ES2531098T3 - Nuevos mutantes de proteína de superficie del antígeno de superficie del virus HVB de Hepatitis B (HBsAg) - Google Patents
Nuevos mutantes de proteína de superficie del antígeno de superficie del virus HVB de Hepatitis B (HBsAg) Download PDFInfo
- Publication number
- ES2531098T3 ES2531098T3 ES08869063T ES08869063T ES2531098T3 ES 2531098 T3 ES2531098 T3 ES 2531098T3 ES 08869063 T ES08869063 T ES 08869063T ES 08869063 T ES08869063 T ES 08869063T ES 2531098 T3 ES2531098 T3 ES 2531098T3
- Authority
- ES
- Spain
- Prior art keywords
- hepatitis
- leucine
- hbsag
- arginine
- protein mutants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 102000018697 Membrane Proteins Human genes 0.000 title 1
- 108010052285 Membrane Proteins Proteins 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 208000002672 hepatitis B Diseases 0.000 title 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 5
- 239000004475 Arginine Substances 0.000 abstract 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 4
- 150000001413 amino acids Chemical group 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 229940024606 amino acid Drugs 0.000 abstract 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 2
- 229960001230 asparagine Drugs 0.000 abstract 2
- 235000009582 asparagine Nutrition 0.000 abstract 2
- 235000018417 cysteine Nutrition 0.000 abstract 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
- G01N33/5764—Hepatitis B surface antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/02—Hepadnaviridae, e.g. hepatitis B virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un oligo- o polipéptido que comprende (a) una secuencia de aminoácidos que es una secuencia parcial de la SEQ ID No: 3 que tiene al menos 75 aminoácidos consecutivos de la SEQ ID No: 3, donde esta secuencia parcial incluye todas las ocho posiciones 100, 105, 110, 118, 120, 142, 160 y 173 de la SEQ ID No: 3; o (b) un fragmento de un antígeno HBs de un virus de hepatitis B, donde el fragmento tiene una longitud de al menos 15 aminoácidos, el antígeno HBs tiene cisteína en la posición 100, arginina en la posición 105, leucina en la posición 110, arginina en la posición 118, leucina en la posición 120, leucina en la posición 142, asparagina en la posición 160 y prolina en la posición 173, y el fragmento comprende cisteína 100, arginina 105, arginina 118, leucina 120, leucina 142, asparagina 160 y prolina 173.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007062962A DE102007062962A1 (de) | 2007-12-21 | 2007-12-21 | Neue Oberflächen-Protein-Mutante des Hepatitis B Virus HBV surface Antigen (HBsAg) |
| PCT/EP2008/010708 WO2009083136A1 (de) | 2007-12-21 | 2008-12-16 | Neue oberflächen-protein-mutante des hepatitis b virus hbv surface antigen (hbsag) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2531098T3 true ES2531098T3 (es) | 2015-03-10 |
Family
ID=40551435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08869063T Active ES2531098T3 (es) | 2007-12-21 | 2008-12-16 | Nuevos mutantes de proteína de superficie del antígeno de superficie del virus HVB de Hepatitis B (HBsAg) |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8729231B2 (es) |
| EP (1) | EP2220493B1 (es) |
| DE (1) | DE102007062962A1 (es) |
| ES (1) | ES2531098T3 (es) |
| WO (1) | WO2009083136A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107001429B (zh) * | 2014-11-28 | 2022-01-04 | 赛特瑞恩股份有限公司 | 乙型肝炎病毒表面抗原的表位及与其特异性结合以中和乙型肝炎病毒的结合分子 |
| CN117843811A (zh) | 2019-09-30 | 2024-04-09 | 吉利德科学公司 | Hbv疫苗和治疗hbv的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202354B2 (en) | 2001-03-30 | 2007-04-10 | Abbott Laboratories | Hepatitis B virus surface antigen mutant and methods of detection thereof |
| WO2003087351A1 (en) * | 2002-04-12 | 2003-10-23 | Melbourne Health | Hepatitis b viral variants with redused susceptibility to nucleoside analogs and uses thereof |
| EP1638995B1 (de) * | 2003-06-20 | 2015-08-26 | Siemens Healthcare Diagnostics Products GmbH | Neue oberflächenprotein-(hbsag-) variante des hepatitis b virus |
| JP2007509614A (ja) | 2003-10-21 | 2007-04-19 | メルボルン ヘルス | Ｈｂｖ変種の検出および適用 |
| ES2470318T3 (es) | 2005-03-15 | 2014-06-23 | Rheinische Friedrich-Wilhelms-Universit�T Bonn | Variantes del virus de la hepatitis B resistentes a ciertos análogos nucle�sidos, pero sensibles a otros, y usos de las mismas |
-
2007
- 2007-12-21 DE DE102007062962A patent/DE102007062962A1/de not_active Withdrawn
-
2008
- 2008-12-16 WO PCT/EP2008/010708 patent/WO2009083136A1/de active Application Filing
- 2008-12-16 ES ES08869063T patent/ES2531098T3/es active Active
- 2008-12-16 EP EP08869063.1A patent/EP2220493B1/de not_active Not-in-force
- 2008-12-16 US US12/809,983 patent/US8729231B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2220493B1 (de) | 2015-01-28 |
| WO2009083136A1 (de) | 2009-07-09 |
| DE102007062962A1 (de) | 2009-06-25 |
| EP2220493A1 (de) | 2010-08-25 |
| US20110033838A1 (en) | 2011-02-10 |
| US8729231B2 (en) | 2014-05-20 |
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