ES2551053B1 - Polyvitamin food supplement for pregnant women - Google Patents

Polyvitamin food supplement for pregnant women Download PDF

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ES2551053B1
ES2551053B1 ES201531147A ES201531147A ES2551053B1 ES 2551053 B1 ES2551053 B1 ES 2551053B1 ES 201531147 A ES201531147 A ES 201531147A ES 201531147 A ES201531147 A ES 201531147A ES 2551053 B1 ES2551053 B1 ES 2551053B1
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vitamin
pregnant women
food supplement
magnesium
polyvitamin
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ES2551053A1 (en
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Roberto COSTILLAS PÉREZ
Ángel DELPUEYO VERNIOL
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Fertypharm S L
Fertypharm Sl
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Fertypharm S L
Fertypharm Sl
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    • AHUMAN NECESSITIES
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    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
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    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415Pyridoxine, i.e. Vitamin B6
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51Thiamines, e.g. vitamin B1
    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525Isoalloxazines, e.g. riboflavins, vitamin B2
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    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis

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Abstract

Complemento alimenticio polivitamínico para mujeres embarazadas que comprende una asociación de ácido docosahexaenoico (DHA), Magnesio, Vitamina C, hierro, vitaminas B1, B2, B3, B5, B6 y B12, vitamina E, ácido fólico, biotina, yodo y zinc, y una mezcla de agentes probióticos constituida por Lactobacillus Rhamnosus y Lactobacillus Reuteri.Polyvitamin food supplement for pregnant women comprising an association of docosahexaenoic acid (DHA), Magnesium, Vitamin C, iron, vitamins B1, B2, B3, B5, B6 and B12, vitamin E, folic acid, biotin, iodine and zinc, and a mixture of probiotic agents consisting of Lactobacillus Rhamnosus and Lactobacillus Reuteri.

Description

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DESCRIPCIONDESCRIPTION

Complemento alimenticio polivitammico para mujeres embarazadas Campo de la invencionMultivitamin food supplement for pregnant women Field of the invention

La presente invencion se refiere al uso de probioticos en la composition de complementos alimenticios polivitammicos para mujeres embarazadas.The present invention relates to the use of probiotics in the composition of polyvinyl food supplements for pregnant women.

Antecedentes de la invencionBackground of the invention

Los Complementos Alimenticios son productos cuyo fin es complementar una dieta normal y consisten en fuentes concentradas de nutrientes o de otras sustancias que tienen un efecto nutricional o fisiologico en forma simple o combinada. Son comercializados en forma dosificada, es decir capsulas, pastillas, tabletas, pfldoras que deben tomarse en pequenas cantidades unitarias.Food Supplements are products whose purpose is to complement a normal diet and consist of concentrated sources of nutrients or other substances that have a nutritional or physiological effect in a simple or combined form. They are marketed in a dosage form, that is capsules, pills, tablets, pills that must be taken in small unit quantities.

Estos complementos o suplementos alimenticios no son considerados medicamentos ya que no curan enfermedades, sino que mejoran el bienestar de la persona, por lo que estan destinados a individuos con buena salud y no necesitan prescription medica.These supplements or nutritional supplements are not considered medications since they do not cure diseases, but improve the well-being of the person, so they are intended for individuals in good health and do not need a prescription.

Se conocen complementos polivitammicos para a mujeres embarazadas cuya finalidad es mejorar las condiciones del embarazo de la madre y ayudar al desarrollo del feto.Polivitammicos supplements are known for pregnant women whose purpose is to improve the conditions of the mother's pregnancy and help the development of the fetus.

La patente WO2003017945, describe un suplemento para mujeres embarazadas, que contienen DHA, varias vitaminas y minerales. Se reivindica que tomando estos suplementos se podria beneficiar la salud tanto de la madre como del bebe.WO2003017945, discloses a supplement for pregnant women, containing DHA, various vitamins and minerals. It is claimed that taking these supplements could benefit the health of both the mother and the baby.

Los componentes principales descritos en el estado de la tecnica para este tipo de complemento alimenticio son: Acidos grasos omega 3, Magnesio, Vitamina C, hierro, vitaminas del grupo B, vitamina E, acido folico, biotina, yodo y zinc.The main components described in the state of the art for this type of food supplement are: Omega 3 fatty acids, Magnesium, Vitamin C, iron, B vitamins, vitamin E, folic acid, biotin, iodine and zinc.

Los acidos grasos omega 3 son acidos grasos esenciales poliinsaturados, que se encuentran en alta proportion en los tejidos de ciertos pescados, y en algunas fuentes vegetales. El ser humano no puede generar acidos a partir de otros componentes, por lo que los acidos omega 3 deben ingerirse con la dieta. Los acidos omega-3 tienen diversos efectos entre ellos se destaca, el aumentar el tiempo de coagulation de la sangre, efectos beneficos sobre el cerebro, y durante el embarazo tienen influencia en el desarrollo del feto.Omega 3 fatty acids are polyunsaturated essential fatty acids, which are found in high proportion in the tissues of certain fish, and in some plant sources. The human being cannot generate acids from other components, so omega 3 acids must be ingested with the diet. Omega-3 acids have various effects among them, the increase in blood clotting time, beneficial effects on the brain, and during pregnancy have an influence on the development of the fetus.

Existen seis tipos diferentes de acido omega 3, el acido docosahexaenoico (DHA) es uno de ellos.There are six different types of omega 3 acid, docosahexaenoic acid (DHA) is one of them.

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El DHA tiene un efecto positivo sobre la estructura y funcion de las membranas celulares y es un precursor de metabolitos anti-inflamatorios y neuroprotectores. Se usa como complemento alimenticio en diversos preparados habiendose probado que mejora el desarrollo del feto.DHA has a positive effect on the structure and function of cell membranes and is a precursor of anti-inflammatory and neuroprotective metabolites. It is used as a food supplement in various preparations having been proven to improve the development of the fetus.

El magnesio es un mineral que cumple un rol fundamental durante el embarazo ya que interviene en la generation y reparation de tejidos. Ademas tiene una action reequilibrante sobre el sistema circulatorio, protege contra los infartos y estimula la contractilidad cardiaca.Magnesium is a mineral that plays a fundamental role during pregnancy as it is involved in the generation and repair of tissues. It also has a rebalancing action on the circulatory system, protects against heart attacks and stimulates cardiac contractility.

Las deficiencias de magnesio se asocian a mayor riesgo de preeclampsia, eclampsia, mortalidad infantil y malformaciones congenitas. Varias investigaciones coinciden en que manteniendo unos niveles adecuados de magnesio durante el embarazo, se reducen las contracciones uterinas antes de la semana 35 del embarazo.Magnesium deficiencies are associated with an increased risk of preeclampsia, eclampsia, infant mortality and congenital malformations. Several investigations agree that maintaining adequate levels of magnesium during pregnancy reduces uterine contractions before the 35th week of pregnancy.

La vitamina C es uno de los nutrientes esenciales para mujeres embarazadas ya que proporciona protection antioxidante contra la enfermedad y protection contra los defectos de nacimiento. Aumenta la inmunidad, una ventaja especialmente util para las mujeres embarazadas que limitan su medication por temor a poner en peligro a los bebes. El acido ascorbico tambien protege de la anemia, ya ayuda al cuerpo a absorber el hierro. Tambien de interes para las mujeres preocupadas por las estrias es la capacidad del acido ascorbico para construir el colageno.Vitamin C is one of the essential nutrients for pregnant women as it provides antioxidant protection against disease and protection against birth defects. Increases immunity, an especially useful advantage for pregnant women who limit their medication for fear of endangering babies. Ascorbic acid also protects against anemia, it already helps the body absorb iron. Also of interest to women concerned with stretch marks is the ability of ascorbic acid to build collagen.

El hierro reduce la probabilidad de riesgo de anemia, interviniendo en la formation de hemoglobina y globulos rojos.Iron reduces the likelihood of anemia risk, intervening in the formation of hemoglobin and red blood cells.

Las vitaminas del grupo B durante el embarazo influyen en el desarrollo del sistema nervioso y la formacion de los globulos rojos del feto.B vitamins during pregnancy influence the development of the nervous system and the formation of the red blood cells of the fetus.

• B1 tiamina: Es una vitamina hidrosoluble, actua como coenzima y tiene un papel esencial en el sistema nervioso y el metabolismo de macro-nutrientes. Su ingesta se ha relacionado con el control de los calambres durante el embarazo.• B1 thiamine: It is a water-soluble vitamin, acts as coenzyme and has an essential role in the nervous system and macro-nutrient metabolism. Its intake has been related to the control of cramps during pregnancy.

• B2 riboflavina: Vitamina hidrosoluble que participa en varios procesos metabolicos vitales del organismo, para un funcionamiento celular normal, crecimiento y production de energia. La riboflavina puede prevenir en el feto bajo peso al nacer, asi como defectos congenitos y muerte.• B2 riboflavin: Water-soluble vitamin that participates in several vital metabolic processes of the organism, for normal cellular functioning, growth and energy production. Riboflavin can prevent low birth weight in the fetus, as well as birth defects and death.

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• B3 niacina: Esta vitamina estimula el apetito e interviene en la absorcion de los alimentos en el tubo digestivo. Tambien ayuda a contrarrestar la hiperlipemia, as^ como hipoglucemia. Durante el embarazo aumenta el requerimiento de niacina• B3 niacin: This vitamin stimulates appetite and is involved in the absorption of food in the digestive tract. It also helps counteract hyperlipidemia, as well as hypoglycemia. During pregnancy the niacin requirement increases

• B6 piridoxina: Esta vitamina es importante para el metabolismo de aminoacidos y carbohidratos. Tiene un papel fundamental en el desarrollo del sistema nervioso central y en la formacion de compuestos relacionados con la hemoglobina, por lo que su ingesta durante el embarazo y la lactancia previene anormalidades neurologicas y del comportamiento en el recien nacido. Tambien se ha observado que los suplementos con vitamina B6 reducen las nauseas y los vomitos durante el embarazo.• B6 pyridoxine: This vitamin is important for the metabolism of amino acids and carbohydrates. It has a fundamental role in the development of the central nervous system and in the formation of hemoglobin-related compounds, so its intake during pregnancy and lactation prevents neurological and behavioral abnormalities in the newborn. It has also been observed that supplements with vitamin B6 reduce nausea and vomiting during pregnancy.

• B12 cianocobalamina: Esencial para el mantenimiento de las celulas nerviosas y de los globulos rojos. Un aporte adecuado de vitamina B12 evita el desarrollo de anemia perniciosa en el bebe. Tambien interviene en el proceso de almacenamiento del acido folico, por lo que contribuye en la prevencion de malformaciones fetales. Tambien previene defectos del tubo neural, retraso en el proceso de obtencion de mielina de las fibras nerviosas, del sistema nervioso del feto; abortos espontaneos y preeclampsia.• B12 cyanocobalamin: Essential for the maintenance of nerve cells and red blood cells. An adequate supply of vitamin B12 prevents the development of pernicious anemia in the baby. It also intervenes in the process of storage of folic acid, so it contributes to the prevention of fetal malformations. It also prevents defects of the neural tube, delay in the process of obtaining myelin from the nerve fibers, from the nervous system of the fetus; spontaneous abortions and preeclampsia.

La vitamina E, es un nutriente clave en embarazadas, pues tiene un impacto positivo en el sistema nervioso, contribuye a impulsar el desarrollo neurologico del bebe y le fortalece contra las infecciones. Niveles inadecuados de vitamina E estan asociados con un aumento de las infecciones, con anemia, asma y retraso del crecimiento del feto. Tambien, varias investigaciones confirman que la ingesta de una combination de vitamina E y C por dia disminuye el riesgo de desarrollar hipertension arterial en mujeres con alto riesgo cuando comenzaron la ingesta durante las semanas 16-22 del embarazo.Vitamin E is a key nutrient in pregnant women, as it has a positive impact on the nervous system, helps boost the baby's neurological development and strengthens it against infections. Inadequate levels of vitamin E are associated with an increase in infections, with anemia, asthma and stunting of the fetus. Also, several investigations confirm that the ingestion of a combination of vitamin E and C per day decreases the risk of developing high blood pressure in women at high risk when they began intake during weeks 16-22 of pregnancy.

El acido folico es un tipo de vitamina del complejo B. Es la forma artificial del folato que se encuentra en suplementos y en los alimentos. Es hidrosoluble por lo que las cantidades sobrantes de la vitamina, se excretan por la orina no acumulandose en el organismo, por lo que debe recibirse un aporte continuo de acido folico. Contribuye al trabajo celular y en el crecimiento de los tejidos. La ingesta adecuada de acido folico antes y durante el embarazo ayuda a prevenir ciertas anomalias congenitas, o alteraciones como la anemia.Folic acid is a type of vitamin B complex. It is the artificial form of folate found in supplements and food. It is water soluble so that the remaining amounts of the vitamin are excreted in the urine not accumulating in the body, so you must receive a continuous supply of folic acid. It contributes to cell work and tissue growth. Adequate intake of folic acid before and during pregnancy helps prevent certain congenital anomalies, or alterations such as anemia.

La biotina en compuestos alimenticios se usa para prevenir y tratar la deficiencia de biotina asociada con el embarazo, por lo que se administra de forma preventiva durante el embarazo. El diagnostico de esta deficiencia es clmico, y sus principales manifestaciones son perdida de cabello (a menudo con perdida de color), y erupciones rojas y escamosas alrededor de losBiotin in food compounds is used to prevent and treat biotin deficiency associated with pregnancy, so it is administered preventively during pregnancy. The diagnosis of this deficiency is climactic, and its main manifestations are hair loss (often with loss of color), and red and scaly rashes around the

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ojos, nariz y boca. Otros smtomas incluyen depresion, apatia, alucinaciones y hormigueo en los brazos y piernaseyes, nose and mouth Other symptoms include depression, apathy, hallucinations and tingling in the arms and legs

El yodo es imprescindible para la smtesis de las hormonas tiroideas, claves para el desarrollo mental y el crecimiento del feto y neonato.Iodine is essential for the synthesis of thyroid hormones, keys for mental development and the growth of the fetus and neonate.

El zinc es un mineral que es fundamental para el correcto funcionamiento del sistema reproductivo y el desarrollo fetal, ya que ademas de ser responsable de la calidad del esperma y ovulos, contribuye en el rapido crecimiento del bebe durante el embarazo.Zinc is a mineral that is essential for the proper functioning of the reproductive system and fetal development, since in addition to being responsible for the quality of sperm and ovules, it contributes to the rapid growth of the baby during pregnancy.

Los componentes de estos complementos alimenticios tienen como finalidad el mejorar las condiciones del embarazo y ayudar al desarrollo del feto, sin embargo sin embargo hay algunas patologias como vulvovaginitis, vaginosis, partos prematuros e infecciones del tracto urinario que no pueden prevenirse con ellos.The components of these food supplements are intended to improve pregnancy conditions and help the development of the fetus, however there are some pathologies such as vulvovaginitis, vaginosis, premature births and urinary tract infections that cannot be prevented with them.

No se han descrito formulaciones de complementos alimenticios destinados a la mejora de la fertilidad femenina que incorporen combinaciones de agentes probioticos.Formulations of food supplements intended to improve female fertility that incorporate combinations of probiotic agents have not been described.

Descripcion de la invencionDescription of the invention

La invencion se refiere un complemento alimenticio polivitammico para mujeres embarazadas que incluye una combination de probioticos con la finalidad de preservar a la embarazada de algunas patologias comunes, modulando una respuesta inmune y reduciendo el riesgo de determinadas respuestas alergicas. Tambien actuan regulando la adherencia de protemas, aspecto fundamental en el papel de barrera de la mucosa epitelial, degradan toxinas y reducen la posibilidad de implantation y el efecto negativo que provocan otras bacterias oportunistas que invaden la mucosa vaginal.The invention relates to a multivitamin nutritional supplement for pregnant women that includes a combination of probiotics in order to preserve the pregnant woman from some common pathologies, modulating an immune response and reducing the risk of certain allergic responses. They also act by regulating the adhesion of proteins, a fundamental aspect in the barrier role of the epithelial mucosa, degrade toxins and reduce the possibility of implantation and the negative effect caused by other opportunistic bacteria that invade the vaginal mucosa.

El nuevo complemento alimenticio comprende una asociacion de:The new food supplement includes an association of:

a) Una mezcla constituida por acido docosahexaenoico (DHA), Magnesio, Vitamina C, hierro, vitaminas B1, B2, B3, B5, B6Y B12, vitamina E, acido folico, biotina, yodo y zinc.a) A mixture consisting of docosahexaenoic acid (DHA), Magnesium, Vitamin C, iron, vitamins B1, B2, B3, B5, B6Y B12, vitamin E, folic acid, biotin, iodine and zinc.

b) Una mezcla de agentes probioticos constituida por Lactobacillus Rhamnosus y Lactobacillus Reuteri.b) A mixture of probiotic agents consisting of Lactobacillus Rhamnosus and Lactobacillus Reuteri.

La primera mezcla tiene objeto la mejora las condiciones del embarazo y la ayuda al desarrollo del feto.The first mixture is aimed at improving pregnancy conditions and helping the fetus to develop.

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Respecto a la segunda mezcla, los Lactobacillus Rhamnosus y Reuteri, estan presentes de forma natural en la microflora vaginal. La administration de ambas cepas en mujeres embarazadas ha demostrado una mejora de la microbiota, aspecto fundamental para prevenir algunas patologias como son la vulvovaginitis, vaginosis, partos prematuros, e infecciones del tracto urinario.Regarding the second mixture, Lactobacillus Rhamnosus and Reuteri, are naturally present in the vaginal microflora. The administration of both strains in pregnant women has shown an improvement in the microbiota, a fundamental aspect to prevent some pathologies such as vulvovaginitis, vaginosis, premature births, and urinary tract infections.

El complemento alimenticio esta formulado para administrarse por via oral, por lo tanto, puede presentarse en forma de capsula, comprimido, granulado, ventajosamente en forma de capsula. Si el complemento alimenticio se presenta en forma de capsula blanda o capsula, la envuelta de dichas capsulas blandas o dichas capsulas puede contener especialmente gelatina animal, como gelatina de pescado, glicerina o un material de origen vegetal, como un derivado de celulosa o de almidon, o una protema vegetal. Si el complemento alimenticio se presenta en forma de capsula, comprimido o granulado, la mezcla de activos puede fijarse en un soporte polvoriento, como sflice, celulosa y maltodextrina.The food supplement is formulated to be administered orally, therefore, it can be presented as a capsule, compressed, granulated, advantageously as a capsule. If the food supplement is in the form of a soft capsule or capsule, the shell of said soft capsules or said capsules may contain especially animal gelatin, such as fish jelly, glycerin or a material of plant origin, such as a cellulose or starch derivative , or a vegetable protein. If the food supplement is in the form of a capsule, tablet or granulate, the active mixture can be fixed on a dusty support, such as silica, cellulose and maltodextrin.

El complemento alimenticio de la invention responde preferiblemente a la siguiente composition ponderal:The food supplement of the invention preferably responds to the following weight composition:

Para una capsulaFor a capsule

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acido docosahexaenoico (DHA) 350-410 mg  Docosahexaenoic acid (DHA) 350-410 mg

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Magnesio, 90-95 mg  Magnesium, 90-95 mg

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Vitamina C 79-82 mg  Vitamin C 79-82 mg

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Hierro, 27-29 mg  Iron, 27-29 mg

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Vitamina B1 1-1,5 mg  Vitamin B1 1-1.5 mg

-  -
Vitamina B2 1-1,5 mg  Vitamin B2 1-1.5 mg

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Vitamina B3 14-17 mg  Vitamin B3 14-17 mg

-  -
Vitamina B5 6-7 mg  Vitamin B5 6-7 mg

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Vitamina B6 1-2 mg  Vitamin B6 1-2 mg

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Vitamina B12 2-3 mg  Vitamin B12 2-3 mg

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Vitamina E 16-19 mg  Vitamin E 16-19 mg

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Acido Folico 0,3-0,8 mg  Folic Acid 0.3-0.8 mg

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Biotina 0,02-0,4 mg  Biotin 0.02-0.4 mg

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Yodo 0,1-0,5 mg  Iodine 0.1-0.5 mg

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Zinc 11-13 mg  Zinc 11-13 mg

-  -
Lactobacillus Rhamnosus 5x1010 UFC  Lactobacillus Rhamnosus 5x1010 CFU

-  -
Lactobacillus Reuteri 5x1010 UFC  Lactobacillus Reuteri 5x1010 UFC

Para esta capsula en particular la dosis recomendada es de una unidad al dia.For this particular capsule the recommended dose is one unit per day.

Claims (1)

55 1010 15fifteen 20twenty 2525 3030 E S 2 55 1 053 A1E S 2 55 1 053 A1 REIVINDICACIONES 1a.- Complemento alimenticio polivitammico para mujeres embarazadas caracterizado porque comprende una asociacion de:1st.- Multivitamin food supplement for pregnant women characterized in that it includes an association of: a) Una mezcla constituida por acido docosahexaenoico (DHA), Magnesio, Vitamina C, hierro, vitaminas B1, B2, B3, B5, B6 y B12, vitamina E, acido folico, biotina, yodo y zinc.a) A mixture consisting of docosahexaenoic acid (DHA), Magnesium, Vitamin C, iron, vitamins B1, B2, B3, B5, B6 and B12, vitamin E, folic acid, biotin, iodine and zinc. b) Una mezcla de agentes probioticos constituida por Lactobacillus Rhamnosus y Lactobacillus Reuteri.b) A mixture of probiotic agents consisting of Lactobacillus Rhamnosus and Lactobacillus Reuteri. 2a.- Complemento alimenticio polivitammico para mujeres embarazadas segun reivindicacion primera caracterizado porque comprende por capsula:2a.- Multivitamin food supplement for pregnant women according to the first claim characterized in that it comprises: - 350-410 mg de acido docosahexaenoico (DHA)- 350-410 mg docosahexaenoic acid (DHA) - 90-95 mg de Magnesio,- 90-95 mg of Magnesium, - 79-82 mg de Vitamina C- 79-82 mg of Vitamin C - 27-29 mg de Hierro,- 27-29 mg of iron, - 1-1,5 mg de Vitamina B1- 1-1.5 mg of Vitamin B1 - 1-1,5 mg de Vitamina B2- 1-1.5 mg of Vitamin B2 - 14-17 mg de Vitamina B3- 14-17 mg of Vitamin B3 - 6-7 mg de Vitamina B5- 6-7 mg of Vitamin B5 - 1-2 mg de Vitamina B6- 1-2 mg of Vitamin B6 - 2-3 mg de Vitamina B12- 2-3 mg of Vitamin B12 - 16-19 mg de Vitamina E- 16-19 mg of Vitamin E - 0,4 mg de Acido Folico- 0.4 mg Folic Acid - 0,3-0,8 mg de Biotina- 0.3-0.8 mg of Biotin - 0,02-0,4 mg de Yodo- 0.02-0.4 mg of iodine - 11-13 mg de Zinc- 11-13 mg of Zinc - 5x1010 UFC Lactobacillus Rhamnosus- 5x1010 UFC Lactobacillus Rhamnosus - 5x1010 UFC Lactobacillus Reuteri- 5x1010 CFU Lactobacillus Reuteri 3a Uso de la combination de probioticos Lactobacillus Rhamnosus y Lactobacillus Reuteri para preparar un complemento alimenticio polivitammico para mujeres embarazadas.3a Use of the combination of probiotics Lactobacillus Rhamnosus and Lactobacillus Reuteri to prepare a food supplement for pregnant women.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107373487A (en) * 2017-07-20 2017-11-24 赵成群 A kind of ferrous bisglycinate chelate electuary
WO2023209224A1 (en) * 2022-04-29 2023-11-02 Université Libre de Bruxelles Probiotics for the prevention or treatment of viral respiratory infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4905300A (en) * 1999-05-25 2000-12-12 Andrew W. Bruce Oral administration of lactobacillus for the maintenance of health in women
EP2011506A1 (en) * 2007-07-05 2009-01-07 Nestec S.A. Supplementation of maternal diet
EP2609814A1 (en) * 2011-12-30 2013-07-03 Nestec S.A. Lactobacillus reuteri DSM 17938 for the development of cognitive function
US9241923B2 (en) * 2013-07-16 2016-01-26 Mead Johnson Nutrition Company Methods for promoting neuronal development and/or health

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107373487A (en) * 2017-07-20 2017-11-24 赵成群 A kind of ferrous bisglycinate chelate electuary
WO2023209224A1 (en) * 2022-04-29 2023-11-02 Université Libre de Bruxelles Probiotics for the prevention or treatment of viral respiratory infections

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