ES2574238T3 - Adhesivo tisular de hidrogel para uso médico - Google Patents
Adhesivo tisular de hidrogel para uso médico Download PDFInfo
- Publication number
- ES2574238T3 ES2574238T3 ES10730327.3T ES10730327T ES2574238T3 ES 2574238 T3 ES2574238 T3 ES 2574238T3 ES 10730327 T ES10730327 T ES 10730327T ES 2574238 T3 ES2574238 T3 ES 2574238T3
- Authority
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- Spain
- Prior art keywords
- solution
- aldehyde
- dextran
- water
- functionalized
- Prior art date
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- 239000000017 hydrogel Substances 0.000 title description 70
- 239000000853 adhesive Substances 0.000 title description 3
- 230000001070 adhesive effect Effects 0.000 title description 3
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- 239000005017 polysaccharide Substances 0.000 abstract description 38
- 150000001412 amines Chemical class 0.000 abstract description 34
- 125000003172 aldehyde group Chemical group 0.000 abstract description 32
- 238000006467 substitution reaction Methods 0.000 abstract description 24
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract description 13
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
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- 150000001299 aldehydes Chemical class 0.000 description 72
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22271309P | 2009-07-02 | 2009-07-02 | |
| US222713P | 2009-07-02 | ||
| PCT/US2010/040606 WO2011002888A2 (en) | 2009-07-02 | 2010-06-30 | Hydrogel tissue adhesive for medical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2574238T3 true ES2574238T3 (es) | 2016-06-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10730327.3T Active ES2574238T3 (es) | 2009-07-02 | 2010-06-30 | Adhesivo tisular de hidrogel para uso médico |
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| US (1) | US8778326B2 (enExample) |
| EP (1) | EP2448604B1 (enExample) |
| JP (2) | JP5872463B2 (enExample) |
| ES (1) | ES2574238T3 (enExample) |
| WO (1) | WO2011002888A2 (enExample) |
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| WO2006042161A2 (en) | 2004-10-07 | 2006-04-20 | E.I. Dupont De Nemours And Company | Polysaccharide-based polymer tissue adhesive for medical use |
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| US20100160960A1 (en) * | 2008-12-19 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hydrogel tissue adhesive having increased degradation time |
| JP2012523289A (ja) | 2009-04-09 | 2012-10-04 | アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー | 減少した分解時間を有するハイドロゲル組織接着剤 |
| EP2448604B1 (en) | 2009-07-02 | 2016-03-23 | Actamax Surgical Materials LLC | Hydrogel tissue adhesive for medical use |
| US8796242B2 (en) | 2009-07-02 | 2014-08-05 | Actamax Surgical Materials, Llc | Hydrogel tissue adhesive for medical use |
| WO2012142470A1 (en) | 2011-04-13 | 2012-10-18 | Massachusetts Institute Of Technology | Biocompatible adhesive materials and methods |
| US8859705B2 (en) | 2012-11-19 | 2014-10-14 | Actamax Surgical Materials Llc | Hydrogel tissue adhesive having decreased gelation time and decreased degradation time |
| US20160184474A1 (en) * | 2013-07-29 | 2016-06-30 | Actamax Surgical Materials, Llc | Low swell tissue adhesive and sealant formulations |
| US10286101B2 (en) * | 2013-12-10 | 2019-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for adhering tissue surfaces and materials and biomedical uses thereof |
| US10526457B2 (en) * | 2015-09-30 | 2020-01-07 | Nof Corporation | Narrowly distributed multi-armed polyethylene glycol compounds, hydrogels, and methods |
| US10590257B2 (en) | 2016-09-26 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications |
| CA3055985A1 (en) | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| US11969526B2 (en) | 2017-04-03 | 2024-04-30 | The Board Of Trustees Of The Leland Stanford Junior University | Adhesion prevention with shear-thinning polymeric hydrogels |
| US11975123B2 (en) | 2018-04-02 | 2024-05-07 | The Board Of Trustees Of The Leland Stanford Junior University | Adhesion prevention with shear-thinning polymeric hydrogels |
| WO2020072495A1 (en) | 2018-10-01 | 2020-04-09 | The Board Of Trustees Of The Leland Stanford Junior University | Injectable hydrogels for controlled release of immunomodulatory compounds |
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| EP2448604B1 (en) | 2009-07-02 | 2016-03-23 | Actamax Surgical Materials LLC | Hydrogel tissue adhesive for medical use |
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-
2010
- 2010-06-30 EP EP10730327.3A patent/EP2448604B1/en not_active Not-in-force
- 2010-06-30 JP JP2012517893A patent/JP5872463B2/ja not_active Expired - Fee Related
- 2010-06-30 WO PCT/US2010/040606 patent/WO2011002888A2/en not_active Ceased
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2012531954A (ja) | 2012-12-13 |
| EP2448604A2 (en) | 2012-05-09 |
| JP2015186652A (ja) | 2015-10-29 |
| EP2448604B1 (en) | 2016-03-23 |
| WO2011002888A2 (en) | 2011-01-06 |
| JP5872463B2 (ja) | 2016-03-01 |
| WO2011002888A3 (en) | 2011-03-10 |
| US8778326B2 (en) | 2014-07-15 |
| JP6017646B2 (ja) | 2016-11-02 |
| US20120148523A1 (en) | 2012-06-14 |
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