ES2713681T3 - Moduladores de ROR gamma de sulfona carbocíclica - Google Patents
Moduladores de ROR gamma de sulfona carbocíclica Download PDFInfo
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- ES2713681T3 ES2713681T3 ES15700817T ES15700817T ES2713681T3 ES 2713681 T3 ES2713681 T3 ES 2713681T3 ES 15700817 T ES15700817 T ES 15700817T ES 15700817 T ES15700817 T ES 15700817T ES 2713681 T3 ES2713681 T3 ES 2713681T3
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- substituted
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- 0 Cc1ccccc1* Chemical compound Cc1ccccc1* 0.000 description 2
- DRNCQCDBLRUPTF-UHFFFAOYSA-N C=C(C1)CC1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc2ccccc2)cc1)S(c(cc1)ccc1F)(=O)=O Chemical compound C=C(C1)CC1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc2ccccc2)cc1)S(c(cc1)ccc1F)(=O)=O DRNCQCDBLRUPTF-UHFFFAOYSA-N 0.000 description 1
- NAANTXMPGNCWAC-UHFFFAOYSA-N C=C(CC1)CC1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O Chemical compound C=C(CC1)CC1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O NAANTXMPGNCWAC-UHFFFAOYSA-N 0.000 description 1
- LWLOKSXSAUHTJO-UHFFFAOYSA-N CC(C(C)O1)OC1=O Chemical compound CC(C(C)O1)OC1=O LWLOKSXSAUHTJO-UHFFFAOYSA-N 0.000 description 1
- PDDSQSXQMDEZNY-LROBGIAVSA-N CC(C)(C)OC(N[C@@H](CC1)CC(c2ccc(C(C(F)(F)F)(C(F)(F)F)O)cc2)[S]1(c(cc1)ccc1F)(=O)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](CC1)CC(c2ccc(C(C(F)(F)F)(C(F)(F)F)O)cc2)[S]1(c(cc1)ccc1F)(=O)=O)=O PDDSQSXQMDEZNY-LROBGIAVSA-N 0.000 description 1
- KTBCAKLWHXDRFA-UHFFFAOYSA-N Cc1cccc(CC=C)c1COC(C(F)(F)F)(C(F)(F)F)c1ccc(C2(Cc(cc3)ccc3I)CCCC2)cc1 Chemical compound Cc1cccc(CC=C)c1COC(C(F)(F)F)(C(F)(F)F)c1ccc(C2(Cc(cc3)ccc3I)CCCC2)cc1 KTBCAKLWHXDRFA-UHFFFAOYSA-N 0.000 description 1
- ONDXCLSPLCKXBH-UHFFFAOYSA-N O=S(c(cc1)ccc1F)=O Chemical compound O=S(c(cc1)ccc1F)=O ONDXCLSPLCKXBH-UHFFFAOYSA-N 0.000 description 1
- POHUGWWERDRLAU-CPJLOUKISA-N OC([C@H](CC1)C[C@@]1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O)=O Chemical compound OC([C@H](CC1)C[C@@]1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O)=O POHUGWWERDRLAU-CPJLOUKISA-N 0.000 description 1
- IBIASEDVWTYQEO-GKVSMKOHSA-N OC[C@@H](CC1)C[C@@]1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O Chemical compound OC[C@@H](CC1)C[C@@]1(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O IBIASEDVWTYQEO-GKVSMKOHSA-N 0.000 description 1
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- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
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- A61P37/02—Immunomodulators
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- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/20—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C07C317/30—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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EP3044219A1 (en) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Rorgamma modulators |
JP6397488B2 (ja) | 2013-09-20 | 2018-09-26 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | RORγ調節因子 |
CN106061947B (zh) | 2014-01-06 | 2019-12-03 | 百时美施贵宝公司 | 环己基砜RORγ调节剂 |
CA2936116A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators |
ES2705400T3 (es) | 2014-01-06 | 2019-03-25 | Bristol Myers Squibb Co | Sulfonas heterocíclicas como moduladores de ROR gamma |
ES2713681T3 (es) | 2014-01-06 | 2019-05-23 | Bristol Myers Squibb Co | Moduladores de ROR gamma de sulfona carbocíclica |
JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
ME03306B (me) | 2014-10-30 | 2019-10-20 | Janssen Pharmaceutica Nv | Tiazoli kao modulatori roryt |
JP6695335B2 (ja) | 2014-10-30 | 2020-05-20 | ヤンセン ファーマシューティカ エヌ.ベー. | RORγtのモジュレーターとしてのアミド置換チアゾール |
AU2016258087B2 (en) | 2015-05-07 | 2020-01-02 | Bristol-Myers Squibb Company | Tricyclic sulfones as RORϒ modulators |
TWI691486B (zh) * | 2016-01-29 | 2020-04-21 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
US10610520B2 (en) | 2016-03-31 | 2020-04-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為RORγT調節劑之6-胺基吡啶-3-基噻唑 |
WO2018089402A1 (en) * | 2016-11-09 | 2018-05-17 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror gamma modulators |
JPWO2019022234A1 (ja) * | 2017-07-27 | 2020-05-28 | 東レ株式会社 | 炎症性腸疾患の治療剤又は予防剤 |
CA3071235A1 (en) * | 2017-07-27 | 2019-01-31 | Toray Industries, Inc. | Therapeutic agent or preventive agent for alopecia areata |
CA3103932A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Pyridinyl pyrazoles as modulators of roryt |
CN112334450A (zh) | 2018-06-18 | 2021-02-05 | 詹森药业有限公司 | 作为RORγt的调节剂的苯基和吡啶基取代的咪唑 |
CN112292183A (zh) | 2018-06-18 | 2021-01-29 | 詹森药业有限公司 | 作为RORγt的调节剂的6-氨基吡啶-3-基吡唑 |
WO2019243999A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl substituted pyrazoles as modulators of roryt |
US12012374B2 (en) | 2019-05-13 | 2024-06-18 | Bristol-Myers Squibb Company | Agonists of ROR GAMMAt |
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US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
AU2013259737A1 (en) * | 2012-05-08 | 2014-10-02 | Lycera Corporation | Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease |
JP6236067B2 (ja) | 2012-05-08 | 2017-11-22 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγ活性を阻害し疾患を治療するための二環式スルホン化合物 |
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WO2014028669A1 (en) * | 2012-08-15 | 2014-02-20 | Biogen Idec Ma Inc. | Novel compounds for modulation of ror-gamma activity |
US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
EP3044219A1 (en) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Rorgamma modulators |
JP6397488B2 (ja) | 2013-09-20 | 2018-09-26 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | RORγ調節因子 |
CA2936116A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators |
ES2705400T3 (es) | 2014-01-06 | 2019-03-25 | Bristol Myers Squibb Co | Sulfonas heterocíclicas como moduladores de ROR gamma |
ES2713681T3 (es) | 2014-01-06 | 2019-05-23 | Bristol Myers Squibb Co | Moduladores de ROR gamma de sulfona carbocíclica |
CN106061947B (zh) | 2014-01-06 | 2019-12-03 | 百时美施贵宝公司 | 环己基砜RORγ调节剂 |
-
2015
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- 2015-01-05 JP JP2016562464A patent/JP6574444B2/ja not_active Expired - Fee Related
- 2015-01-05 EP EP15700817.8A patent/EP3092216B1/en not_active Not-in-force
- 2015-01-05 CN CN201580012077.3A patent/CN106132931B/zh not_active Expired - Fee Related
- 2015-01-05 US US15/109,741 patent/US9771320B2/en active Active
- 2015-01-05 WO PCT/US2015/010085 patent/WO2015103508A1/en active Application Filing
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US20160326103A1 (en) | 2016-11-10 |
US9771320B2 (en) | 2017-09-26 |
CN106132931B (zh) | 2019-08-02 |
EP3092216A1 (en) | 2016-11-16 |
JP2017508782A (ja) | 2017-03-30 |
CN106132931A (zh) | 2016-11-16 |
EP3092216B1 (en) | 2018-12-12 |
JP6574444B2 (ja) | 2019-09-11 |
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