CN106544563B - A kind of biodegradable Mg-Ca-Mn-Sn magnesium alloy materials and preparation method and application - Google Patents
A kind of biodegradable Mg-Ca-Mn-Sn magnesium alloy materials and preparation method and application Download PDFInfo
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- CN106544563B CN106544563B CN201610958729.9A CN201610958729A CN106544563B CN 106544563 B CN106544563 B CN 106544563B CN 201610958729 A CN201610958729 A CN 201610958729A CN 106544563 B CN106544563 B CN 106544563B
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- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 49
- 239000000956 alloy Substances 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 229910018645 Mn—Sn Inorganic materials 0.000 title claims description 27
- 239000011777 magnesium Substances 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 14
- 229910052718 tin Inorganic materials 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 11
- 239000007943 implant Substances 0.000 claims abstract description 9
- 239000012535 impurity Substances 0.000 claims abstract description 7
- 238000000137 annealing Methods 0.000 claims abstract description 6
- 238000001192 hot extrusion Methods 0.000 claims abstract description 4
- 238000002844 melting Methods 0.000 claims abstract description 4
- 230000008018 melting Effects 0.000 claims abstract description 4
- 239000011135 tin Substances 0.000 claims description 15
- 239000011575 calcium Substances 0.000 claims description 14
- 229910052749 magnesium Inorganic materials 0.000 claims description 14
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 12
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 10
- 229910045601 alloy Inorganic materials 0.000 claims description 10
- 238000001125 extrusion Methods 0.000 claims description 9
- 239000007789 gas Substances 0.000 claims description 9
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 6
- 229910002804 graphite Inorganic materials 0.000 claims description 6
- 239000010439 graphite Substances 0.000 claims description 6
- 238000007670 refining Methods 0.000 claims description 6
- 229910052786 argon Inorganic materials 0.000 claims description 5
- 238000000265 homogenisation Methods 0.000 claims description 5
- 238000010792 warming Methods 0.000 claims description 5
- 238000005266 casting Methods 0.000 claims description 4
- 230000001681 protective effect Effects 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 4
- 238000012545 processing Methods 0.000 abstract description 4
- 239000012567 medical material Substances 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract 1
- 239000007769 metal material Substances 0.000 description 5
- 230000007797 corrosion Effects 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 238000005275 alloying Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 231100000701 toxic element Toxicity 0.000 description 2
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000002138 osteoinductive effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/02—Making non-ferrous alloys by melting
- C22C1/03—Making non-ferrous alloys by melting using master alloys
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Mechanical Engineering (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Abstract
The invention discloses a kind of biodegradable Mg Ca Mn Sn magnesium alloy materials and preparation method and application, the biodegradable Mg Ca Mn Sn magnesium alloy materials are prepared from the following components according to mass percent：Ca 0.5~3%, Mn 0.1~2%, Sn 1~5%, remaining is Mg and the inevitable impurity element brought by raw material.Specific preparation method includes melting, cast molding, the homogenizing annealing processing of raw material, hot extrusion processing.The biodegradable Mg Ca Mn Sn magnesium alloys of the present invention are to human body without any toxicity, good mechanical properties, preparation method is simple and at low cost, plate, the club-shaped material of different sizes and section requirement can be prepared according to demand, can be used as the preparation of the medical materials such as the orthopaedics implants such as bone plate, nail and angiocarpy bracket.
Description
Technical field
The invention belongs to medical implant material technical fields, are related to a kind of biodegradable Mg-Ca-Mn-Sn magnesium alloy materials
Material and preparation method and application.
Background technology
At present, the conventional medical metal material clinically generally used mainly has medical stainless steel, medical titanium alloy, medical
Cobalt alloy etc., but these materials as medical implant often there are certain hidden danger, such as：Corrode in human body fluid environment
The release of toxic element can be generated；The elasticity modulus of conventional medical metal material is higher than the elasticity modulus of skeleton；Need into
Row second operation is drawn off.
Before magnesium alloy can trace back to more than 100 years as medical metal material, still, since the corrosion resistance of magnesium alloy is poor,
The too fast performance requirement that can not meet as medical implant of degradation speed in human body, therefore magnesium alloy is limited as medicine
The extensive use of implantation material.But the clinical practice of early stage has confirmed that feasibility of the magnesium alloy as medical material.
Development and maturation with different processing method and process for treating surface, the corrosion resistance and mechanics of magnesium alloy
Performance is obtained for very big raising.Recent years, countries in the world have more researchers to proceed by magnesium alloy as biology
The research of material.Many In vitroandin vivotrial results are also it was demonstrated that degradable magnesium alloy has much as medical implant material
Outstanding performance.
Compared with conventional medical metal material, research of the biodegradable magnesium alloy as the medical metal material of a new generation
Hot spot has unique degradability and bio-compatibility, therefore contains in the application aspect of degradable medical implant
Huge potentiality.Magnesium be nutrient indispensable in human body, elasticity modulus and density closer to people's bone, can avoid producing
Raw " stress-shielding effect ", and with good osteoinductive energy, the growth and healing of bone can be promoted.Moreover, high intensity
Magnesium alloy has good mechanical performance, meets the performance requirement of preferable medical implant.After knitting, magnesium alloy implantation material
Without taking out, second operation is avoided to the injury that patient brings and additional financial burden.
Invention content
The object of the present invention is to provide it is a kind of to human body without any toxicity, good mechanical properties, preparation method it is simple and into
This relatively low biodegradable Mg-Ca-Mn-Sn magnesium alloy materials and preparation method and application.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of biodegradable Mg-Ca-Mn-Sn magnesium alloy materials, are prepared from the following components according to mass percent：
Ca 0.5~3%, Mn 0.1~2%, Sn 1~5%, remaining is Mg and the inevitable impurity element brought by raw material.
A kind of preparation method of above-mentioned biodegradable Mg-Ca-Mn-Sn magnesium alloy materials, includes the following steps：
（1）Using high-purity magnesium ingot, high-purity calcium grain, Mg-10%Mn intermediate alloys and high purity tin grain as raw material, by above-mentioned quality
Percentage carries out the configuration of alloy raw material, using graphite crucible and is continually fed into high-purity argon gas as protective gas during melting；
（2）When graphite crucible is preheating to 450~550 DEG C, coverture is equably sprinkled in the bottom of crucible, adds in fritter
High-purity magnesium ingot is warming up to 700~740 DEG C and keeps the temperature 10~30min, after high-purity magnesium ingot is completely melt, removes surface scum, melts
Liquid is warming up to 760~780 DEG C and sequentially adds high-purity calcium grain, tin grain and Mg-Mn intermediate alloys, stirs 3~5 times, and standing 10~
20min；
（3）After whole metal moltens, metallic solution is cooled to 735~745 DEG C, adds in refining agent and is stirred continuously, stirs
After mixing 3~5min, metallic solution carries out the standing refining of 20~40min；
（4）When metallic solution is cooled to 690~710 DEG C, it is then poured into the metal that preheating temperature is 340~360 DEG C
In mould, as cast condition biodegradable Mg-Ca-Mn-Sn magnesium alloy ingots are obtained after ingot casting cooling.
Further, as cast condition biodegradable Mg-Ca-Mn-Sn magnesium alloy ingots carry out 6 at 350~450 DEG C~for 24 hours
Homogenizing annealing processing, obtain homogenization state biodegradable Mg-Ca-Mn-Sn magnesium alloys.
Further, the mold of different sizes and shaped cross-section is selected, by homogenizing annealing treated Mg-Ca-Mn-Sn
Magnesium alloy carries out conventional hot extrusion, and rodlike or lath-shaped extruded Magnesium Alloy, the extrusion temperature of different extrusion ratios are needed for acquisition
250~400 DEG C, extrusion speed is 0.5~8mm/s.
Compared with prior art, the present invention has the advantage that and has the beneficial effect that：
（1）Mg-Ca-Mn-Sn magnesium alloys in the present invention are using the addition design of nontoxic trace alloying element, to ensure that magnesium closes
Gold will not generate toxic element after degrading in human body, while the addition of alloying element can improve magnesium alloy as medicine
It is implanted into the mechanical property and corrosion resistance of material, it is ensured that the effect that magnesium alloy is played as implantation material.
（2）Biodegradable magnesium alloy in the present invention selects Mg, Ca, Sn and Mg-10%Mn intermediate alloy as former material
Material, wherein Mg, Ca, Mn, Sn are the indispensable nutrients of human body, with automatic degradation of the magnesium alloy in human body, are released
The non-toxic alloys element of releasing can be absorbed by the body, and avoid biosafety issues caused by alloying element.At the same time, Ca can
To improve the creep-resistant property of magnesium alloy；Mn has the function of crystal grain thinning；Sn is conducive to the growth and development of body, can promote
The healing of wound participates in influencing the function of hemoglobin, meanwhile, Sn, which is added in magnesium alloy, to be improved magnesium with crystal grain thinning and be closed
The mechanical property and corrosion resistance of gold.
（3）The preparation method of the biodegradable Mg-Ca-Mn-Sn magnesium alloys of the present invention is simple and at low cost, can basis
Demand prepares the plate of different sizes and section requirement, club-shaped material, can be used as the orthopaedics implants such as bone plate, nail and painstaking effort
The preparation of the medical materials such as pipe holder.
Specific embodiment
Technical scheme of the present invention is further described with reference to embodiment, however, it is not limited to this, every right
Technical solution of the present invention is modified or replaced equivalently, and without departing from the spirit and scope of technical solution of the present invention, should all be contained
It covers in protection scope of the present invention.
Embodiment 1：
Biodegradable Mg-Ca-Mn-Sn magnesium alloy materials in the present embodiment are according to mass percent by following components system
It is standby to form：Ca 0.5%, Mn 1%, Sn 2%, remaining is Mg and the inevitable impurity element brought by raw material.Specifically
Preparation process is as follows：
（1）Using high-purity magnesium ingot, high-purity calcium grain, Mg-10%Mn intermediate alloys and high purity tin grain as raw material, by above-mentioned quality
Percentage carries out the configuration of alloy raw material, using graphite crucible and is continually fed into high-purity argon gas as protective gas during melting；
（2）When graphite crucible is preheating to 500 DEG C, suitable RJ-2 covertures are equably sprinkled in the bottom of crucible, are kept away
Exempt to generate combustion phenomena.Then the high-purity magnesium ingot of fritter is added in, 720 ± 20 DEG C is warming up to and keeps the temperature 20min, treat that high-purity magnesium ingot is complete
After fusing, surface scum is removed, melt is warming up to 780 DEG C and sequentially adds high-purity calcium grain, tin grain and Mg-Mn intermediate alloys, stirring 4
It is secondary, stand 15min；
（3）After whole metal moltens, metallic solution is cooled to 740 ± 5 DEG C, adds in suitable RJ-5 refining agents and continuous
Stirring avoids generating combustion phenomena, and after stirring 5min, metallic solution carries out the standing refining of 30min；
（4）When metallic solution is cooled to 700 ± 10 DEG C, then it is poured into the metal pattern that preheating temperature is 350 DEG C, treats
As cast condition biodegradable Mg-Ca-Mn-Sn magnesium alloy ingots are obtained after ingot casting cooling.Casting cycle uniform speed slow, and it is molten in metal
The argon gas of the continuous transport flow in liquid surface is protected.
Embodiment 2：
As different from Example 1, as cast condition biodegradable Mg-Ca-Mn-Sn magnesium alloy ingots are at 400 DEG C for the present embodiment
The lower homogenizing annealing processing for carrying out 12h, obtains homogenization state biodegradable Mg-Ca-Mn-Sn magnesium alloys.
Embodiment 3：
The present embodiment as different from Example 2, selects the mold of different sizes and shaped cross-section, at homogenizing annealing
Mg-Ca-Mn-Sn magnesium alloys after reason carry out conventional hot extrusion, the rodlike or lath-shaped As-extruded of different extrusion ratios needed for acquisition
Magnesium alloy, extrusion temperature are 300 DEG C, extrusion speed 5mm/s.
Embodiment 4：
The present embodiment is unlike embodiment 1,2 or 3, and biodegradable Mg-Ca-Mn-Sn magnesium alloy materials are according to matter
Amount percentage is prepared from the following components：Ca 1%, Mn 1.5%, Sn 3%, remaining for Mg and by raw material bring into can not
The impurity element avoided.
Embodiment 5：
The present embodiment is unlike embodiment 1,2 or 3, and biodegradable Mg-Ca-Mn-Sn magnesium alloy materials are according to matter
Amount percentage is prepared from the following components：Ca 1.25%, Mn 0.8%, Sn 1%, remaining is Mg and is brought by raw material
Inevitable impurity element.
Embodiment 6：
The present embodiment is unlike embodiment 1,2 or 3, and biodegradable Mg-Ca-Mn-Sn magnesium alloy materials are according to matter
Amount percentage is prepared from the following components：Ca 2%, Mn 0.5%, Sn 2%, remaining for Mg and by raw material bring into can not
The impurity element avoided.
Claims (2)
1. a kind of preparation method of biodegradable Mg-Ca-Mn-Sn magnesium alloy materials, it is characterised in that the method is in argon gas
It carries out, includes the following steps as under conditions of protective gas：
(1) using high-purity magnesium ingot, high-purity calcium grain, Mg-10%Mn intermediate alloys and high purity tin grain as raw material, graphite is used during melting
Crucible is simultaneously continually fed into high-purity argon gas as protective gas；
(2) when graphite crucible being preheating to 450~550 DEG C, coverture is equably sprinkled in the bottom of crucible, it is high-purity to add in fritter
Magnesium ingot is warming up to 700~740 DEG C and keeps the temperature 10~30min, after high-purity magnesium ingot is completely melt, removes surface scum, melt liter
Temperature sequentially adds high-purity calcium grain, tin grain and Mg-Mn intermediate alloys to 760~780 DEG C, stirs 3~5 times, stands 10~20min；
(3) after whole metal moltens, metallic solution is cooled to 735~745 DEG C, adds in refining agent and is stirred continuously, and stirring 3~
After 5min, metallic solution carries out the standing refining of 20~40min；
(4) it when metallic solution is cooled to 690~710 DEG C, is then poured into the metal pattern that preheating temperature is 340~360 DEG C,
As cast condition biodegradable Mg-Ca-Mn-Sn magnesium alloy ingots are obtained after ingot casting cooling；
(5) as cast condition biodegradable Mg-Ca-Mn-Sn magnesium alloy ingots carry out to 6 at 350~450 DEG C~homogenization for 24 hours
Annealing obtains homogenization state biodegradable Mg-Ca-Mn-Sn magnesium alloys；
(6) homogenization state biodegradable Mg-Ca-Mn-Sn magnesium alloys are subjected to conventional hot extrusion, different extrusion ratios needed for acquisition
Rodlike or lath-shaped extruded Magnesium Alloy, extrusion temperature be 250~400 DEG C, extrusion speed be 0.5~8mm/s；
The biodegradable Mg-Ca-Mn-Sn magnesium alloy materials are prepared from the following components according to mass percent：
Ca1.25%, Mn0.8%, Sn1%, remaining is Mg and the inevitable impurity element brought by raw material.
2. biodegradable Mg-Ca-Mn-Sn magnesium alloy materials described in claim 1 can be used as the preparation of medical implant material.
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| CN109972007A (en) * | 2019-03-20 | 2019-07-05 | 北京科技大学 | A kind of anastomosis staple material and preparation method thereof of biology degradable in vivo Mg-Zn-Ca-M |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3656884B1 (en) * | 2017-07-18 | 2024-05-29 | National Institute for Materials Science | Magnesium-based alloy wrought product and method for producing same |
| CN108103335A (en) * | 2017-09-12 | 2018-06-01 | 广东省材料与加工研究所 | A kind of method for refining Mg-Zn systems alloy grain |
| CN108570585B (en) * | 2018-06-13 | 2020-01-03 | 河南科技大学 | Corrosion-resistant magnesium alloy and preparation method thereof |
| CN111218596A (en) * | 2020-01-15 | 2020-06-02 | 太原科技大学 | Short-term degradable magnesium alloy material for uterine cavity stent and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813966A (en) * | 2012-08-29 | 2012-12-12 | 哈尔滨工程大学 | Medical degradable magnesium alloy bone-fixing screw |
| CN105401033A (en) * | 2015-12-28 | 2016-03-16 | 太原理工大学 | High strength and toughness anti-corrosion biomedical magnesium alloy |
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| US20110192500A1 (en) * | 2008-06-06 | 2011-08-11 | Synthes Usa, Llc | Resorbable magnesium alloy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813966A (en) * | 2012-08-29 | 2012-12-12 | 哈尔滨工程大学 | Medical degradable magnesium alloy bone-fixing screw |
| CN105401033A (en) * | 2015-12-28 | 2016-03-16 | 太原理工大学 | High strength and toughness anti-corrosion biomedical magnesium alloy |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109972007A (en) * | 2019-03-20 | 2019-07-05 | 北京科技大学 | A kind of anastomosis staple material and preparation method thereof of biology degradable in vivo Mg-Zn-Ca-M |
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