ES2555235A1 - Nuevo proceso de fabricación en un solo paso de biomateriales espumados - Google Patents

Nuevo proceso de fabricación en un solo paso de biomateriales espumados Download PDF

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Publication number
ES2555235A1
ES2555235A1 ES201430964A ES201430964A ES2555235A1 ES 2555235 A1 ES2555235 A1 ES 2555235A1 ES 201430964 A ES201430964 A ES 201430964A ES 201430964 A ES201430964 A ES 201430964A ES 2555235 A1 ES2555235 A1 ES 2555235A1
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Prior art keywords
biomaterials
foamed
translation
machine
manufacturing process
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Granted
Application number
ES201430964A
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English (en)
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ES2555235B1 (es
Inventor
David PASTORINO CARRAZ
Cristina Canal Barnils
Maria Pau Ginebra Molins
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Universitat Politecnica de Catalunya UPC
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Universitat Politecnica de Catalunya UPC
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Priority to ES201430964A priority Critical patent/ES2555235B1/es
Priority to EP15845889.3A priority patent/EP3160422B1/en
Priority to ES15845889T priority patent/ES2755421T3/es
Priority to PCT/IB2015/001241 priority patent/WO2016051244A2/en
Priority to US15/321,409 priority patent/US20170197008A1/en
Publication of ES2555235A1 publication Critical patent/ES2555235A1/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/327—After-treatment
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
    • C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
    • C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C04B38/10—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by using foaming agents or by using mechanical means, e.g. adding preformed foam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)

Abstract

Nuevo proceso de fabricación de biomateriales espumados en una sola etapa. Esta invención se refiere a procesos para la preparación de biomateriales, en particular espumas y estructuras sólidas, aptas para su utilización en cirugía del hueso y odontología, regeneración ósea, relleno de defectos óseos, estabilización de fracturas óseas, recubrimientos de prótesis o implantes, fijación de prótesis o implantes, sistemas de liberación de fármacos y andamios para ingeniería de tejidos, y a los biomateriales obtenidos a partir del mismo. Además, esta invención se refiere también a espumas de fosfato de calcio autofraguables que pueden ser obtenidas a través de un proceso que comprende el mezclado y espumado simultáneos de una polvo y de una fase líquida.

Description

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Claims (1)

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ES201430964A 2014-06-25 2014-06-25 Nuevo proceso de fabricación en un solo paso de biomateriales espumados Active ES2555235B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES201430964A ES2555235B1 (es) 2014-06-25 2014-06-25 Nuevo proceso de fabricación en un solo paso de biomateriales espumados
EP15845889.3A EP3160422B1 (en) 2014-06-25 2015-06-25 New single-step manufacturing process for foamed biomaterials
ES15845889T ES2755421T3 (es) 2014-06-25 2015-06-25 Nuevo procedimiento de fabricación en una única etapa de biomateriales alveolares
PCT/IB2015/001241 WO2016051244A2 (en) 2014-06-25 2015-06-25 New single-step manufacturing process for foamed biomaterials
US15/321,409 US20170197008A1 (en) 2014-06-25 2015-06-25 New single-step manufacturing process for foamed biomaterials

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201430964A ES2555235B1 (es) 2014-06-25 2014-06-25 Nuevo proceso de fabricación en un solo paso de biomateriales espumados

Publications (2)

Publication Number Publication Date
ES2555235A1 true ES2555235A1 (es) 2015-12-29
ES2555235B1 ES2555235B1 (es) 2016-10-05

Family

ID=54883775

Family Applications (2)

Application Number Title Priority Date Filing Date
ES201430964A Active ES2555235B1 (es) 2014-06-25 2014-06-25 Nuevo proceso de fabricación en un solo paso de biomateriales espumados
ES15845889T Active ES2755421T3 (es) 2014-06-25 2015-06-25 Nuevo procedimiento de fabricación en una única etapa de biomateriales alveolares

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15845889T Active ES2755421T3 (es) 2014-06-25 2015-06-25 Nuevo procedimiento de fabricación en una única etapa de biomateriales alveolares

Country Status (4)

Country Link
US (1) US20170197008A1 (es)
EP (1) EP3160422B1 (es)
ES (2) ES2555235B1 (es)
WO (1) WO2016051244A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016012746A1 (de) * 2016-10-25 2018-04-26 WindplusSonne GmbH Vorprodukte zur Herstellung von porösen, mineralischen Leichtbaumaterialien, Verfahren zur Herstellung von porösen, mineralischen Leichtbaumaterialien und ihre Verwendung
RU2705084C1 (ru) * 2019-03-29 2019-11-01 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения пористых материалов из альгината натрия и поливинилпирролидона, содержащих фосфаты кальция
TWI791260B (zh) * 2021-08-12 2023-02-01 行政院農業委員會 一種從含鈣生物廢棄物製備雙相磷酸鈣多孔陶瓷的兩階段燒結方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340648B1 (en) * 1999-04-13 2002-01-22 Toshiba Ceramics Co., Ltd. Calcium phosphate porous sintered body and production thereof
US20140012271A1 (en) * 2010-11-10 2014-01-09 Stryker Trauma Gmbh Polymeric bone foam composition and method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880610A (en) * 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US20030199615A1 (en) * 1999-12-09 2003-10-23 Cyril Chaput Mineral-polymer hybrid composition
JP4540969B2 (ja) * 2003-11-27 2010-09-08 Ｈｏｙａ株式会社 リン酸カルシウムセラミックス多孔体及びその製造方法
US7351280B2 (en) * 2004-02-10 2008-04-01 New York University Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment
US20060110422A1 (en) * 2004-11-19 2006-05-25 Tas Ahmet C Conversion of calcite powders into macro- and microporous calcium phosphate scaffolds for medical applications
WO2010116321A2 (en) * 2009-04-06 2010-10-14 Universitat Politecnica De Catalunya Biopolymer-containing calcium phosphate foam, process for obtaining thereof and use for bone regeneration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340648B1 (en) * 1999-04-13 2002-01-22 Toshiba Ceramics Co., Ltd. Calcium phosphate porous sintered body and production thereof
US20140012271A1 (en) * 2010-11-10 2014-01-09 Stryker Trauma Gmbh Polymeric bone foam composition and method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MONTUFAR, E. B., et al. Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration. Acta Biomaterialia, 2010, vol. 6, no 3, p. 876-885; apartado 2, 3.2, Tabla 1. *
MONTUFAR, Edgar B., et al. Comparison of a low molecular weight and a macromolecular surfactant as foaming agents for injectable self setting hydroxyapatite foams: Polysorbate 80 versus gelatine. Materials Science and Engineering: C, 2011, vol. 31, no 7, p. 1498-1504; apartados 2.1,-2.2, 3.2, figura 3. *

Also Published As

Publication number Publication date
EP3160422B1 (en) 2019-08-14
EP3160422A4 (en) 2018-01-24
US20170197008A1 (en) 2017-07-13
WO2016051244A3 (en) 2016-05-26
ES2755421T3 (es) 2020-04-22
EP3160422A2 (en) 2017-05-03
WO2016051244A2 (en) 2016-04-07
ES2555235B1 (es) 2016-10-05

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