ES2558030T3 - Método anticonceptivo oral multifásico de ciclo prolongado - Google Patents
Método anticonceptivo oral multifásico de ciclo prolongado Download PDFInfo
- Publication number
- ES2558030T3 ES2558030T3 ES07750352.2T ES07750352T ES2558030T3 ES 2558030 T3 ES2558030 T3 ES 2558030T3 ES 07750352 T ES07750352 T ES 07750352T ES 2558030 T3 ES2558030 T3 ES 2558030T3
- Authority
- ES
- Spain
- Prior art keywords
- equivalent amount
- estrogen
- phase
- ethinyl estradiol
- mcg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/285—Arsenic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Abstract
Una combinación multifásica y un kit anticonceptivo que comprende un envase que contiene: (a) de 7 a 14 dosificaciones diarias de una composición de Fase I que contiene un progestógeno en una cantidad equivalente de 0,3 a 1,5 mg de acetato de noretindrona y un estrógeno en una cantidad equivalente de 5 a 15 mcg de etinil estradiol; (b) de 14 a 22 dosificaciones diarias de una composición de Fase II que contiene un progestógeno en una cantidad equivalente de 0,3 a 1,5 mg de acetato de noretindrona y un estrógeno en una cantidad equivalente de 10 a 25 mcg de etinil estradiol; (c) de 20 a 31 dosificaciones diarias de una composición de Fase III que contiene un progestógeno en una cantidad equivalente de 0,3 a 1,5 mg de acetato de noretindrona y un estrógeno en una cantidad equivalente de 15 a 35 mcg de etinil estradiol; y (d) de 2 a 8 dosificaciones diarias de una composición de Fase IV, que contiene i. un estrógeno en una cantidad equivalente de 5 a 20 mcg de etinil estradiol, o ii. un placebo o un componente no esteroideo, o iii. una combinación de i. e ii., donde la cantidad equivalente de etinil estradiol de estrógeno en cada una de las Fases II y III sucesivas es al menos 5 mcg mayor que la cantidad equivalente de etinil estradiol de estrógeno en la fase inmediatamente anterior y donde las dosificaciones combinadas de las composiciones de Fase I, II, III y IV en el kit son de 54 a 58.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77806706P | 2006-03-02 | 2006-03-02 | |
US778067P | 2006-03-02 | ||
US79265306P | 2006-04-18 | 2006-04-18 | |
US792653P | 2006-04-18 | ||
PCT/US2007/003508 WO2007106264A2 (en) | 2006-03-02 | 2007-02-09 | Extended cycle multiphasic oral contraceptive method |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2558030T3 true ES2558030T3 (es) | 2016-02-01 |
Family
ID=38229300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07750352.2T Active ES2558030T3 (es) | 2006-03-02 | 2007-02-09 | Método anticonceptivo oral multifásico de ciclo prolongado |
Country Status (8)
Country | Link |
---|---|
US (1) | US8063030B2 (es) |
EP (1) | EP1993531B1 (es) |
CA (1) | CA2640520C (es) |
ES (1) | ES2558030T3 (es) |
IL (1) | IL193013A (es) |
MX (1) | MX2008011074A (es) |
SG (1) | SG172654A1 (es) |
WO (1) | WO2007106264A2 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2542854C (en) * | 2003-11-14 | 2012-04-17 | Warner Chilcott Company, Inc. | Graduated estrogen contraceptive |
US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
HRP20211377T1 (hr) | 2011-11-23 | 2022-01-07 | Therapeuticsmd, Inc. | Prirodne kombinirane hormonske supstitucijske formulacije i terapije |
WO2013090117A1 (en) * | 2011-12-13 | 2013-06-20 | Arstat, Inc. | A multiphasic contraceptive regimen for oral combination drug formulation of progestin and estrogen |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
UA123098C2 (uk) | 2015-06-18 | 2021-02-17 | Естетра Спрл | Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент |
CN107810001A (zh) | 2015-06-18 | 2018-03-16 | 密特拉制药公司 | 含雌四醇的口腔分散片剂 |
EP3310333B1 (en) | 2015-06-18 | 2020-04-29 | Estetra SPRL | Orodispersible dosage unit containing an estetrol component |
MA44206B1 (fr) | 2015-06-18 | 2021-04-30 | Estetra Sprl | Comprimé orodispersible comprenant estetrol |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
CA3020153A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
CA3178291A1 (en) | 2016-08-05 | 2018-04-12 | Estetra Srl | Method for the management of dysmenorrhea and menstrual pain |
JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE35724E (en) * | 1982-04-28 | 1998-02-03 | Bio-Technology General Corp. | Contraception system and method |
US4962098A (en) * | 1987-06-15 | 1990-10-09 | Warner-Lambert Company | Graduated estrogen contraceptive |
US5010070A (en) * | 1987-06-15 | 1991-04-23 | Warner-Lambert Company | Graduated estrogen contraceptive |
DE4313926A1 (de) * | 1993-04-28 | 1994-11-03 | Jenapharm Gmbh | Pharmazeutisches Mehrphasenpräparat zur hormonalen Kontrazeption |
DE4411585A1 (de) * | 1994-03-30 | 1995-10-05 | Schering Ag | Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption |
DE19525017A1 (de) | 1995-06-28 | 1997-01-02 | Schering Ag | Pharmazeutisches Kombinatonspräparat, Kit und Methode zur hormonalen Kontrazeption |
DE19531936A1 (de) | 1995-08-17 | 1997-02-20 | Schering Ag | Kombinationspräparat zur Kontrazeption, Kits diese enthaltend und eine Methode diese verwendend |
DE19540253C2 (de) | 1995-10-28 | 1998-06-04 | Jenapharm Gmbh | Mehrphasenpräparat zur Kontrazeption auf der Basis natürlicher Estrogene |
CA2261687A1 (en) | 1996-07-26 | 1998-02-05 | American Home Products Corporation | Oral contraceptive |
US5898032A (en) | 1997-06-23 | 1999-04-27 | Medical College Of Hampton Roads | Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy |
US6251956B1 (en) | 1998-08-20 | 2001-06-26 | Ortho Pharmaceutical Corporation | Combination progestin oral contraceptive regimen |
DE19739916C2 (de) | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
WO2002094280A1 (en) | 2001-05-23 | 2002-11-28 | Pantarhei Bioscience B.V. | Means and method for hormonal contraception |
PL213122B1 (pl) | 2001-12-05 | 2013-01-31 | Duramed Pharmaceuticals | Zestaw i preparat zawierajacy estrogen i progestagen |
US20040142914A1 (en) | 2002-03-11 | 2004-07-22 | Friedman Andrew Joseph | Extended transdermal contraceptive regimens |
CA2478206A1 (en) | 2002-03-11 | 2003-09-25 | Patrick Michel Caubel | Sulfatase inhibiting continuous progestogen contraceptive regimens |
US20030219471A1 (en) | 2002-03-11 | 2003-11-27 | Caubel Patrick Michel | Extended cycle estrogen and sulfatase inhibiting progestogen contraceptive regimens |
EP1624848A4 (en) | 2003-05-02 | 2009-02-25 | Duramed Pharmaceuticals Inc | METHOD FOR HORMONY TREATMENT WITH CONTRAZEPTVA SCHEMATES WITH EXTENDED CYCLE |
CN101001631B (zh) | 2003-07-16 | 2014-08-06 | 特卫华妇女健康有限公司 | 利用连续给予雌激素的避孕方案的激素治疗方法 |
KR20060129175A (ko) | 2003-10-01 | 2006-12-15 | 얀센 파마슈티카 엔.브이. | 확장된 3상 피임 요법 |
CA2542854C (en) | 2003-11-14 | 2012-04-17 | Warner Chilcott Company, Inc. | Graduated estrogen contraceptive |
US20050113350A1 (en) | 2003-11-26 | 2005-05-26 | Bernd Duesterberg | Extended use combination comprising estrogens and progestins |
CA2556459C (en) | 2004-03-19 | 2013-01-15 | Warner Chilcott Company, Inc. | Extended cycle multiphasic oral contraceptive method |
DE102004019743B4 (de) | 2004-04-20 | 2008-11-27 | Bayer Schering Pharma Aktiengesellschaft | Mehrphasenpräparat zur Kontrazeption auf der Basis eines natürlichen Estrogens |
BRPI0510024A (pt) * | 2004-05-14 | 2007-09-25 | Irm Llc | compostos e composições como modulares de ppar |
SG166107A1 (en) | 2005-06-29 | 2010-11-29 | Warner Chilcott Co Llc | Quadraphasic continuous graduated estrogen contraceptive |
-
2007
- 2007-02-09 WO PCT/US2007/003508 patent/WO2007106264A2/en active Application Filing
- 2007-02-09 ES ES07750352.2T patent/ES2558030T3/es active Active
- 2007-02-09 CA CA2640520A patent/CA2640520C/en active Active
- 2007-02-09 SG SG2011039344A patent/SG172654A1/en unknown
- 2007-02-09 EP EP07750352.2A patent/EP1993531B1/en active Active
- 2007-02-09 US US11/704,307 patent/US8063030B2/en active Active
- 2007-02-09 MX MX2008011074A patent/MX2008011074A/es active IP Right Grant
-
2008
- 2008-07-24 IL IL193013A patent/IL193013A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US20070207945A1 (en) | 2007-09-06 |
SG172654A1 (en) | 2011-07-28 |
US8063030B2 (en) | 2011-11-22 |
CA2640520A1 (en) | 2007-09-20 |
WO2007106264A2 (en) | 2007-09-20 |
EP1993531B1 (en) | 2015-10-14 |
WO2007106264A3 (en) | 2008-05-02 |
IL193013A0 (en) | 2009-08-03 |
EP1993531A2 (en) | 2008-11-26 |
IL193013A (en) | 2011-11-30 |
CA2640520C (en) | 2014-04-22 |
MX2008011074A (es) | 2008-09-10 |
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