ES2481140A1 - Proceso para la preparación en forma cristalina de tibolona, (7 alfa, 17 alfa)-17-hidroxi-7-metil-19-norpregn-5(10)-en-20-in-3-ona - Google Patents

Proceso para la preparación en forma cristalina de tibolona, (7 alfa, 17 alfa)-17-hidroxi-7-metil-19-norpregn-5(10)-en-20-in-3-ona Download PDF

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Publication number
ES2481140A1
ES2481140A1 ES201430062A ES201430062A ES2481140A1 ES 2481140 A1 ES2481140 A1 ES 2481140A1 ES 201430062 A ES201430062 A ES 201430062A ES 201430062 A ES201430062 A ES 201430062A ES 2481140 A1 ES2481140 A1 ES 2481140A1
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ES
Spain
Prior art keywords
alpha
norpregn
tibolone
hydroxy
methyl
Prior art date
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Granted
Application number
ES201430062A
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English (en)
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ES2481140B1 (es
Inventor
Andrea VANOSSI
Giovanni LIZZANO
Cristina FOCHI
Silvestro LUCARIELLO
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Industriale Chimica SRL
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Industriale Chimica SRL
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Publication of ES2481140A1 publication Critical patent/ES2481140A1/es
Application granted granted Critical
Publication of ES2481140B1 publication Critical patent/ES2481140B1/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Proceso para la preparación en forma cristalina de tibolona, (7α, 17α)-17-hidroxi-7-metil-19-norpregn-5(10)-en-20-in-3-ona. Se describe un proceso para la preparación del compuesto (7α, 17α)-17-hidroxi-7-metil-19-norpregn-5(10)-en-20-in-3-ona), comúnmente conocido como Tibolona, que permite la obtención del compuesto con una alta pureza y el control de la composición polimórfica. MP/md.

Description

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Claims (1)

  1. imagen1
ES201430062A 2013-01-25 2014-01-22 Proceso para la preparación en forma cristalina de tibolona, (7 alfa, 17 alfa)-17-hidroxi-7-metil-19-norpregn-5(10)-en-20-in-3-ona Active ES2481140B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000120A ITMI20130120A1 (it) 2013-01-25 2013-01-25 Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one
ITMI2013A000120 2013-01-25

Publications (2)

Publication Number Publication Date
ES2481140A1 true ES2481140A1 (es) 2014-07-29
ES2481140B1 ES2481140B1 (es) 2015-05-06

Family

ID=47749930

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201430062A Active ES2481140B1 (es) 2013-01-25 2014-01-22 Proceso para la preparación en forma cristalina de tibolona, (7 alfa, 17 alfa)-17-hidroxi-7-metil-19-norpregn-5(10)-en-20-in-3-ona

Country Status (5)

Country Link
AR (1) AR094416A1 (es)
BR (1) BR102014001688A2 (es)
ES (1) ES2481140B1 (es)
IT (1) ITMI20130120A1 (es)
MX (1) MX2014000999A (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023460A1 (en) * 1998-10-16 2000-04-27 Akzo Nobel N.V. HIGH PURITY COMPOSITION COMPRISING (7α,17α)- 17-HYDROXY- 7-METHYL- 19-NOR-17-PREGN- 5(10)-EN-20-YN-3-ONE
WO2006125453A1 (en) * 2005-05-23 2006-11-30 Newchem S.P.A. Process for the preparation of pure crystalline tibolone
IT1349813B1 (it) * 2003-12-19 2008-12-01 Processo per la preparazione di tibolone in forma di miscela polimorfica a composizione definita

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63051B1 (en) * 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023460A1 (en) * 1998-10-16 2000-04-27 Akzo Nobel N.V. HIGH PURITY COMPOSITION COMPRISING (7α,17α)- 17-HYDROXY- 7-METHYL- 19-NOR-17-PREGN- 5(10)-EN-20-YN-3-ONE
IT1349813B1 (it) * 2003-12-19 2008-12-01 Processo per la preparazione di tibolone in forma di miscela polimorfica a composizione definita
WO2006125453A1 (en) * 2005-05-23 2006-11-30 Newchem S.P.A. Process for the preparation of pure crystalline tibolone

Also Published As

Publication number Publication date
MX2014000999A (es) 2014-11-21
AR094416A1 (es) 2015-07-29
ITMI20130120A1 (it) 2014-07-26
ES2481140B1 (es) 2015-05-06
BR102014001688A2 (pt) 2016-11-08

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