ES2534514T3 - Acetato de eslicarbazepina y métodos de uso - Google Patents
Acetato de eslicarbazepina y métodos de uso Download PDFInfo
- Publication number
- ES2534514T3 ES2534514T3 ES11174403.3T ES11174403T ES2534514T3 ES 2534514 T3 ES2534514 T3 ES 2534514T3 ES 11174403 T ES11174403 T ES 11174403T ES 2534514 T3 ES2534514 T3 ES 2534514T3
- Authority
- ES
- Spain
- Prior art keywords
- eslicarbazepine
- once
- daily
- use according
- eslicarbazepine acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QIALRBLEEWJACW-INIZCTEOSA-N eslicarbazepine acetate Chemical compound CC(=O)O[C@H]1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 QIALRBLEEWJACW-INIZCTEOSA-N 0.000 title claims abstract description 102
- 229960003233 eslicarbazepine acetate Drugs 0.000 title claims abstract description 102
- 238000000034 method Methods 0.000 title description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 24
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- BMPDWHIDQYTSHX-AWEZNQCLSA-N (S)-MHD Chemical compound C1[C@H](O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-AWEZNQCLSA-N 0.000 claims description 59
- 229960004028 eslicarbazepine Drugs 0.000 claims description 59
- 230000036470 plasma concentration Effects 0.000 claims description 21
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 239000012876 carrier material Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 229960003511 macrogol Drugs 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- 229940100692 oral suspension Drugs 0.000 claims description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
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- 229940068196 placebo Drugs 0.000 description 21
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- BMPDWHIDQYTSHX-CQSZACIVSA-N (R)-MHD Chemical compound C1[C@@H](O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-CQSZACIVSA-N 0.000 description 19
- BMPDWHIDQYTSHX-UHFFFAOYSA-N licarbazepine Chemical compound C1C(O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-UHFFFAOYSA-N 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
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- ZFXVFMBOFIEPII-UHFFFAOYSA-N 1h-azepine-4-carboxamide Chemical compound NC(=O)C1=CC=CNC=C1 ZFXVFMBOFIEPII-UHFFFAOYSA-N 0.000 description 6
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 6
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- CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 description 4
- 229960001816 oxcarbazepine Drugs 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- PHNLCHMJDSSPDQ-UHFFFAOYSA-N 5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide Chemical class C1CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 PHNLCHMJDSSPDQ-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
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- 239000008280 blood Substances 0.000 description 3
- 229960003120 clonazepam Drugs 0.000 description 3
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 3
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- 239000001116 FEMA 4028 Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- 108010052164 Sodium Channels Proteins 0.000 description 2
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- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PT2005/000006 WO2006121363A1 (en) | 2005-05-06 | 2005-05-06 | Eslicarbazepine acetate and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2534514T3 true ES2534514T3 (es) | 2015-04-23 |
Family
ID=35464075
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11174403.3T Expired - Lifetime ES2534514T3 (es) | 2005-05-06 | 2005-05-06 | Acetato de eslicarbazepina y métodos de uso |
| ES11174415.7T Expired - Lifetime ES2534560T3 (es) | 2005-05-06 | 2005-05-06 | Acetato de eslicarbazepina y su uso |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11174415.7T Expired - Lifetime ES2534560T3 (es) | 2005-05-06 | 2005-05-06 | Acetato de eslicarbazepina y su uso |
Country Status (8)
| Country | Link |
|---|---|
| EP (6) | EP2386303A1 (enExample) |
| JP (1) | JP2008540405A (enExample) |
| KR (1) | KR101236227B1 (enExample) |
| CN (1) | CN101217959A (enExample) |
| ES (2) | ES2534514T3 (enExample) |
| PT (2) | PT2380573E (enExample) |
| RU (1) | RU2010154008A (enExample) |
| WO (1) | WO2006121363A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0603008D0 (en) * | 2006-02-14 | 2006-03-29 | Portela & Ca Sa | Method |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| US8372431B2 (en) * | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| RU2012113844A (ru) | 2009-09-10 | 2013-10-20 | Биал-Портела Энд К.А., С.А. | Пероральные суспензионные лекарственные формы ацетата эсликарбазепина |
| TR201008460A1 (tr) * | 2010-10-15 | 2012-05-21 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Eslikarbazepinin saşe formülasyonları. |
| RU2639120C2 (ru) * | 2011-08-26 | 2017-12-19 | Биал-Портела Энд Ка, С.А. | Лечение с использованием ацетата эсликарбазепина или эсликарбазепина |
| US20140243342A1 (en) * | 2013-02-23 | 2014-08-28 | Lixin Zhang | Compositions and methods for prophylaxis and therapy for menieres disease |
| US9814723B2 (en) | 2013-02-23 | 2017-11-14 | Lixin Zhang | Compositions and methods for prophylaxis and therapy for Meniere's disease |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| GB201306095D0 (en) * | 2013-04-04 | 2013-05-22 | Bial Portela & Ca Sa | New treatments |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| US6296873B1 (en) | 1997-01-23 | 2001-10-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Zero-order sustained release delivery system for carbamazephine derivatives |
| DE60228988D1 (de) * | 2001-11-12 | 2008-10-30 | Novartis Ag | Monohyroxycarbamezepin zur verwendung bei der herstellung eines medikaments zur behandlung von affektiver psychose, aufmerksamkeits störungen und neuropathischen schmerzen |
| US7465723B2 (en) * | 2002-08-06 | 2008-12-16 | Novartis | Use of carboxamides for the treatment of tinnitus |
| US20040038874A1 (en) * | 2002-08-22 | 2004-02-26 | Osemwota Omoigui | Method of treatment of persistent pain |
| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| BRPI0407569A (pt) * | 2003-02-17 | 2006-02-14 | Novartis Ag | uso de s-10-hidróxi-10, 11-diidro-carbamazepina para o tratamento de ansiendade e distúrbios bipolares |
| TW200502222A (en) * | 2003-04-02 | 2005-01-16 | Novartis Ag | Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders |
| GB2401605A (en) * | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
| PE20051156A1 (es) * | 2004-03-22 | 2006-02-13 | Novartis Ag | Formulaciones de matriz orales que comprenden licarbazepina |
| AR048672A1 (es) * | 2004-03-22 | 2006-05-17 | Novartis Ag | Tabletas de desintegracion que comprenden licarbazepina |
| BRPI0520258A2 (pt) * | 2005-05-06 | 2009-09-15 | Portela & Ca Sa | uso de uma composição farmacêutica, método para preparar uma composição farmacêutica, e, uso de uma quantidade eficaz de acetato de eslicarbazepina |
-
2005
- 2005-05-06 EP EP11174413A patent/EP2386303A1/en not_active Withdrawn
- 2005-05-06 EP EP11174411A patent/EP2384755A1/en not_active Withdrawn
- 2005-05-06 JP JP2008509964A patent/JP2008540405A/ja active Pending
- 2005-05-06 PT PT111744033T patent/PT2380573E/pt unknown
- 2005-05-06 EP EP05740623A patent/EP1879590A1/en not_active Ceased
- 2005-05-06 ES ES11174403.3T patent/ES2534514T3/es not_active Expired - Lifetime
- 2005-05-06 WO PCT/PT2005/000006 patent/WO2006121363A1/en not_active Ceased
- 2005-05-06 PT PT111744157T patent/PT2380575E/pt unknown
- 2005-05-06 CN CNA2005800509788A patent/CN101217959A/zh active Pending
- 2005-05-06 EP EP11174405A patent/EP2380574A1/en not_active Withdrawn
- 2005-05-06 KR KR1020077028320A patent/KR101236227B1/ko not_active Expired - Lifetime
- 2005-05-06 EP EP11174415.7A patent/EP2380575B1/en not_active Expired - Lifetime
- 2005-05-06 EP EP11174403.3A patent/EP2380573B1/en not_active Expired - Lifetime
- 2005-05-06 ES ES11174415.7T patent/ES2534560T3/es not_active Expired - Lifetime
-
2010
- 2010-12-28 RU RU2010154008/15A patent/RU2010154008A/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080015429A (ko) | 2008-02-19 |
| EP2380575B1 (en) | 2015-02-25 |
| EP2386303A1 (en) | 2011-11-16 |
| CN101217959A (zh) | 2008-07-09 |
| EP2384755A1 (en) | 2011-11-09 |
| WO2006121363A1 (en) | 2006-11-16 |
| KR101236227B1 (ko) | 2013-02-21 |
| EP1879590A1 (en) | 2008-01-23 |
| EP2380573B1 (en) | 2015-02-25 |
| RU2010154008A (ru) | 2012-07-10 |
| PT2380573E (pt) | 2015-06-11 |
| EP2380573A1 (en) | 2011-10-26 |
| PT2380575E (pt) | 2015-06-17 |
| EP2380575A1 (en) | 2011-10-26 |
| JP2008540405A (ja) | 2008-11-20 |
| ES2534560T3 (es) | 2015-04-24 |
| EP2380574A1 (en) | 2011-10-26 |
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