ES2542055T3 - Un procedimiento para preparar un hidrogel a través del uso de alcóxidos, el producto así obtenido y el uso del mismo - Google Patents

Un procedimiento para preparar un hidrogel a través del uso de alcóxidos, el producto así obtenido y el uso del mismo Download PDF

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Publication number
ES2542055T3
ES2542055T3 ES07804982.2T ES07804982T ES2542055T3 ES 2542055 T3 ES2542055 T3 ES 2542055T3 ES 07804982 T ES07804982 T ES 07804982T ES 2542055 T3 ES2542055 T3 ES 2542055T3
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Prior art keywords
hydrogel
bisacrylamide
polymer
monomer
double bonds
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ES07804982.2T
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English (en)
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Gerardo Balestrieri
Francesco Cefali'
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PHARMAFILL Srl
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PHARMAFILL Srl
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
    • C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/30—Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
    • C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
    • C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

Un proceso para la preparación de un hidrogel completamente no tóxico y biocompatible, que incluye una primera etapa en la que al menos un polímero o copolímero que contiene funciones hidroxilo se hace reaccionar con al menos un compuesto que contiene al menos dos dobles enlaces carbono-carbono, en un entorno básico acuoso que consiste en una solución acuosa de KOH o NaOH a una concentración de entre un 10% y un 30% en agua para dar un hidrogel reticulado, en el que la reticulación se produce a través de la formación de enlaces éter entre los grupos hidroxilo de dicho polímero y/o un copolímero y los dobles enlaces de dicho al menos un monómero, e incluyendo además una etapa en la que el hidrogel reticulado obtenido se lava con agua bidestilada no pirogénica y se neutraliza; en el que dicho al menos un monómero está seleccionado de: diacrilatos, diacrilato de polietilenglicoles, diacrilato de glicerol 1-3 diglicerolato; bisacrilamidas, metilenbisacrilamida, etilenbisacrilamida, isopropilenbisacrilamida; dialilurea.

Description

imagen1
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E07804982
09-07-2015
 sustitutos de derivados hialurónicos, también para problemas relativos a articulaciones, o  vehículos de agentes antiparasitarios en el campo de las plantas (por ejemplo, contra la carcoma del chopo y de la madera en general), o  películas y/o membranas insolubles con un efecto barrera de gases.
5 En un modo de realización preferente de la invención, el hidrogel de la presente invención entra dentro de la familia de dispositivos médicos y se inyecta por vía subcutánea por especialistas como una carga de partes blandas y como corrector inestético en cirugía estética.
10 Uno de los usos preferentes es, por tanto, el de carga que se puede inyectar y modelar en el sitio después de la aplicación y es biodegradable en tiempos más o menos largos, dependiendo del tipo de polímero y del tipo y el número de monómeros de reticulación usado para preparar el mismo.
De forma ventajosa, el hidrogel obtenible con el procedimiento de la presente invención cumple a la perfección las 15 necesidades expuestas anteriormente, como:
 está libre de monómeros residuales (de catalizadores o productos de reacción colaterales tales como dímeros) mantiene su propia viscosidad con el tiempo  es degradable con el tiempo y biocompatible es bacteriológicamente puro
20  tiene pH neutro  tiene una alta resistencia al agua caliente en agua  permite obtener varias variedades de características viscométricas, elastoméricas y de resistencia temporal  tiene viscosidad y consistencia homogénea y constante correspondiente con el tipo de aplicación que se ha de realizar en un campo médico.
25 La innovación generada por el procedimiento de la presente invención por tanto permite producir y proporcionar al experto en la técnica una amplia gama de hidrogeles homogéneos, estables y diferentemente estructurados, adecuados para cumplir la mayoría de los diferentes requisitos.
7

Claims (1)

  1. imagen1
ES07804982.2T 2006-11-03 2007-09-17 Un procedimiento para preparar un hidrogel a través del uso de alcóxidos, el producto así obtenido y el uso del mismo Active ES2542055T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITNO20060012 2006-11-03
IT000012A ITNO20060012A1 (it) 2006-11-03 2006-11-03 Procedimento per la preparazione di hydrogel con alcossidi
PCT/IB2007/002809 WO2008053289A1 (en) 2006-11-03 2007-09-17 A method for preparing a hydrogel through the use of alkoxydes, the product thus obtained and the use thereof

Publications (1)

Publication Number Publication Date
ES2542055T3 true ES2542055T3 (es) 2015-07-30

Family

ID=38829587

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07804982.2T Active ES2542055T3 (es) 2006-11-03 2007-09-17 Un procedimiento para preparar un hidrogel a través del uso de alcóxidos, el producto así obtenido y el uso del mismo

Country Status (6)

Country Link
US (1) US9902795B2 (es)
EP (1) EP2094769B1 (es)
ES (1) ES2542055T3 (es)
IT (1) ITNO20060012A1 (es)
PL (1) PL2094769T3 (es)
WO (1) WO2008053289A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114213789B (zh) * 2021-12-17 2022-11-22 厦门大学 一种硼酸酯聚合物/离子液体复合导电凝胶及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2394776A (en) * 1943-11-12 1946-02-12 Du Pont Modified polymeric polyhydric alcohols
JPS55142075A (en) * 1979-04-23 1980-11-06 Mitsubishi Electric Corp Thermal energy storage material
USRE32649E (en) * 1985-06-18 1988-04-19 The Procter & Gamble Company Hydrogel-forming polymer compositions for use in absorbent structures
FR2586359B1 (fr) * 1985-08-23 1989-09-08 Commissariat Energie Atomique Support solide a base d'alcool polyvinylique capable d'adsorber les lipoproteines et son utilisation pour la separation des lipoproteines de basse densite presentes dans un liquide tel que du plasma sanguin
US4874500A (en) * 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
US5880216A (en) * 1995-12-22 1999-03-09 Kuraray Co., Ltd. Polyvinyl alcohol and gel containing the same
US6007712A (en) * 1997-02-28 1999-12-28 Kuraray Co., Ltd. Waste water treatment apparatus
US6615078B1 (en) * 1999-04-22 2003-09-02 Cygnus, Inc. Methods and devices for removing interfering species
AUPR340701A0 (en) * 2001-02-27 2001-03-22 Life Therapeutics Limited Polymeric membranes and uses thereof
US7602498B2 (en) * 2001-10-19 2009-10-13 Invivosense Asa Optical sensing of measurands
KR100443165B1 (ko) * 2003-10-06 2004-08-11 (주)정상 엔지니어링 아크릴 고분자를 토사에 혼합·포설시켜 차수성능을 발현시키기 위한 차수제 제조방법
TW200517128A (en) * 2003-11-17 2005-06-01 China Testile Inst Micro-particles of hydrogel containing polysaccharide or its derivatives composition and method for preparing the same
ATE437902T1 (de) * 2004-09-16 2009-08-15 Polymekon S R L Verfahren zur herstellung eines polymeren hydrogels auf basis eines hochreinen polyvinylalkohols und dessen verwendung
US7235592B2 (en) * 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US20080140037A1 (en) * 2004-12-03 2008-06-12 Newman Thomas H Crosslinker for Superabsorbent Polymers
CN100358926C (zh) * 2005-11-24 2008-01-02 陕西科技大学 一种环保型保水剂的制备方法

Also Published As

Publication number Publication date
US20100099812A1 (en) 2010-04-22
PL2094769T3 (pl) 2015-10-30
EP2094769B1 (en) 2015-04-29
US9902795B2 (en) 2018-02-27
ITNO20060012A1 (it) 2008-05-04
WO2008053289A1 (en) 2008-05-08
EP2094769A1 (en) 2009-09-02

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