ES257673A1 - Procedure for obtaining derivatives of pirimide- [5,4-d] - pyrimidine (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for obtaining derivatives of the pyrimido- [5,4-d] -pyrimidine of the general formula ** (See formula) ** where from two to four of the residues R1 to R4, which may be the same or different from each other, represent a free amino group, a monosubstituted amino group, a disubstituted amino group or a nitrogen-containing heterocyclic ring, linked through the nitrogen with the structure of the pyrimidopyrimidine, and the other residues, from zero to two, which may also be the same or different from each other, represent a free or substituted hydroxyl or thio group, hydrogen or a hydrocarbon residue, characterized by being transformed, eventually in the presence of a solvent and/or a reaction accelerator and optionally under pressure, compounds of the general formula ** (See formula) ** where from one to four of the residues Z1 to Z4, which may be the same or different from each other, represent a free or substituted hydroxyl, thio or amino group, a nitrogen-containing heterocyclic ring, linked through the nitrogen atom with the structure of the pyrimidopyrimidine, or a quaternary ammonium group, and from zero to two of the residues Z1 to Z4, which may be the same or different from each other, represent hydrogen or a hydrocarbon residue with ammonia, a primary or secondary amine whose nitrogen atom it may also be a member of a heterocyclic ring, preferably at an increased temperature and preferably with an excess of the amine used, and the reaction products obtained may be optionally converted into their acid addition salts. (Machine-translation by Google Translate, not legally binding)