-11-07 |
| AU2011322482A1 (en) | 2013-05-23 |
| AU2011322482B2 (en) | 2017-03-23 |
| AU2017204267B2 (en) | 2019-05-23 |
| US20160280775A1 (en) | 2016-09-29 |
| CA2847197C (en) | 2020-11-03 |
| US10273296B2 (en) | 2019-04-30 |
| CA2847197A1 (en) | 2012-05-03 |
| US20190322733A1 (en) | 2019-10-24 |
| JP2017014266A (ja) | 2017-01-19 |
| JP6004494B2 (ja) | 2016-10-12 |
| DK2632446T3 (en) | 2019-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2715204T3 (es) | Tratamiento de la enfermedad de Dupuytren | |
| WO2015027120A1 (en) | Compositions and methods for targeting connexin hemichannels | |
| KR20210106531A (ko) | 암 치료를 위한 조성물 및 방법 | |
| US20240117023A1 (en) | Method | |
| US20240101658A1 (en) | Osteopontin monoclonal antibodies for cancer and osteoporosis immunotherapy | |
| EP1812797B1 (en) | Compositions and methods for the treatment and prevention of hyperproliferative diseases | |
| US12221463B2 (en) | Method of promoting wound healing by inhibiting CCR3 | |
| Gilpin | Self-Healing Hyaluronic Acid as a Viscosupplement and Biomolecule Carrier to Mitigate Post-Traumatic Osteoarthritis | |
| Nanchahal et al. | Treatment for dupuytren's disease | |
| CN120242032A (zh) | 一种用于肝内胆管癌化疗的组合物及其应用 | |
| CN121003696A (zh) | 一种靶向b细胞和软骨细胞衰老的骨关节炎治疗药物 | |
| Blessing | The antifibrotic properties of relaxin-2 and its novel use for the treatment of adhesive capsulitis | |
| ES2710220A1 (es) | Compuestos anti-conexina para su uso en la prevención y/o el tratamiento de enfermedades degenerativas de las articulaciones | |
| CN111281864A (zh) | S-烯丙基-半胱氨酸在制备延缓及治疗骨关节炎药物中的应用 | |
| Copenhagen | 7th Joint Meeting of the European Tissue Repair Society (ETRS) with the Wound Healing Society | |
| Castellucci et al. | 43nd Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung eV (ADF) | |
| HK1102626B (en) | Compositions and methods for the treatment and prevention of hyperproliferative diseases |