ES2420629T3 - Procedimiento para la preparación de l-3,4-dihidroxi-6-[18f]fluoro-fenilalanina y de 2-[18f]fluoro-l-tirosina y de sus derivados metilados en posición alfa a partir de un compuesto precursor - Google Patents

Procedimiento para la preparación de l-3,4-dihidroxi-6-[18f]fluoro-fenilalanina y de 2-[18f]fluoro-l-tirosina y de sus derivados metilados en posición alfa a partir de un compuesto precursor Download PDF

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Publication number
ES2420629T3
ES2420629T3 ES11001114T ES11001114T ES2420629T3 ES 2420629 T3 ES2420629 T3 ES 2420629T3 ES 11001114 T ES11001114 T ES 11001114T ES 11001114 T ES11001114 T ES 11001114T ES 2420629 T3 ES2420629 T3 ES 2420629T3
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Spain
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preparation
fluoro
formula
compound according
mmol
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ES11001114T
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English (en)
Spanish (es)
Inventor
Franziska Wagner
Johannes Ermert
Heinrich Hubert Coenen
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Forschungszentrum Jülich
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Forschungszentrum Jülich
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
ES11001114T 2007-12-07 2008-11-21 Procedimiento para la preparación de l-3,4-dihidroxi-6-[18f]fluoro-fenilalanina y de 2-[18f]fluoro-l-tirosina y de sus derivados metilados en posición alfa a partir de un compuesto precursor Active ES2420629T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007059313A DE102007059313A1 (de) 2007-12-07 2007-12-07 Verfahren zur Herstellung von Vorläufern für L-3,4-Dihydroxy-6-[18F]fluor-phenylalanin und 2-[18F]Fluor-L-tyrosin und deren α-methylierten Derivaten, Vorläufer, sowie Verfahren zur Herstellung von L-3,4-Dihydroxy-6-[18F]fluor-phenylalanin und 2-[18F]Fluor-L-tyrosin und deren α-methylierten Derivaten aus dem Vorläufer
DE102007059313 2007-12-07

Publications (1)

Publication Number Publication Date
ES2420629T3 true ES2420629T3 (es) 2013-08-26

Family

ID=40679782

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11001114T Active ES2420629T3 (es) 2007-12-07 2008-11-21 Procedimiento para la preparación de l-3,4-dihidroxi-6-[18f]fluoro-fenilalanina y de 2-[18f]fluoro-l-tirosina y de sus derivados metilados en posición alfa a partir de un compuesto precursor

Country Status (9)

Country Link
US (2) US20100261913A1 (enExample)
EP (2) EP2336114B1 (enExample)
JP (1) JP5680418B2 (enExample)
CN (1) CN101889002A (enExample)
AT (1) ATE519745T1 (enExample)
DE (1) DE102007059313A1 (enExample)
DK (2) DK2336114T3 (enExample)
ES (1) ES2420629T3 (enExample)
WO (1) WO2009071049A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2821383B1 (en) * 2013-07-02 2017-08-30 Trasis S.A. Stabilization of radiosynthetic intermediates
JPWO2015152128A1 (ja) * 2014-03-31 2017-04-13 長瀬産業株式会社 アミノ酸前駆体、アミノ酸およびその製造方法、ならびに該アミノ酸を用いたｐｅｔ診断用トレーサー

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886814A (en) * 1986-03-13 1989-12-12 Dr. Karl Thomas Gmbh Substituted thiazoles and oxazoles and 2-hydroxy-morpholines
DE3901550A1 (de) * 1989-01-20 1990-07-26 Basf Ag Neue tetrahydroindazole mit phenyletherstruktur
DE10346228B4 (de) * 2003-09-25 2009-04-09 Eberhard-Karls-Universität Tübingen Universitätsklinikum Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren

Also Published As

Publication number Publication date
US20130060063A1 (en) 2013-03-07
DK2336114T3 (da) 2013-07-29
DK2220049T3 (da) 2011-10-24
WO2009071049A3 (de) 2009-09-17
ATE519745T1 (de) 2011-08-15
JP5680418B2 (ja) 2015-03-04
EP2220049A2 (de) 2010-08-25
EP2220049B1 (de) 2011-08-10
US20100261913A1 (en) 2010-10-14
EP2336114A1 (de) 2011-06-22
WO2009071049A2 (de) 2009-06-11
CN101889002A (zh) 2010-11-17
EP2336114B1 (de) 2013-04-17
DE102007059313A1 (de) 2009-06-18
JP2011505392A (ja) 2011-02-24

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