ES2540742T3 - Absorbable magnesium alloy - Google Patents
Absorbable magnesium alloy Download PDFInfo
- Publication number
- ES2540742T3 ES2540742T3 ES09758679.6T ES09758679T ES2540742T3 ES 2540742 T3 ES2540742 T3 ES 2540742T3 ES 09758679 T ES09758679 T ES 09758679T ES 2540742 T3 ES2540742 T3 ES 2540742T3
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- alloy
- magnesium
- magnesium alloy
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Classifications
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
- C22C23/04—Alloys based on magnesium with zinc or cadmium as the next major constituent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
- C22C23/06—Alloys based on magnesium with a rare earth metal as the next major constituent
Abstract
Una aleación de magnesio, que consiste, en porcentaje de peso: 0,5 a 8,0 por ciento de iterbio; 0,1 a 2,0 por ciento de calcio; y 0,2 a 6,0 por ciento de zinc; y opcionalmente hasta 4,0 por ciento de escandio; hasta 2,0 por ciento de itrio; 0,05 a 1,0 por ciento de manganeso; hasta 1,0 por ciento de circonio; y hasta 2,0 por ciento de aluminio, en el que el equilibrio hasta 100% en peso es de magnesio.A magnesium alloy, consisting of weight percentage: 0.5 to 8.0 percent of ytterbium; 0.1 to 2.0 percent calcium; and 0.2 to 6.0 percent zinc; and optionally up to 4.0 percent of scandium; up to 2.0 percent yttrium; 0.05 to 1.0 percent manganese; up to 1.0 percent zirconium; and up to 2.0 percent aluminum, in which the balance up to 100% by weight is magnesium.
Description
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E09758679 E09758679
25-06-2015 06-25-2015
Aleación de magnesio reabsorbible Absorbable magnesium alloy
La invención se refiere a una aleación de magnesio, según la reivindicación 1 y un implante hecho de la aleación según la reivindicación 4. The invention relates to a magnesium alloy according to claim 1 and an implant made of the alloy according to claim 4.
En la tecnología médica moderna, los implantes se utilizan para una amplia gama de aplicaciones, por ejemplo, para fines ortopédicos, como apoyo a los vasos sanguíneos, y para conectar o fijar los tejidos o los huesos. A menudo los implantes tienen sólo una función temporal hasta la finalización de la curación. Para evitar complicaciones como resultado de estos implantes que quedan permanentemente en el cuerpo, a menudo se deben eliminar o se deben hacer de un material bio anticorrsivo que será gradualmente degradado por el cuerpo. Se conocen un gran número de estos materiales bio anticorrosivos basados en polímeros o aleaciones. De especial interés son las aleaciones hechas de metales biodegradables como magnesio, hierro y tungsteno. In modern medical technology, implants are used for a wide range of applications, for example, for orthopedic purposes, as support for blood vessels, and for connecting or fixing tissues or bones. Often the implants have only a temporary function until the end of healing. To avoid complications as a result of these implants that remain permanently in the body, they must often be removed or made from a bio-corrosive material that will gradually be degraded by the body. A large number of these bio anticorrosive materials based on polymers or alloys are known. Of special interest are the alloys made of biodegradable metals such as magnesium, iron and tungsten.
La Patente Europea 1 270 023 describe una aleación de magnesio que al parecer es adecuada para la fabricación de implantes ortopédicos o endovasculares. La aleación contiene más de un 50% de magnesio y hasta el 5% de metales raros de la tierra. Otros elementos como el aluminio, el litio y el hierro también pueden estar contenidos en la aleación descrita. European Patent 1 270 023 describes a magnesium alloy that is apparently suitable for the manufacture of orthopedic or endovascular implants. The alloy contains more than 50% magnesium and up to 5% of rare earth metals. Other elements such as aluminum, lithium and iron may also be contained in the alloy described.
La aplicación W02008/035948 describe una aleación a base de magnesio biodegradable, compuesta de hasta 40 por ciento de calcio así como más del 40 por ciento atómico de uno o más elementos de indicio. Los elementos de indicio descritos incluyen Zr, Mo, Nb, Ta, Ti, Sr, Cr, Mn, Zn, Si, P, Ni y Fe. Através de la incorporación de los elementos de indicio, el ritmo de degradación de la aleación de magnesio es al parecer muy variada. Application W02008 / 035948 describes a biodegradable magnesium-based alloy, composed of up to 40 percent calcium as well as more than 40 atomic percent of one or more indication elements. The indicative elements described include Zr, Mo, Nb, Ta, Ti, Sr, Cr, Mn, Zn, Si, P, Ni and Fe. Through the incorporation of the indicative elements, the degradation rate of the alloy of Magnesium is apparently very varied.
Se sabe que las aleaciones biodegradables del magnesio también contienen itrio. W002/100452 describe una aleación que comprende opcionalmente 0,01 a 7% en peso de itrio y 0,01 a 8% en peso de metales raros de la tierra. La aleación también puede contener litio y/o aluminio. It is known that biodegradable magnesium alloys also contain yttrium. W002 / 100452 describes an alloy that optionally comprises 0.01 to 7% by weight of yttrium and 0.01 to 8% by weight of rare earth metals. The alloy may also contain lithium and / or aluminum.
El iterbio se ha utilizado como elemento marcador radiopaco en implantes. US2008/0033530 describe una aleación de marcador compuesta por 40 a 90 por ciento atómico de iterbio, así como 10 a 60 por ciento de magnesio atómico y 0 a 10 por ciento atómico de uno o varios elementos seleccionados del grupo Ag, el Zn, Au, Ga, Pd, Pt, Al, Sn, Ca, Nd, Ba, Si, y Ge. Así pues, la aleación tiene una densidad de rayos X suficiente en espesores de materiales bajos. La degradación de iterbio se informa como aproximadamente igual a la degradación del cuerpo principal. Ytterbium has been used as a radiopaque marker element in implants. US2008 / 0033530 describes a marker alloy composed of 40 to 90 percent atomic of iterbium, as well as 10 to 60 percent of atomic magnesium and 0 to 10 atomic percent of one or more elements selected from the group Ag, Zn, Au , Ga, Pd, Pt, Al, Sn, Ca, Nd, Ba, Si, and Ge. Thus, the alloy has a sufficient X-ray density in low material thicknesses. The degradation of ytterbium is reported as approximately equal to the degradation of the main body.
La Solicitud de Patente JP2004099940 describe una ligera aleación de magnesio basada según los informes con una gran resistencia de alta ductilidad. La composición de la aleación comprende de 0,5 a 5 por ciento atómico de elementos de tierras raras seleccionados de Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu y metales diversos metal. La aleación comprende además 0,2 a 4 por ciento de zinc atómico. Patent Application JP2004099940 describes a slight magnesium alloy based on reports with high resistance of high ductility. The alloy composition comprises 0.5 to 5 atomic percent of rare earth elements selected from Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu and various metal metals. The alloy further comprises 0.2 to 4 percent atomic zinc.
Una aleación de magnesio resistente al calor con un 6-12% de aluminio se conoce de US 2005/0095166. A heat-resistant magnesium alloy with 6-12% aluminum is known from US 2005/0095166.
La aleación según la invención está relacionada con una aleación bio anticorrosiva y endurecible por envejecimiento, compuesta esencialmente de magnesio, iterbio, zinc y calcio, con componentes opcionales tal como se definen en la reivindicación 1. The alloy according to the invention is related to an anti-corrosive and aging-hardenable bio alloy, essentially composed of magnesium, ytterbium, zinc and calcium, with optional components as defined in claim 1.
El contenido de la invención también incluye un implante que incorpora una aleación de magnesio de acuerdo con cualquiera de las reivindicaciones 1 a 3. The content of the invention also includes an implant incorporating a magnesium alloy according to any one of claims 1 to 3.
Según la invención la aleación de magnesio incluye iterbio, calcio y zinc. Los tres elementos están presentes en las siguientes cantidades: According to the invention the magnesium alloy includes ytterbium, calcium and zinc. The three elements are present in the following quantities:
Iterbio: 0,5 a 8,0 por ciento en peso Zinc: 0,2 a 6,0 por ciento en peso Calcio: 0,1 a 2,0 por ciento en peso Iterbium: 0.5 to 8.0 percent by weight Zinc: 0.2 to 6.0 percent by weight Calcium: 0.1 to 2.0 percent by weight
El balance hasta 100 por ciento en peso incluye magnesio así como inevitables impurezas. Por ejemplo, tales impurezas pueden provenir del proceso de producción de la aleación o de las impurezas contenidas en el material de origen. The balance up to 100 percent by weight includes magnesium as well as inevitable impurities. For example, such impurities may come from the process of producing the alloy or from the impurities contained in the source material.
Sorprendentemente se encontró que las aleaciones de magnesio que contienen iterbio muestran un significativo aumento de la edad de tempabilidad que se utiliza si el zinc y el calcio están presentes. Por otra parte, dichas personificaciones de aleación también presentan propiedades de corrosión favorables que contienen cloro en medios acuosos. Surprisingly it was found that magnesium alloys containing ytterbium show a significant increase in the age of tempability that is used if zinc and calcium are present. Moreover, said alloy personifications also have favorable corrosion properties that contain chlorine in aqueous media.
Esta aleación se produce, en algunas personificaciones, por un proceso de realización de micro-aleación This alloy is produced, in some personifications, by a process of realization of micro-alloy
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E09758679 E09758679
25-06-2015 06-25-2015
tal como se conoce convencionalmente. El proceso de micro-aleación en combinación con los elementos escogidos de personificaciones descritas en el presente documento, que es de una gran restricción en el crecimiento de grano, permite la fabricación de una aleación que tiene muy buenas propiedades de conformación en frío y una baja anisotropía mecánica. La composición descrita aquí en inducir una estructura de grano fino de la aleación durante as conventionally known. The micro-alloy process in combination with the elements chosen from personifications described herein, which is of great restriction in grain growth, allows the manufacture of an alloy that has very good cold forming properties and low mechanical anisotropy The composition described here in inducing a fine-grained structure of the alloy during
5 solidificación, así como durante sus posteriores procesos de formación en caliente. Esto se debe principalmente a la formación de finas precipitaciones de estos elementos que restringen el crecimiento no deseable de grano durante la recristalización. 5 solidification, as well as during its subsequent hot forming processes. This is mainly due to the formation of fine precipitations of these elements that restrict undesirable grain growth during recrystallization.
Según la invención, la aleación de magnesio que se describen en este documento pueden contener opcionalmente otros elementos, a saber, manganeso, circonio, aluminio, escandio, itrio en las cantidades indicadas en la reivindicación1. According to the invention, the magnesium alloy described herein may optionally contain other elements, namely manganese, zirconium, aluminum, scandium, yttrium in the amounts indicated in claim 1.
Un implante que contiene la aleación como se puso de manifiesto en este documento puede producirse utilizando técnicas conocidas en el arte. El implante puede tener cualquier forma, especialmente en forma de placa, 15 en concreto una placa ósea, un tornillo, un clavo, un clavo de hueso, un stent, una varilla. Los implantes de la An implant containing the alloy as revealed herein can be produced using techniques known in the art. The implant can have any shape, especially in the form of a plate, in particular a bone plate, a screw, a nail, a bone nail, a stent, a rod. The implants of the
aleación especificada son adecuados para la implantación en los animales o en el cuerpo humano. Specified alloy are suitable for implantation in animals or in the human body.
EJEMPLO EXAMPLE
Las aleaciones novedosas de magnesio que contienen 4 wt % Yb, 0,8 wt-% Zn y 0,25 wt % Ca se fundieron y echaron en un horno de inducción en Atmósfera de Ar. Los alojamientos se colocaron a una temperatura de 350°C a un diámetro final de 8,6 mm, que corresponde a una relación de extrusión de 12,5. La microestructura de las aleaciones extrudidas mostró una estructura de grano muy fino con un tamaño de grano de aproximadamente 5 fxm. Este material presentó un rendimiento promedio de 150 MPa, resistencia a la tracción de 250 MPa,Novel magnesium alloys containing 4 wt% Yb, 0.8 wt-% Zn and 0.25 wt% Ca were melted and cast in an induction furnace in Ar Atmosphere. The housings were placed at a temperature of 350 ° C at a final diameter of 8.6 mm, which corresponds to an extrusion ratio of 12.5. The microstructure of the extruded alloys showed a very fine grain structure with a grain size of approximately 5 fxm. This material presented an average yield of 150 MPa, tensile strength of 250 MPa,
25 alargamiento uniforme del 20% y alargamiento en rotura de un 28%. Las medidas de dureza indicaron una edad de respuesta al endurecimiento, donde los valores aumentaron de aproximadamente 50 HV5 en la solución del estado tratado térmicamente a aproximadamente 70 HV5 en la edad de estado endurecido. 25 uniform elongation of 20% and elongation at break of 28%. Hardness measurements indicated a hardening response age, where the values increased from about 50 HV5 in the solution of the heat treated state to about 70 HV5 in the hardened state age.
35 35
3 3
Claims (3)
- 2. 2.
- La aleación de la reivindicación 1, en la cual la aleación tiene una estructura de grano con granos de aproximadamente 5 µm. The alloy of claim 1, wherein the alloy has a grain structure with grains of approximately 5 µm.
- 3. 3.
- La aleación de cualquiera de las reinvidicaciones 1 o 2, en la cual la aleación tiene un valor de dureza en edad endurecida de aproximadamente 70 en una escala de Vickers HV5. The alloy of any of the 1 or 2 reinvidications, in which the alloy has a hardened age hardness value of about 70 on a Vickers HV5 scale.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5937008P | 2008-06-06 | 2008-06-06 | |
US59370 | 2008-06-06 | ||
PCT/US2009/003138 WO2009148515A1 (en) | 2008-06-06 | 2009-05-21 | Resorbable magnesium alloy |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2540742T3 true ES2540742T3 (en) | 2015-07-13 |
Family
ID=41398381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09758679.6T Active ES2540742T3 (en) | 2008-06-06 | 2009-05-21 | Absorbable magnesium alloy |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110192500A1 (en) |
EP (1) | EP2294236B1 (en) |
JP (2) | JP2011524465A (en) |
KR (1) | KR101722918B1 (en) |
CN (1) | CN102057068B (en) |
AU (1) | AU2009255698B2 (en) |
BR (1) | BRPI0912151A2 (en) |
CA (1) | CA2726572C (en) |
ES (1) | ES2540742T3 (en) |
PL (1) | PL2294236T3 (en) |
WO (1) | WO2009148515A1 (en) |
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EP2224032A1 (en) * | 2009-02-13 | 2010-09-01 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Process for manufacturing magnesium alloy based products |
AT510087B1 (en) | 2010-07-06 | 2012-05-15 | Ait Austrian Institute Of Technology Gmbh | MAGNESIUM ALLOY |
CA2804636A1 (en) | 2010-09-08 | 2012-03-15 | Synthes Usa, Llc | Fixation device with magnesium core |
KR101730777B1 (en) * | 2010-11-09 | 2017-04-26 | 트랜스루미널 테크놀로지스, 엘엘씨 | Specially designed magnesium-aluminum alloys and medical uses thereof in a hemodynamic environment |
WO2013052791A2 (en) * | 2011-10-06 | 2013-04-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Biodegradable metal alloys |
DE102012006454A1 (en) * | 2012-03-30 | 2013-10-02 | Heraeus Medical Gmbh | Anti-infective spacer for osteosynthesis plates |
CN104284993B (en) | 2012-06-26 | 2017-06-23 | 百多力股份公司 | Magnesium alloy, its production method and application thereof |
RU2015101291A (en) | 2012-06-26 | 2016-08-10 | Биотроник Аг | MAGNESIUM ALLOY, METHOD OF ITS PRODUCTION AND USE |
CN104302798B (en) | 2012-06-26 | 2018-10-16 | 百多力股份公司 | Magnesium alloy, its manufacturing method and application thereof |
SG11201406026TA (en) | 2012-06-26 | 2014-10-30 | Biotronik Ag | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
US10246763B2 (en) | 2012-08-24 | 2019-04-02 | The Regents Of The University Of California | Magnesium-zinc-strontium alloys for medical implants and devices |
US9469889B2 (en) | 2012-08-31 | 2016-10-18 | DePuy Synthes Products, Inc. | Ultrapure magnesium alloy with adjustable degradation rate |
WO2014159328A1 (en) | 2013-03-14 | 2014-10-02 | DePuy Synthes Products, LLC | Magnesium alloy with adjustable degradation rate |
SI2857536T1 (en) | 2013-10-03 | 2016-06-30 | Annelie-Martina Weinberg | Implant for patients in growth, method for its preparation and use |
US9863020B2 (en) | 2014-04-03 | 2018-01-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biodegradable metal alloys |
KR101594857B1 (en) * | 2015-02-25 | 2016-02-17 | 이인영 | Method of High Thermal Conductive and Flame Retardant Wrought Magnesium Alloy |
KR101670043B1 (en) * | 2015-03-17 | 2016-10-27 | 전북대학교산학협력단 | Calcium added magnesium alloy and its manufacturing method |
US11696976B2 (en) | 2015-08-21 | 2023-07-11 | University of Pittsburgh—of the Commonwealth System of Higher Education | Degradable magnesium-based implant devices for bone fixation |
WO2017209566A1 (en) | 2016-06-02 | 2017-12-07 | 울산과학기술원 | Magnesium alloy and method for manufacturing same |
CN106435315B (en) * | 2016-10-17 | 2018-03-16 | 南京镐极信息技术有限公司 | High-strength cast magnesium alloy containing europium and preparation method thereof |
CN106544563B (en) * | 2016-11-04 | 2018-06-19 | 哈尔滨理工大学 | A kind of biodegradable Mg-Ca-Mn-Sn magnesium alloy materials and preparation method and application |
CN108300918B (en) * | 2017-01-11 | 2020-05-12 | 北京科技大学 | Calcium-containing rare earth magnesium alloy sheet with high room temperature forming performance and preparation method thereof |
CN108309421B (en) * | 2017-01-18 | 2022-05-10 | 香港中文大学 | Internal plant mixing system and manufacturing method |
EP3609433B1 (en) * | 2017-04-12 | 2024-02-21 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Properties and parameters of novel biodegradable metallic alloys |
CN108236495B (en) * | 2018-03-30 | 2023-09-22 | 西安卓恰医疗器械有限公司 | Low-alloying degradable miniature internal fixation assembly and magnesium alloy preparation method |
CN109457130B (en) * | 2019-01-14 | 2020-11-20 | 兰州理工大学 | High-toughness biomedical magnesium alloy and preparation method thereof |
CN109778197A (en) * | 2019-03-07 | 2019-05-21 | 洛阳理工学院 | One kind anode magnesium alloy containing Yb and the preparation method and application thereof |
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JP2005068550A (en) * | 2003-08-06 | 2005-03-17 | Aisin Seiki Co Ltd | Inexpensive heat resistant magnesium alloy for casting having excellent heat resistance and casting property |
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JP2006002184A (en) * | 2004-06-15 | 2006-01-05 | Toudai Tlo Ltd | High-toughness magnesium-base alloy, drive system part using the same, and method for manufacturing high-toughness magnesium-base alloy material |
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-
2009
- 2009-05-21 PL PL09758679T patent/PL2294236T3/en unknown
- 2009-05-21 CA CA2726572A patent/CA2726572C/en active Active
- 2009-05-21 CN CN2009801206672A patent/CN102057068B/en active Active
- 2009-05-21 US US12/995,767 patent/US20110192500A1/en not_active Abandoned
- 2009-05-21 BR BRPI0912151A patent/BRPI0912151A2/en not_active Application Discontinuation
- 2009-05-21 JP JP2011512450A patent/JP2011524465A/en active Pending
- 2009-05-21 KR KR1020107026910A patent/KR101722918B1/en active IP Right Grant
- 2009-05-21 ES ES09758679.6T patent/ES2540742T3/en active Active
- 2009-05-21 EP EP09758679.6A patent/EP2294236B1/en active Active
- 2009-05-21 AU AU2009255698A patent/AU2009255698B2/en active Active
- 2009-05-21 WO PCT/US2009/003138 patent/WO2009148515A1/en active Application Filing
-
2014
- 2014-07-10 JP JP2014142666A patent/JP5913459B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2294236B1 (en) | 2015-04-08 |
EP2294236A1 (en) | 2011-03-16 |
JP2011524465A (en) | 2011-09-01 |
CN102057068B (en) | 2012-08-29 |
EP2294236A4 (en) | 2011-10-26 |
KR20110014617A (en) | 2011-02-11 |
JP5913459B2 (en) | 2016-04-27 |
US20110192500A1 (en) | 2011-08-11 |
JP2014205920A (en) | 2014-10-30 |
AU2009255698A1 (en) | 2009-12-10 |
AU2009255698B2 (en) | 2015-03-26 |
PL2294236T3 (en) | 2015-09-30 |
CA2726572A1 (en) | 2009-12-10 |
CA2726572C (en) | 2017-09-12 |
BRPI0912151A2 (en) | 2018-11-06 |
KR101722918B1 (en) | 2017-04-04 |
WO2009148515A1 (en) | 2009-12-10 |
CN102057068A (en) | 2011-05-11 |
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