ES2666097T3 - Método de tratamiento para la elaboración de implantes o prótesis de polímeros con liberación controlada de principios activos - Google Patents

Método de tratamiento para la elaboración de implantes o prótesis de polímeros con liberación controlada de principios activos Download PDF

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Publication number
ES2666097T3
ES2666097T3 ES13766595.6T ES13766595T ES2666097T3 ES 2666097 T3 ES2666097 T3 ES 2666097T3 ES 13766595 T ES13766595 T ES 13766595T ES 2666097 T3 ES2666097 T3 ES 2666097T3
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Spain
Prior art keywords
prostheses
implants
polymers
cell
active ingredients
Prior art date
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Active
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ES13766595.6T
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English (en)
Inventor
Jean-Marie André
Elisabeth BADENS
Olivier FORZANO
Yasmine MASMOUDI
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/408—Virucides, spermicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

Método de tratamiento para la elaboración de implantes o de prótesis de polímeros con liberación controlada de principios activos que comprende una primera etapa denominada " de tratamiento previo ", seguida por una etapa denominada "de impregnación" de los implantes o prótesis de polímeros tratados previamente con principios activos, comprendiendo la primera etapa: - la introducción de los implantes o prótesis de polímeros en una celda a alta presión o autoclave, - la alimentación de la celda con CO2 en una fase de presurización y de calentamiento que sigue una cinética controlada con una tasa de presurización comprendida entre 0,01 y 1 MPa/min, hasta alcanzar condiciones supercríticas o subcríticas líquidas del CO2, con una presión comprende entre 5 y 20 MPa y una temperatura entre 20 ºC y 50 ºC, - una fase de puesta en contacto de los implantes o prótesis de polímeros con el CO2 en modo discontinuo o en modo continuo, comprendiendo la fase de puesta en contacto: * en el modo discontinuo: el aislamiento de la celda a alta presión o autoclave durante un periodo de tiempo de varios minutos a una hora, y * en el modo continuo: el arrastre de la celda a alta presión o autoclave por un flujo de cruce de CO2 durante un período de tiempo que varía de varios minutos a 1 hora, estando el caudal de CO2 comprendido entre un intervalo de caudales que varían de varios gramos por hora a 1 Kg/h, y una fase de despresurización que sigue una cinética controlada con una tasa de despresurización comprendida entre 0,01 y 1 MPa/min, en condiciones isotermas.

Description

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Claims (1)

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ES13766595.6T 2012-09-04 2013-08-29 Método de tratamiento para la elaboración de implantes o prótesis de polímeros con liberación controlada de principios activos Active ES2666097T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1258210A FR2994850B1 (fr) 2012-09-04 2012-09-04 Procede de traitement pour l'elaboration d'implants ou de protheses de polymeres a liberation controlee de principes actifs.
FR1258210 2012-09-04
PCT/FR2013/051990 WO2014037651A1 (fr) 2012-09-04 2013-08-29 Procédé de traitement pour l'élaboration d'implants ou de prothèses de polymères à libération contrôlée de principes actifs

Publications (1)

Publication Number Publication Date
ES2666097T3 true ES2666097T3 (es) 2018-05-03

Family

ID=47178126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13766595.6T Active ES2666097T3 (es) 2012-09-04 2013-08-29 Método de tratamiento para la elaboración de implantes o prótesis de polímeros con liberación controlada de principios activos

Country Status (6)

Country Link
EP (1) EP2892940B1 (es)
CN (1) CN104822730B (es)
ES (1) ES2666097T3 (es)
FR (1) FR2994850B1 (es)
HK (1) HK1209443A1 (es)
WO (1) WO2014037651A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107205955B (zh) 2014-09-29 2021-11-09 内布拉斯加大学董事会 纳米纤维结构及其合成方法和用途
US11318224B2 (en) 2016-09-28 2022-05-03 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of use thereof
US11738116B2 (en) 2017-06-09 2023-08-29 Board Of Regents Of The University Of Nebraska Expanded nanofiber structures comprising electrospun nanofibers and a plurality of holes and methods of making and use thereof
WO2019060393A1 (en) * 2017-09-19 2019-03-28 Board Of Regents Of The University Of Nebraska NANOFIBER STRUCTURES AND METHODS OF USE THEREOF

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2699544B1 (fr) * 1992-12-17 1995-02-03 Valois Procédé pour éliminer les polluants à bas poids moléculaire contenus dans les joints élastomères et les matières plastiques.
US5607518A (en) * 1995-02-22 1997-03-04 Ciba Geigy Corporation Methods of deblocking, extracting and cleaning polymeric articles with supercritical fluids
DK1515699T3 (da) * 2002-03-07 2009-05-04 Eurand Pharmaceuticals Ltd Fremgangsmåde til ladning og termodynamisk aktivering af lægemidler på polymerer ved hjælp af superkritiske fluida
EP1611877A1 (en) * 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs

Also Published As

Publication number Publication date
EP2892940B1 (fr) 2018-02-14
CN104822730A (zh) 2015-08-05
FR2994850A1 (fr) 2014-03-07
EP2892940A1 (fr) 2015-07-15
WO2014037651A1 (fr) 2014-03-13
HK1209443A1 (en) 2016-04-01
FR2994850B1 (fr) 2015-07-17
CN104822730B (zh) 2018-01-09

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