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Merck and Co Inc
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Merck and Co Inc
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Publication date
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Publication of ES270384A1publicationCriticalpatent/ES270384A1/en
C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Process for the preparation of amino acids and particularly of histidines α -alkyl and their esters under alkyl, which consists of reacting a α -nitroalcanoic acid, of at least three carbons, with 4-chloromethylimidazole by contacting said ester with a solvent inert with sodium hydride, adding said chloromethylimidazole, stirring it until the reaction is complete, isolating the ester α-nitro- α -imidazole, reducing said nitro imidazolyl ester under pressure with hydrogen and Raney nickel and, if desired, hydrolyzing the resulting ester by heating with a mineral acid and, if desired, re-esterifying the resulting carboxylic acid by heating it with a low alkanol in the presence of a mineral acid. (Machine-translation by Google Translate, not legally binding)
ES270384A1960-08-191961-08-18Procedure for the preparation of amino acids (Machine-translation by Google Translate, not legally binding)
ExpiredES270384A1
(en)
Procedure for the preparation of carboxylic acids 1-cycloundecomes isomers and their esters (Machine-translation by Google Translate, not legally binding)
A procedure for the obtaining of hydro-soluble compounds of diglycerid esters of colinfosphoric acid (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of dialkylamine esters alcohols with acids-1-hydroxy-cycle-alkyphenylene, therapeutically active (Machine-translation by Google Translate, not legally binding)