ES2580172T3 - Una célula madre mesenquimal multipotente aislada de glomérulos humanos adultos (HGL-MSC), un método para preparar la misma y usos de la misma en la medicina regenerativa del riñón - Google Patents
Una célula madre mesenquimal multipotente aislada de glomérulos humanos adultos (HGL-MSC), un método para preparar la misma y usos de la misma en la medicina regenerativa del riñón Download PDFInfo
- Publication number
- ES2580172T3 ES2580172T3 ES09744160.4T ES09744160T ES2580172T3 ES 2580172 T3 ES2580172 T3 ES 2580172T3 ES 09744160 T ES09744160 T ES 09744160T ES 2580172 T3 ES2580172 T3 ES 2580172T3
- Authority
- ES
- Spain
- Prior art keywords
- mesenchymal stem
- hgl
- msc
- stem cell
- adult human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000003734 kidney Anatomy 0.000 title abstract 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 230000001172 regenerating effect Effects 0.000 title 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract description 2
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 abstract description 2
- 101100518992 Mus musculus Pax2 gene Proteins 0.000 abstract description 2
- 102100038081 Signal transducer CD24 Human genes 0.000 abstract description 2
- 230000001434 glomerular Effects 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 210000003584 mesangial cell Anatomy 0.000 abstract 1
- 210000000557 podocyte Anatomy 0.000 abstract 1
- 102100022464 5'-nucleotidase Human genes 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- 102100032912 CD44 antigen Human genes 0.000 description 1
- 108090000397 Caspase 3 Proteins 0.000 description 1
- 102100029855 Caspase-3 Human genes 0.000 description 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 description 1
- 102100025304 Integrin beta-1 Human genes 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- 102000013127 Vimentin Human genes 0.000 description 1
- 108010065472 Vimentin Proteins 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 210000005048 vimentin Anatomy 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0687—Renal stem cells; Renal progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08425708 | 2008-11-04 | ||
| EP08425708A EP2186883A1 (en) | 2008-11-04 | 2008-11-04 | An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney |
| PCT/EP2009/064468 WO2010052192A1 (en) | 2008-11-04 | 2009-11-02 | An isolated multipotent mesenchymal stem cell from human adult glomeruli (hgl-msc), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2580172T3 true ES2580172T3 (es) | 2016-08-19 |
Family
ID=40260686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09744160.4T Active ES2580172T3 (es) | 2008-11-04 | 2009-11-02 | Una célula madre mesenquimal multipotente aislada de glomérulos humanos adultos (HGL-MSC), un método para preparar la misma y usos de la misma en la medicina regenerativa del riñón |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9499796B2 (https=) |
| EP (2) | EP2186883A1 (https=) |
| JP (1) | JP5795737B2 (https=) |
| CN (1) | CN102292434B (https=) |
| ES (1) | ES2580172T3 (https=) |
| PL (1) | PL2361303T3 (https=) |
| WO (1) | WO2010052192A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2363136A1 (en) | 2010-03-02 | 2011-09-07 | Fresenius Medical Care Deutschland GmbH | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
| TWI762890B (zh) | 2010-05-12 | 2022-05-01 | 開曼群島商英瑞金公司 | 生物活性腎細胞 |
| WO2012030968A1 (en) * | 2010-08-31 | 2012-03-08 | Renovocyte, LLC | Systemic, allogenic stem cell therapies for treatment of diseases in animals |
| CN103261407B (zh) * | 2010-12-22 | 2016-03-02 | 杜兰教育基金委员会 | 用于识别和培养具有高度增殖潜能的多能间充质干细胞的方法 |
| AU2012279995C1 (en) | 2011-07-06 | 2019-10-24 | Cell Therapy Limited | Progenitor cells of mesodermal lineage |
| EP2760995B1 (en) * | 2011-09-30 | 2019-08-07 | The University Of Miami | Renal stem cells isolated from kidney |
| RU2702721C2 (ru) | 2012-10-24 | 2019-10-09 | инРиджен | Популяции клеток почек и их применение |
| WO2014113704A2 (en) * | 2013-01-18 | 2014-07-24 | Escape Therapeutics, Inc. | Enhanced differentiation of mesenchymal stem cells |
| CN104977414B (zh) * | 2014-04-09 | 2016-09-28 | 上海交通大学医学院 | 鉴定骨髓中是否存在保护白血病干细胞微环境的试剂盒及其应用 |
| CN106715683A (zh) * | 2014-08-21 | 2017-05-24 | 味之素株式会社 | 间充质干细胞用培养基 |
| TWI689589B (zh) * | 2016-08-31 | 2020-04-01 | 宣捷細胞生物製藥股份有限公司 | 區別間質幹細胞的方法及測定間質幹細胞的純度的方法 |
| CN106265745A (zh) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种干细胞制剂及其在制备治疗慢性肾炎的药物中的应用 |
| JP7072777B2 (ja) * | 2018-07-03 | 2022-05-23 | 株式会社生命科学インスティテュート | 慢性腎障害治療のための多能性幹細胞 |
| EP4146787A4 (en) | 2020-05-08 | 2024-06-26 | Gallant Pet, Inc. | Uterine-derived regenerative cell compositions and uses thereof |
| CN117871216B (zh) * | 2024-03-12 | 2024-06-04 | 中日友好医院(中日友好临床医学研究所) | 一种石蜡标本中肾小球裂隙膜的三维可视化方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4085410B2 (ja) * | 2003-03-14 | 2008-05-14 | 株式会社 バイオリンクインク | 腎臓幹細胞／前駆細胞、腎臓幹細胞／前駆細胞の分離方法、及び腎疾患の治療方法 |
| ITFI20060099A1 (it) * | 2006-04-28 | 2007-10-29 | Azienda Ospedaliera Careggi | Popolazione di cellule staminali renali, sua identificazione ed uso per finalita' terapeutiche |
| CN101595212B (zh) * | 2006-10-12 | 2014-04-30 | 伊西康公司 | 肾源细胞及在组织修复和再生中的使用方法 |
-
2008
- 2008-11-04 EP EP08425708A patent/EP2186883A1/en not_active Withdrawn
-
2009
- 2009-11-02 US US13/127,589 patent/US9499796B2/en active Active
- 2009-11-02 WO PCT/EP2009/064468 patent/WO2010052192A1/en not_active Ceased
- 2009-11-02 CN CN200980154241.9A patent/CN102292434B/zh active Active
- 2009-11-02 PL PL09744160.4T patent/PL2361303T3/pl unknown
- 2009-11-02 EP EP09744160.4A patent/EP2361303B8/en active Active
- 2009-11-02 JP JP2011535090A patent/JP5795737B2/ja active Active
- 2009-11-02 ES ES09744160.4T patent/ES2580172T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012507304A (ja) | 2012-03-29 |
| US9499796B2 (en) | 2016-11-22 |
| CN102292434B (zh) | 2014-03-12 |
| WO2010052192A1 (en) | 2010-05-14 |
| US20110256111A1 (en) | 2011-10-20 |
| JP5795737B2 (ja) | 2015-10-14 |
| EP2361303B8 (en) | 2016-08-10 |
| CN102292434A (zh) | 2011-12-21 |
| EP2361303B1 (en) | 2016-04-06 |
| PL2361303T3 (pl) | 2016-10-31 |
| EP2361303A1 (en) | 2011-08-31 |
| EP2186883A1 (en) | 2010-05-19 |
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