ES251166A1 - New steroid compounds and a process for their preparation - Google Patents
New steroid compounds and a process for their preparationInfo
- Publication number
- ES251166A1 ES251166A1 ES0251166A ES251166A ES251166A1 ES 251166 A1 ES251166 A1 ES 251166A1 ES 0251166 A ES0251166 A ES 0251166A ES 251166 A ES251166 A ES 251166A ES 251166 A1 ES251166 A1 ES 251166A1
- Authority
- ES
- Spain
- Prior art keywords
- salt
- testosterone
- alkali metal
- preparation
- disulphamylbenzoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises salts of testerone 3,5-disulphamylbenzoate of the general formula <FORM:0915129/IV (b)/1> wherein M represents an alkali metal or a quaternary ammonium salt forming group, and the 3,5-dinitrobenzoate of testosterone, and the preparation of the salts of the above general formula wherein M represents an alkali metal by esterifying testosterone with a functional derivative of 3,5-dinitrobenzoic acid to form testosterone 3,5-dinitrobenzoate, treating this compound with a mixture of alkali metal sulphite and bisulphite in the presence of a solvent e.g. dimethylformamide, to form the 3,5-disulphamylbenzoate of testosterone and isolating this compound in the form of a relatively water insoluble salt, and converting this salt into the required alkali metal salt by double decomposition. The above process may be modified for the preparation of the sodium salt in that the potassium salt is first produced, the free sulphonic acid groups are then liberated e.g. by contact with an ion exchange resin, and are then neutralised with sodium hydroxide to form the sodium salt which is precipitated by the addition of a water-miscible solvent e.g. ethanol. A quaternary ammonium salt may be added to form the insoluble salt in the above process e.g. benzyl dimethyl 2 - [2- (p-1,1,3,3-tetramethylbutyl - phenoxy) - ethoxy] - ethyl ammonium chloride.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR771805A FR1238739A (en) | 1958-08-04 | 1958-08-04 | Process for the preparation of water-soluble testosterone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES251166A1 true ES251166A1 (en) | 1959-11-01 |
Family
ID=8707176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0251166A Expired ES251166A1 (en) | 1958-08-04 | 1959-07-30 | New steroid compounds and a process for their preparation |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE581323A (en) |
CH (1) | CH378876A (en) |
ES (1) | ES251166A1 (en) |
FR (1) | FR1238739A (en) |
GB (1) | GB915129A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004025966A1 (en) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estradiol prodrugs |
DE102004025985A1 (en) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estriol and estetrol prodrugs |
-
1958
- 1958-08-04 FR FR771805A patent/FR1238739A/en not_active Expired
-
1959
- 1959-07-07 CH CH7544259A patent/CH378876A/en unknown
- 1959-07-16 GB GB2449259A patent/GB915129A/en not_active Expired
- 1959-07-30 ES ES0251166A patent/ES251166A1/en not_active Expired
- 1959-08-03 BE BE581323A patent/BE581323A/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB915129A (en) | 1963-01-09 |
BE581323A (en) | 1960-02-03 |
CH378876A (en) | 1964-06-30 |
FR1238739A (en) | 1960-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1007020A (en) | Photographic processes, emulsions and developer solutions | |
GB1209919A (en) | Substituted benzotriazoles and the use thereof as metal deactivators | |
ES251166A1 (en) | New steroid compounds and a process for their preparation | |
ES8104213A1 (en) | Process for preparing 4,4'-dinitrostilbene-2,2'-disulfonic acid and its salts and its use. | |
GB690816A (en) | Improvements in or relating to the manufacture of substituted phenoxy acetic acids | |
GB1204514A (en) | Process for the manufacture of alkali paraffin sulphonate solutions containing small amounts of alkali sulphate | |
GB1198829A (en) | Process for Preparing Pyrryl-(2)-Acetic Acid Esters | |
GB799716A (en) | Primary galvanic cells | |
GB852384A (en) | Process for preparing dihydroxy alkyl acrylates and methacrylates | |
GB986071A (en) | Improvements in or relating to n-alkane sulphonic acids | |
GB904112A (en) | Improvements in or relating to heparine and derivatives thereof | |
GB820895A (en) | Improvements in and relating to photo-conductive cells | |
GB785047A (en) | Anhydrotetracycline compounds | |
GB932523A (en) | Process for the production of lead hydroxide oxide of the formula 5 pbo.2ho | |
GB727472A (en) | Improvements in or relating to salts of formaldehyde sulphoxylic acid | |
SU143025A1 (en) | The method of obtaining simple water-soluble cellulose ethers | |
GB1470492A (en) | Ion-exchange materials | |
GB970481A (en) | Improvements in or relating to the bromination of steroid compounds | |
ES309491A3 (en) | Procedure for preparation of vinylloxiarene-sulphonic derivatives. (Machine-translation by Google Translate, not legally binding) | |
GB951412A (en) | Process for the manufacture of water-insoluble azo-dyestuffs on the fibre | |
GB1130214A (en) | Process for the manufacture of fatty acid condensation products easy to dilute with water | |
GB586526A (en) | Improvements in or relating to the manufacture of salts of di-isopropyl-salicylic acid | |
ES8201176A1 (en) | A procedure for obtaining alkaline salts from hydroxy-steroid esters (Machine-translation by Google Translate, not legally binding) | |
GB698995A (en) | Process for the preparation of nuclear sulphonated 1-carboxy-3-monocyclic aryl-benzo [f] quinoline compounds | |
GB1282493A (en) | A process for the preparation of dithioesters |