ES2392283B1 - COSMETIC COMPOSITION FOR THE CARE OF IMPROVED COUPEROSIS. - Google Patents

Abstract

The present invention relates to a series of improvements introduced in the object of the Spanish Invention Patent with application number P200900368, consisting of the addition of an added dermocosmetic indication of the topical administration dermocosmetic composition of the application P200900368 comprising Stearyl glycerretinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter, for the care and repair of couperose and facial telangiectasias and the method of administration thereof.

Description

OBJECT OF THE INVENTION

The present invention relates to a series of improvements introduced in the object of the Spanish Invention Patent with application number P200900368, consisting of the addition of an added dermocosmetic indication of the topical administration dermocosmetic composition of the application P200900368 comprising glycerretinate of stearyl, tocopheryl nicotinate, talc, titanium dioxide and shea butter.

Spanish invention with solkitude number P200900368 also refers to a process for the preparation of the dermocosmetic composition comprising the following steps: a) preparing an aqueous phase from stained water; b) prepare an alcoholic phase from ethanol; e) prepare an oily phase from vaseHna filante and stearyl glycyrrheinate and shea butter and heat up to 80 'C (± 2' C); d) Heat the aqueous phase of stage a) to 80 'C (± 2' C) and mix with the oil phase of stage e); e) keep stirring the mixture obtained from step d) until it reaches a temperature of 50 oC; f) add tocopheryl nicotinate with continuous stirring until it reaches a temperature of 45 oC; g) add the alcoholic phase to the mixture of step f) with constant stirring until obtaining a white primary emulsion, and h) add the rest of insoluble compounds (talc and titanium dioxide) after homogenization and pass through a sieve of 0.600 mm light of maUa as well as the use of said cosmetic composition for the preparation of a composition for the care and repair of telangiectasias.

The improvements of the present invention specifically affect certain aspects related to a new use of said composition for the preparation of a cosmetic cosmetic composition for the care and repair of facial telangiectasias or facial vascular spiders and couperose.

BACKGROUND OF THE INVENTION

As noted in the previous paragraph, the composition object of the Spanish Invention Patent with application number P200900368 has been developed with the

in order to provide a composition that solves the inconveniences of the state of the art, by the topical administration of said composition for the care and repair of telangiectasias thanks to the fact that it comprises stearyl glycerinate. tocopheryl nicotinate, talc, titanium dioxide and shea butter.

This composition fulfilling the basic function for which it has been planned, fully presents some limitations, which are summarized in general form in that it not only works for the care and repair of telangiectasias but also works for the care and repair of facial telangiectasias or facial spider veins and couperose.

Cuperosis is an alteration in the form of dilation of the superficial capillaries of the skin of the face, mainly in the central area (cheeks, nose), whose origin is multifactorial. Among the causes that cause this disorder include a genetic predisposition, prior involvement with acne and / or rosacea, whose outbreaks subsequently lead to the presence of permanent superficial capillary dilations, as well as hormonal and environmental changes.

It is therefore an alteration that entails permanent reddening of the face, which is worsened by vasodiJatación with the sudden changes in ambient temperature (heat-cold, closed premises, etc.) leading to concern, insecurity and decreased self-esteem of people who they suffer from it (Balkrishnan R, McMichael Aj. Hu iY et al. Correlates of health-related quality oflije in \ Vomen \ Vith seFerefacial blemishes. Int Soc Dermatol. 200 <5; 45: 111-115).

Exact incidence figures are not available because there is no uniform definition of the clinical picture presenting this type of condition. The difficulty lies in defining the point at which a patient with pink cheeks presents a dermatological problem, rosacea type. However, a Swedish study published an incidence of 10%, which is a reasonable percentage to take into account the repair and care of such patients (Berg M, Liden S. An epidemiological study of rosacea. Acta Dennatovenerol. 1989 ; 69: 419-23).

Currently, there are different treatments to alleviate or eliminate these alterations, which can be summarized as follows:

Cosmetic treatments: These are topical products such as creams, tonics and makeup, aimed at alleviating] a burning sensation and redness that is usually linked to couperose, and that cover, camouflaging venous dilations. These cosmetic products are not included in the European Pharmacopoeia, and due to their cost-benefit balance, only a small part of the

population is willing to use them.

Surgical treatments: There are several procedures that are useful for removing capillaries that constitute couperose and facial telangiectasias. Until a few years ago, eleclrocoagulation of the facial veins was used, one at a time, which involved pain and often residual scars. The laserllPL (Pulsed Intense Light Laser) technology is now used successfully for the

Treatment of couperose. Both pulsed dye lasers and Neodymium:

Yag (usually 1064 nm laser) and intense pulsed light (lPL) get,

acting gradually on the venous pathways its gradual decrease and

elimination. They are techniques that do not require anesthesia or analgesic medication, but

5

Several sessions are necessary, and the cost is high. They are cutting edge technologies,

that need to be performed by an expert doctor, and still there is a risk of

residual hypo-hyperpigmented lesions, therefore, although it is the current treatment of

choice to treat couperose and spider veins, its cost Limits its usefulness to

a small portion of patients.

the

Ex: therefore, the need to find a non-invasive, safe alternative,

Effective, fast and efficient for the cosmetic care of cupeTOsis and spiders

vascular facials or facial telangiectasias that leads to a real decrease in

facial redness, which facilitates patient comfort and comfortable administration

fifteen

of it, without assuming a health risk because it is a product

corrective and topical administration repairman on the pi el.

Thus the present invention of addition on the application P200900368

solves the drawbacks of the state of the art when referring to a composition

twenty

topical administration dennocosmetics located on the cupeTOsis or the

facial telangiectasias or facial vascular spider veins (not in vasiva) that allows the

patient controlled administration of the mi sma without the security issues and

toxicity posed by surgical treatments as well as treatments

Cosmetics known in the state of the art.

25

DESCRIPTION OF THE INVENTION

At present, the problems of couperose and spider veins are frequent.

5

Facials or facial telangiectasias, with the consequent inconvenience that this entails for the affected patients, in their physical state, in addition to the Hmitations that it gives rise to, in many cases restricting the activity, with impediment even for the development of certain work functions , sport, etc. For the purpose of the present invention, the terms are understood interchangeably as "facial telangiectasias" or "facial spider veins".

I O

In this sense, to alleviate, as far as possible, these discomforts and harmful consequences of facial couperose and telangiectasias, it is mainly due to the unsightly effect, in accordance with the object of the present invention, a topical cream with a dermocosmetic action is proposed, which is very advantageous. to lessen the aforementioned effects as well as the unsightly problems produced by the cuperosis and facial telangiectasias or facial vascular spiders.

15 20

The improvements that the invention proposes solve in a fully satisfactory manner the aforementioned problem, in all the aforementioned aspects, referring to the use of the dermocosmetic or dephylopharmaceutical composition of the patent application P200900368 topically for the treatment of couperosis and telangiectasias. facial

Thus, for the purpose of the present invention, the improvements introduced consist of:

25

the use of the dermocosmetic composition of the application P200900368 for the preparation of a dermocosmetic composition for the care and repair of couperose and facial telangiectasias.

the use of the dermocosmetic composition of the application P200900368 for the preparation of a dermocosmetic composition of topical application in cream and / or emulsion form.

the use of the dermocosmetic composition of the application P200900368 for the preparation of a dephylocoosmetic composition to make up and disguise cuperosis and facial telangiectasias.

the use of the dermocosmetic composition of application P200900368 for the preparation of a dermocosmetic composition for topical application by means of an application device selected from the group consisting of: a brush, a spatula, a cotton pad, gauze and a swab, sponge, tube with applicator .

Therefore, the essential technical effect of the improved invention is to provide a new dermocosmetic or dermopharmaceutical indication of the dermocosmetic composition.

or dermopharmaceutical claimed in patent application P200900368.

This composition also lacks conicoids, which also makes it possible for its continued use without causing side effects, such as atrophy of the skin and the appearance of stretch marks and fissures.

The present invention relates to the use of the dermocosmetic comJX) patent application P200900368 in the form of a cream comprising a cosmetically effective amount of g stearyl licirretinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter for the preparation of a comJX) dennocosmetic position for the care and repair of couperose and facial vascular spiders or facial telangiectasias.

The present invention also protects the method of application on the facial skin of said composition comprising the steps of taking a sample of the dermocosmetic composition with an application device and applying it locally on the couperose and facial vascular spider 6 facial telangiectasia and optionally apply heat on said couperose or telangiectasia.

In relation to the method of obtaining the cream object of the present invention, this is as detailed in the patent application P200900368:

5 10

PHASE (A) WATER: In a beaker, weigh the distilled water, with the help of a magnetic stirrer add the maltitol and stir with magnetic stirring until completely di solution. Add NIKKOSOME OS (squalene + glycerin + hydrogenated lecithin), and optionally hydrogenated silk and stir until completely dispersed. Cover and store until used. PHASE (B) HOLIC ALCO: In a beaker weigh 96 ° ethanol, weigh propylene glycol, diethylene glycol monoethyl ether add and stir on a magnetic stirrer until dissolved. Weigh the rest of the components (preserved and silicone) and add one by one until its total solution. Keep covered until use.

twenty

PHASE (C) INSOLUBLE PHASE: Weigh each of the components (dye, talc and titanium dioxide) and transfer them to a mortar. Mix homogeneously and pass the mixture through a 0.600 mm light mesh screen. Return the mixture to the mortar, homogenize and keep covered until it is used.

25

PHASE (D) or tocopheryl cotinate: Weigh in a tocopheryl nicotinate watch glass. Preserve from light and air. Save until use.

PHASE (O) OLEOSE: Weigh petroleum jelly in a 250-ml beaker and melt in a bath Weigh the other components of this phase one by one (liquid paraffin,

pentamer cyclomethicone, gJjirretinato esteariJo, tribehenin, propiJenglycol dicaprilat, cholesterol esters and lanoesterol, serbitan laurate and shea butter) and add to the glass containing vaseHna filan te. Heat up to 80 oC (± 2 OC) until the total melting of all components. Keep the molten mixture at 80 oC (± 2 oC).

The beneficial properties of this cream are due to the selection and proportion of each of the components of the cream.

For example, glycyretinic acid is a complex triterpene that is used locally in preparations for the treatment of non-infectious inflammatory disorders of the skin, it is also a potent inhibitor of the II-b-hydroxysteroid dehydrogenase enzyme that inactivates corusol. In fact it has been shown that the concomitant application of gLicirretinic acid together with hydroconisone enhances the activity of the latter in the skin. Another property of glycyrrhizinic acid is that it can be esterified with steanolic alcohol, which favors its absorption through the skin, acting as stearic alcohol as a vehicle, conferring an emollient, moisturizing and surfactant action.

Stearyl glycyrrheinate, a derivative of glycyrrhizinic acid is involved in skin whitening, therefore being used in sunscreen preparations because it has an inhibitory effect of melanogenesis. In this sense for the present invention, stearyl glycyrrheinate has been selected as an active compound because it increases the solubility of lipids and has anti-laminar properties at low concentrations.

Tocopheryl nicotinate is a substance with lipid-lowering and vasodilating properties, which is why it is commonly used in the treatment of hyperlipidemias, in peripheral vasculopathies (atherosclerotic or occlusive vasculopathy, as well as venous disorders resulting from atherosclerosis, a vasospasm or a

thromboembolism) as well as vascular brain diseases.

For the purpose of the present invention, tocopheric nicotinate favors oxygenation of the hair bulb and cutaneous rhinocirculation, it also has an antioxidant and conditioning function of the skin, not being an irritating or sensitizing compound.

The purified talc, used topically, relieves irritation and prevents chafing. It is usually mixed with starch and zinc oxide, to increase moisture absorption. The purified talc is also used as a lubricant and diluent excipient in the manufacture of tablets and capsules, and for bleaching liquids. Talc is also used as a sclerosant in malignant effusions and in recurrent spontaneous pneumothorax.

For the cosmetic field, sizing is used to facilitate application and dispersion as well as offers slip and adhesion properties. Its coverage power and moisture absorption capacity are relatively low. Therefore, it is frequently combined with other products such as kaolin and zinc oxide.

Titanium dioxide is one of the whitest chemical substances that exist: It reflects practically all the visible radiation that comes to it and keeps the color permanently. It is one of the substances with the highest refractive index, even pulverized or mixed with other substances. And for the same reason, it is very opaque and that is why it serves to protect from sunlight. Titanium dioxide pigments are also used in cosmetics as ultraviolet absorbers in cosmetic products.

Titanium dioxide also {X) see the advantages of being harmless, of being compatible with mucous membranes and skin and having good dispersibility in organic solutions. Why in

The field of cosmetic titanium dioxide is commonly used as ingredient. In addition JX titanium dioxide> see an action on the skin similar to the of zinc oxide and is used together with titanium peroxide and titanium salicylate in the treatment of diaper rash. It has been demonstrated in the topical use of titanium dioxide that is not absorbed, it is that is, the titanium dioxide pigments when analyzed were only found in the stratum corneum of the skin.

Shea butter, has a protective action against dry skin, being moisturizing for both skin and hair. It also has an action protective against solar erythema, prevents and treats skin aging, It stimulates the metabolism of cells and prevents wrinkles.

Shea butter also has a wound healing action, suitable for squamous dermis treatment, for dry and cracked hands, for treatment of ulcers, eczema and stretch marks on the skin.

CREAM FORMATION: In a suitable container, melt phase (O) and in the same bath, heat the phase (A) up to 80 'C (± 2' C).

With phases (O) and (A) at the same temperature, manually shake phase (O) and add slowly and stirring phase (A). While stirring, stir the mixture of the bathroon.

When the mixture reaches 50 oC and while stirring, add phase (D) (njcotinate of tocopheryl), until fully incorporated.

Then, while stirring, add phase (B), until fully incorporated. In

This point should obtain a well-emulsified white fluid cream base.

Pass the base obtained to the mortar where phase (C) is and work with the mortar hand until obtaining a cream with a homogeneous texture and color. Pass the obtained cream 5 to a container and cover well.

AND IEMPI 05 OF REA liZA a6N

The following specific examples provided here serve to illustrate the

10 nature of the present invention. These examples are included for illustrative purposes only and should not be construed as limitations on the invention claimed herein.

A homogeneous flesh-colored cream is obtained. After 24 hours of preparation

15 increases the consistency of the cream until a paste is obtained that applied on top of the skin forms a consistent and well-bonded layer, waterproof (slips when it falls from the tap on the skin) but easily removable by rubbing with water and shower gel.

20 The cream obtained is suitable for topical application, presenting good organoleptic, covering, bioadhesive and water resistance characteristics.

According to an important aspect the present invention relates to a composition

Topical dermocosmetic administration for couperose and facial telangiectasias comprising stearyl glycyretin, tocopheryl nicotinate, talc, titanium dioxide and shea butter.

Claims (6)

1.-Improvement introduced in the Spanish Invention Patent with application number P200900368 for "cosmetic composition for the care and repair of telangiectasias" characterized in that it is additionally used for the preparation of a dermocosmetic composition for the care and repair of couperosis and telangiectasias facial 2. Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim 1 characterized in that it is used for the preparation of a dermocosmetic composition of topical application in the form of cream and / or emulsion. 3.-Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim 1, characterized in that it is used for the preparation of a topical derno-cosmetic composition in the form of cream and / or emulsion. 4.-Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim 1 characterized in that it is used for the preparation of a dermocosmetic composition for machining and concealing the couperose and facial telangiectasias. 5.-Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim I characterized in that it is used for the preparation of a dermocosmetic composition of topical application by means of an application device selected from the group consisting of: a brush, a spatula, cotton, gauze and a swab, sponge, tube with applicator. 6.-Improvement introduced in the Spanish Invention Patent with application number P200900368 JXlf "cosmetic composition for the care and repair of telangiectasias" characterized in that the method of administration of the  composition comprises the steps of taking a sample of the composition dermocosmetics with the application device, apply locally on the couperose, facial vascular spider or facial telangiectasia and optionally apply heat on said couperose or telangiectasia.