ES408977A1 - Process for the manufacture of n-substituted indoles and new n- substituted indoles - Google Patents

Process for the manufacture of n-substituted indoles and new n- substituted indoles

Info

Publication number
ES408977A1
ES408977A1 ES408977A ES408977A ES408977A1 ES 408977 A1 ES408977 A1 ES 408977A1 ES 408977 A ES408977 A ES 408977A ES 408977 A ES408977 A ES 408977A ES 408977 A1 ES408977 A1 ES 408977A1
Authority
ES
Spain
Prior art keywords
substituted indoles
manufacture
new
indoles
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES408977A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1724071A external-priority patent/CH556839A/en
Priority claimed from CH1547472A external-priority patent/CH572035A5/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES408977A1 publication Critical patent/ES408977A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of N-substituted indoles, characterized in that an indole is treated in sulfoxidedimethyl or a dipolar, aprotic solvent, with a tertiary acid amide group, such as dimethylformamide or dimethylacetamide with a base and then reacted with a compound of the formula R-X in which X is a nucleofuge group and R means an aralkyl radical or an optionally substituted alkyl or alkenyl radical, or it is allowed to react with an alkene, which carries an electron extracting substituent on the double bond, or with an epoxide. (Machine-translation by Google Translate, not legally binding)
ES408977A 1971-11-26 1972-11-25 Process for the manufacture of n-substituted indoles and new n- substituted indoles Expired ES408977A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1724071A CH556839A (en) 1971-11-26 1971-11-26 N-substd indole prodn - by treating with base in dmso or aprotic solvents and alkylating
CH1547472A CH572035A5 (en) 1972-10-23 1972-10-23 N-substd indole prodn - by treating with base in dmso or aprotic solvents and alkylating

Publications (1)

Publication Number Publication Date
ES408977A1 true ES408977A1 (en) 1976-03-16

Family

ID=25716494

Family Applications (1)

Application Number Title Priority Date Filing Date
ES408977A Expired ES408977A1 (en) 1971-11-26 1972-11-25 Process for the manufacture of n-substituted indoles and new n- substituted indoles

Country Status (12)

Country Link
JP (1) JPS4992064A (en)
AU (1) AU474547B2 (en)
BE (1) BE791899A (en)
CA (1) CA998680A (en)
CS (1) CS161969B2 (en)
DE (1) DE2257710C3 (en)
ES (1) ES408977A1 (en)
FR (1) FR2160884B1 (en)
GB (1) GB1377901A (en)
IT (1) IT973691B (en)
NL (1) NL7215833A (en)
SU (1) SU457216A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW270114B (en) * 1993-10-22 1996-02-11 Hoffmann La Roche
JP2009091294A (en) * 2007-10-09 2009-04-30 Nippon Shokubai Co Ltd Method for producing n-(hydroxyalkyl)pyrrole compound

Also Published As

Publication number Publication date
SU457216A3 (en) 1975-01-15
FR2160884B1 (en) 1975-04-25
DE2257710B2 (en) 1981-05-27
FR2160884A1 (en) 1973-07-06
JPS4992064A (en) 1974-09-03
IT973691B (en) 1974-06-10
AU474547B2 (en) 1976-07-29
GB1377901A (en) 1974-12-18
DE2257710A1 (en) 1973-05-30
DE2257710C3 (en) 1982-04-15
CA998680A (en) 1976-10-19
BE791899A (en) 1973-05-24
AU4869272A (en) 1974-05-09
CS161969B2 (en) 1975-06-10
NL7215833A (en) 1973-05-29

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