ES270834A1 - Procedure for the preparation of a new imidazoline derivative (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of a new imidazoline derivative of the formula I, ** (See formula) ** characterized by the fact that a) 2,6-dimethyl-3-hydroxy-4-tert.butyl-phenylacetic acid or one of its functional acid derivatives is reacted with ethylene diamine, or with a reactive nitrogenous derivative of ethylenediamine, or with ammonia or ammonia-yielding substances and a compound that by ammonia treatment is transformed into ethylenediamine, with direct or step formation of the derivative of formula I, or b) a compound of the formula II is decarboxylated or reduced, ** (See formula) ** where Y designates a radical transformable by reduction or dacarboxylation in a CH2 group, using a method known per se, or c) of a compound of formula III ** (See formula) ** where X = OR or a halogen, and R = H, an acyl or a hydrocarbon radical, preferably lower aliphatic, is separated by known methods the radical x as HX, with formation of double bond 1, 2 in the heterocyclic radical , or d) in a compound of formula IV or V ** (See formula) ** it is passed to position 2,3, using known isomerization methods, the double bond that starts from the C2 atom (compound IV) or is in the 3,4 position (compound V), and by the fact that, eventually, e) the salts prepared on the basis of the imidazoline derivative of the formula I obtained are converted into the free base of the formula I. (Machine-translation by Google Translate, not legally binding)