ES248697A1 - Procedure for the preparation of new derivatives of isoindoline (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new isoindoline derivatives, characterized in that they prepare compounds of general formula ** (See formula) ** in which they mean R1 is a halogen atom or an alkyl or alkoxy group of low molecular weight, R 2 is hydrogen, a halogen atom, an alkyl, alkoxy, alkanoylamino, carbalkoxy, carbalkoxyalkoxy or low molecular weight carbamylalkoxy group, a nitro group, a hydroxyl group, a carbamyl or a sulfamyl group or a carbamyl carbamyl alkoxy or sulfamyl group substituted by one or two low molecular weight alkyl, alkenyl or hydroxyalkyl radicals or a polymethylene- or 3-oxa-pentylene- (1,5) moiety, R3 hydrogen, chlorine, bromine or a low molecular weight alkyl or alkoxy group, and R4 is hydrogen, a low molecular weight alkyl, alkenyl or hydroxyalkyl group or a cycloalkyl group, by reacting a compound of the general formula ** (See formula) ** O well ** (See formula) ** in which they mean X chlorine or bromine, And hydrogen or a low molecular weight alkyl group, R2 'a radical corresponding to the definition for R2, a chloro- or bromosulfonyl group or a chloro- or bromocarbonyl group, and R2 "a radical corresponding to the definition for R2, a carboxyl group or a chloro- or bromo-sulfonyl group, with a compound of the general formula R4 - NH2 IV in a molar quantity corresponding to at least the number of halogen atoms bonded non-aromatically or of carboxyl and carbalkoxy groups. (Machine-translation by Google Translate, not legally binding)