ES2622714T8 - Agonistas de los receptores TLR 4 y 9 para prevenir las complicaciones sépticas de la inmunodepresión post-traumática en los pacientes hospitalizados por traumatismos severos - Google Patents

Agonistas de los receptores TLR 4 y 9 para prevenir las complicaciones sépticas de la inmunodepresión post-traumática en los pacientes hospitalizados por traumatismos severos

Info

Publication number
ES2622714T8
ES2622714T8 ES10790854T ES10790854T ES2622714T8 ES 2622714 T8 ES2622714 T8 ES 2622714T8 ES 10790854 T ES10790854 T ES 10790854T ES 10790854 T ES10790854 T ES 10790854T ES 2622714 T8 ES2622714 T8 ES 2622714T8
Authority
ES
Spain
Prior art keywords
tlr
post
receptor agonists
patients hospitalized
septic complications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10790854T
Other languages
English (en)
Other versions
ES2622714T3 (es
Inventor
Karim Asehnoune
Antoine Roquilly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Nantes
Original Assignee
Universite de Nantes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Nantes filed Critical Universite de Nantes
Application granted granted Critical
Publication of ES2622714T3 publication Critical patent/ES2622714T3/es
Publication of ES2622714T8 publication Critical patent/ES2622714T8/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES10790854.3T 2009-12-28 2010-12-17 Agonistas de los receptores TLR 4 y 9 para prevenir las complicaciones sépticas de la inmunodepresión post-traumática en los pacientes hospitalizados por traumatismos severos Active ES2622714T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0906372 2009-12-28
FR0906372A FR2954703B1 (fr) 2009-12-28 2009-12-28 Agonistes des recepteurs tlr 4 et 9 pour prevenir les complications septiques de l'immunodepression post-traumatique chez les patients hospitalises pour traumatismes severes
PCT/EP2010/070111 WO2011080126A1 (fr) 2009-12-28 2010-12-17 Agonistes des recepteurs tlr 4 et 9 pour prevenir les complications septiques de l'immunodepression post-traumatique chez les patients hospitalises pour traumatismes severes

Publications (2)

Publication Number Publication Date
ES2622714T3 ES2622714T3 (es) 2017-07-07
ES2622714T8 true ES2622714T8 (es) 2019-02-12

Family

ID=42262013

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10790854.3T Active ES2622714T3 (es) 2009-12-28 2010-12-17 Agonistas de los receptores TLR 4 y 9 para prevenir las complicaciones sépticas de la inmunodepresión post-traumática en los pacientes hospitalizados por traumatismos severos

Country Status (6)

Country Link
US (1) US8636979B2 (es)
EP (1) EP2519259B1 (es)
CA (1) CA2785909C (es)
ES (1) ES2622714T3 (es)
FR (1) FR2954703B1 (es)
WO (1) WO2011080126A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR091569A1 (es) 2012-06-28 2015-02-11 Intervet Int Bv Receptores de tipo toll
US20170172651A1 (en) * 2015-12-17 2017-06-22 Rainbow Medical Ltd. Transluminal electrode catheters
WO2018067730A1 (en) 2016-10-04 2018-04-12 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid a (asla) based therapeutics
AU2017370942A1 (en) 2016-12-07 2019-06-13 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
CA3046019A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a tlr modulator
CN111615386A (zh) * 2017-11-03 2020-09-01 台湾基督长老教会马偕医疗财团法人马偕纪念医院 调节肿瘤相关髓样细胞及增强免疫检查点阻断的方法
FR3087338B1 (fr) * 2018-10-22 2020-10-09 Amadeite Extrait d'algues pour son utilisation pour le traitement ou la prevention de l'immunosuppression post-traumatique
US20200188511A1 (en) 2018-12-12 2020-06-18 Anergis S.A. Methods of improving efficacy of allergy vaccines
WO2021174024A1 (en) 2020-02-28 2021-09-02 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
EP3912996A1 (en) * 2020-05-18 2021-11-24 Université de Nantes Treg expressing tnf receptor type 2 play a major role in cd4+ t cell impairment during acute post-stress immunodepression
WO2022003598A1 (en) 2020-07-02 2022-01-06 Viiv Healthcare Company Method of achieving hiv viral remission using long-acting antiretroviral agents
CN114796273A (zh) * 2022-07-01 2022-07-29 中国人民解放军总医院第一医学中心 Tlr4激动的外泌体或外泌体制剂在制备防治放射性肺损伤药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE328890T1 (de) 1994-07-15 2006-06-15 Univ Iowa Res Found Immunomodulatorische oligonukleotide
CN1259052A (zh) 1997-04-01 2000-07-05 科里克萨有限公司 单磷酰基脂质a的水性免疫佐剂组合物
CA2538418A1 (en) * 2003-09-17 2005-04-21 Eli Lilly And Company Synthetic polysaccharide antigens for immunological intervention in disease
US20060265767A1 (en) * 2005-03-02 2006-11-23 Bruce Beutler Compositions and methods for treatment of autoimmune and related diseases
WO2009088401A2 (en) 2007-09-24 2009-07-16 Government Of The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Immunostimulatory combinations of tlr ligands and methods of use

Also Published As

Publication number Publication date
US20130028936A1 (en) 2013-01-31
EP2519259A1 (fr) 2012-11-07
CA2785909C (fr) 2019-03-26
EP2519259B1 (fr) 2017-01-18
ES2622714T3 (es) 2017-07-07
US8636979B2 (en) 2014-01-28
WO2011080126A1 (fr) 2011-07-07
CA2785909A1 (fr) 2011-07-07
FR2954703B1 (fr) 2013-12-13
FR2954703A1 (fr) 2011-07-01

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