ES2392283A1 - Cosmetic composition for couperosis care - Google Patents

Abstract

The present invention relates to the use of a cosmetic composition in the form of a cream, which comprises a cosmetically effective amount of stearyl glycyrrhetinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter, for the preparation of a cosmetic composition for the care and treatment of couperosis, and to the method for the administration thereof.

Description

OBJECT OF THE INVENTION

The present invention relates to a series of improvements introduced in the object of the Spanish Invention Patent with application number P200900368, consisting of the addition of an added dermocosmetic indication of the topical administration dermocosmetic composition of the application P200900368 comprising glycerretinate of stearyl, tocopheryl nicotinate, talc, titanium dioxide and shea butter.

Spanish invention with application number P200900368 also refers to a process for the preparation of the dermocosmetic composition comprising the following steps: a) preparing an aqueous phase from distilled water; b) prepare an alcoholic phase from ethanol; c) prepare an oil phase from petroleum jelly and stearyl glycyrrheinate and shea butter and heat to 80 oC (± 2 OC); d) Heat the aqueous phase of stage a) to 80 oC (± 2 OC) and mix with the oil phase of stage c); e) keep stirring the mixture obtained from step d) until it reaches a temperature of 50 oC; f) add tocopheryl nicotinate with continuous stirring until it reaches a temperature of 45 oC; g) add the alcoholic phase to the mixture of step f) with constant stirring until obtaining a white primary emulsion, and h) add the rest of insoluble compounds (talc and titanium dioxide) after homogenization and pass through a sieve of 0.600 mm light mesh as well as the use of said cosmetic composition for the preparation of a composition for the care and repair of telangiectasias.

The improvements of the present invention specifically affect certain aspects related to a new use of said composition for the preparation of a dermocosmetic composition for the care and repair of facial telangiectasias or facial vascular spiders and couperose.

BACKGROUND OF THE INVENTION

As noted in the previous paragraph, the composition object of the Spanish Invention Patent with application number P200900368 has been developed in order to provide a composition that solves the inconveniences of the state of the art, by the topical administration of said Composition for the care and repair of telangiectasias thanks to the fact that it comprises stearyl glycerretinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter.

This composition fulfilling in a fully satisfactory way the basic function for which it has been foreseen, presents in practice some limitations, which are summarized in general in that it not only works for the care and repair of telangiectasias but also works for care. and repair of facial telangiectasias or facial spider veins and couperose.

Cuperosis is an alteration in the form of dilation of the superficial capillaries of the skin of the face, mainly in the central area (cheeks, nose), whose origin is multifactorial. Among the causes that cause this disorder include a genetic predisposition, prior involvement with acne and / or rosacea, whose outbreaks subsequently lead to the presence of permanent superficial capillary dilations, as well as hormonal and environmental changes.

It is therefore an alteration that involves permanent redness of the face,

which is worsened by vasodilation with the sudden changes in ambient temperature (heat-cold, enclosed premises, etc.) leading to concern, insecurity and decreased self-esteem of people who suffer from it (Balkrishnan R, McMichael Aj, Hu lY et al. Correlates ofhealth-related quality of lije in women with severe facial blemishes. Int Soc Dermatol. 2006; 45: 111-115).

Exact incidence figures are not available because there is no uniform definition of the clinical picture presenting this type of condition. The difficulty lies in defining the point at which a patient with pink cheeks presents a dermatological problem, rosacea type. However, a Swedish study published an incidence of 10%, which is a reasonable percentage to take into account the repair and care of such patients (Berg M, Liden S. An epidemiological study of rosacea. Acta Dermatovenerol. 1989; 69: 419-23).

Currently, there are different treatments to alleviate or eliminate these alterations, which can be summarized as follows:

Cosmetic treatments: These are topical products such as creams, tonics and makeup, aimed at alleviating the burning sensation and redness that is usually linked to couperose, and that cover, camouflaging venous dilations. These cosmetic products are not included in the European Pharmacopoeia, and due to their cost-benefit balance, only a small part of the population is willing to use them.

Quinirgic treatments: There are several procedures that are useful for removing capillaries that constitute couperose and facial telangiectasias. Until a few years ago, electrocoagulation of the facial veins was used, one at a time, which involved pain and often residual scars. Currently, IPL (Intense Pulsed Light Laser) technology is used successfully for the treatment of couperose. Both the pulsed dye lasers and the Neodymium: Yag (laser generally 1064 nm) and the intense pulsed light (lPL) achieve, gradually acting on the venous paths, their gradual decrease and elimination. They are techniques that do not require anesthesia or analgesic medication, but several sessions are necessary, and the cost is high. They are cutting-edge technologies, which need to be performed by an expert doctor, and there is still a risk of hypo-hyperpigmented residual lesions, therefore, although it is the current treatment of choice to treat couperose and vascular spiders, its cost limits its utility to a small portion of patients.

There is therefore a need to find a non-invasive, safe, effective, rapid and effective alternative for the cosmetic care of couperose and facial vascular spiders or facial telangiectasias that leads to a real decrease in facial redness, which facilitates the patient the correct and comfortable administration of the same, without involving a health risk because it is a corrective and reparative product of topical administration on the skin.

In this way the present invention of addition on the application P200900368 solves the inconveniences of the state of the art by referring to a dermocosmetic composition of topical administration located on the couperose or the facial telangiectasias or facial spider veins (non-invasive) that allows the patient the controlled administration thereof without the safety and toxicity problems posed by surgical treatments as well as cosmetic treatments known in the state of the art.

DESCRIPTION OF THE INVENTION

Currently, problems with cuperosls and spider veins are frequent

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Facials or facial telangiectasias, with the consequent discomforts that this entails for the affected patients, in their physical state, in addition to the limitations that it gives rise, in many cases restricting the activity, with impediment even for the development of certain work functions, sport, etc. For the purpose of the present invention, the terms "facial telangiectasias" or "facial vascular spiders" are understood interchangeably.

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In this sense, in order to alleviate as much as possible these discomforts and harmful consequences of couperose and facial telangiectasias, especially due to the unsightly effect, in accordance with the object of the present invention, a topical cream with a dermocosmetic action is proposed, which is very advantageous to reduce the aforementioned effects as well as the unsightly problems produced by couperose and facial telangiectasias or facial spider veins. The improvements proposed by the invention fully and satisfactorily solve the above-mentioned problem, in all the aspects mentioned, referring to the use of the dermocosmetic or dermopharmaceutical composition of patent application P200900368 topically for the treatment of couperosis and facial telangiectasias .

Thus, for the purpose of the present invention, the improvements introduced consist of:

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the use of the dermocosmetic composition of application P200900368 for the preparation of a dermocosmetic composition for the care and repair of couperose and facial telangiectasias.

the use of the dermocosmetic composition of application P200900368 for the preparation of a dermocosmetic composition for topical application in the form of cream and / or emulsion.

the use of the dermocosmetic composition of the application P200900368

for the preparation of a dermocosmetic composition to make up and hide cuperosis and facial telangiectasias.

the use of the dermocosmetic composition of application P200900368 for the preparation of a dermocosmetic composition for topical application by means of an application device selected from the group consisting of: a brush, a spatula, a cotton pad, gauze and a swab, sponge, tube with applicator .

Therefore, the essential technical effect of the improved invention is to provide a new dermocosmetic or dermopharmaceutical indication of the dermocosmetic composition.

or dermopharmaceutical claimed in patent application P200900368.

This composition also lacks corticosteroids which also makes it possible to use it without causing side effects, such as stunting of the skin and the appearance of stretch marks and fissures.

The present invention relates to the use of the dermocosmetic composition, the patent application P200900368 in the form of a cream comprising a cosmetically effective amount of stearyl glycinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter for the preparation of a dermocosmetic composition for the care and repair of couperose and facial vascular spiders or facial telangiectasias.

The present invention also protects the method of application on the facial skin of said composition comprising the steps of taking a sample of the dermocosmetic composition with an application device and applying it on a localized form on the cuperosis and facial vascular spider or facial telangiectasia and applying optionally heat on said couperose or telangiectasia.

In relation to the method of obtaining the cream object of the present invention

This is as detailed in patent application P200900368:

Aqueous PHASE (A): In a beaker, weigh the distilled water, with the help of a stirrer Magnetic add the maltitol and stir with magnetic stirring until completely dissolved. Add NIKKOSOME OS (squalene + glycerin + hydrogenated lecithin), and optionally hydrolyzed silk and stir until completely dispersed. Cover and save up Its use.

PHASE (B) ALCOHOLIC: In a beaker weigh 96 ° ethanol, weigh propylene glycol, diethylene glycol Monoethyl ether add and stir on a magnetic stirrer until dissolved. Weigh the rest of the components (preservatives and silicone) and add one by one to its total dissolution. Keep covered until use.

PHASE (C) INSOLUBLE PHASE: Weigh each of the components (dye, talc and titanium dioxide) and transfer them to a mortar Mix homogeneously and pass the mixture through a 0.600 mm sieve Mesh light. Return the mixture to the mortar, homogenize and keep covered until utilization.

PHASE (D) tocopheryl nicotinate: Weigh in a tocopheryl nicotinate watch glass. Preserve from light and air. Save until use.

OLEOUS (O) PHASE: Weighing petroleum jelly in a 250 ml beaker and melt in a bath Weigh the other components of this phase one by one (liquid paraffin,

pentamer cyclomethicone, stearyl glycyrrhetinate, tribehenin, propylene glycol dicaprilate, cholesterol esters and lanoesterol, sorbitan laurate and shea butter) and add to the vessel containing filament petrolatum. Heat up to 80 oC (± 2 OC) until the total melting of all components. Keep the molten mixture at 80 oC (± 2 OC).

The beneficial properties of this cream are due to the selection and proportion of each of the components of the cream.

For example, glycyretinic acid is a complex triterpene that is used locally in preparations for the treatment of non-infectious inflammatory disorders of the skin, it is also a potent inhibitor of the enzyme ll-b-hydroxysteroid dehydrogenase that inactivates cortisol. In fact it has been shown that the concomitant application of glycyrrhizinic acid together with hydrocortisone enhances the activity of the latter in the skin. Another property of glycyrrhizinic acid is that it can be esterified with steanic alcohol, which favors its absorption through the skin, acting as steanic alcohol as a vehicle, conferring an emollient, moisturizing and surfactant action.

Stearyl glycyrrheinate, a derivative of glycyrrhizinic acid is involved in skin whitening, therefore being used in sunscreen preparations because it has an inhibitory effect of melanogenesis. In this sense for the present invention, stearyl glycyrrheinate has been selected as an active compound because it increases lipid solubility and has anti-inflammatory properties at low concentrations.

Tocopheryl nicotinate is a substance with lipid-lowering and vasodilatory properties, which is why it is commonly used in the treatment of hyperlipidemias, in peripheral vasculopathies (atherosclerotic or occlusive vasculopathy, as well as venous disorders resulting from atherosclerosis, a vasospasm or a

thromboembolism) as well as cerebrovascular diseases.

For the purpose of the present invention, tocopheryl nicotinate favors oxygenation of the hair bulb and skin microcirculation, it also has an antioxidant and conditioning function of the skin, not being an irritating or sensitizing compound.

The purified talc, used topically, relieves irritation and prevents chafing. It is usually mixed with starch and zinc oxide, to increase moisture absorption. The purified talc is also used as a lubricant and diluent excipient in the manufacture of tablets and capsules, and for bleaching liquids. Talc is also used as a sclerosant in malignant effusions and in recurrent spontaneous pneumothorax.

For the cosmetic field, talc is used to facilitate application and dispersion as well as offers slip and adhesion properties. Its coverage power and moisture absorption capacity are relatively low. Therefore, it is frequently combined with other products such as kaolin and zinc oxide.

Titanium dioxide is one of the whitest chemical substances that exist: It reflects practically all the visible radiation that comes to it and keeps the color permanently. It is one of the substances with the highest refractive index, even pulverized or mixed with other substances. And for the same reason, it is very opaque and that is why it serves to protect from sunlight. Titanium dioxide pigments are also used in cosmetics as ultraviolet absorbers in cosmetic products.

Titanium dioxide also has the advantages of being harmless, of being compatible with mucous membranes and skin and having good dispersibility in organic solutions. Why in

The field of cosmetic titanium dioxide is commonly used as ingredient. In addition, titanium dioxide has an action on the skin similar to the of zinc oxide and is used together with titanium peroxide and titanium salicylate in the treatment of diaper rash. It has been demonstrated in the topical use of titanium dioxide that is not absorbed, it is that is, the titanium dioxide pigments when analyzed were only found in the stratum corneum of the skin.

Shea butter, has a protective action against dry skin, being moisturizing for both skin and hair. It also has an action protective against solar erythema, prevents and treats skin aging, It stimulates the metabolism of cells and prevents wrinkles.

Shea butter also has a wound healing action, suitable for squamous dermis treatment, for dry and cracked hands, for treatment of ulcers, eczema and stretch marks on the skin.

CREAM FORMATION: In a suitable container, melt phase (O) and in the same bath, heat the phase (A) up to 80 oC (± 2 OC).

With phases (O) and (A) at the same temperature, manually shake phase (O) and add slowly and stirring phase (A). While stirring, stir the mixture of the bathroon.

When the mixture reaches 50 oC and while stirring, add phase (D) (nicotinate of tocopheryl), until fully incorporated.

Then, while stirring, add phase (B), until fully incorporated. In

This point should obtain a well-emulsified white fluid cream base.

Pass the base obtained to the mortar where phase (e) is and work with the mortar hand until obtaining a cream with a homogeneous texture and color. Pass the obtained cream to a container and cover well.

AND TEMPLES OF REA TIZA CTÓN

The following specific examples provided herein serve to illustrate the nature of the present invention. These examples are included for illustrative purposes only and should not be construed as limitations on the invention claimed herein.

A homogeneous flesh-colored cream is obtained. After 24 h of its preparation, the consistency of the cream increases until a paste is obtained that applied on top of the skin forms a consistent and well adhered layer, resistant to water (slips when it falls from the tap on the skin) but easily removable by rubbing with Water and shower gel.

The cream obtained is suitable for topical application, presenting good organoleptic, covering, bioadhesive and water resistance characteristics.

According to an important aspect, the present invention relates to a dermocosmetic composition of topical administration for cuperosis and facial telangiectasias comprising stearyl glycerinate, tocopheryl nicotinate, talc, titanium dioxide and shea butter.

Claims (6)

1.-Improvement introduced in the Spanish Invention Patent with application number P200900368 for "cosmetic composition for the care and repair of telangiectasias" characterized in that it is additionally used for the preparation of a dermocosmetic composition for the care and repair of couperosis and telangiectasias facial 2. Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim 1 characterized in that it is used for the preparation of a dermocosmetic composition of topical application in the form of cream and / or emulsion. 3. Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim 1 characterized in that it is used for the preparation of a dermocosmetic composition of topical application in the form of cream and / or emulsion. 4.-Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim 1 characterized in that it is used for the preparation of a dermocosmetic composition to make up and disguise cuperosis and facial telangiectasias. 5. Improvement introduced in the Spanish Invention Patent with application number P200900368 according to claim 1 characterized in that it is used for the preparation of a dermocosmetic composition for topical application by means of an application device selected from the group consisting of: a brush, a spatula , a cotton, gauze and a swab, sponge, tube with applicator. 6.-Improvement introduced in the Spanish Invention Patent with application number P200900368 for "cosmetic composition for the care and repair of telangiectasias" characterized in that the method of administration of the composition comprises the steps of taking a sample of the dermocosmetic composition with the application device, apply locally on the couperose, facial vascular spider or facial telangiectasia and optionally apply heat on said couperose or telangiectasia.