ES2428010T3 - Pharmaceutical composition containing microcolloidal silver and carboxymethyl-beta-glucan for the disinfection of nasal mucous membranes - Google Patents
Pharmaceutical composition containing microcolloidal silver and carboxymethyl-beta-glucan for the disinfection of nasal mucous membranes Download PDFInfo
- Publication number
- ES2428010T3 ES2428010T3 ES10711743T ES10711743T ES2428010T3 ES 2428010 T3 ES2428010 T3 ES 2428010T3 ES 10711743 T ES10711743 T ES 10711743T ES 10711743 T ES10711743 T ES 10711743T ES 2428010 T3 ES2428010 T3 ES 2428010T3
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical composition
- composition according
- silver
- disinfection
- glucan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
Composición farmacéutica para la desinfección de las mucosas nasales, caracterizada porque contiene plata micronizada coloidal con carboximetil-ß-glucano, y al menos un conservante, y posiblemente al menos un aromatizante natural.Pharmaceutical composition for the disinfection of nasal mucous membranes, characterized in that it contains micronized colloidal silver with carboxymethyl-β-glucan, and at least one preservative, and possibly at least one natural flavoring.
Description
DESCRIPCION� Composición farmacéutica que contiene plata microcoloidal y carboximetil--glucano para la desinfección de las DESCRIPTION� Pharmaceutical composition containing microcolloidal silver and carboxymethyl - glucan for the disinfection of
mucosas nasales. nasal mucous membranes
La presente invención se refiere a una composición farmacéutica que contiene una cantidad adecuada de plata microcoloidal y de carboximetil--glucano para su uso en la desinfección de las mucosas nasales, según la reivindicación 1. The present invention relates to a pharmaceutical composition containing a suitable amount of microcolloidal silver and carboxymethyl glucan for use in the disinfection of nasal mucous membranes according to claim 1.
Las propiedades terapéuticas de la plata ya eran conocidas en la antigua Grecia: es un hecho conocido que las infecciones eran menos frecuentes en familias que utilizaban cubiertos de plata para comer. The therapeutic properties of silver were already known in ancient Greece: it is a known fact that infections were less frequent in families who used silverware to eat.
La plata presenta importantes propiedades antimicrobianas, ya que la presencia de una parte en 100 millones de plata elemental en solución es suficiente para obtener una eficaz acción antimicrobiana. Se conoce que los iones o radicales libres de la plata son un principio activo antimicrobiano. Silver has important antimicrobial properties, since the presence of one part in 100 million elemental silver in solution is sufficient to obtain an effective antimicrobial action. It is known that ions or free radicals of silver are an active antimicrobial principle.
Para conseguir que la plata sea hidrosoluble, es preciso utilizar su forma coloidal (una suspensión en agua de partículas de plata extremadamente finas), que se obtuvo por primera vez en 1920, mediante un proceso de hidrólisis en el que se utilizan dos electrodos de plata pura, sumergidos en agua desmineralizada o destilada, a los que se aplica una diferencia de potencial. To make the water soluble, it is necessary to use its colloidal form (a suspension in water of extremely fine silver particles), which was first obtained in 1920, through a hydrolysis process in which two silver electrodes are used pure, submerged in demineralized or distilled water, to which a potential difference is applied.
Antes del descubrimiento de los antibióticos en 1938, la plata coloidal obtenida de este modo (cuya denominación más apropiada debería ser plata iónica-coloidal), se recetaba en abundancia para una gran variedad de enfermedades e infecciones: de hecho, se había demostrado su eficacia frente a más de 650 patógenos diferentes. Before the discovery of antibiotics in 1938, colloidal silver obtained in this way (whose most appropriate denomination should be ionic-colloidal silver), was prescribed in abundance for a wide variety of diseases and infections: in fact, its efficacy had been demonstrated against more than 650 different pathogens.
De hecho, la plata coloidal permite una mejora en la función del sistema inmunitario ya que actúa como catalizador, desactivando las enzimas concretas necesarias para el metabolismo de diversas especies bacterianas, fúngicas y víricas. In fact, colloidal silver allows an improvement in the function of the immune system as it acts as a catalyst, deactivating the specific enzymes necessary for the metabolism of various bacterial, fungal and viral species.
La concentración ideal de plata coloidal es de entre 5 y 20 ppm, ya que una concentración superior podría provocar que las partículas en suspensión se volvieran a unir, aunque fueran del tamaño óptimo de 0,05 μm, provocando así una menor capacidad de absorción celular por parte del organismo. The ideal concentration of colloidal silver is between 5 and 20 ppm, since a higher concentration could cause the suspended particles to rejoin, even if they were of the optimum size of 0.05 μm, thus causing a lower cell absorption capacity by the body.
El interés en la plata se detuvo con el descubrimiento de los antibióticos, pero a partir de los años setenta del siglo XX se volvió a considerar su uso, sobretodo como antiséptico en el tratamiento de quemaduras. The interest in silver stopped with the discovery of antibiotics, but from the seventies of the twentieth century its use was considered again, especially as an antiseptic in the treatment of burns.
Dicho éxito es debido al hecho de que es un antiséptico seguro; de hecho, cuando la plata se utiliza en forma coloidal, los tejidos la absorben muy lentamente para no provocar efectos tóxicos. Por tanto, se puede ingerir por vía oral, y llegar a formar parte de aquellas preparaciones que tanto adultos como niños pueden ingerir a diario sin riesgo de sufrir ningún tipo de intolerancia, aunque se trate de un uso prolongado. Such success is due to the fact that it is a safe antiseptic; in fact, when silver is used colloidally, the tissues absorb it very slowly so as not to cause toxic effects. Therefore, it can be taken orally, and become part of those preparations that both adults and children can ingest daily without risk of suffering any type of intolerance, even if it is a prolonged use.
La plata coloidal se utiliza principalmente como antiséptico en dermatología para el tratamiento de ciertos tipos de lesión. Se conoce asimismo su aplicación como agente potabilizador de agua y como conservante en la industria de la cosmética, pero, debido a su elevado coste de producción, su uso es muy limitado. Colloidal silver is mainly used as an antiseptic in dermatology for the treatment of certain types of lesions. Its application is also known as a water purification agent and as a preservative in the cosmetics industry, but, due to its high production cost, its use is very limited.
En el campo de la otorrinolaringología, el conocido efecto antimicrobiano de la plata se ha utilizado extensamente para producir diversas composiciones farmacéuticas. In the field of otolaryngology, the known antimicrobial effect of silver has been widely used to produce various pharmaceutical compositions.
La solicitud de patente US nº. 2008/0020060 revela composiciones farmacéuticas que comprenden una suspensión coloidal de nanopartículas de plata elemental para su administración en forma de espray en las mucosas nasales de un paciente para controlar y tratar la rinitis. US Patent Application No. 2008/0020060 discloses pharmaceutical compositions comprising a colloidal suspension of elemental silver nanoparticles for administration as a spray in the nasal mucous membranes of a patient to control and treat rhinitis.
La patente US nº. 6.454.754 describe unos medios y un protocolo para tratar la infección de las vías respiratorias del paciente. El dispositivo objetivo de la presente invención es un nebulizador o unos medios de espray para producir una nebulización de gotículas de un tamaño apropiado, de un fluido que comprende un coloide de plata pura. Según los inventores, dicha administración de coloide de plata iónica permite un tratamiento más eficaz de una infección con una cantidad de agente antimicrobiano 10.000 veces inferior a la de las técnicas recetadas habitualmente. El uso de una composición terapéutica con base de plata, con aplicación en el campo de la medicina, para prevenir, tratar o reducir la velocidad de propagación o transmisión de bacterias, infecciones y similares, es el objeto de la solicitud de patente US nº. 2006/122082 para producir una espuma líquida o formulaciones en espray y/o gel. US Patent No. 6,454,754 describes a means and a protocol for treating the patient's respiratory tract infection. The objective device of the present invention is a nebulizer or spray means for producing a nebulization of droplets of an appropriate size, of a fluid comprising a pure silver colloid. According to the inventors, said administration of ionic silver colloid allows a more effective treatment of an infection with an amount of antimicrobial agent 10,000 times lower than that of commonly prescribed techniques. The use of a therapeutic composition based on silver, with application in the field of medicine, to prevent, treat or reduce the rate of spread or transmission of bacteria, infections and the like, is the subject of US Patent Application No. 2006/122082 to produce a liquid foam or spray and / or gel formulations.
Llegados a este punto es necesario diferenciar entre la plata metálica y la plata en forma de sales. At this point it is necessary to differentiate between metallic silver and silver in the form of salts.
Estas últimas poseen una acción terapéutica pero se caracterizan por una elevada toxicidad; de hecho, los tejidos las absorben con facilidad, lo que puede causar irritación. Además, pueden provocar el fenómeno de la acumulación, con la aparición de un color azulado en la piel, un proceso patológico conocido como quot;argiriaquot;. The latter have a therapeutic action but are characterized by high toxicity; In fact, tissues absorb them easily, which can cause irritation. In addition, they can cause the phenomenon of accumulation, with the appearance of a bluish color in the skin, a pathological process known as `` argiriaquot ;.
Claims (7)
- ComponentesComponents
- Cantidad Quantity
- Plata microcoloidal Carboximetil--glucano Sorbato potásico Imidazolidina urea Aromatizante natural Agua purificada Microcolloidal silver Carboxymethyl - glucan Potassium sorbate Imidazolidine urea Natural flavoring Purified water
- 50 ppm 1 g 1 g 1 g 1 g Hasta alcanzar 1000 g 50 ppm 1 g 1 g 1 g 1 g Up to 1000 g
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM2009A000077A IT1393272B1 (en) | 2009-02-20 | 2009-02-20 | PHARMACEUTICAL COMPOSITION CONTAINING MICROCOLLOIDAL SILVER AND CARBOSSIMETHYLBETHAGLAN FOR DISINFECTION OF NASAL MUCOSA AND ITS PREPARATION PROCEDURE |
| ITRM20090077 | 2009-02-20 | ||
| PCT/IT2010/000064 WO2010095158A1 (en) | 2009-02-20 | 2010-02-19 | Pharmaceutical composition containing microcolloidal silver and carboxymethyl beta glucan for disinfection of the nasal mucosae, and process for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2428010T3 true ES2428010T3 (en) | 2013-11-05 |
Family
ID=41257118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10711743T Active ES2428010T3 (en) | 2009-02-20 | 2010-02-19 | Pharmaceutical composition containing microcolloidal silver and carboxymethyl-beta-glucan for the disinfection of nasal mucous membranes |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2398458B8 (en) |
| ES (1) | ES2428010T3 (en) |
| IT (1) | IT1393272B1 (en) |
| WO (1) | WO2010095158A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA118192C2 (en) | 2015-10-22 | 2018-12-10 | Юрій Захарович Толчеєв | ANTI-VIRUS PHARMACEUTICAL COMPOSITION |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500165B1 (en) * | 1998-10-29 | 2002-12-31 | Steven R. Frank | Active antisepsis device |
| US20060122082A1 (en) * | 2000-02-17 | 2006-06-08 | Leonard Paul | Foam/spray producing compositions and dispensing system therefor |
| US20080020060A1 (en) * | 2006-07-21 | 2008-01-24 | Williamson Robert R | Process for treating rhinitis |
-
2009
- 2009-02-20 IT ITRM2009A000077A patent/IT1393272B1/en active
-
2010
- 2010-02-19 WO PCT/IT2010/000064 patent/WO2010095158A1/en active Application Filing
- 2010-02-19 EP EP10711743.4A patent/EP2398458B8/en active Active
- 2010-02-19 ES ES10711743T patent/ES2428010T3/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2398458B1 (en) | 2013-07-17 |
| ITRM20090077A1 (en) | 2010-08-21 |
| IT1393272B1 (en) | 2012-04-12 |
| EP2398458B8 (en) | 2013-10-30 |
| WO2010095158A8 (en) | 2010-12-23 |
| WO2010095158A1 (en) | 2010-08-26 |
| EP2398458A1 (en) | 2011-12-28 |
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