ES2593789T3 - Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia - Google Patents
Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia Download PDFInfo
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07101604 | 2007-02-01 | ||
| EP07101604 | 2007-02-01 | ||
| EP07122424 | 2007-12-05 | ||
| EP07122424 | 2007-12-05 | ||
| PCT/EP2008/051144 WO2008092905A2 (en) | 2007-02-01 | 2008-01-30 | Specific activation of a regulatory t cell and its use for treatment of asthma, allergic disease, autoimmune disease, graft rejection and for tolerance induction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2593789T3 true ES2593789T3 (es) | 2016-12-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16166807T Active ES2825718T3 (es) | 2007-02-01 | 2008-01-30 | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
| ES08708459.6T Active ES2593789T3 (es) | 2007-02-01 | 2008-01-30 | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16166807T Active ES2825718T3 (es) | 2007-02-01 | 2008-01-30 | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
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| US (4) | US8557533B2 (enExample) |
| EP (2) | EP3112866B1 (enExample) |
| JP (2) | JP5867795B2 (enExample) |
| CA (1) | CA2676170C (enExample) |
| ES (2) | ES2825718T3 (enExample) |
| WO (1) | WO2008092905A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007127787A2 (en) | 2006-04-25 | 2007-11-08 | Joslin Diabetes Center, Inc. | Insulin autoantigen-specific regulatory cd4+ t cells |
| ES2825718T3 (es) * | 2007-02-01 | 2021-05-17 | Univ Der Johannes Gutenberg Univ Mainz | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
| JP5604311B2 (ja) | 2008-03-13 | 2014-10-08 | バイオテスト・アクチエンゲゼルシヤフト | 疾患治療剤 |
| CN102027017A (zh) | 2008-03-13 | 2011-04-20 | 生物测试股份公司 | 一种治疗疾病的试剂 |
| RU2540013C2 (ru) | 2008-03-13 | 2015-01-27 | Биотест Аг | Средство для лечения заболевания |
| US20110223145A1 (en) * | 2008-06-30 | 2011-09-15 | Universitatsklinikum Heidelberg | Immunosuppressive blood cells and methods of producing the same |
| GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
| EP2471543A1 (en) * | 2010-12-02 | 2012-07-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Tolerance induction or immunosupression to prevent in particular Graft-versus-Host-Disease (GvHD) by short-term pre-incubation of transplanted cell suspensions, tissues or organs coated with ligands to cell surface molecules |
| US20140112898A1 (en) * | 2011-03-31 | 2014-04-24 | President And Fellows Of Harvard College | Unique population of regulatory t cells that regulate tissue regeneration and wound healing |
| AU2014342086A1 (en) * | 2013-10-31 | 2016-05-19 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for inducing regulatory T-cell generation |
| WO2019099788A1 (en) * | 2017-11-16 | 2019-05-23 | Benaroya Sesearch Institute At Virginia Mason | Antigen-specific t regulatory cell assay |
| GB202401501D0 (en) | 2024-02-05 | 2024-03-20 | T Balance Therapeutics Gmbh | Medical use of regulatory t cell activator |
Family Cites Families (20)
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| US4695459A (en) * | 1984-12-26 | 1987-09-22 | The Board Of Trustees Of Leland Stanford Junior University | Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells |
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| IL138654A0 (en) * | 1998-03-25 | 2001-10-31 | Mayo Foundation | Methods and materials for treating inflammatory diseases |
| US7608273B2 (en) * | 1998-08-12 | 2009-10-27 | University Of Western Ontario | Recombinant lentivirus encoding modified GP 120 signal sequences |
| US6337181B1 (en) * | 1998-12-21 | 2002-01-08 | Jeffrey Joseph Stewart | Method of specifying vaccine components for viral quasispecies |
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| WO2005010215A2 (en) * | 2003-07-17 | 2005-02-03 | Tolerrx, Inc. | Methods for identifying tolerance modulatory compounds and uses therefor |
| WO2006085959A2 (en) * | 2004-06-08 | 2006-08-17 | Novartis Vaccines And Diagnostics Inc. | Fusion proteins comprising cd4 minimal modules and methods of use thereof |
| WO2007035551A1 (en) * | 2005-09-19 | 2007-03-29 | Eisai R & D Management Co., Ltd. | Methods for identifying gpr83 agonists and antagonists capable of modulating regulatory t cell function |
| ES2825718T3 (es) | 2007-02-01 | 2021-05-17 | Univ Der Johannes Gutenberg Univ Mainz | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
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| US20140093509A1 (en) | 2014-04-03 |
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| US8557533B2 (en) | 2013-10-15 |
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