ES2453148T3 - Carnitine derivative, salt thereof, external skin preparation and cosmetic preparation - Google Patents

Abstract

External preparation for the skin comprising a carnitine derivative represented by formula (1) and/or a carnitine derivative salt represented by formula (2): **Formula** in which a combination of R1 and R2 is select from methyl/isopropyl, methyl/n-hexyl, methyl/n-octyl, methyl/n-decyl, methyl/n-tetradecyl, methyl/n-hexadecyl, ethyl/isopropyl, ethyl/n-butyl, ethyl/n -pentyl, ethyl/n-hexyl, ethyl/n-octyl, ethyl/n-decyl, ethyl/n-tetradecyl, ethyl/n-hexadecyl, n-propyl/n-butyl, n-propyl/n-pentyl, n -propyl/n-hexyl, n-butyl/n-hexyl, n-butyl/n-octyl and n-hexyl/n-octyl; **Formula** where R1 and R2 are as defined in formula (1 ), X- is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative, and Y+ is an inorganic or organic cation that maintains electrical neutrality with an anionic part of the carnitine derivative.

Description

Carnitine derivative, salt thereof, external skin preparation and cosmetic preparation.

5 Field of the invention

The present invention relates to external preparations and cosmetics for the skin. More particularly, the invention relates to external preparations and cosmetics for the skin that contain carnitine derivatives and / or salts thereof and that stimulate lipid metabolism. The invention further relates to new

10 carnitine derivatives and salts thereof.

Background of the invention

It is known that carnitine plays an important role in lipid metabolism in humans. In

In the cells, carnitine is enzymatically linked to fatty acids in fats and transports fatty acids into the mitochondria, an organelle in which fats are burned. According to the above, carnitine has the role of carrier of fatty acids and is essential for lipid metabolism. Fatty acids are oxidized in the mitochondria and converted into energy in the form of ATP in the living organism.

20 Lipids are important not only as a source of energy, but also as constituents of the human body. All cell membranes are composed of lipids. On a macroscopic scale, lipids control the evaporation of moisture from the body in the form of sebum and intercellular lipids.

25 Excess lipids lead to obesity as a result of the accumulation of subcutaneous fat and causes many cosmetic and CDV (quality of life) problems, including cellulite formation, shiny skin and fat due to excess sebum, dermatitis seborrheic and the consequent loss of hair, acne, body odor and skin aging due to a reduction in lipid metabolism.

30 As mentioned above, lipid metabolism requires that fatty acids be transported inside the mitochondria, for which carnitine is responsible. In accordance with the above, the metabolic rate of lipids depends on the amount of carnitine in the cells. The increased concentration of carnitine in target tissues stimulates lipid metabolism and avoids and eliminates excess lipids and associated problems.

35 For these reasons, percutaneous absorption of various external skin preparations containing carnitine has been studied and has been proposed to stimulate lipid metabolism (patent documents No. 1 to No. 4). However, such external skin preparations, which contain L-carnitine and salts thereof, have failed to achieve satisfactory effects. The reason is probably because L-carnitine and salts of the

The same hydrates quite easily, its direct use results in an affinity for the skin and reduced percutaneous absorption properties, and not enough carnitine reaches the tissue in which lipid metabolism should occur.

External slimming preparations for the skin are proposed, which contain a chain acylcarnitine

Linear (in which carnitine has been modified with a linear chain fatty acid residue) capable of more potent dermatological effects than carnitine itself. As an example, an external skin slimming preparation contains palmitoyl-L-carnitine (L-carnitine palmitate), carnitine, caffeine and coenzyme A (patent document No. 5).

50 [Patent document No. 1] Japanese patent No. 3434995

[Patent Document No. 2] JP-A-H07-309711

[Patent document No. 3] JP-A-2000-16916

55 [Patent Document No. 4] JP-A-2001-64147

[Patent document No. 5] French patent No. 2694195

60 WO-A-00/04870 discloses external skin preparations comprising carnitine derivatives such as isobutyrylcarnitine and alpha-methylbutyrylcarnitine.

WO-A-2005/115326 is prior art according to art. 54 (3) CPE and discloses carnitine derivatives contained in cosmetic slimming compositions used to stimulate lipid metabolism.

Exhibition of the invention

[Problems to be solved by the invention]

5 Linear chain acylcarnitine penetrates the skin and produces excellent lipid metabolism stimulation effects. However, the linear chain acyl group is susceptible to being hydrolyzed and is easily decomposed forming aqueous products that are a frequent form of external skin preparations, particularly cosmetics. Consequently, the products have reduced storage stability and a short life.

The present invention relates to the resolution of the problems indicated above. Therefore, it is an object of the invention to provide external skin preparations and cosmetics that exhibit excellent storage stability, product life, affinity for the skin and percutaneous absorption properties.

It is another object of the invention to provide new carnitine derivatives and salts thereof that are resistant to hydrolysis in the presence of aqueous media.

[Means to solve the problems]

In the context of the present invention, exhaustive studies have been carried out and it has been found that the a-branched acylcarnitine derivatives, particularly L-carnitine 2-hexyldecanoate, L-carnitine 2-methylpalmitate and L-carnitine 2-butyl octanoctanoate, have a superior stability in the presence of aqueous media. The present invention has been completed based on this result.

The present invention provides the following.

[1] An external skin preparation comprising a carnitine derivative represented by the formula (1) and / or a carnitine derivative salt represented by the formula (2):

wherein a combination of R1 and R2 is selected from methyl / isopropyl, methyl / n-hexyl, methyl / n-octyl, methyl / n-decyl, methyl / n-tetradecyl, methyl / n-hexadecyl, ethyl / isopropyl , ethyl / n-pentyl, ethyl / n-hexyl, ethyl / n-octyl, ethyl / n-decyl, ethyl / n-tetradecyl, ethyl / n-hexadecyl, n-propyl / n-butyl, n-propyl / n -pentyl, n-propyl / n-hexyl, n-butyl / n

Hexyl, n-butyl / n-octyl and n-hexyl / n-octyl,

wherein R1 and R2 are as defined in formula (1), X - is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative, and Y + is an inorganic or organic cation which maintains electrical neutrality with an anionic part of the carnitine derivative.

[2] The external skin preparation according to [1], above, wherein X- in formula (2) is an anion selected from the group consisting of hydroxide ion, nitrate ion, sulfate ion, carbonate ion, ion

45 hydrogen carbonate, halide ion, format ion, acetate ion, citrate ion, tartrate ion, oxalate ion, fumarate ion, saturated or unsaturated fatty acid anion with 3 to 20 carbon atoms that may have a branch, carnitine anion, derivative anion of carnitine, ascorbate anion, ascorbyl phosphate anion and ascorbyl phosphate derivative anion.

[3] The external skin preparation according to [1] or [2], above, in which Y + in formula (2) is a cation selected from the group consisting of hydrogen ion, sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine cation and carnitine-derived cation.

[4] The external preparation for the skin according to any of [1] and [3], above, in which the derivative of

The carnitine represented by the formula (1) and / or the salt of the carnitine derivative represented by the formula (2) constitutes 0.01% to 20% by mass of the external skin preparation.

[5] A cosmetic comprising 0.01% to 20% by mass of the carnitine derivative and / or salt of the derivative of

carnitine indicated in any of [1] to [4], above. 10

[6] Preparation according to [5], above, for use in the treatment of obesity associated with excess lipids and a reduction in lipid metabolism, to prevent cellulite, seborrheic dermatitis and acne.

[7] A carnitine derivative represented by formula (3):

or a carnitine derivative salt represented by the formula (4):

wherein X - is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative, and Y + is an inorganic or organic cation that maintains electrical neutrality with an anionic part of the carnitine derivative.

[8] The salt of the carnitine derivative according to [7], above, wherein X - in the formula (4) is an anion selected from the group consisting of hydroxide ion, nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, halide ion, format ion, acetate ion, citrate ion, tartrate ion, oxalate ion, fumarate ion, saturated or unsaturated fatty acid anion with 3 to 20 carbon atoms that may have a branch, carnitine anion, derivative anion from

Carnitine, ascorbate anion, ascorbyl phosphate anion and ascorbyl phosphate derivative anion.

[9] The salt of the carnitine derivative according to [7] or [8], wherein Y + in formula (4) is a cation selected from the group consisting of hydrogen ion, sodium ion, potassium ion, calcium ion , magnesium ion, zinc ion, ammonium ion, carnitine cation and carnitine derivative cation.

[10] A carnitine derivative represented by the formula (5):

or a carnitine derivative salt represented by the formula (6):

5 in which X - is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative, and Y + is an inorganic or organic cation that maintains electrical neutrality with an anionic part of the carnitine derivative.

[11] The salt of the carnitine derivative according to [10], above, wherein X - in the formula (6) is an anion selected from the group consisting of hydroxide ion, nitrate ion, sulfate ion, carbonate ion , hydrogen carbonate ion, halide ion, format ion, acetate ion, citrate ion, tartrate ion, oxalate ion, fumarate ion, saturated or unsaturated fatty acid anion with 3 to 20 carbon atoms that can have a branch, carnitine anion, anion of Carnitine derivative, ascorbate anion, ascorbyl phosphate anion and ascorbyl phosphate derivative anion.

[12] The carnitine derivative salt according to [10] or [11], above, in which Y + in formula (6) is a cation selected from the group consisting of hydrogen ion, sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine cation and carnitine derivative cation.

20 [Effects of the invention]

The external preparations and cosmetics for the skin according to the present invention have a long life due to the decomposition resistant carnitine derivatives in the presence of aqueous media. Consequently, carnitine derivatives, and carnitine derivatives originating from the salts of

Carnitine derivatives in the products produce superior effects (affinity for the skin, percutaneous absorption properties and stimulating activity of lipid metabolism in tissues) stably for a prolonged period.

In accordance with the foregoing, external skin preparations and cosmetics can be conveniently used to stimulate lipid metabolism.

The new carnitine derivatives and salts thereof according to the present invention are practically not hydrolyzed in the presence of aqueous media.

35 Brief description of the drawings

Figure 1 is a graph showing the concentrations of carnitine and free carnitine derivatives originating from the test substances that have passed into the chamber on the dermis side after 24 hours in Example 1.

Figure 2 is a graph showing the changes in time of the residual proportion of carnitine derivatives originated from the test substances in aqueous solutions in Example 2.

Preferred embodiments of the invention

The present invention will be described in detail below.

The external skin preparations and cosmetics of the present invention contain a specific carnitine derivative and / or a salt thereof. That is, external preparations and cosmetics for the skin may contain a

50 derived from specific carnitine or a salt thereof or both.

<Carnitine derivatives>

Carnitine derivatives used in the preparations and external cosmetics for the skin of the invention are represented by the formula (1):

in which a combination of R1 and R2 is selected from:

5 methyl / isopropyl, methyl / n-hexyl, methyl / n-octyl, methyl / n-decyl, methyl / n-tetradecyl, methyl / n-hexadecyl, ethyl / isopropyl, ethyl / n-pentyl, ethyl / n-hexyl , ethyl / n-octyl, ethyl / n-decyl, ethyl / n-tetradecyl, ethyl / n-hexadecyl, npropyl / n-butyl, n-propyl / n-pentyl, n-propyl / n-hexyl, n-butyl / n-hexyl, n-butyl / n-octyl and n-hexyl / n-octyl.

The carnitine fraction in carnitine derivatives is generally of type L. Carnitine derivatives contain

10 an a-branched acyl group having R1 and R2. In the event that R1 and R2 are different, the carbon atom a at the branch point is an asymmetric carbon atom and optical isomers result. Optical isomers are not particularly limited. Any optical isomers and mixtures of said isomers can be used in the invention.

The carnitine derivatives are stable for a prolonged period probably because they contain an a-branched acyl group that has R1 and R2, and the branched chain reduces electron donation to the ester bond to hinder the hydrolysis of the acyl group in the presence of aqueous media

The external skin preparations and cosmetics of the invention may contain one or more carnitine derivatives having different combinations of R1 and R2.

Among the embodiments of the carnitine derivatives represented by the formula (1) include known compounds and new compounds. New representative carnitine derivatives are described below.

Preferably, one of R1 and R2 in formula (1) is a linear alkyl group of 6 carbon atoms, and the other is a linear alkyl group of 8 carbon atoms. That is, the carnitine derivative having the combination of n-hexyl and n-octyl, specifically the L-carnitine 2-hexyldecanoate represented by the formula (3), subsequently, is particularly preferable. This carnitine derivative is exceptionally stable in the presence of media.

30 aqueous.

Also preferably, one of R1 and R2 in formula (1) is a methyl group and the other is an alkyl group

35 linear with 14 carbon atoms (n-tetradecyl group). Specifically, Lcarnitine 2-methyl palmittate represented by the formula (7) is preferable. Also preferably, one of R1 and R2 in formula (1) is a linear alkyl group with 4 carbon atoms and the other is a linear alkyl group with 6 carbon atoms. That is, the carnitine derivative having the combination of n-butyl and n-hexyl, specifically L-carnitine 2-butyl octanoctanoate represented by the formula (5), is subsequently preferable.

40 <Carnitine derivative salts>

The salts of carnitine derivatives used in the external preparations and skin cosmetics of the invention are represented by the formula (2):

In formula (2), X - is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative. Medically acceptable anions are preferred, and examples thereof include inorganic ions such as hydroxide ion, nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion and halide ion, and organic ions such as format ion, acetate ion, ion citrate, tartrate ion, ion

Oxalate, fumarate ion, saturated or unsaturated fatty acid anion with 3 to 20 carbon atoms that may have a branch, carnitine anion, carnitine derivative anion, ascorbate anion, ascorbyl phosphate anion and ascorbyl phosphate derivative anion. Among them are preferably hydroxide ion, halide ion, citrate ion, carnitine anion and carnitine derivative anion, according to the miscibility in external skin preparations, in particular cosmetics.

In formula (2), Y + is an inorganic or organic cation that maintains electrical neutrality with an anionic part of the carnitine derivative. Medically permissible cations are preferred and examples thereof include hydrogen ion, sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine cation and carnitine derivative cation. Among them, hydrogen ion, sodium ion, potassium ion are preferred,

Carnitine cation and carnitine derivative cation, according to the miscibility in external preparations for the skin, particularly cosmetics.

In formula (2), R1 and R2 are as defined in formula (1).

The external skin preparations and cosmetics of the invention may contain one or more salts of carnitine derivatives having different combinations of X -, Y +, R1 and R2.

Salts of carnitine derivatives represented by formula (2) include known compounds and new compounds. Subsequently, new salts of representative carnitine derivatives are indicated.

Preferably, one of R1 and R2 in formula (2) is a linear alkyl group with 6 carbon atoms and the other is a linear alkyl group with 8 carbon atoms. That is, the salt of the carnitine derivative having the combination of n-hexyl and n-octyl, specifically the L-carnitine 2-hexyldecanoate salt represented by the formula (4), subsequently, is particularly preferred. The carnitine derivative that originates from

Said salt is exceptionally stable in the presence of aqueous media.

wherein X-and Y + are as defined in formula (2).

Also preferably, one of R1 and R2 in formula (2) is a methyl group, and the other is a linear alkyl group with 14 carbon atoms (n-tetradecyl group). Specifically, the L-carnitine 2-methylpalmitate salt represented by formula 8 is subsequently preferred. Also preferably, one of R1 and R2 in formula (2) is a linear alkyl group with 4 carbon atoms, and the other is a linear alkyl group with 6 carbon atoms. That is, the salt of the carnitine derivative that presents the combination of n-butyl and n-hexyl, specifically

The salt of L-carnitine 2-butyloctanoate represented by the formula (5) is subsequently preferred.

15 in which X-and Y + are as defined in formula (2).

<Production of carnitine derivatives and salts thereof>

The carnitine derivatives and salts thereof used in the external skin cosmetics and preparations of the invention can be synthesized from commercially available L-carnitines, for example by the reaction of the L-carnitines and fatty acid chlorides.

By way of example, the synthesis of L-carnitine 2-hexyldecanoate hydrochloride is described below. Be

25 mix L-carnitine and 2-hexyldecanoiso acid chloride in trifluoroacetic acid, followed by heating and stirring at a temperature between 50oC and 80oC to carry out the reaction. The trifluoroacetic acid is then evaporated by distillation and petroleum ether is added to the residue for recovery, and water is added to the residue to deactivate the acid chloride. Then, ethanol and diethyl ether are added to the residue for extraction thereof and the water-ethanol phase is separated. The water-ethanol phase is combined with n

30 butanol and wash with water, as required. The n-butanol is then removed by distillation in order to obtain L-carnitine 2-hexyldecanoate hydrochloride.

Examples of carnitines as raw materials for producing carnitine derivatives and salts thereof include internal salts, inorganic salts such as hydrochlorides and sodium salts, and organic salts.

35 such as oxalates, tartrates and smokers.

<External skin preparations and cosmetics>

External preparations and cosmetics for the skin, in particular cosmetics that improve the metabolism of

the lipids contain the carnitine derivatives and / or salts thereof indicated above. Cosmetics that improve lipid metabolism are cosmetics intended to improve and prevent problems and skin aging, as well as obesity associated with excess lipids and a reduced lipid metabolism. Examples of the desired effects of cosmetics include slimming, cellulite prevention, skin tightening, prevention of shiny and oily skin and makeup run due to excess sebum, improvement and prevention of seborrheic dermatitis and the consequent hair loss, acne prevention, prevention of body odor and anti-aging skin, skin activation and skin care by stimulating the conversion of lipids into energy.

In the total amount of external preparations for the skin, the carnitine derivative and / or the salt thereof is generally contained in an amount of between 0.01% and 20% by mass, preferably between 0.05% and 12 % by mass, more preferably between 0.1% and 5% by mass. This amount indicates a content of the carnitine derivative or salt thereof in the case that it is used individually, and a content of the carnitine derivative and salt thereof combined in the case that they are used in combination.

In the event that the external preparations for the skin contain the carnitine derivatives and / or salts thereof in the amounts indicated above, the carnitine derivatives and / or salts thereof will quickly penetrate the skin and produce the desired effects. .

Cosmetics and cosmetics that improve lipid metabolism desirably contain carnitine derivatives and / or salts thereof in the amounts indicated above with respect to external skin preparations.

External skin preparations and cosmetics may contain other common components in external skin preparations and general cosmetics, and also maintain the effects of the invention.

These components include:

hydrocarbons such as ozoquerite, α-olefin oligomers, light isoparaffin, light liquid isoparaffin, squalene, squalane, synthetic squalane, vegetable squalane, ceresin, paraffin, polyethylene powder, polybutene, microcrystalline wax, liquid isoparaffin, liquid paraffin, mineral oil and petrolatum ,

natural fats and oils, such as natural waxes, including jojoba oil, carnauba wax, candelilla wax, rice bran wax, shellac, lanolin, mink oil wax, whale wax, sugar cane wax, oil of sperm, beeswax and mountain wax; Avocado oil, almond oil, olive oil, extra virgin olive oil, sesame oil, rice bran oil, rice oil, rice germ oil, corn oil, soybean oil, corn oil, Persian oil, palm seed oil, palm oil, castor oil, grape seed oil, cottonseed oil, coconut oil, hydrogenated coconut oil, beef tallow, hydrogenated oil, horse oil, oil of mink, egg yolk oil, egg yolk fatty oil, rosehip oil, kukui nut oil, evening primrose oil, wheat germ oil, peanut oil, camellia oil, Sasanqua oil, butter cocoa, Japanese wax, ox bone fat, ox leg oil, lard, horse fat, ram tallow, shea butter, macadamia nut oil and shambrilla oil (Limnanthes),

fatty acids, such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, isostearic acid, 12-hydroxystearic acid, undecylenic acid and coconut fatty oil,

higher alcohols, such as isostearyl alcohol, octyldodecanol, hexyldecanol, cholesterol, phytosterol, lauryl alcohol, myristyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, behenyl alcohol and ketostearyl alcohol,

alkylglyceryl ethers, such as batyl alcohol, chimyl alcohol, selakyl alcohol and isostearylglyceryl ether,

esters, such as isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprilate, hexyl laurate, isooctyl myristate, decyl, myristyl myristate, cetyl myristate, octadecyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isocetyl myristate, isostataryl myristate Octyldodecyl myristate, 2-ethylhexyl palmitate, isocetyl palmitate, isostearyl palmitate, 2-ethylhexyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate,

ethyl isoestearate, isopropyl isostearate, cetyl 2-ethylhexanoate, 2-ethylhexanoate of ketostearyl, 2-stearylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprylate, propylene glycol dicaprilate of propylene glycol, propylene glycol dioleate neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprilate, glyceryl tri-2-ethylhexanoate,

Glyceryl tri (caprylate caprate), glyceryl tri (capryrate stearate), glyceryl triumphacrylate, glyceryl triisopalmitate, glyceryl triisoestearate, tri-2-ethylhexanoate, trimethylolpropane triisoethane-trimethylpropane trimethylethane, trimethylpropane trimethyl ethane, trimethylpropane trimethyl ethane, trimethylpropane trimethyl ethane, trimethylpropane trimethyl ethane pentaerythrityl, pentaerythrityl tetramiristate,

Pentaerythrityl tetraisoestearate, diglyceryl tetraisoestearate, octyldodecyl neopentanoate, isocetyl octanoate, isostearyl octanoate, 2-ethylhexyl isopelargonate, dimethyl octadecyl dimethyl octanoctate, isostethyl stearate octyldodecyl, lauryl lactate, myristyl lactate, cetyl lactate, octyldodecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, trioctyl citrate, triisocetyl citrate, trioctyldodecyl citrate, diisoxyl dihydrate, dixyl dihydrate ethylhexyl, di-2-ethylhexyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diheptylundecyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate,

cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihidrocolesterilo oleate, isostearyl fitoesterilo oleate fitoesterilo, 12-estearoilhidroxiestearato isocetyl 12-estearoilhidroxiestearato stearyl 12-estearoilhidroxiestearato isostearate, cetyl acetate polyoxyethylene (3) polyoxypropylene (1) ether, polyoxyethylene (3) polyoxypropylene (1) isocetyl ether (1), isononyl isononanoate, octyl isononanoate, tridecyl isononanoate and isotridecyl isononanoate,

silicone oils such as methylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, metilciclopolisiloxano, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethyl-cyclohexasiloxane, octamethyl trisiloxane, decamethyl tetrasiloxane, tetradecametil-hexasiloxane, methylpolysiloxane highly polymerized copolymer, dimethylsiloxane / methyl (polyoxyethylene) siloxane / methyl (polyoxypropylene) siloxane, dimethylsiloxane / methyl copolymer (polyoxyethylene) siloxane, dimethylsiloxane / methyl (polyoxypropylene) siloxane, dimethylsiloxane / metilcetiloxisiloxano copolymer, dimethylsiloxane / metilestearoxisiloxano copolymer, polyether-modified silicones, silicones modified with alcohol, modified silicones alkyl copolymer and amino modified silicones,

polymers, such as sodium alginate, carrageenan, agar, fuceleran, cymo-porosis gum, Pyrus cydonia seed, kanjac mannan, tamarind gum, tara gum, dextrin, garrofin gum, arabic gum, ghatti gum, karaya gum, tragacanth gum, arabinogalactan, pectin , marmelo, chitosan, starch, curdlan, xanthan gum, gellan gum, cyclodextrin, dextran, pululane, microcrystalline cellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxy-cationized starch, starch, cationic starch , carboxymethyl / hydroxypropylated cyamoposis gum, hydroxypropylated cyamoposis gum, albumin, casein, gelatin, sodium polyacrylate, polyacrylic acid amide, carboxyvinyl polymers, polyethyleneimine,

Highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl ether, polyacrylamide, acrylic acid copolymers, methacrylic acid copolymers, maleic acid copolymers, vinylpyridine copolymers, ethylene / acrylic acid copolymers, vinylpyrrolidone vinylpyrrolidone polymers , nitrogenous acrylamide polymers, amino modified silicones, cationized polymers, dimethylacrylammonium polymers, anionic polymers based on acrylic acid, anionic polymers based on methacrylic acid, modified silicones, acrylic / alkyl (C10-30) methacrylate copolymer and polyoxyethylene / polyoxypropylene copolymer,

lower alcohols, such as ethanol, isopropyl alcohol, 1-butanol, 2-butanol and benzyl alcohol,

polyhydric alcohols, such as ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 1,3-butanediol, triethylene glycol, dipropylene glycol, 3-methyl-1,3-butanediol, 1,2-pentanediol, 1,2-pentanediol, 1,2-pentanediol, 1,2-pentanediol, 1,2-pentanediol, 1,2-pentanediol, 1,2-pentanediol, 1,2-pentanediol, 1,2 , 1,5-pentanediol, 2,4-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 1,2-hexanediol and 1,6-hexanediol,

anionic surfactants, such as coco-potassium fatty acid, coconut-sodium fatty acid, cocotriethanolamine fatty acid, potassium laurate, sodium laurate, triethanolamine laurate, potassium myristate, sodium myristate, isopropanolamine myristate, potassium palmitate, sodium palmitate isopropanolamine palmitate, potassium stearate, sodium stearate, triethanolamine stearate, potassium oleate, sodium oleate, castor-sodium oil fatty acid, zinc undecylenate, zinc laurate, zinc myristate, magnesium myristate, zinc palmitate, stearate Zinc, calcium stearate, magnesium stearate, aluminum stearate, calcium myristate, magnesium myristate, aluminum dimiristate, aluminum isostearate,

polyoxyethylene acetic acid lauryl ether, polyoxyethylene sodium lauryl ether acetate, polyoxyethylene acetic acid tridecyl ether, sodium polyoxyethylene tridecyl ether acetate, sodium stearoyl lactate, sodium isostearoyl lactate, sodium fatty acid lauroylsarcosine sarcosine, cocosarcosine sodium fatty acid, coconut-sarcosine-triethanolamine fatty acid, lauroyl-sarcosine, lauroyl-sarcosine potassium, lauroyl-sarcosine from triethanolamine, oleoyl-sarcosine, myristoyl-sarcosine sodium, stearoyl-glutamate, sodium fatty acid - acylglutamic acid, coconut potassium fatty acid acylglutamate, sodium coconut fatty acid acylglutamate, coconut fatty acid triethanolamine acylglutamate, lauroyl acylglutamic acid, lauroyl

potassium acylglutamate,

sodium lauroylacylglutamate, triethanolamine lauroyl acylglutamate, myristoyl acylglutamic acid, potassium myristoyl acylglutamate, sodium myristoyl acyloglutamate, stearoyl acylglutamate acid, potassium stearoyl acylglutamate, acyloglutamate acylglutamate acidic acid of coconut sodium / hydrogenated tallow fatty acid acylglutamate, methylalanine-sodium coconut fatty acid, lauroyl-methylalanine, lauroyl-methylalanine sodium, lauroyl-methylalanine-triethanolamine, myristoyl-methyl-methylalanine sodium, lauroyl-methyl-methyltaurine sodium potassium coconut, methyl courine-sodium coconut fatty acid, methyltaurine-coconut magnesium fatty acid, sodium myristoyl methyltaurine,

Sodium palmitoyl-methyltaurine, sodium stearoyl-methyltaurine, sodium oleyl-methyltaurine, sodium alkanesulfonate, sodium tetradecenesulfonate, dioctyl sodium sulfosuccinate, sodium lauryl disodium sulphosuccinate, triethyl acetate sulfate, coethyl acetate sulfate of triethanolamine (11, 13, 15), sodium alkyl sulfates (12, 13), triethanolamine alkyl sulfates (12, 13), ammonium alkyl sulfates (12, 14, 16), diethanolamine alkyl sulfates (12, 13), triethanolamine alkyl sulfates ( 12-14), triethanolamine alkyl sulfates (12-15), triethanolamine magnesium cocalkylsulfate, ammonium lauryl sulfate, potassium lauryl sulfate, magnesium lauryl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate,

sodium myristyl sulfate, sodium stearylsulfate, sodium oleyl sulfate, triethanolamine oleyl sulfate, sodium polyoxyethylene lauryl ether sulfate, triethanolamine lauryl ester sulfate, alkyl sulfate (11, 13, 15) polyoxyethylene (1) polyoxyethylene ether alkyl sulfate (11, 13, 15) -polyoxyethylene ether (1) of triethanolamine, alkyl sulfate (11-15) -sodium polyoxyethylene (3) ether, alkyl sulfate (12, 13) -polyoxyethylene ether ( 2) sodium, alkyl sulfate (12-14) -sodium polyoxyethylene ether (3), alkyl sulfate (12-15) -sodium polyoxyethylene ether (3), sodium polyoxyethylene lauryl ether (2) sulfate, polyoxyethylene (3) sodium myristyl ether sulfate, sodium higher fatty acid alkanolamine sulfate, lauryl phosphoric acid, sodium lauryl phosphate,

potassium cetyl phosphate, diethanolamine cetyl phosphate, polyoxyethylene phosphoric acid oleyl ether, polyoxyethylene phosphoric acid lauryl ether, sodium polyoxyethylene lauryl ether phosphate, polyoxyethylene ether phosphoric acid cetyl ether sodium, polyoxyethylene-phosphoric acid stearyl ether, polyoxyethylene-phosphoric acid oleyl ether, sodium polyoxyethylene phosphoryl ether phosphate, polyoxyethylene phosphoric acid alkylphenyl ether, sodium polyoxyethylene alkylphenyl ether phosphate, alkylphenyl alkyl phosphate phosphate -Triethanolamine polyoxyethylene ether, polyoxyethylene-phosphoric acid octyl ether, (12, 13) -polyoxyethylene (10) -phosphoric acid, alkyl (12-15) -polyoxyethylene-phosphoric acid, alkyl (12 -16) polyoxyethylene phosphoric acid ether, triethanolamine polyoxyethylene lauryl ether phosphate and diethanolamine polyoxyethylene oleyl ether phosphate,

anionic surfactants such as dioctylamine, dimethylstearylamine, trilaurylamine, diethylaminoethylamide of stearic acid, lauryl trimethylammonium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, cetyltrimethylammonium saccharin, stearyltrimethylammonium chloride, alkyl chloride (20-22) trimethylammonium bromide, lauryl , alkyl (16, 18) -trimethylammonium chloride, stearyltrimethylammonium bromide, stearyltrimethylammonium saccharin, alkyl (28) -trimethylammonium chloride, di (polyoxyethylene) oleylmethylmethylammonium (2EO) chloride, dipolyloxyethylenemethylammoniummethylammonium methoxymethyl ammonium methylene chloride ) -polyoxypropylene (25), tri (polyoxyethylene) stearylammonium chloride (5EO), distearyl dimethyl ammonium chloride,

dialkyl (12-15) -dimethylammonium chloride, dialkyl (12-18) -dimethylammonium chloride, dialkyl (14-18) dimethylammonium chloride, dicocoyldimethylammonium chloride, dithyldimethylammonium chloride, isostearylauryl dimethyl ammonium chloride, benzalkonium chloride myristyldimethylbenzyl ammonium, lauryl dimethyl (ethylbenzyl) ammonium chloride, stearyl dimethylbenzyl ammonium chloride, laurylpyridinium chloride, cetylpyridinium chloride, lauroylcholaminoformylmethylpyridinium chloride, stearoylcholaminofornylmethylpyriumthiobenzenethiobenzenethiobenzenylthiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzylthiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenethiobenzenylthiobenzenethiobenzenethiobenzenethiobenzenethiobenzenylthiobenzenylthiobenzene chloride

amphoteric surfactants such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine hydrochloride alquildiamonoetilglicina, laurildiaminoetilglicina sodium, undecilhidroxietilimidazolio betaine sodium, undecyl-Ncarboximetilimidazolio betaine, acyl-N-carboxyethyl-N-hydroxyethylethylenediamine disodium ester of coconut fatty acid, coconut fatty acid acyl-N-carboxy-ethoxylenediamine disodium ester of coconut fatty acid, acyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine disodium coconut fatty acid ester, sodium laurylamine propionate, laurylamopropylamine propionate Sodium Acyl-N-Carboxyethyl-N-Hydroxyethylenediamine Palm Oil Fatty Acid ester, Betaine Lauryldimethylaminoacetate, Coconut-betaine Alkyldimethylaminoacetate, Betaine Stearyldimethylaminoacetate, Stearyldimethyl betaine Acetate, Acid Fatty Acid Ester of palm amidopropyl betaine, lauric acid betaine amide propylacetate, amidopropyl betaine ricinoleate, stearyl dihydroxyethyl betaine and laurylhydroxysulfo betaine,

nonionic surfactants, such as alkyl (12, 13) -polyoxyethylene ether (10), polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene ether ether, alkyl (12-14) polyoxyethylene ether (3, 7, 12), polyoxyethylene tridecyl ether, polyoxyethylene myristyl ether, sec-alkyl (14) polyoxyethylene ether, polyoxyethylene isocetyl ether, polyoxyethylene ether ketoestearyl, polyoxyethylene ether (2, 10, 20), oleyl ethyl ether

of polyoxyethylene, araxyl polyoxyethylene ether (20), octyldodecyl ether of polyoxyethylene, behenyl ether of polyoxyethylene, octylphenyl ether of polyoxyethylene,

polyoxyethylene nonylphenyl ether, polyoxyethylene dinonylphenyl ether, polyoxyethylene cetyl ether (1) polyoxypropylene (1, 2, 4, 8), polyoxypropylene cetyl ether (1, 2, 4, 8) polyoxyethylene (5), polyoxypropylene cetyl ether (1, 2, 4, 8) polyoxyethylene (10), polyoxypropylene cetyl ether (1, 2, 4, 8) polyoxyethylene (20), polyoxypropylene polyoxypropylene lauryl ether, polyoxypropylene stearyl ether (34) polyoxyethylene (3), polyoxypropylene stearyl ether (30) polyoxyethylene (4), polyoxypropylene stearyl ether (23) polyoxyethylene (34), polyoxyethylene polyoxypropylene polyoxypropylene ether, polyoxypropylene polyoxypropylene ether,

polyethylene glycol monolaurate, ethylene glycol monostearate, polyethylene glycol monostearate, polyethylene glycol monooleate, ethylene glycol fatty acid ester, self-emulsifying ethylene glycol monostearate, diethylene glycol laurate, polyethylene glycol monomethylene glycol monohydrate, polyethylene glycol monohydrate glycol monostearate self-emulsifier, polyethylene glycol isoestearate, ethylene glycol dioctanoate, diethylene glycol dilaurate, polyethylene glycol dilaurate, polyethylene glycol dipalmitate (150), ethylene glycol distearate, diethylene glycol distearate, polyethylene glycol diol, ethylene glycol dioterate,

polyethylene glycol diricinoleate, polyoxyethylene (20) -sorbitan monolaurate, polyoxyethylene (20) sorbitan monopalmitate, polyoxyethylene (6) -sorbitan monostearate, polyoxyethylene (20) -sorbitan monostearate, polyoxyethylene polyethylene sorbitan (20) polyoxyethylene (6) -sorbitan, polyoxyethylene (20) -sorbitan monooleate, polyoxyethylene (20) -sorbitan trioleate, polyoxyethylene (20) -sorbitan-coconut fatty acid ester, polyoxyethylene (10-80) -sorbitan monolaurate, Polyoxyethylene sorbitan triestearate, polyoxyethylene (20) -sorbitan isostearate, polyoxyethylene (150) -sorbitan triestearate,

polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene (10) hydrogenated castor oil (20), polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (50) hydrogenated castor oil, polyoxyethylene (60) -hydrogenated castor oil, lipophilic glyceryl monostearate, lipophilic glyceryl monooleate, self-emulsifying glyceryl monostearate, coconut fatty acid glyceryl, glyceryl laurate, glyceryl myristate, glyceryl isostearate, glyceryl glyceryl glyceryl, glyceryl hydrochloride glyceryl, glyceryl linoleate, glyceryl erucate, glyceryl behenate, wheat germ oil fatty acid glyceride, safflower oil fatty acid glyceryl, hydrogenated soybean fatty acid glyceryl, saturated fatty acid glyceride,

cottonseed oil fatty acid glyceryl, monoisostearic acid glyceryl monomiristate, mono-tallow fatty acid glyceride, monoglyceryl-lanolin fatty acid, glyceryl sesquioleate, glyceryl distearate, glyceryl diisoarate, glyceryl diaraquidate, glyceryl monoralate sorbitan monopalmitate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monooleate, sorbitan sesquistearate, sorbitan sesquioleate, sorbitan tristearate, sorbitan trioleate, sorbitan coconut fatty acid, sorbitan isostearate sesquiisostearate, sorbitan distearate of sorbitan, diglyceryl isopalmitate, poly (4-10) -glyceryl monolaurate, poly (10) -glyceryl monomiristate, poly (2-10) -glyceryl monostearate, poly (2-10) -glyceryl monostearate, monooleate of poly (2-10) glyceryl, diglyceryl sesquioleate,

poly (2-10) -glyceryl diiso stearate, poly (6-10) -glyceryl distearate, diglyceryl triisoestearate, poly (10) -glyceryl triestearate, poly (10) -glyceryl trioleate, poly (2) tetraiso stearate -glyceryl, decaglyceryl pentaestearate, poly (6-10) -glyceryl, pentaoleate, poly (10) -glyceryl heptaarate, decaglyceryl decaestearate, poly (10) -glyceryl decaoate, poly (6) -condensed glyceryl , cane sugar fatty acid ester, cane-cocoa sugar fatty acid ester, alkyl glycoside, coconut oil alkyldimethylamine oxide, lauryl dimethylamine oxide, dihydroxyethylauryl dimethylamine oxide, stearyl dimethylamine oxide, oleyl dimethylamine oxide and oxide of polyoxyethylene-coconut oil alkyldimethylamine,

Natural surfactants, such as saponin, lecithin, soy phospholipid, hydrogenated soy phospholipid, soy lysophospholipid, hydrogenated soy lysophospholipid, bone yolk lecithin, lysophosphatidylcholine hydrogenated egg yolk, phosphatidylcholine, phosphophenylephyriphyrylphyriphyrylphysphinephysphiliphyrylphyriphyrylphosphinephosphine phospholiphyrylphosphine phospholiphyrylphysphinephyspholiphyrylphosphine phospholiphyrylphosphine phospholiphyrylphosphine phospholiphyphosphine phospholipidine ganglioside, bile acid, colic acid, deoxycholic acid, sodium colato, sodium deoxycholate, spiculisphoric acid, ramnolipid, trehalose lipid, soforolipid and mannosyritritol lipid,

ultraviolet light absorbers, including para-aminobenzoic acid, para-aminobenzoic acid derivatives, such as ethyl para-aminobenzoate, glyceryl para-aminobenzoate, amyl paradimethylaminobenzoate and 2-ethylhexyl para-dimethylaminobenzoate, cinnamic acid derivatives, such as benzyl cinnamate, glyceryl diparamethoxycinnamate mono-2-ethylhexanoate, methyl 2,4-diisopropylcinamate, ethyl 2,9-diisopropylcinamate, potassium paramethoxycinnamate, sodium parametoxycinnamate, isopropyl paramethoxycinnamate, 2- 2-ethoxyhematoxylate, 2- ethoxyethyl and ethyl paraethoxycinnamate, urocanic acid, urocanic acid derivatives, such as ethyl urocanate,

benzophenone derivatives, such as 2,9-dihydroxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4methoxy-5-sulfobenzophenone-sodium, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2 -hydroxy-4

methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone and 2,2'-dihydroxy-4,4'-dimethoxy-5-sulfobenzophenonasodium,

Salicylic acid derivatives, such as ethylene glycol salicylate, 2-ethylhexyl salicylate, phenyl salicylate, benzyl salicylate, p-tert-butylphenyl salicylate, homomentyl salicylate and 3,3,5-trimethylcyclohexyl salicylate, 2- (2 ' -hydroxy-5'-methoxyphenyl) benzotriazole and 4-tert-butyl-4'-methoxybenzoylmethane,

powders and colored materials, such as kaolin, silicic anhydride, magnesium aluminum silicate, sericite, talcum, boron nitride, mica, montmorillonite, hemp cellulose powder, wheat starch, silk powder, corn starch, pigment nitro, azo pigment, nitrous pigment, triphenylmethane pigment, xanthene pigment, quinoline pigment, anthraquinone pigment, indigo pigment, pyrene pigment, phthalocyanine pigment,

Natural pigments, including flavonoid, quinone, porphyrin, water-soluble annatto, squid ink powder, caramel, guaiazulene, gardenia blue, gardenia yellow, coquineal extract, shiconin, sodium copper chlorophyllin, paprika pigment, safflower red, Safflower yellow, laccaic acid and riboflavin butyrate, carbon black, yellow iron oxide, black iron oxide, red iron oxide, iron blue, ultramarine blue, zinc oxide, chromium oxide, titanium oxide, oxide black titanium, zirconium oxide, chromium hydroxide, alumina, magnesium oxide, barium sulfate, aluminum hydroxide, calcium carbonate, lithiocobalt titanate, manganese violet and pearl pigment,

plant extracts, such as Angelica keiskei extract, gambir extract, avocado extract, Hydrangea serrata leaf extract, Gynostemma pentaphyllum extract, Althea extract, Arnica extract, oil soluble Arnica extract, almond extract, extract of aloe, benzoin styrax resin extract, gingko extract, Urtica extract, orris root extract, fennel extract, turmeric extract, rose fruit extract, echinacea leaf extract, root extract Scutellaria baicalensis, Phellodendron bark extract, Coptis rhizome extract, Hordeum vulgare seed extract, gumbo extract, Hypericum erectum extract, oil-soluble Hypericum erectum extract, Lamium album flower extract, flower extract Oil-soluble Lamium album, Ononis extract, Nasturtium officinale extract, orange blossom water, persimmon tannin, Puerariae radix extract, valerian extract, Enea extract, chamomile extract, oat extract, carrot extract, oil-soluble carrot extract, carrot oil, Artemisia capillaris extract, licorice extract, licorice powder extract, licorice flavonoid, Cantharis tincture, raspberry extract, kiwi extract, cinchona bark extract,

cucumber extract, apricot kernel extract, quince seed extract, gardenia extract, Sasa veitchii extract, Sophora angustifolia extract, walnut shell extract, Clematis extract, brown sugar extract, Chlorella extract, extract of mulberry, cinnamon bark extract, gentian extract, geranium extract, tea extract, yellow water lily extract, Arctium lappa root extract, oil soluble Arctium lappa root extract, wheat germ extract, wheat Powdered hydrolyzate, rice bran extract, rice bran fermentation extract, comfrey herb extract, Asiasarum root extract, saffron extract, Saponaria officialis extract, oil soluble sage extract, Crataegus fruit extract cuneata, Xanthoxylum extract, Shiitake mushroom extract, Shiitake mushroom extract powder, Rehmannia glutinosa extract, Sycon extract, Sycon sol extract Uble in oil, Japanese basil extract, linden extract, oil-soluble linden extract, Filipendula multijuga extract, raw drug extract, Coil lacryma-jobi seed extract, gin extract, oil soluble gin extract , gin tincture, Acorus calamus root extract, Betula alba extract, oil soluble Betula alba extract, Betula alba sap, Lonicera extract, Equisetum arvense extract, Oil soluble Equisetum arvense extract,

Scordinin, Stevia extract, ivy extract, Crataegus oxyacantha extract, Sambucus nigra flower extract, Juniperus communis extract, Achillea millefolium extract, oil soluble Achillea millefolium extract, Mentha piperita extract, sage extract, extract Malva sylvestris, celery extract, Cnidium officinale extract, Cnidium officinale water, Swertia japonica extract, soy extract, jujube extract, thyme extract, Camellia sinensis leaf extract, Camellia sinensis dry distillate, Camellia sinensis extract, Camellia sinensis seed, clove flower extract, Citrus unshiu peeling extract, Camellia japonica seed extract, Centella asiatica extract, oil-soluble Juglans regia extract, Duke extract, Terminalia extract, Angelica acutiloba extract , oil-soluble Angelica acutiloba extract, Angelica acutiloba water, Calendula officinalis flower extract, f extract Oil-soluble Calendula officinalis lor, powdered soy milk, Prunus persica extract, Citrus aurantium-amara extract, Houttuynia cordata extract, tomato extract, Potentilla erecta root extract, natto extract, ginseng extract, oil soluble ginseng extract, garlic extract, canine rose fruit extract,

Oil-soluble canine Rosa fruit extract, malt extract, malt root extract, Ophiopogon tuber extract, parsley extract, Hordeum vulgare leaf juice concentrate, distilled mint water, Witch hazel extract Witch hazel, Rosa centifolia flower extract, parietaria extract, Isodonis japonicus extract, Eriobotrya japonica leaf extract, Eriobotrya japonica leaf extract

oil soluble, farfara herb flower extract, coconut Poria extract, Ruscus aculeatus root extract, Ruscus aculeatus root extract powder, grape extract, vine leaf extract, grape water, flower extract of hay, Luffa cylindrica fruit extract, Luffa cylindrica fruit water, safflower extract, oil-soluble Tilia miqueliana extract, Tilia miqueliana water, Paeonia suffruticosa root extract, hops extract, soluble hops extract in oil, pineapple extract from Pinus sylvestris, fruit extract from Silybum marianum, horse chestnut extract, oil-soluble horse chestnut extract, Sapindus mukurossi peeling extract, Melissa officinalis leaf extract, Melilotus officinalis extract, peach leaf extract, oil soluble peach leaf extract, soy bean extract, Centaurea cyanus flower extract, Centaurea cyanus flower water, extract Eucalyptus, Saxifraga sarmentosa extract, Lilium candidum bulb extract, Coix lacryma jobi seed extract, oil soluble Coix lacryma-jobi seed extract, Artemisia princeps extract, Artemisia princeps water, lavender extract, water lavender, apple extract, Ganoderma lucidum extract, lettuce extract, Astragalus sinicus extract, rose water, rosemary extract, oil-soluble rosemary extract, Anthemis nobilis flower extract and Sanguisorba officinalis root extract,

amino acids and peptides, such as glycine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, tryptophan, cystine, cysteine, methionine, hydroxyproline, aspartic acid, asparagine, glutamic acid, glutamine, histidine, v-aminobutyric acid, acid DL-pyrrolidoncarboxylic, £ -aminocaproic acid, hydrolyzed elastin, water soluble elastin, hydrolyzed collagen, water soluble collagen, casein, glutathione, wheat peptide and soy peptide,

vitamins and vitamin affecters, including vitamin A, such as retinol, retinal, retinoic acid, retinol acetate and retinol palmitate, carotenoids such as a-carotene, -carotene, v-carotene, a-carotene, lycopene, zeaxanthin , cryptoxanthin, equinenone and astaxanthin, B1 vitamins such as thiamines, B2 vitamins such as riboflavin, B6 vitamins such as pyridoxine, pyridoxal and pyridoxamine, B12 vitamins such as cyanocobalamin,

folic acid, nicotinic acid, nicotinic acid amide, pantothenic acids, biotins, vitamin C such as L-ascorbic acid, sodium L-ascorbate, L-ascorbyl stearate, L-ascorbyl palmitate, L-ascorbyl dipalmitate, tetraisopalmitate L-ascorbyl, disodium L-ascorbate sulfate, magnesium L-ascorbate, sodium L-ascorbyl phosphate, 2-ascorbic acid phosphate and L-ascorbic acid 2-glucoside, D vitamins such as ergocalciferol and cholecalciferol, vitamins E such as da-tocopherol, DL-a-tocopherol, dl-a-tocopherol acetate, dl-atocopherol succinate, -tocopherol, v-tocopherol and da-tocopherol, ubiquinones, vitamin K, carnitine, ferulic acid, v-oryzanol , a-lipoic acid and orotic acid,

antiseptics such as benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate paraoxybenzoate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate benzyl, methyl paraoxibenzoate, methyl sodium paraoxibenzoate, phenoxyethanol, photosensitive agent No. 101, photosensitive agent No. 201 and photosensitive agent No. 401,

antioxidants, such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, erythorbic acid, sodium erythorbate, parahydroxyanisole and octyl gallate,

sequestrants, including metal ionic compounds, such as trisodium ethylenediaminohydroxyethyltriacetate, edetic acid, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, gluconic acid, phytic acid, sodium polyphosphate and sodium metaphosphate,

moisturizers, such as hyaluronic acid, sodium hyaluronate, sodium chondroitinsulfate, sodium lactate, sodium pyrrolidoncarboxylate, betaine, bacterial lactic acid culture solution, yeast extract and ceramide,

anti-inflammatory agents, such as glycyrrhizinic acid, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonic glycyrrhizinate, glyceryl glycinate, glyceryl glycinate, stearyl glycinate, lysozyme chloride, hydrocortisone and allanto

pH adjusters, such as sodium hydroxide, potassium hydroxide and triethanolamine,

salts, such as sodium chloride, potassium chloride, magnesium chloride and sodium sulfate,

α-hydroxy acids, such as citric acid, glycolic acid, tartaric acid and lactic acid,

bleaching agents, such as arbutin, a-arbutin and placental extract,

essential oils, such as angelica oil, Ylang ylang oil, elemi oil, German chamomile oil, Anthemis nobilis oil, cardamom oil, calamus oil, gipsy oil, oil

Camphor, carrot seed oil, Roman sage oil, clove oil, cinnamon bark oil, coriander oil, cypress oil, sandalwood oil, cedar oil, Citronella oil, cinnamon leaf oil, jasmine absolute, juniper berry oil, gin extract, spearmint oil, sage oil, cedar oil, geranium oil, thyme oil, tea tree oil, nutmeg oil, Niaouli oil, neroli oil, Pine oil, basil oil, peppermint oil, patchouli oil, palm kernel oil, fennel oil, Petitgrain oil, black pepper oil, incense oil, Vetivert oil, peppermint oil, bergamot oil, benzoin oil Aniba rosaeodora oil, marjoram oil, myrrh oil, melissa oil, eucalyptus oil, Ravensara oil, lavender oil, lavender oil, lindane oil, rose oil, rosewood oil, rosemary and oil of plantain,

terpenes, such as pinene, terpinenne, terpinolene, myrcene and longifolene,

Perfumes and water.

The formulations and forms of external skin preparations and cosmetics are not particularly limited with the condition that they be used directly on the skin. It is more preferred that external skin preparations and cosmetics be applied to the skin in proximity to the site where subcutaneous fat metabolism is desired. Broadly speaking, external formulations and cosmetics for the skin include any formulations that are used directly on the skin, such as body milks, skin creams, makeup bases, massage creams, cleansing creams, shaving foams, foams cleansers, skin toners, lotions, packages, lipsticks, blushes, eye shadows, hand creams, soaps, body shampoos, hand soaps, shampoos, conditioners, hair toners, treatment conditioners, hair creams , hair sprays, hair growth toners, baldness remedies, hair pigments, hair dyes, hair fixation spritz, depilatories, anti-dandruff agents, toothpastes, denture adhesives, mouth washes , permanent hair waving agents, hair curling agents, fixing agents, ointments, adhesive skin patches, bandage agents, agents bath, antiperspirants and sunscreen agents. External skin preparations and cosmetics can be used regardless of the sex and age of the user, and can be used for animal skin in addition to human skin.

The external skin preparations and cosmetics according to the present invention can be found in any form, including solids, liquids, semi-solids, gases, powders, granules, tablets, gels and foams.

Although not mandatory, formulations and forms that include aqueous media are preferably selected because the present invention is particularly effective in improving the low stability of conventional carnitine derivatives and salts thereof in aqueous preparations. In this case, water may conveniently constitute 0.01% to 99.99% by mass of external skin preparations or cosmetics.

The cosmetics according to the present invention may also contain existing cosmetic ingredients different from the components indicated above, however achieving the effects of the invention. Examples of these ingredients include those listed in The Japanese Standards of Cosmetic Ingredients, 2nd edition (edited by the Society of Japanese Pharmacopeia and published by Yakuji Nippo, Ltd., 1984), The Japanese Cosmetic Ingredients Codex (edited by Ministry of Health and Welfare, Pharmaceutical Examination Division and published by Yakuji Nippo, Ltd., 1993), The Japanese Cosmetic Ingredients Codex supplement (edited by Ministry of Health and Welfare, Pharmaceutical Examination Division and published by Yakuji Nippo, Ltd., 1993) , The Comprehensive Licensing Standards of Cosmetics by Category (edited by Ministry of Health and Welfare, Pharmaceutical Examination Division and published by Yakuji Nippo, Ltd., 1997), Dictionary of Cosmetic Ingredients (Nikko Chemicals, Co., Ltd., 1991) and 300 Latest Cosmetic Functional Materials (CMS Publishing Co., Ltd., 2002).

The external skin preparations and cosmetics of the present invention can be produced by common methods according to the formulations, for example by dissolving, mixing or dispersing the ingredients indicated above in predetermined amounts.

The present invention is described in greater detail by the examples below. In the examples, the% are in bulk, unless otherwise indicated.

Examples

[Synthetic example 1]

Synthesis of L-Carnitine 2-Hexyldecanoate Hydrochloride

In an ice bath, 45.6 g (0.283 mol) of L-carnitine was dissolved in 150 ml of trifluoroacetic acid. To the resulting solution, 116.6 g (0.425 mol) of 2-hexyldecanoic acid chloride was added dropwise over a period of 10 minutes, followed by heating and stirring at 80 ° C for 4 hours. The solvent was removed

by distillation under reduced pressure. The resulting dark brown oily substance weighing 264.6 g was washed with 200 ml of n-hexane three times and 200 ml of a black oily substance was collected. They were extracted with 20 ml of ethanol, 30 ml of n-butanol and 60 ml of water 3.0 g of the oily substance. The organic phase obtained was washed with 60 ml of water and with a mixture of 20 ml of ethanol and 60 ml of water. The organic phase was washed with 60 ml of water, collected and dried. Removal by solvent distillation resulted in 2.0 g of L-carnitine 2-hexyldecanoate hydrochloride.

The structure of the compound obtained was identified by NMR, liquid chromatography-mass spectroscopy (LC-MS) and elemental analysis as indicated in Synthetic Example 1.

<RMN>

1H NMR (CDCl3): 0.90 ppm (6H, t, 7.0 Hz), 1.29-1.62 ppm (24H, m), 2.41 ppm (1H, m), 2.76 ppm (2H, d, 6.0 Hz), 3.21 ppm (9H, s), 3.75 ppm (1H, d, 14.6 Hz), 3.92 ppm (1H, dd, 8.2, 14 , 6 Hz), 5.60-5.64 (1H, m).

NMR apparatus: Burker Advanced 500

Sample concentration: 40 mg of sample / 422 mg of heavy chloroform

Room temperature

<Liquid chromatography-mass spectroscopy (LC / MS)>

MS (IEP) m / z: 400.5 [M +] (CL / MS)

Liquid chromatography (CL): Agilent 1100 series

Column: C8-5B silica shodex

Column temperature: 40oC

Elution solution: 20 mM aqueous solution of ammonium acetate / acetonitrile (30/70)

Flow rate: 1.0 ml / min

Sample concentration and injected quantity: 10 μl x 5 mg / ml elution solution

Detection: 200-700 nm UV photodiode matrix

Mass spectrometer (EM): Thermoquest LCQ Advantage

Ionization method: IEP (electrospray ionization)

Scanning interval: m / z 50-1000 (alternating positive and negative charges)

EM / EM collision energy: 40%

<Elementary analysis>

Elemental analysis: C: 62.8%, H: 10.6%, N: 3.5%, O: 14.9%, Cl: 8.2%.

C, H, N and O: CHNS-932 organic elemental analyzer and VTF-900 oxygen analysis option (manufactured by LECO)

References: difeniltiourea sim. (for the analysis of C, H and N) and p-nitroaniline (for the analysis of O)

Cl: ion chromatography (exactly 1 mg of the sample was mixed with an elution solution (1.8 mM Na2CO3 + 1.7 mM NaHCO3) to a constant volume of 100 ml and analyzed with an anion chromatograph (DIONEX DX- 500) to determine the Cl in the sample).

Column: Shodex SI-90 4E

Flow rate: 1.0 ml / min

Injected amount: 25 μl

Detector: electrical conductivity detector

Suppressor: ASRS-I

[Synthetic example 2]

Synthesis of L-carnitine 2-methylpalmitate hydrochloride

In an ice bath, 45.6 g (0.283 mol) of L-carnitine was dissolved in 150 ml of trifluoroacetic acid. To the resulting solution, 122.4 g (0.425 mol) of 2-methylpalmitic acid chloride was added dropwise over a period of 10 minutes, followed by heating and stirring at 80 ° C for 4 hours. The solvent was removed by distillation under reduced pressure. The resulting dark brown oily substance weighing 278.0 g was washed with 200 ml of n-hexane three times and 200 ml of a black oily substance was collected. They were extracted with 20 ml of ethanol, 30 ml of n-butanol and 60 ml of water 3.0 g of the oily substance. The organic phase obtained was washed with 60 ml of water and with a mixture of 20 ml of ethanol and 60 ml of water. The organic phase was washed with 60 ml of water, collected and dried. Removal by solvent distillation resulted in 2.2 g of L-carnitine 2-methylpalmitate hydrochloride.

The structure of the compound obtained was identified by NMR, liquid chromatography-mass spectroscopy (LC-MS) and elemental analysis as indicated in Synthetic Example 1.

<RMN>

1H NMR (CDCl3): 2.50 ppm (1H, m), 2.75 ppm (1H, dd, 6.2, 1.5 Hz), 2.80 ppm (1H, m), 3.73 ppm (1H, d, 14.4

Hz), 3.91 ppm (1H, dd, 14.4, 8.5 Hz), 5.61-5.65 ppm (1H, m) <Liquid chromatography-mass spectroscopy (LC / MS)>

MS (IEP) m / z: 414.5 [M +] <Elemental analysis>

C: 64.3%, H: 10.3%, N: 3.2%, O: 14.2%, Cl: 8.0%

[Synthetic example 3]

Synthesis of L-Carnitine 2-Butyloctanoate Hydrochloride

In an ice bath, 45.6 g (0.283 mol) of L-carnitine was dissolved in 150 ml of trifluoroacetic acid. To the resulting solution, 92.7 g (0.425 mol) of 2-butyloctanoic acid chloride was added dropwise over a period of 10 minutes, followed by heating and stirring at 80 ° C for 4 hours. The solvent was removed by distillation under reduced pressure. The resulting dark brown oily substance weighing 250.0 g was washed with 200 ml of n-hexane three times and 200 ml of a black oily substance was collected. They were extracted with 20 ml of ethanol, 30 ml of n-butanol and 60 ml of water 3.0 g of the oily substance. The organic phase obtained was washed with 60 ml of water and with a mixture of 20 ml of ethanol and 60 ml of water. The organic phase was washed with 60 ml of water, collected and dried. Removal by solvent distillation resulted in 1.6 g of L-carnitine 2-butyl octanoctanoate hydrochloride.

The structure of the compound obtained was identified by NMR, liquid chromatography-mass spectroscopy (LC-MS) and elemental analysis as indicated in Synthetic Example 1.

<RMN>

1H NMR (CDCl3): 2.76 ppm (1H, d, 6.0 Hz), 2.80 ppm (1H, m), 3.76 ppm (1H, d, 14.4 Hz), 3.94 ppm (1H, dd, 14.4, 8.2 Hz), 5.60-5.64 ppm (1H, m)

<Liquid chromatography-mass spectroscopy (LC / MS)>

MS (IEP) m / z: 344.5 [M +]

<Elementary analysis>

C: 60.1%, H: 9.5%, N: 3.5%, O: 16.7%, Cl: 10.2%

[Example 1]

Percutaneous absorption properties

The following five substances were tested:

1) L-carnitine hydrochloride (Sigma-Aldrich)

2) L-carnitine palmitate hydrochloride (Sigma-Aldrich)

3) L-carnitine 2-hexyldecanoate hydrochloride (Synthetic Example 1)

4) L-carnitine 2-methylpalmitate hydrochloride (Synthetic Example 2)

5) L-carnitine 2-butyloctanoate hydrochloride (Synthetic Example 3)

Test substances (1) and (2) were standard references.

Each of the test substances was dissolved in Dulbecco PBS (-) containing 5% by mass of 1,2-hexanediol, followed by the addition of 1N NaOH to adjust the pH to 7. Accordingly, solutions of 0, 3% by mass of the test substances. Two cameras were separated by a three-dimensional model of human skin tissue (TESTSKIN TM LSD-d, available from Toyobo Co., Ltd.). 3 ml of each test substance solution was placed in a chamber on the side of the epidermis and 3 ml of Dulbecco PBS (-) in a chamber in the

Dermis side. They were stirred using magnetic stirrers at 35 ° C for 24 hours.

After a period of 24 hours, 1 ml of the buffer solution was collected in the dermis side chamber and 0.5 ml of the collected solution was analyzed to determine the level of free carnitine. The remaining part of the collected solution was adjusted to pH 11 with 1N NaOH, encapsulated in a 1.5 ml screw-in vial and allowed to stand at 80 ° C for 6 hours, followed by cooling. The pH of the solution was adjusted to 7 with 1N HCl, observing that all of the acylcarnitine derivatives had decomposed into free carnitine. Each of these solutions was combined with 0.02 ml of 1N hydrochloric acid, 0.1 ml of 1.6% mass solution of 1-aminoanthracene in acetone and 0.1 ml of 16% mass aqueous solution of EDC (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride), followed by sufficient stirring. The solutions were allowed to stand at room temperature for 20 minutes and washed with 3 ml of diethyl ether. The aqueous phases were filtered and analyzed by reverse phase high performance liquid chromatography (RPHPLC) (column: Phenomenex Synergi-RP, elution solution: 45% acetonitrile, flow rate: 1.0 ml / min) to determine the intensities of the peaks assigned to carnitine modified with 1 amino-anthracene (excitation wavelength: 248 nm, fluorescent wavelength: 418 nm). The concentrations of carnitine and free carnitine derivatives originating from the test substances in the solution in the chamber on the dermis side were calculated and determined from the peak intensities indicated above. The sample treated with alkali and with heat indicated that the joint concentration of free carnitine and carnitine derivatives. The untreated sample indicated the concentration of free carnitine.

The results are provided in Figure 1.

Figure 1 shows that L-carnitine 2-hexyldecanoate, L-carnitine 2-methylpalmitate and Lcarnitine 2-butyloctanoate penetrated the skin and reached comparable or higher concentrations of L-carnitine than those obtained with L-carnitine palmitate.

[Example 2]

Stability

The following five substances were tested:

1) Acetyl-L-carnitine hydrochloride (Sigma-Aldrich),

2) L-carnitine palmitate hydrochloride (Sigma-Aldrich),

3) L-carnitine 2-hexyldecanoate hydrochloride (Synthetic Example 1),

4) L-carnitine 2-methylpalmitate hydrochloride (Synthetic Example 2),

5) L-carnitine 2-butyloctanoate hydrochloride (Synthetic Example 3).

Test substances (1) and (2) were the standard references.

Each of the test substances was dissolved in Dulbecco's (-) PBS containing 5% by mass of 1,2-hexanediol, followed by the addition of 1N NaOH to adjust the pH to 7. Then 0.3 solutions were prepared. Mass% of test substances. The solutions were tightly encapsulated in glass vials and subjected to controlled temperature conditions of 80oC in a water bath.

After the predetermined period, the solutions were collected and analyzed by RPHPLC (column: Shodex C8-5B, elution solution: 70% acetonitrile, flow rate: 1.0 ml / min). The remaining carnitine derivatives originating from the test substances were determined from the UV absorption intensity at 210 nm. Figure 2 shows the changes over time of the residual proportion of carnitine derivatives originating from the test substances.

Figure 2 shows that the carnitine derivatives having an a-branched acyl group: L-carnitine 2-hexyldecanoate, L-carnitine 2-methylpalmitate and L-carnitine 2-butyloctanoate indicated a higher residual ratio and were exceptionally more stable in aqueous solutions than acylcarnitines with a linear chain acyl group.

[Example 3]

Fat degradation stimulation

Human preadipocytes (available from Toyobo Co., Ltd.) were seeded in a 96-well microplate and incubated at 37 ° C and 5% CO2 using TAGM human preadipocyte growth medium (available from Toyobo Co., Ltd.), renewing The medium every two days. The growth medium was changed to TADM human adipocyte differentiation medium (available from Toyobo Co., Ltd.) and incubation was carried out for 5 days. Then, the medium was changed to an evaluation medium, as shown in Table 1, subsequently, without

or with 50 μM of any of the test substances indicated below. The incubation was carried out for 5 days.

The following five substances were tested:

1) L-carnitine hydrochloride (Sigma-Aldrich),

5 2) L-carnitine palmitate hydrochloride (Sigma-Aldrich), 3) L-carnitine 2-hexyldecanoate hydrochloride (Synthetic example 1), 4) L-Carnitine 2-methylpalmitate hydrochloride (Synthetic example 2), 5) L-carnitine 2-butyloctanoate hydrochloride (Synthetic Example 3).

10 Test substances (1) and (2) were standard references.

Table 1

(Means of evaluation)

Components

 Concentration (g / l)

Calcium chloride dihydrate

0.265

Iron nitrate nonahydrate

0.0001

Magnesium sulphate

0.09767

Potassium chloride

0.4

Sodium carbonate

3.7

Sodium chloride

6.4

Sodium Dihydrogen Phosphate

0.109

L-arginine hydrochloride

0.084

L-Cystine Hydrochloride

0.0626

L-glutamine

 0.584

Glycine

 0.030

L-histidine hydrochloride hydrate

0.042

L-Isoleucine

 0.105

L-Leucine

 0.105

L-lysine hydrochloride

0.166

L-methionine

 0.030

L-phenylalanine

 0.066

L-serine

 0.042

L-threonine

 0.095

L-tryptophan

 0.016

L-tyrosine dihydrate disodium

0.10379

L-valine

 0.094

Choline hydrochloride

0.004

Folic acid

0.004

Myo-inositol

 0.0072

Niacinamide

 0.004

Calcium D-pantothenate

0.004

Pyridoxine hydrochloride

0.004

Riboflavin

 0.0004

Thiamine Hydrochloride

0.004

Phenol red sodium

0.0159

Sodium pyruvate

0.11

pH

 7.3

15 Adipocytes were washed with Dulbecco PBS (-) three times and fixed with formalin. The adipocytes were stained with a solution of Red Oil / water-isopropanol (1/1) and extracted with isopropanol. The triglycerides accumulated in the adipocytes were determined by a colorimetric method. Table 2 shows the accumulation of triglycerides obtained with the test substances compared to untreated adipocytes (100).

20 Table 2 Table 2 shows that, like acylcarnitines, L-carnitine 2-hexyldecanoate, L-carnitine 2-methylpalmitate and L-carnitine 2-butyloctanoate showed positive effects of fat metabolism stimulation.

Test substances

Accumulation of triglycerides

Not added

100

L-carnitine hydrochloride

98

L-carnitine palmitate hydrochloride

87

L-Carnitine 2-Hexyldecanoate Hydrochloride

89

L-carnitine 2-methylpalmitate hydrochloride

89

L-Carnitine 2-Butyloctanoate Hydrochloride

90

[Example 4]

A cosmetic containing L-carnitine 2-hexyldecanoate hydrochloride was prepared according to Table 3. The cosmetic was stored at 40 ° C for 3 months and proved stable without separation or precipitation. 10 Table 3

Components

 %

Sodium chloride

0.2

Tetrasodium EDTA

0.2

1,2-hexanediol

 4.0

Dipotassium Glycyrrhizinate

0.1

1% aqueous solution of sodium hyaluronate

4.0

L-Carnitine 2-Hexyldecanoate Hydrochloride

0.3

Purified water

Up to total

Note: values are given in mass% with respect to 100% in total. fifteen

[Example 5]

Preparation of skin toners

20 Skin toners were prepared according to Formulation Examples 1 to 4, subsequently, in which the total of components A and B was 100%.

[Formulation example 1]

A. Dipotassium glycyrrhizinate 0.2% L-carnitine 2-hexyldecanoate hydrochloride 1.0% Citric acid 0.1% Sodium citrate 0.3% Purified water Up to total

B.  Polyoxyethylene Sorbitol Tetraoleate 0.9% 0.1% sorbitan monooleate  0.1% olive oil  Dipropylene Glycol 5.0%  Methylparaben 0.1%  Ethanol 10.0%

(Formulation example 2)

A. Sodium citrate 0.1% Glycerin 8.0% Sodium pyrrolidoncarboxylate 1.0% Trehalose 0.03% 1,3-butylene glycol 5.0% Purified water Up to total

B. Decytetradecyl ether of polyoxypropylene-polyoxyethylene 0.6%  Methylparaben 0.1%  Ethanol 10.0% L-carnitine 2-hexyldecanoate hydrochloride 0.3%

(Formulation example 3)

TO.  0.1% polyvinyl alcohol

0.2% carboxyvinyl polymer  3.0% glycerin  0.1% trisodium edetate  0.05% sodium hydroxide  2-amino-2-methyl-1-propanol 0.06%  0.1% caffeine Purified water Up to total

B. 20.0% ethanol 0.3% polyoxyethylene oleyl ether  Methylparaben 0.1%  0.1% menthol 0.1% L-carnitine 2-methylpalmitate hydrochloride

In formulation examples 1, 2 and 3, the ingredients of A and B were mixed separately and heated to 50 ° C, providing solutions. Then, while stirring A, small portions of B were added to A and dissolved therein. The resulting solution was cooled under stirring. At 30 ° C, stirring stopped

5 and the solution was left at rest, providing a skin toner.

(Formulation example 4)

TO.  1,3-Butylene Glycol 5.02% Di (cholesteryl / behenyl / octyldodecyl) lauroyl glutamate 5%  Trehalose 0.03%  0.03% Trioctanoin Hydrogenated castor oil isostearate PEG-58 1.5% Hydrogenated castor oil PEG-60 0.5%  0.2% methylparaben  0.01% propylparaben  Tocopherol 0.05% L-carnitine 2-butyloctanoate hydrochloride 0.3%

B. Sodium malate 0.1% Malic acid Moderate amount Purified water Up to total

The ingredients of A and B were mixed separately and heated to 60 ° C, providing solutions. Then, while stirring A, B was mixed with A and the mixture cooled, forming a uniform skin toner.

[Example 6]

15 Preparation of body milks

Skin milks were prepared according to Formulation Examples 5 to 7. In Formulation Examples 5 and 6, the total of components A and B was 100%. In Formulation Example 7, the total of components A to C was

20 of 100%.

(Formulation example 5)

A. Squalane 10.0% Polyoxyethylene Glyceryl Isoesterate 3.5% Polyoxyethylene Hydrogenated Castor Triisoestearate 6.5% Polyoxyethylene Pyroglutamate Isoestearate Hydrogenated Castor Oil 12.0% Methylparaben 0.1%

B. 0.5% L-carnitine 2-hexyldecanoate hydrochloride Purified water Up to total

The ingredients of A and B were mixed separately, and A and B were heated to 70oC and 50oC, respectively, providing solutions. Then, while stirring A, small portions of B were added to A, forming an emulsion. The emulsion was cooled under stirring to obtain emulsified product, and the emulsified product was diluted ten times with purified water to provide a body milk.

(Formulation example 6)

TO.  10.6% liquid paraffin  0.6% isopropyl myristate  1.2% oleyl alcohol Polyoxyethylene Stearyl Ether 3.4%  1.9% PEG Dystearate Tetradecyl ether of polyoxypropylene polyoxyethylene 0.4% L-carnitine 2-hexyldecanoate hydrochloride 0.3%

B.  0.1% sodium stearoylglutamate  Propylene Glycol 1.4%  Methylparaben 0.1%  PEG-400 0.2% Purified water Up to total

The ingredients of A and B were mixed separately and A and B were heated to 70oC and 75oC, respectively, providing solutions. Then, while stirring B, small portions of A to B were added, forming an emulsion. The emulsion was cooled under stirring, providing a body milk.

(Formulation example 7)

TO. 1.0% polyoxyethylene sorbitan monostearate  Polyoxyethylene Sorbitan Tetraoleate 0.5% 1.0% sorbitan monostearate  0.5% stearic acid  0.5% Behenyl Alcohol  0.5% beeswax  Squalane 10.0% Glyceryl Tri-2-ethylhexanoate 10.0%  Decaglyceryl Decaoleate 3.0%  1,3-Butylene Glycol 7.0%  Methylparaben 0.1% L-carnitine 2-methylpalmitate hydrochloride 0.3%

B. Xanthan gum 0.04% Carboxyvinyl polymer 0.08% Purified water Up to total

C.  Triethanolamine 0.05%  Purified water 4.95%

The ingredients of A, B and C were mixed separately, and A and B were heated to 80 ° C, providing solutions, while C was homogenized at room temperature. Then, while stirring A, B was added to A, forming an emulsion, to which C. Cooling under stirring formed a milky liquid at practically 40 ° C. The milky liquid composition was cooled to room temperature, providing

15 a body milk.

[Example 7]

Gels Preparation

20 Gels were prepared according to Formulation Examples 8 to 13. In Formulation Example 8, the total of components A and B was 100%. In Formulation Example 9, the total of components A to E was 100%. In Formulation Examples 10 to 13, the total of components A to C was 100%.

25 (Formulation example 8)

TO. 2.0% agar  0.2% xanthan gum  0.1% caffeine  50.0% purified water

B.

 Glycerin 7.0% PEG-1500 8.0% Methylparaben 0.1% L-Carnitine 2-Hexyldecanoate Hydrochloride 0.8% Purified water Up to total

The ingredients of A and B were mixed separately, and A and B were heated at 90 ° C and 50 ° C, respectively, to provide dispersions. Then, A was cooled to 50 ° C. While stirring A, B was added to A and the mixture was gelled by cooling to a temperature not exceeding 30 ° C under stirring. After the gel solidified sufficiently, it was crushed to form a microgel by using a dispersion device, followed by deaeration, producing a uniform gel (semi-transparent).

(Formulation example 9)

TO.

 Carboxyvinyl polymer

0.35%

 Purified water

50.0%

B.

 Sodium hydroxide

0.1%

 Purified water

10.0%

C.

1% aqueous solution of sodium hyaluronate

6.0%

Purified water

Up to total

D.

 Tetradecyl ether of polyoxypropylene-polyoxyethylene

0.3%

 Ethanol

5.0%

 Methylparaben

0.1%

L-Carnitine 2-Hexyldecanoate Hydrochloride

0.3%

AND.

 Perfluoropolyether

0.2%

The ingredients of A, B, C and D were mixed separately. A and B were allowed to form solutions at room temperature, and C and D were heated at 50 ° C and 40 ° C, respectively, providing solutions. Then, while stirring A, B was added to A and the mixture gelled. Next, C, D and E were added to the gel and mixed by stirring, followed by deaeration, producing a uniform gel (semi-transparent).

(Formulation example 10)

A. 0.5% carboxyvinyl polymer Purified water 40.0%

B. Potassium hydroxide 0.1% Purified water 10.0%

C. Dipropylene glycol 10.0% Methylparaben 0.1% Dipotassium glycyrrhizinate 0.05% Hydrolyzed collagen 0.05% L-carnitine 2-methylpalmitate hydrochloride 0.5% Purified water Up to total

The ingredients of A, B and C were mixed separately. A and B were allowed to form solutions at room temperature and C was heated to 50 ° C, providing a solution. Then, while stirring A, B was added to A and the mixture gelled. Next, C was added to the gel and mixed by stirring, followed by deaeration, yielding a uniform (semi-transparent) gel.

(Formulation example 11)

A. Glycerin 10.0% 1,3-Butylene Glycol 6.0% Dimethicone 2.0% Hydrogenated castor oil PEG-60 0.6% Laureth-2 0.1% Laureth-21 0.1% Methylparaben 0.26 % Propylparaben 0.1% Ethylparaben 0.1% Phenoxyethanol 0.1% Tocopherol acetate 0.1% Chitosan succinamide 0.01% Yeast extract 0.1% Ethanol 0.01% Perfume 0.01% Hydrochloride 2 0.3% L-carnitine hexyldecanoate

B.  0.5% carboxyvinyl polymer  Urea 0.02%  0.01% glucosamine hydrochloride  0.01% disodium edetate  50.0% purified water

C. Arginine 0.63% Purified water Up to the rest

The ingredients of A, B and C were mixed separately. A was heated to 60 ° C to provide a solution, and B and C were allowed to form solutions at room temperature. Then, while stirring A, B was added to A and the mixture gelled. Then, C was added to the gel and mixed under stirring, followed by cooling to

5 room temperature, producing a uniform gel (semi-transparent).

(Formulation example 12)

TO.  Glycerin 50.0% 0.5% L-carnitine 2-hexyldecanoate hydrochloride  Tourmalina 5.0%  1.0% olive oil  PEG-12 28.0%  PEG-75 7.5% 1.0% polyglyceryl Laurate  0.49% ethanol Acrylic / alkyl (C10-30) -acrylate 0.11% acrylic copolymer  Methylparaben 0.11%  0.02% propylparaben Gingkgo Extract 0.02% 0.02% tea extract Horse chestnut extract 0,02% Brown seaweed extract 0,02%

B.  0.07% carboxyvinyl polymer  3.0% purified water

C. Sodium hydroxide 0.01% Purified water Up to the rest

The ingredients of A, B and C were mixed separately. A was heated to 60 ° C to provide a solution, and B and C were allowed to form solutions at room temperature. Then, while stirring A, B was added to A and the mixture gelled. Next, C was added to the gel and mixed under stirring, followed by cooling to room temperature, yielding a uniform gel (semi-transparent).

15 (Formulation example 13)

TO.  Decamethylcyclopentasiloxane 20.0%  3.0% potassium ascorbate L-carnitine 2-butyloctanoate hydrochloride 0.3%

B. Squalane 50.0% Light liquid isoparaffin Up to total dextrin palmitate 8.0%

C.

 Octyl Paramethoxycinnamate 1.0% Phenoxyethanol 0.5% A-Tocopherol 0.1%

The ingredients of A, B and C were weighed separately. The ingredients of A were kneaded at room temperature with a ball mill. The ingredients of B were heated, providing a uniform solution. The ingredients of C were allowed to form a solution at room temperature. Then while stirring

5 B, C was added to B. The mixture was homogenized and cooled to room temperature under stirring. Next, A was added and the mixture was sufficiently stirred to produce a uniform (semi-transparent) gel.

[Example 8]

10 Preparation of sera

Serums were prepared according to Formulation Examples 14 to 16. In Formulation Example 14, the total of components A to D was 100%. In Formulation Example 15, the total of components A and B was 100%. In Formulation Example 16, the total of components A to C was 100%.

(Formulation example 14)

TO.  0.4% xanthan gum  0.1% hydroxyethyl cellulose  0.1% carboxyvinyl polymer  1,3-Butylene Glycol 5.0% L-carnitine 2-hexyldecanoate hydrochloride 0.3%  50.0% purified water

B. Potassium hydroxide (1% aqueous solution) 2.5%  Purified water 10.0%

C. Caffeine 1.0% Purified water Up to total

D.  Methylparaben 0.1%  3.0% ethanol

The ingredients of A, B, C and D were mixed separately. A, B and D were allowed to form solutions to

20 room temperature and C was heated to 50 ° C, providing a solution. Then, while stirring A, B was added to A, forming a viscous liquid. Then, C and D were added to the above and mixed by stirring, yielding a uniform liquid (serum).

(Formulation example 15)

A. 1,3-Butylene Glycol 10.0% Glycerin 5.0% Sodium Hyaluronate 0.2% Xanthan Gum 0.2% Dipotassium Glycyrrhizinate 0.02% L-Carnitine 2-Methylpalmitate Hydrochloride 0.3% Purified Water Up the total

B. 3.0% ethanol  0.5% hydrogenated lecithin  Trioctanoin 0.3%  0.2% diphenyl dimethicone  Methylparaben 0.22%  Phenoxyethanol 0.08% Hydrogenated castor oil PEG-50 0.1% PEG-60 0.1% hydrogenated castor oil a-tocopherol 0.01%  Polyglyceryl myristate-10 0.05%

The ingredients of A and B were mixed separately and A and B were heated to 50 ° C, providing solutions. Then, while stirring A, B was mixed with A under stirring and the mixture was cooled under stirring,

producing a uniform liquid (serum).

(Formulation example 16)

A. Xanthan gum 0.4% Hydroxyethylcellulose 0.4% 1,3-Butylene Glycol 3.0% Glycerin 3.0% Methylparaben 0.1% Purified water Up to total

B. L-carnitine 2-butyloctanoate hydrochloride 0.3%  1,2-hexanediol 4.0%  50.0% purified water

C. 1.5% ascorbic acid-2-phosphate magnesium salt Sodium salt of ascorbic acid-2-phosphate 1.5%  0.5% sodium citrate  0.1% tetrasodium edetate  Purified water 9.4%

5 The ingredients of A, B and C were mixed separately. A and C were allowed to form solutions at room temperature and B was heated to 50 ° C to provide a solution. Then, while stirring A, B was added to A, forming a viscous liquid. Then, C was mixed under stirring, producing a uniform liquid (serum).

10 [Example 9]

Cream Preparation

Creams were prepared according to Formulation Examples 17 to 19, in which the total of components A and B was 100%.

(Formulation example 17)

TO. 4.2% hydrogenated rapeseed oil alcohol  Isononyl Isononanoate 6.0%  Squalane 9.6%  Octyldodecyl myristate 4.8% 2.0% Polyglyceryl Monostearate 1.0% glyceryl stearate  0.05% propylparaben  0.1% xanthan gum 0.5% a-tocopherol

B. 1,3-Butylene Glycol 4.8% Glycerin 4.8% L-Carnitine 2-Hexyldecanoate Hydrochloride 0.8% Ascorbic Acid-2-Phosphoric Acid 6-Palmitate Sodium Salt 0% Methyl Paraben 0 , 1% Purified water Up to total

The ingredients of A and B were mixed separately and A and B were heated to 85 ° C, providing solutions. Then, while stirring A, B was added to A, providing an emulsion. The emulsion was cooled under stirring. Upon reaching the temperature 40 ° C, stirring was stopped and the emulsion deaerated, producing a cream.

(Formulation example 18)

A cream was prepared according to Formulation Example 17, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-methylpalmitate hydrochloride.

(Formulation example 19)

A cream was prepared according to Formulation Example 17, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-butyloctanoate hydrochloride.

[Example 10]

Preparation of cosmetic foil packages

5 Cosmetic packages of the sheet type were prepared according to Formulation Examples 20 to 23, in which the total of components A and B was 100%.

(Formulation example 20)

A. Glycerin 30.0% Alumina-magnesium hydroxide 1.0%

B. Diisopropanolamine 1.0% Sodium polyacrylate 2.0% Acrylic acid / sodium acrylate copolymer (50/50 molar ratio) 2.0% L-carnitine 2-hexyldecanoate hydrochloride 0.3% Ascorbic acid magnesium salt -2-phosphate 3.0% Purified water Up to total

(Formulation example 21)

A. 1,3-Butylene Glycol 30.0% Coprecipitate of aluminum hydroxide gel / sodium hydrogen carbonate 0.05%

B. Sodium acrylate / acrylic acid copolymer (70/30 molar ratio) 1.0% Polyacrylic acid 1.0% N-vinyl acetamide / sodium acrylate copolymer (9/1 weight ratio) 3.0% Aluminum lactate 0 , 05% 10% aqueous solution of ammonium 0.01% L-carnitine 2-hexyldecanoate hydrochloride 2.0% Ascorbic acid-2-phosphate magnesium salt 0.01% Purified water Up to total

In the Formulation Examples, above, the ingredients of A and B were mixed separately. A dispersion was allowed to form at room temperature and B was heated to 50% to provide a solution. Then, B was cooled to room temperature under stirring and A was added gradually to B while kneading. The resulting sun was applied on a polypropylene support with a blade coater with 0.5 mm spaces. Next, a nonwoven fabric was attached to the sun and it was placed in an aluminum foil bag that

20 then heat sealed. After three days of aging, a cosmetic package of sheet type was obtained.

(Formulation example 22)

A cosmetic sheet-type package was prepared according to Formulation Example 20, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-methylpalmitate hydrochloride.

(Formulation example 23)

A sheet-type cosmetic package was prepared according to Formulation Example 20, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-butyloctanoate hydrochloride.

[Example 11]

35 Package preparation

Packages (detachable packages) were prepared according to Formulation Examples 24 to 26, in which the total of components A and B was 100%.

40 (Formulation example 24)

A. Polyvinyl alcohol 13.0% Carrageenan 0.5%

Purified water Up to total

B. 1,3-Butylene Glycol 3.0% Methyl Paraben 0.1% Ethanol 8.0% L-Carnitine 2-Hexyl Decanoate Hydrochloride 1.0%

The ingredients of A and B were mixed separately. Swelling of A was caused by heating at 50 ° C and B was allowed to form a solution at room temperature. Then, while stirring A, B was added gradually to A and mixed together. The mixture was cooled under stirring. After reaching the temperature

At approximately 30 ° C, stirring was stopped and the mixture was allowed to stand, producing a detachable package.

(Formulation example 25)

A detachable packet was prepared according to Formulation Example 24, except that L-carnitine 10 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-methylpalmitate hydrochloride.

(Formulation example 26)

A detachable package was prepared according to Formulation Example 24, except that L-carnitine hydrochloride of 15-2-hexyldecanoate was replaced by L-carnitine 2-butyloctanoate hydrochloride.

[Example 12]

Preparation of bathing agents

Bathing agents were prepared according to Formulation Examples 27 and 28, in which the total ingredients were 100%.

(Formulation example 27)

25 Polyoxyethylene Sorbitol Tetraoleate 14.0% Polyoxyethylene Oleyl Ether 3.0% Sorbitan Sesquioleate 3.0% Squalane 10.0% Jojoba Oil 20.0% Avocado Oil 5.0% Propyparaben 0.1% L-Carnitine 2-Hexyldecanoate Hydrochloride 1.0% Liquid Paraffin Up to total

(Formulation example 28)

Sodium hydrogen carbonate 35.5% Citric acid 37.1% Polyethylene glycol 2.1% Magnesium oxide 1.1% a-tocopherol 1.2% Sodium salt of ascorbic acid-2-phosphate 1.5% Ascorbic acid-2-glucoside 1.5% L-carnitine 2-methylpalmitate hydrochloride 0.5%

In the Formulation Examples, above, the ingredients were stirred at room temperature to uniformity, producing bathing agents.

[Example 13]

35 Preparation of facial cleansing agents

Facial cleansing agents were prepared according to Formulation Examples 29 to 31. In Formulation Examples 29 and 30, the total of components A to C was 100%. In Formulation Example 31, the total of components A and B was 100%.

(Formulation example 29)

TO.  Myristic acid 15.0%  5.0% palmitic acid  Stearic Acid 3.0%  Beeswax 3.0%  PEG-6000 2.0%  Ethylene Glycol Diestearate 2.0% Coconut Fatty Acid Diethanolamide 3.0%  15.0% concentrated glycerin 0.5% L-carnitine 2-hexyldecanoate hydrochloride

B.  5.5% potassium hydroxide  14.5% purified water

C. Sodium N-lauroylsarcosine 10.0% Purified water Up to total

The ingredients of A, B and C were mixed separately. A and B were heated to 80 ° C, providing solutions and

5, C was allowed to form a solution at room temperature. Then, while stirring A, B was gradually added to A and then C. The mixture was cooled under stirring. Upon reaching the temperature approximately 30 ° C, stirring was stopped and the solution was allowed to stand. In this way, a facial cleansing agent was obtained.

10 (Formulation example 30)

A facial cleansing agent was prepared according to Formulation Example 29, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-methylpalmitate hydrochloride.

15 (Formulation example 31)

TO.  2.0% lauric acid  Myristic acid 17.0%  4.0% palmitic acid  Stearic Acid 4.0% Coconut Fatty Acid Potassium Salt 8.0% Coconut Fatty Acid Diethanolamide 3.0%  Sodium N-cocoylmethyltaurine 10.0%  10.0% concentrated glycerin  1,3-Butylene Glycol 10.0% 1.0% L-carnitine 2-butyloctanoate hydrochloride

B. Potassium hydroxide 5.5% Tetrasodium edetate 0.2% Purified water Up to total

The ingredients of A and B were mixed separately. A was heated to 80 ° C to provide a solution and B was allowed to form a solution at room temperature. Then, while stirring A, it was gradually added

20 B to A. The mixture was cooled under stirring. After reaching the temperature approximately 30 ° C, stirring was stopped and the solution was allowed to stand. In this way a facial cleansing agent was obtained.

[Example 14]

25 Preparation of shampoos

Shampoos were prepared according to Formulation Examples 32 to 34, in which the total of the components was 100%.

30 (Formulation example 32)

Sodium lauryl ether sulfate (2) 30.0% Sodium lauryl ether sulfate (2) ammonium 20.0% Betaine lauryldimethylaminoacetate 6.0% O- [2-hydroxy-3- (trimethylammonium chloride) ) propyl] hydroxyethyl cellulose 0.25%

Coconut fatty acid diethanolamide 4.0% Ethylene Glycol Diestearate 2.0% 1,3-Butylene Glycol 3.0% 0.2% disodium edetate 1.0% L-carnitine 2-hexyldecanoate hydrochloride Purified water Up to total

The ingredients were mixed and heated at 80 ° C, followed by stirring, to provide an emulsion. The emulsion was cooled under stirring. Upon reaching the temperature approximately 30 ° C, stirring was stopped and the emulsion was allowed to stand. In this way a shampoo was obtained.

(Formulation example 33)

A shampoo was prepared according to Formulation Example 32, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-methylpalmitate hydrochloride.

(Formulation example 34)

A shampoo was prepared according to Formulation Example 32, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-butyloctanoate hydrochloride.

[Example 15]

Preparation of hair toners

Hair toners were prepared according to Formulation Examples 35 to 37, in which the total ingredients were 100%.

(Formulation example 35)

0.3% salicylic acid Menthol 0.2% 60.0% ethanol 5.0% glycerin 1.0% L-carnitine 2-hexyldecanoate hydrochloride Purified water Up to total

The ingredients were mixed and allowed to give rise to a solution at room temperature. Consequently, a hair toner was obtained.

(Formulation example 36)

A hair toner was prepared according to Formulation Example 35, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-methylpalmitate hydrochloride.

(Formulation example 37)

A hair toner was prepared according to Formulation Example 35, except that L-carnitine 2-hexyldecanoate hydrochloride was replaced by L-carnitine 2-butyloctanoate hydrochloride.

Claims (9)

1. External skin preparation comprising a carnitine derivative represented by the formula (1) and / or a carnitine derivative salt represented by the formula (2): wherein a combination of R1 and R2 is selected from methyl / isopropyl, methyl / n-hexyl, methyl / n-octyl, methyl / n-decyl, methyl / n-tetradecyl, methyl / n-hexadecyl, ethyl / isopropyl , ethyl / n-butyl, ethyl / n-pentyl, ethyl / n-hexyl, ethyl / n-octyl, ethyl / n-decyl, ethyl / n-tetradecyl, ethyl / n-hexadecyl, n-propyl / n- butyl, n-propyl / n-pentyl, n-propyl / nhexyl, n-butyl / n-hexyl, n-butyl / n-octyl and n-hexyl / n-octyl; Wherein R1 and R2 are as defined in formula (1), X - is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative, and Y + is an inorganic or organic cation that maintains electrical neutrality with an anionic part of the carnitine derivative. 2. External skin preparation according to claim 1, wherein X - in formula (2) is a selected anion Among the group consisting of hydroxide ion, nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, halide ion, format ion, acetate ion, citrate ion, tartrate ion, oxalate ion, fumarate ion, saturated fatty acid anion or unsaturated with 3 to 20 carbon atoms which may have a branching, carnitine anion, carnitine derivative anion, ascorbate anion, ascorbyl phosphate anion and ascorbyl phosphate derivative anion. 3. External skin preparation according to claim 1 or 2, wherein Y + in formula (2) is a cation selected from the group consisting of hydrogen ion, sodium ion, potassium ion, calcium ion, magnesium ion , zinc ion, ammonium ion, carnitine cation and carnitine derivative cation. 4. External skin preparation according to any one of claims 1 to 3, wherein the carnitine derivative 30 represented by the formula (1) and / or the carnitine derivative salt represented by the formula (2) represents 0.01 to 20% by mass of the external skin preparation. 5. Cosmetic comprising 0.01 to 20% by mass of the carnitine derivative and / or of the carnitine derivative salt described according to any one of claims 1 to 4. 35 6. Preparation according to claim 5 for the use in the treatment of obesity associated with an excess of lipids and a reduced lipid metabolism, the prevention of cellulite, seborrheic dermatitis and acne. 7. Carnitine derivative represented by formula (3) 40 or a carnitine derivative salt represented by the formula (4): 5 in which X - is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative, and Y + is an inorganic or organic cation that maintains electrical neutrality with an anionic part of the carnitine derivative. 8. The carnitine derivative salt according to claim 7, wherein X - in the formula (4) is an anion selected from the group consisting of hydroxide ion, nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, halide ion, format ion, acetate ion, citrate ion, tartrate ion, oxalate ion, fumarate ion, saturated or unsaturated fatty acid anion with 3 to 20 carbon atoms that may have a branching, carnitine anion, carnitine derivative anion, ascorbate anion, ascorbyl phosphate anion and ascorbyl phosphate derivative anion. 9. The carnitine derivative salt according to claim 7 or 8, wherein Y + in formula (4) is a cation selected from the group consisting of hydrogen ion, sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine cation and carnitine derivative cation. 20 10. Carnitine derivative represented by formula (5): or a carnitine derivative salt represented by the formula (6): wherein X - is an inorganic or organic anion that maintains electrical neutrality with a cationic part of the carnitine derivative, and Y + is an inorganic or organic cation that maintains electrical neutrality with an anionic part of the carnitine derivative. 11. The carnitine derivative salt according to claim 10, wherein X - in the formula (6) is an anion selected from the group consisting of hydroxide ion, nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, ion halide, format ion, acetate ion, citrate ion, tartrate ion, oxalate ion, fumarate ion, saturated fatty acid anion or 35 unsaturated with 3 to 20 carbon atoms which may have a branching, carnitine anion, carnitine derivative anion, ascorbate anion, ascorbyl phosphate anion and ascorbyl phosphate derivative anion. 12. Carnitine derivative salt according to claim 10 or 11, wherein Y + in formula (6) is a cation selected from the group consisting of hydrogen ion, sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine cation and carnitine derivative cation.