ES268248A1 - Procedimiento de preparaciën de esteroides polihidroxilados - Google Patents
Procedimiento de preparaciën de esteroides polihidroxiladosInfo
- Publication number
- ES268248A1 ES268248A1 ES0268248A ES268248A ES268248A1 ES 268248 A1 ES268248 A1 ES 268248A1 ES 0268248 A ES0268248 A ES 0268248A ES 268248 A ES268248 A ES 268248A ES 268248 A1 ES268248 A1 ES 268248A1
- Authority
- ES
- Spain
- Prior art keywords
- pregnan
- dihydroxy
- hydrogen atom
- oxidation
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 steroid compounds Chemical class 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 230000003647 oxidation Effects 0.000 abstract 3
- 238000007254 oxidation reaction Methods 0.000 abstract 3
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- WRDWQVFVGGZVOA-VAEALJQBSA-N (3R,5R,8S,9S,10S,13S,14S)-3-hydroxy-17-(2-hydroxyethylidene)-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one Chemical compound O[C@H]1C[C@H]2CC[C@H]3[C@@H]4CCC(=CCO)[C@]4(CC([C@@H]3[C@]2(CC1)C)=O)C WRDWQVFVGGZVOA-VAEALJQBSA-N 0.000 abstract 1
- QLOWYEXJOFUPQR-JYUSHERBSA-N (3R,5R,8S,9S,10S,13S,14S,17S)-17-(1,3-dihydroxyprop-1-en-2-yl)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one Chemical compound O[C@H]1C[C@H]2CC[C@H]3[C@@H]4CC[C@H](C(CO)=CO)[C@]4(CC([C@@H]3[C@]2(CC1)C)=O)C QLOWYEXJOFUPQR-JYUSHERBSA-N 0.000 abstract 1
- DIRFKRKDYVZWDV-CWZKNBAESA-N (5s,8s,9s,10s,13r,14s,17s)-17-ethyl-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one Chemical class C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1=O DIRFKRKDYVZWDV-CWZKNBAESA-N 0.000 abstract 1
- VWPIZSZUNBMFBM-JTDCBSPISA-N 2-[(5S,8S,9S,10S,13R,14S,17R)-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]acetaldehyde Chemical class C(C[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3C(C[C@]12C)=O)=O VWPIZSZUNBMFBM-JTDCBSPISA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 239000003610 charcoal Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR830184A FR1363865A (fr) | 1960-06-16 | 1960-06-16 | Nouveaux stéroïdes polyhydroxylés et obtention de ces composés |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES268248A1 true ES268248A1 (es) | 1961-09-16 |
Family
ID=8733554
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0268248A Expired ES268248A1 (es) | 1960-06-16 | 1961-06-15 | Procedimiento de preparaciën de esteroides polihidroxilados |
| ES0268249A Expired ES268249A1 (es) | 1960-06-16 | 1961-06-15 | Procedimiento de preparaciën de esteroides polihidroxilados |
| ES0268247A Expired ES268247A1 (es) | 1960-06-16 | 1961-06-15 | Procedimiento de preparaciën de esteroides polihidroxilados |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0268249A Expired ES268249A1 (es) | 1960-06-16 | 1961-06-15 | Procedimiento de preparaciën de esteroides polihidroxilados |
| ES0268247A Expired ES268247A1 (es) | 1960-06-16 | 1961-06-15 | Procedimiento de preparaciën de esteroides polihidroxilados |
Country Status (5)
| Country | Link |
|---|---|
| CH (3) | CH413831A (forum.php) |
| ES (3) | ES268248A1 (forum.php) |
| FR (4) | FR1363865A (forum.php) |
| GB (2) | GB967080A (forum.php) |
| SE (2) | SE301966B (forum.php) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536599A (zh) | 2008-05-28 | 2014-01-29 | 雷沃根生物医药有限公司 | 用于治疗疾病的NF-κB的非激素甾体调节剂 |
| US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
-
1960
- 1960-06-16 FR FR830184A patent/FR1363865A/fr not_active Expired
- 1960-08-19 FR FR836270A patent/FR335M/fr active Active
- 1960-08-26 FR FR836866A patent/FR341M/fr active Active
- 1960-08-26 FR FR836867A patent/FR342M/fr active Active
-
1961
- 1961-06-09 SE SE6085/61A patent/SE301966B/xx unknown
- 1961-06-09 SE SE6086/61A patent/SE302454B/xx unknown
- 1961-06-15 CH CH699961A patent/CH413831A/fr unknown
- 1961-06-15 ES ES0268248A patent/ES268248A1/es not_active Expired
- 1961-06-15 ES ES0268249A patent/ES268249A1/es not_active Expired
- 1961-06-15 CH CH700061A patent/CH411863A/fr unknown
- 1961-06-15 ES ES0268247A patent/ES268247A1/es not_active Expired
- 1961-06-15 CH CH699861A patent/CH418331A/fr unknown
- 1961-06-16 GB GB48946/63A patent/GB967080A/en not_active Expired
- 1961-06-16 GB GB21873/61A patent/GB967078A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE301966B (forum.php) | 1968-07-01 |
| FR335M (fr) | 1961-03-27 |
| CH411863A (fr) | 1966-04-30 |
| CH413831A (fr) | 1966-05-31 |
| CH418331A (fr) | 1966-08-15 |
| GB967078A (en) | 1964-08-19 |
| ES268247A1 (es) | 1961-09-16 |
| GB967080A (en) | 1964-08-19 |
| SE302454B (forum.php) | 1968-07-22 |
| FR1363865A (fr) | 1964-06-19 |
| FR341M (fr) | 1961-03-27 |
| FR342M (fr) | 1961-03-27 |
| ES268249A1 (es) | 1961-09-16 |
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