ES2570205T3 - Sistema terapéutico transdérmico con pequeña tendencia a la cristalización espontánea - Google Patents
Sistema terapéutico transdérmico con pequeña tendencia a la cristalización espontáneaInfo
- Publication number
- ES2570205T3 ES2570205T3 ES12810316T ES12810316T ES2570205T3 ES 2570205 T3 ES2570205 T3 ES 2570205T3 ES 12810316 T ES12810316 T ES 12810316T ES 12810316 T ES12810316 T ES 12810316T ES 2570205 T3 ES2570205 T3 ES 2570205T3
- Authority
- ES
- Spain
- Prior art keywords
- transdermal therapeutic
- layers
- matrix
- melting point
- therapeutic system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
Abstract
Sistema terapéutico transdérmico (TTS) que comprende una capa posterior impermeable a la sustancia activa, una matriz constituida por una, dos o más capas y una capa de protección desprendible, caracterizado por que la capa o capas de matriz o al menos una de las capas de matriz comprenden al menos un pegamento autoadhesivo, al menos un medicamento y partículas de polivinilpirrolidona transversalmente reticulada, y durante la fabricación de la capa o capas de matriz que contienen medicamento y/o el revestimiento de la capa posterior impermeable a la sustancia activa del sistema terapéutico transdérmico se ha realizado un tratamiento a temperatura en el que la temperatura estaba por encima del punto de fusión o el intervalo de punto de fusión de la modificación estable del medicamento o medicamentos, preferiblemente al menos 10ºC por encima del punto de fusión o del intervalo de fusión de dicha modificación estable, consistiendo el pegamento autoadhesivo en un pegamento autoadhesivo fusible.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011090178A DE102011090178A1 (de) | 2011-12-30 | 2011-12-30 | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
PCT/EP2012/077046 WO2013098390A1 (de) | 2011-12-30 | 2012-12-28 | Transdermales therapeutisches system mit geringer neigung zur spontankristallisation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2570205T3 true ES2570205T3 (es) | 2016-05-17 |
Family
ID=47505017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12810316T Active ES2570205T3 (es) | 2011-12-30 | 2012-12-28 | Sistema terapéutico transdérmico con pequeña tendencia a la cristalización espontánea |
Country Status (10)
Country | Link |
---|---|
US (2) | US20140378917A1 (es) |
EP (1) | EP2797588B1 (es) |
JP (1) | JP6335790B2 (es) |
CN (2) | CN110251490A (es) |
BR (1) | BR112014016176B1 (es) |
CA (1) | CA2861782C (es) |
DE (1) | DE102011090178A1 (es) |
ES (1) | ES2570205T3 (es) |
HK (1) | HK1202430A1 (es) |
WO (1) | WO2013098390A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU180500U1 (ru) * | 2017-08-01 | 2018-06-14 | Игорь Александрович Зябрев | Технологическая головка для лазерной аддитивной технологии |
US11607394B2 (en) | 2017-12-19 | 2023-03-21 | Hisamitsu Pharmaceutical Co., Inc. | Rotigotine-containing patch |
CN108358911A (zh) * | 2018-04-19 | 2018-08-03 | 安徽德信佳生物医药有限公司 | 一种磁性诱导结晶分离东莨菪碱的方法 |
US20220117934A1 (en) | 2019-02-15 | 2022-04-21 | Hisamitsu Pharmaceutical Co., Inc. | Rotigotine stabilization method |
CN112891324A (zh) * | 2021-01-19 | 2021-06-04 | 北京亚宝生物药业有限公司 | 一种透皮贴剂 |
CN116829131B (zh) * | 2022-01-12 | 2024-05-07 | 新领医药技术(深圳)有限公司 | 奥氮平透皮给药系统及其制备方法和用途 |
CN117157062A (zh) * | 2022-01-12 | 2023-12-01 | 新领医药技术(深圳)有限公司 | 抑制药物结晶的透皮贴剂及其制备方法 |
WO2024040860A1 (zh) * | 2022-08-24 | 2024-02-29 | 新领医药技术(深圳)有限公司 | 抑制结晶的罗替高汀透皮给药系统及其制备方法和用途 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
DE3910543A1 (de) | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
IT1243745B (it) | 1990-10-17 | 1994-06-21 | Vectorpharma Int | Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione. |
US5906830A (en) * | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
WO1997020550A2 (en) | 1995-12-01 | 1997-06-12 | Alza Corporation | Improved method for preventing crystal formation in a dispersion of a liquid in a matrix |
US5663258A (en) * | 1996-02-20 | 1997-09-02 | Isp Investments Inc. | Strongly swellable, moderately crosslinked copolymers of vinylpyrrolidone and vinyl acetate |
JPH1045571A (ja) * | 1996-07-29 | 1998-02-17 | Sekisui Chem Co Ltd | 貼付剤 |
JPH10306023A (ja) | 1997-05-06 | 1998-11-17 | Sekisui Chem Co Ltd | 経皮吸収製剤及びその製造方法 |
CA2302411C (en) * | 1997-09-02 | 2007-01-30 | Novartis Ag | Improved method for preventing crystal formation in a scopolamine transdermal device |
DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
AR022471A1 (es) | 1999-02-02 | 2002-09-04 | Ortho Mcneil Pharm Inc | Metodo para la fabricacion de matrices transdermicas |
IL147247A0 (en) | 1999-07-02 | 2002-08-14 | Lohmann Therapie Syst Lts | Microreservoir system based on polysiloxanes and ambiphilic solvents |
DE10012908B4 (de) | 2000-03-16 | 2005-03-17 | Lts Lohmann Therapie-Systeme Ag | Stabilisierte übersättigte transdermale therapeutische Matrixsysteme und Verfahren zu ihrer Herstellung |
US6824874B1 (en) * | 2000-08-23 | 2004-11-30 | Dana Corporation | Insulator and seal for fuel cell assemblies |
EP1386605A1 (en) | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
EP1386604A1 (en) | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system |
DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
DE102006054732B4 (de) * | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
US20080226698A1 (en) * | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
CN102281873A (zh) * | 2008-10-06 | 2011-12-14 | 迈兰技术有限公司 | 非晶罗替戈汀(rotigotine)透皮系统 |
DE102009052972A1 (de) * | 2009-11-12 | 2011-09-15 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm |
HUE039447T2 (hu) | 2009-12-22 | 2018-12-28 | Ucb Biopharma Sprl | Polivinilpirrolidon rotigotin nem kristályos formája szilárd diszperziójának stabilizálására |
JP5766475B2 (ja) * | 2010-03-30 | 2015-08-19 | 日東電工株式会社 | 貼付製剤およびその製造方法 |
MY185130A (en) * | 2010-07-12 | 2021-04-30 | Celgene Corp | Romidepsin solid forms and uses thereof |
-
2011
- 2011-12-30 DE DE102011090178A patent/DE102011090178A1/de active Pending
-
2012
- 2012-12-28 US US14/368,864 patent/US20140378917A1/en not_active Abandoned
- 2012-12-28 WO PCT/EP2012/077046 patent/WO2013098390A1/de active Application Filing
- 2012-12-28 EP EP12810316.5A patent/EP2797588B1/de not_active Revoked
- 2012-12-28 CN CN201910674434.2A patent/CN110251490A/zh active Pending
- 2012-12-28 CA CA2861782A patent/CA2861782C/en active Active
- 2012-12-28 CN CN201280068937.1A patent/CN104144683A/zh active Pending
- 2012-12-28 ES ES12810316T patent/ES2570205T3/es active Active
- 2012-12-28 BR BR112014016176-3A patent/BR112014016176B1/pt active IP Right Grant
- 2012-12-28 JP JP2014549486A patent/JP6335790B2/ja active Active
-
2015
- 2015-03-24 HK HK15102996.3A patent/HK1202430A1/zh unknown
-
2019
- 2019-07-08 US US16/504,604 patent/US20190328680A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112014016176A8 (pt) | 2017-07-04 |
DE102011090178A1 (de) | 2013-07-04 |
EP2797588B1 (de) | 2016-04-27 |
JP2015503541A (ja) | 2015-02-02 |
US20190328680A1 (en) | 2019-10-31 |
EP2797588A1 (de) | 2014-11-05 |
HK1202430A1 (zh) | 2015-10-02 |
WO2013098390A1 (de) | 2013-07-04 |
JP6335790B2 (ja) | 2018-05-30 |
BR112014016176A2 (pt) | 2017-06-13 |
CA2861782A1 (en) | 2013-07-04 |
US20140378917A1 (en) | 2014-12-25 |
CN110251490A (zh) | 2019-09-20 |
CN104144683A (zh) | 2014-11-12 |
BR112014016176B1 (pt) | 2022-01-04 |
CA2861782C (en) | 2020-04-14 |
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