ES2505251T3 - Whitening cosmetic composition - Google Patents

Abstract

External use of an alkylglycine and tocopherol ester and / or a salt thereof, for cosmetic whitening of the skin, in which the alkylglycine and tocopherol ester is a compound represented by the formula (1) described below: ** Formula ** wherein R1 and R2 represent the same or different lower alkyl group or hydrogen atom; and R3, R4 and R5 represent a hydrogen atom or a methyl group, provided that R1 and R2 do not represent a hydrogen atom at the same time.

Description

E03710261

09-22-2014

DESCRIPTION

Cosmetic bleaching composition.

5 Technical field

The present invention relates to the external use of an alkyl glycine tocopherol ester and / or a salt thereof, as an active principle, which has the effects of preventing pigmentation or eliminating pigments formed in the skin, by cosmetic skin whitening .

10

Prior art

Until now, many preparations have been proposed for external use on the skin and have been used to reduce skin pigmentation, such as spots and freckles due to exposure to UV rays, or darkening.

15 observed after wound scars or burns or observed after wound healing surgery.

For example, polyphenols are well known in that they reduce the bleaching effects of melanin pigments. In particular, hydroquinone is widely used in the field of clinical medicine in

20 USA However, it is noted that hydroquinone is very irritating on the skin, and for this reason, it is difficult to use as a preparation for external use on the skin, with a satisfactory level of safety.

In addition, vitamin C or its derivatives such as ascorbyl 2-phosphate or ascorbyl 2-glycoside have been widely used as pigmentation preventive agents in cosmetic compositions. However, as is known, the prevention effects of the pigmentation of the ascorbic acids described above are weak, and cannot be believed to be effective in view of many aspects. In addition, they have superior pigmentation prevention effects, but the effects of reducing the deposition of the pigments formed can

or not be enough.

Tocopherols, also known as vitamin E (such as α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol), and derivatives thereof such as tocopherol acetate and tocopherol nicotinate, are known to have such effects as effects of antioxidation, effects of stabilization of vital membranes, effects of immunoactivation and effects of acceleration of blood circulation, and so far they have been added to medicines, cosmetics and the like; however, no reference has been made to its effects of preventing

35 pigmentation or removal of pigments formed. As for tocopherols, there is an example of their effect as a remedy for pigmentation by oral administration (K. Werininghaus et al., Arch. Dermatol., 130, 1257, 1997). In addition, there are examples of the effects of a specific derivative, ester of ferulic acid and tocopherol, on the inhibition of pigmentation of cultured cells (M. Ichihashi et al., Anticancer Res., 19, 3769, 1999, and the like). However, no prevention or elimination effects of pigmentation of

40 pigments formed by the dermal application of tocopherols.

In addition, in order to avoid difficulties in view of the formulation of the fat-soluble tocopherol derivatives described above, tocopherol phosphates, amino acid esters, or water-soluble alkylaminocarbonates have been proposed.

45 Database CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US .; AOKI YUZURU et al.: † SKkin Cosetics containing Vitamin E derivatives and Citrus junos extracts ”XP002250037 retrieved from STN Database Registration No. 134: 256613 CA, US-A-5,932,612 and WO 98/51679. A disclose tocopherol and derivatives thereof including esters for lightening or depigmentating the skin.

fifty

Description of the invention

In view of these circumstances, an object of the present invention is to provide a preparation for external use on the skin that has a high level of safety and that comprises an active ingredient that has effects

55 superiors for preventing skin pigmentation or removing pigments formed on the skin, and in particular, providing a cosmetic composition having the so-called "superior whitening effects".

As a result of a diligent investigation to achieve this object, the present inventors discovered that

60 alkylglycine and tocopherol esters and salts thereof have potent effects of preventing skin pigmentation and eliminating pigments formed in the skin, thereby completing the present invention.

That is, the present invention relates to the features described below. 65

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[1] The external use of an alkylglycine and tocopherol ester and / or a salt thereof, for cosmetic skin whitening, in which the alkylglycine and tocopherol ester is a compound represented by the formula (1) described a continuation:

image 1

wherein R1 and R2 represent an equal or different lower alkyl group or a hydrogen atom; and R3, R4 and R5 represent a hydrogen atom or a methyl group, with the proviso that R1 and R2 do not represent a hydrogen atom at the same time.

[2] The use according to [1] described above, wherein the alkylglycine and tocopherol ester is at least one compound selected from an alkylglycine ester and α-tocopherol, an alkylglycine ester and γ-tocopherol and a alkylglycine ester and δ-tocopherol.

[3] The use according to [1] described above, wherein the alkylglycine and tocopherol ester is an alkylglycine and α-tocopherol ester.

[4] The use according to [3] described above, characterized in that the alkylglycine ester and α-tocopherol is an alkylglycine ester and dl-α-tocopherol.

[5] The use according to [3] described above, characterized in that the alkylglycine ester and α-tocopherol is an alkylglycine ester and d-α-tocopherol.

[6] The use according to [1] described above, characterized in that the alkylglycine and tocopherol ester is a

alkylglycine ester and γ-tocopherol. 25

[7] The use according to [6] described above, characterized in that the alkylglycine ester and γ-tocopherol is an alkylglycine ester and d-γ-tocopherol.

[8] The use according to [1] described above, characterized in that the alkylglycine and tocopherol ester is an alkylglycine ester and δ-tocopherol.

[9] The use according to [8] described above, characterized in that the alkylglycine ester and δ-tocopherol is an alkylglycine ester and d-δ-tocopherol.

[10] The use according to [1] described above, characterized in that the alkylglycine and tocopherol ester is dimethylglycine and tocopherol ester.

[11] The use [1] described above, characterized in that the salt of an alkylglycine ester and tocopherol is

a salt of an organic acid or an inorganic acid. 40

[12] The use according to [11] described above, wherein the salt of an alkylglycine ester and tocopherol is the hydrochloride.

[13] The use according to [1] described above, in which an added amount of the alkylglycine ester and tocopherol and / or the salt thereof is comprised between 0.1 and 10% by mass.

Best way to practice the invention

First, an alkylglycine and tocopherol ester and a salt thereof which are the ingredients used in the present invention are described.

An alkylglycine and tocopherol ester used in the present invention is used as an active ingredient that has effects to prevent pigmentation or the removal of pigments formed in the skin, and is a compound represented by, for example, a formula (1) described in continuation:

55

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image2

wherein R1 and R2 represent the same or different lower alkyl group or a hydrogen atom; and R3, R4 and R5 represent a hydrogen atom or a methyl group; with the proviso that R1 and R2 do not represent a hydrogen atom at the same time.

The term "lower alkyl group" described in the definition of R1 and R2 means a straight or branched chain alkyl group having 1 to 6 carbon atoms. As examples thereof, mention may be made of methyl, ethyl, n-propyl, n-butyl, isopropyl, isobutyl, 1-methylpropyl, tert-butyl, n-pentyl, 1-ethylpropyl, isoamyl, n-hexyl and the like. The most preferable group among these is a methyl group.

As a salt of the compound used in the present invention, the salts are not particularly restricted, provided they are salts of an organic acid or an inorganic acid. As preferable examples thereof, mention may be made of a hydrohalogenated acid salt, an organic acid salt and the like. Among these, hydrochloride is preferable, since it is advantageous because it increases water solubility and facilitates handling

15 due to its powdered form.

The tocopherol derivatives represented by the formula (1) described above have an asymmetric carbon in position 2 of the chromane ring. For this reason, there are stereomers such as form d, form l and form dl. It should be understood that the present invention comprises all the isomers described above.

The compounds used in the present invention can be produced by conventional production methods, and an example thereof is described below.

The compounds can be easily produced by carrying out an esterification reaction between a tocopherol represented by the formula (2) described below:

image3

wherein R3, R4 and R5 represent a hydrogen atom or a methyl group, 30 and any one of an alkyl glycine represented by the formula (3) described below:

image4

wherein R1 and R2 represent an identical or different lower alkyl group or a hydrogen atom; with the proviso that R1 and R2 do not represent a hydrogen atom at the same time, a derivative of reactive acid thereof, and a salt of hydrohalogenated acid thereof, in a conventional manner.

In the case of directly carrying out the esterification using a free alkylglycine, generally, the reaction is preferably carried out in the presence of an active esterification reagent such as dicyclohexylcarbodiimide or N, N-disuccinimide oxalate. The solvent in the most preferable reaction is pyridine.

In addition, in a reaction with a reactive acid derivative, a reaction employing an acyl halide, and, in particular, an acyl chloride, is preferable.

In the case of producing a salt of an alkylglycine ester and tocopherol, the hydrohalogenated acid salt can be produced for once by producing an ester form, and subsequently adding an acid thereto according to a

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Conventional process, thus forming a salt, or alternatively, can be produced by previously using a salt of an alkyl glycine as a starting material.

The present invention relates to the external use of an alkylglycine and tocopherol ester and a salt thereof, for cosmetic skin whitening.

The cosmetic bleaching composition can be produced by adding 0.1 to 10% by mass and preferably 0.5 to 2% by mass of an alkylglycine and tocopherol ester and / or a salt thereof to an alcohol such as ethanol or propylene glycol; preservatives such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate,

Butyl parahydroxybenzoate or propyl parahydroxybenzoate; purified water and the like.

Examples of cosmetic bleaching compositions include, for example, skin milk, skin cream, base cream, massage cream, cleansing cream, lotion, compress, ointment, bath preparations, body soap and the like. Their classes are not restricted, as long as they enter

15 skin contact during use. They can be in gel form. In addition, the user can be anyone regardless of sex or age.

In addition, in cosmetic bleaching compositions, other ingredients apart from those described above, which are normally used in cosmetic bleaching compositions, can be

20 add within a range that does not alter the effects of the present invention.

Examples

Next, the present invention is described in detail with reference to the examples. In the examples, the amount added is expressed in% by mass.

Synthesis Example

To a solution of 59.1 g of dicyclohexylcarbodiimide and 40.0 g of N, N-dimethylglycine hydrochloride dissolved in 320 g

30 of pyridine, a solution of 60.0 g of dl-α-tocopherol dissolved in 240 g of pyridine was added. The mixture was allowed to react for 8 hours while stirring at room temperature, and the pyridine was distilled off. 2000 ml of water and 1000 ml of ethyl acetate were added to the residue, and approximately 40 g of sodium carbonate were added to adjust the pH to between 7 and 8. The ethyl acetate phase was separated. The extraction of the aqueous phase was carried out three times using 200 ml of ethyl acetate each time. The ethyl acetate phase that is

35 separated and the ethyl acetate phases used for the extraction were combined, and the ethyl acetate was distilled off. Ethyl acetate was added to the residue, the mixture was dried over anhydrous sodium sulfate and the solid substances were filtered off. The concentration of dimethylglycine ester and dl-α-tocopherol in the filtrate was adjusted between 7 and 8%. 20% hydrochloric acid in dioxane was added thereto for neutralization in an amount such that the molar amount of the hydrochloric acid is 1.5 times that of the dimethylglycine ester and dl-α-tocopherol. Solid substance

The obtained was collected by filtration, and recrystallized from methanol / acetone solvent to yield 49.2 g of dimethylglycine ester hydrochloride and dl-α-tocopherol.

Example 1

45 Lotion 1

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 1.

50 1) Dimethylglycine ester dl-α-tocopherol hydrochloride 2.00 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 87.8

Lotion 2

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain concentrations

55 described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 2.

1) Dimethylglycine ester hydrochloride and l-α-tocopherol 2.00 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 87.8

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Lotion 3

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 3.

1) Dimethylglycine ester d-γ-tocopherol hydrochloride 2.00 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 87.8

Lotion 4

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 4.

1) Dimethylglycine ester d-δ-tocopherol hydrochloride 2.00 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 87.8

Lotion 5 (Comparative Reference)

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 5.

1) Ascorbil 2-sodium phosphate 2.00 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 87.8

Lotion 6 (negative reference)

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 6.

1) Purified water 2.00 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 87.8

All lotions described above dissolved uniformly and exhibited good stability over time.

Example 2

Lotion 7

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain concentrations

Final 30 described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 7.

1) dimethylglycine ester dl-α-tocopherol hydrochloride 0.10 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 89.7

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Lotion 8

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 8.

1) Dimethylglycine ester d-α-tocopherol hydrochloride 2) Ethanol 3) Propylene glycol 4) Methyl parahydroxybenzoate 5) Purified water

0.10 5.00 5.00 0.20 89.7

Lotion 9

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 9.

1) Dimethylglycine ester d-γ-tocopherol hydrochloride 0.10 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 89.7

Lotion 10

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 10.

1) Dimethylglycine ester d-δ-tocopherol hydrochloride 0.10 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 89.7

Lotion 11 (Comparative Reference)

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 11.

1) Ascorbil 2-sodium phosphate 0.10 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 89.7

Lotion 12 (negative reference)

Ingredients 1) to 4) were dispersed uniformly and dissolved to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 5) with stirring, thereby producing lotion 12.

1) Purified water 0.10 2) Ethanol 5.00 3) Propylene glycol 5.00 4) Methyl parahydroxybenzoate 0.20 5) Purified water 89.7

All lotions described above dissolved uniformly and exhibited good stability over time.

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Example 3

Gel composition 1

Ingredient 1) was dispersed uniformly in ingredient 2) in order to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 3) with stirring, thereby producing the desired gel composition 1.

1) Dimethylglycine ester hydrochloride and dl-α-tocopherol 10 2) Glycerol 20 3) Octyldodecyl myristate 70

Gel composition 2

Ingredient 1) was uniformly dispersed in ingredient 2) in order to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 3) with stirring, thereby producing the desired gel composition 2.

1) Dimethylglycine ester hydrochloride and d-α-tocopherol 10 2) Glycerol 20 3) Octyldodecyl myristate 70

Gel Composition 3

Ingredient 1) was uniformly dispersed in ingredient 2) in order to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 3) with stirring, thereby producing the desired gel composition 3.

1) Dimethylglycine ester d-γ-tocopherol hydrochloride 10 2) Glycerol 20 3) Octyldodecyl myristate 70

Gel composition 4

Ingredient 1) was dispersed uniformly in ingredient 2) in order to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 3) with stirring, thereby producing the desired gel composition 4.

1) Dimethylglycine ester d-hydrochloride hydrochloride 10 2) Glycerol 20 3) Octyldodecyl myristate 70

Gel composition 5 (Comparative reference)

Ingredient 1) was uniformly dispersed in ingredient 2) in order to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 3) with stirring, thereby producing the desired gel composition 5.

1) Ascorbil 2-sodium phosphate 10 2) Glycerol 20 3) Octyldodecyl myristate 70

Gel composition 6 (negative reference)

Ingredient 1) was uniformly dispersed in ingredient 2) in order to obtain the final concentrations described below, and subsequently the resulting mixture was added to ingredient 3) with stirring, thereby producing the desired gel composition 6.

1) Purified water 10 2) Glycerol 20 3) Octyldodecyl myristate 70

All gel compositions described above dissolved uniformly, and exhibited good stability over time.

5

10

fifteen

twenty

25

30

35 E03710261

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Example 4

Pigmentation Prevention Effects

The hair was cut on the entire surface of the back of each of the 50 male Wiser Maple guinea pigs (WM, SPF), 7 weeks old, with electric hair clippers (0.05 mm blade), and subsequently it was shaved with an electric shaver, followed by wrapping with an elastic adhesive bandage (SILKYTEX, covered on the outside of it with aluminum foil) in which 6 holes of 1.5 cm x 1.5 cm had been made .

Each product of lotions 1 to 12 and gel compositions 1 to 6, prepared in examples 1 to 3, in an amount of 0.05 ml, was applied successively to 10 holes described above.

Four hours after application, the application part was cleaned with absorbent cotton containing water, followed by drying. Subsequently, the animal was attached with a hitch, followed by exposure to medium wavelength UV (UVB) with 300 mJ / cm2 to each part from a distance of approximately 10 cm by means of a UV exposure device (Shinano Co., Ltd., fluorescent lamp model Toshiba FL40S / E30, equipped with six SE lamps).

After exposure, 0.05 ml of each of the same lotions 1 to 12 and gel compositions 1 to 6 as described above was applied again to the corresponding part.

The operation described above was repeated for 3 days. Fourteen days after the final exposure, the strength of the pigmentation was evaluated by evaluation points according to the evaluation criteria described below. In addition, the luminosity of the skin was measured at 5 points in total, that is, the four corners and the central part of each of the parts applied and exposed by a color difference meter (Minolta Co., Ltd., CR -twenty).

The pigmentation prevention effects of each of the products were determined by the average value of the evaluation points (10 data sheets per product) and the average brightness value (50 data sheets per product).

Pigmentation Evaluation Criteria

No pigmentation is observed

evaluation point 0

Very little pigmentation is observed

evaluation point 1

Little pigmentation is observed

evaluation point 2

Good pigmentation grade is observed

evaluation point 3

Strong pigmentation was observed

evaluation point 4

Results (average value) Product Evaluation point Luminosity

Lotion 1

0.8 63.0

Lotion 2

0.7 63.1

Lotion 3

0.6 62.8

Lotion 4

0.5 64.0

Lotion 5

2.1 61.8

Lotion 6

3.0 59.5

Lotion 7

2.0 61.7

Lotion 8

2.0 60.7

Lotion 9

1.5 62.0

Lotion 10

1.7 62.0

Lotion 11

3.0 59.9

Lotion 12

3.0 60.1

Gel composition 1

0.4 63.8

Gel composition 2

0.4 62.9

Gel Composition 3

0.4 63.1

Gel composition 4

0.4 63.0

Gel composition 5

1.2 62.1

Gel composition 6

3.0 59.9

As is evident from the results described above, in each of lotions 1 to 4 and 7 to 10, and gel compositions 1 to 4, according to the present invention, superior pigmentation prevention effects were observed.

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Example 5

Effects of pigmentation removal

5 The hair was cut on the entire surface of the back of each of the 50 male Wiser Maple guinea pigs (WM, SPF), 6 weeks old, with electric hair clippers (0.05 mm blade), and then , it was shaved with an electric shaver, followed by wrapping with an elastic adhesive bandage (SILKYTEX, covered on the outside of it with an aluminum foil) in which 6 holes of 1.5 cm x 1.5 had been made cm. Subsequently, the animal was attached with a hitch, followed by exposure to medium wavelength UV rays.

10 (UVB) with 750 mJ / cm2 to each part from a distance of approximately 10 cm by means of a UV exposure device (Shinano Co., Ltd., fluorescent lamp model Toshiba FL40S / E30, equipped with six SE lamps) .

From 4 days after exposure to 28 days, each product of lotions 1 to 12 and the compositions of

Gel 1 to 6, prepared in Examples 1 to 3, in an amount of 0.05 ml, was applied successively to 10 holes described above, twice a day, that is, in the morning and in the afternoon.

Twenty-eight days after exposure, the strength of the pigmentation was evaluated by evaluation points according to the same evaluation criteria described in the example. The effects of pigmentation prevention are

20 evaluated for the average value obtained from the evaluation points (10 data per product).

Product Evaluation Point

Lotion 1 2.2 Lotion 2 2.2 Lotion 3 2.0 Lotion 4 2.0 Lotion 5 3.3 Lotion 6 3.5 Lotion 7 3.0 Lotion 8 3.0 Lotion 9 3.0 Lotion 10 3.0 Lotion 11 3.5 Lotion 12 3.8 Gel composition 1 2.2 Gel composition 2 2.1 Gel composition 3 2.0 Gel composition 4 1.9 Gel composition 5 2.9 Gel composition 6 3 ,5

As can be deduced from the results described above, even in each of the lotions (1 to 4 and 7 to 10) and the gel compositions (1 to 4) according to the present invention, superior elimination effects were observed.

25 of the pigmentation.

Industrial applicability

The compositions used in the present invention have a high level of safety, and have effects

Top 30 prevention of pigmentation or removal of pigments formed in the skin. For these reasons, they are useful as cosmetic compositions that exhibit so-called superior bleaching effects.

Claims (11)

E03710261 09-22-2014 1. External use of an alkylglycine and tocopherol ester and / or a salt thereof, for cosmetic skin whitening, in which the alkylglycine and tocopherol ester is a compound represented by the formula (1) described below: image 1 wherein R1 and R2 represent an equal or different lower alkyl group or a hydrogen atom; and R3, R4 and 10 R5 represent a hydrogen atom or a methyl group, with the proviso that R1 and R2 do not represent a hydrogen atom at the same time. 2. Use according to claim 1, wherein the alkylglycine and tocopherol ester is at least one compound selected from an alkylglycine ester and α-tocopherol, an alkylglycine ester and γ-tocopherol and an alkylglycine ester and δ-tocopherol. 3. Use according to claim 1, wherein the alkylglycine and tocopherol ester is an alkylglycine and αtocopherol ester. Use according to claim 3, characterized in that the alkylglycine and α-tocopherol ester is an alkylglycine ester and dl-α-tocopherol. 5. Use according to claim 3, characterized in that the alkylglycine and α-tocopherol ester is an ester of alkylglycine and d-α-tocopherol. 25 6. Use according to claim 1, characterized in that the alkylglycine and tocopherol ester is an alkylglycine ester and γ-tocopherol. 7. Use according to claim 6, characterized in that the alkylglycine and γ-tocopherol ester is an alkylglycine ester and d-γ-tocopherol. 8. Use according to claim 1, characterized in that the alkylglycine and tocopherol ester is an alkylglycine and δ-tocopherol ester. Use according to claim 8, characterized in that the alkylglycine ester and δ-tocopherol is an alkylglycine ester and d-δ-tocopherol. 10. Use according to claim 1, characterized in that the alkylglycine and tocopherol ester is ester of dimethylglycine and tocopherol. 40 11. Use according to claim 1, characterized in that the salt of an alkylglycine ester and tocopherol is a salt of an organic acid or an inorganic acid. 12. Use according to claim 11, wherein the salt of an alkylglycine ester and tocopherol is the hydrochloride. Four. Five 13. Use according to claim 1, wherein an added amount of the alkylglycine ester and tocopherol and / or the salt thereof is comprised between 0.1 and 10% by mass. eleven