ES2380546T3 - Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma - Google Patents
Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma Download PDFInfo
- Publication number
- ES2380546T3 ES2380546T3 ES08757088T ES08757088T ES2380546T3 ES 2380546 T3 ES2380546 T3 ES 2380546T3 ES 08757088 T ES08757088 T ES 08757088T ES 08757088 T ES08757088 T ES 08757088T ES 2380546 T3 ES2380546 T3 ES 2380546T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- residue
- alkaline phosphatase
- sequence
- signal peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cereal-Derived Products (AREA)
- Adornments (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91758907P | 2007-05-11 | 2007-05-11 | |
| US917589P | 2007-05-11 | ||
| PCT/CA2008/000923 WO2008138131A1 (en) | 2007-05-11 | 2008-05-12 | Bone targeted alkaline phosphatase, kits and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2380546T3 true ES2380546T3 (es) | 2012-05-16 |
Family
ID=40001639
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08757088T Active ES2380546T3 (es) | 2007-05-11 | 2008-05-12 | Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma |
| ES11004496.3T Active ES2471915T3 (es) | 2007-05-11 | 2008-05-12 | Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma |
| ES13002327T Active ES2619332T3 (es) | 2007-05-11 | 2008-05-12 | Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11004496.3T Active ES2471915T3 (es) | 2007-05-11 | 2008-05-12 | Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma |
| ES13002327T Active ES2619332T3 (es) | 2007-05-11 | 2008-05-12 | Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma |
Country Status (25)
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2348114T1 (sl) | 2004-04-21 | 2018-11-30 | Alexion Pharmaceuticals, Inc. | Konjugati za dodajanje kostem in njihova uporaba za ciljanje beljakovin na kosti |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| US8784833B2 (en) * | 2006-06-27 | 2014-07-22 | Saint Louis University | Prenatal enzyme replacement therapy for hypophosphatasia |
| MX394440B (es) | 2007-06-01 | 2025-03-24 | Univ Maryland | Agentes de union al receptor de la region constante fc de inmunoglobulina. |
| US8846603B2 (en) | 2010-03-12 | 2014-09-30 | Synageva Biopharma Corp. | NPP1 fusion proteins |
| CA2797865A1 (en) | 2010-04-30 | 2011-11-03 | Alexion Pharma International Sarl | Methods, compositions, and kits for the treatment of matrix mineralization disorders |
| TR201906652T4 (tr) | 2010-07-28 | 2019-05-21 | Gliknik Inc | Kademeli multimerize immünoglobülin fc bileşimleri oluşturmak için doğal insan protein fragmanları içeren füzyon proteinleri. |
| WO2012088608A1 (en) | 2010-12-27 | 2012-07-05 | Enobia Canada Limited Partnership | Compositions comprising natriuretic peptides and methods of use thereof |
| SG11201401605QA (en) | 2011-10-19 | 2014-09-26 | Alexion Pharma Holding | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| CN104718223A (zh) | 2012-08-20 | 2015-06-17 | 格利克尼克股份有限公司 | 具有抗原结合和多价FCγ受体结合活性的分子 |
| RU2683635C2 (ru) | 2014-01-24 | 2019-03-29 | Ам-Фарма Б.В. | Химерные белки, подобные щелочной фосфатазе |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| CA2967851C (en) | 2014-12-05 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Treating seizure with recombinant alkaline phosphatase |
| JP6868561B2 (ja) | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
| DK3325011T6 (da) | 2015-07-24 | 2023-05-15 | Gliknik Inc | Fusionsproteiner af humane proteinfragmenter til fremstilling af ordnede multimeriserede immunoglobulin Fc-sammensætninger med forstærket komplementbinding |
| CA2993358A1 (en) * | 2015-08-17 | 2017-02-23 | Alexion Pharmaceuticals, Inc. | Manufacturing of alkaline phosphatases |
| WO2017058822A1 (en) | 2015-09-28 | 2017-04-06 | Alexion Pharmaceuticals, Inc. | Identifying effective dosage regimens for tissue non-specific alkaline phosphatase (tnsalp)-enzyme replacement therapy of hypophosphatasia |
| EP3368062A4 (en) * | 2015-10-30 | 2019-07-03 | Alexion Pharmaceuticals, Inc. | METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| WO2017173413A1 (en) * | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Treating muscle weakness with alkaline phosphatases |
| EP3436020A4 (en) | 2016-04-01 | 2019-12-25 | Alexion Pharmaceuticals, Inc. | METHOD FOR TREATING HYPOPHOSPHATASIE IN TEENS AND ADULTS |
| WO2017171871A1 (en) * | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| US11034775B2 (en) | 2016-06-07 | 2021-06-15 | Gliknik Inc. | Cysteine-optimized stradomers |
| EP3474886B1 (en) | 2016-06-27 | 2021-08-04 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children and adolescents |
| US11116821B2 (en) | 2016-08-18 | 2021-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating tracheobronchomalacia |
| JP7649624B2 (ja) * | 2016-11-30 | 2025-03-21 | パーデュー リサーチ ファウンデーション | 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生 |
| CA3043251A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent fc compounds |
| CA3043261A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Manufacturing optimization of gl-2045, a multimerizing stradomer |
| WO2018164995A1 (en) * | 2017-03-09 | 2018-09-13 | Alexion Pharmaceuticals, Inc . | Glycoprotein manufacturing process |
| EP3600383A4 (en) * | 2017-03-31 | 2020-10-28 | Alexion Pharmaceuticals, Inc. | METHODS OF TREATMENT OF HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS |
| WO2019067502A1 (en) | 2017-09-27 | 2019-04-04 | Alexion Pharmaceuticals, Inc. | METHODS FOR IMPROVING CARDIOVASCULAR FUNCTION AND TREATING CARDIOVASCULAR DISEASE USING RECOMBINANT ECTO-NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE |
| US11338020B2 (en) | 2018-01-09 | 2022-05-24 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| JP7214962B2 (ja) * | 2018-01-17 | 2023-01-31 | 東ソー株式会社 | アルカリホスファターゼ高発現動物細胞 |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| US11638699B2 (en) | 2018-03-20 | 2023-05-02 | Theriva Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| JP2021519590A (ja) * | 2018-03-30 | 2021-08-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 糖タンパク質の製造 |
| CN110499285A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Alpl基因在制备预防和/或治疗低碱性磷酸酶症的产品中的应用 |
| WO2019232283A1 (en) | 2018-05-30 | 2019-12-05 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| WO2020033867A2 (en) | 2018-08-10 | 2020-02-13 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| EP3965805A4 (en) | 2019-05-06 | 2023-01-25 | Synthetic Biologics, Inc. | ALKALINE PHOSPHATE BASED ONCOLOGICAL TREATMENTS |
| AU2020398898A1 (en) | 2019-12-09 | 2022-07-21 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| JP2023510195A (ja) | 2020-01-03 | 2023-03-13 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 歯周の健康を促進するために局所投与されるｔｎａｐ |
| KR20230117327A (ko) * | 2020-09-03 | 2023-08-08 | 어빈 에스.와이. 첸 | 가용성 알칼리성 포스파타제 작제물 및 가용성 알칼리성 포스파타제 작제물을 인코딩하는 폴리뉴클레오티드를 포함하는 발현 벡터 |
| KR102571967B1 (ko) * | 2021-01-21 | 2023-08-30 | 주식회사 마라나노텍코리아 | Alp 측정용 바이오 센서 |
| US12083169B2 (en) * | 2021-02-12 | 2024-09-10 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| EP4581048A2 (en) * | 2022-08-31 | 2025-07-09 | University of Utah Research Foundation | Gja1-20k compositions and methods for mitigating ischemia-reperfusion injury |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7008A (en) * | 1850-01-08 | Improvement in alloys for points of lightning-rods | ||
| DE69434486T2 (de) | 1993-06-24 | 2006-07-06 | Advec Inc. | Adenovirus vektoren für gentherapie |
| BR9407956A (pt) | 1993-10-25 | 1996-11-26 | Canji Inc | Composiçao farmacêutica vetor de express o de adenovirus recombinante e kit par reduzir a proliferaçao de células tumorais |
| US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
| EP1232276B8 (en) | 1999-11-16 | 2007-06-27 | Genzyme Corporation | Vectors and transgenes with regulatory elements for gene delivery to the liver |
| ATE437221T1 (de) | 2001-05-14 | 2009-08-15 | Gbp Ip Llc | Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie |
| CA2433479A1 (en) | 2002-07-22 | 2004-01-22 | F. Hoffmann-La Roche Ag | Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof |
| SI2348114T1 (sl) * | 2004-04-21 | 2018-11-30 | Alexion Pharmaceuticals, Inc. | Konjugati za dodajanje kostem in njihova uporaba za ciljanje beljakovin na kosti |
| US20070081984A1 (en) * | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| WO2006002203A2 (en) | 2004-06-23 | 2006-01-05 | Genzyme Corporation | Methods and compositions for the treatment of polycystic diseases |
| WO2006039480A2 (en) * | 2004-09-29 | 2006-04-13 | The Burnham Institute For Medical Research | Tissue non-specific alkaline phosphate (tnap): a therapeutic target for arterial calcification |
| BRPI0515819A (pt) | 2004-12-01 | 2008-08-05 | Genzyme Corp | métodos para o fornecimento direcionado de material genético ao fìgado |
-
2008
- 2008-05-12 JP JP2010507770A patent/JP5732603B2/ja active Active
- 2008-05-12 SI SI200831200T patent/SI2368999T1/sl unknown
- 2008-05-12 DK DK08757088.3T patent/DK2158319T3/da active
- 2008-05-12 US US12/599,679 patent/US20100297119A1/en not_active Abandoned
- 2008-05-12 HU HUE13002327A patent/HUE031655T2/hu unknown
- 2008-05-12 EP EP13002327.8A patent/EP2662448B1/en active Active
- 2008-05-12 PL PL13002327T patent/PL2662448T3/pl unknown
- 2008-05-12 PL PL08757088T patent/PL2158319T4/pl unknown
- 2008-05-12 DK DK13002327.8T patent/DK2662448T3/en active
- 2008-05-12 SI SI200831780A patent/SI2662448T1/sl unknown
- 2008-05-12 DE DE202008018131U patent/DE202008018131U1/de not_active Expired - Lifetime
- 2008-05-12 PT PT130023278T patent/PT2662448T/pt unknown
- 2008-05-12 DK DK11004496.3T patent/DK2368999T3/da active
- 2008-05-12 BR BRPI0811198A patent/BRPI0811198B8/pt active IP Right Grant
- 2008-05-12 CA CA2687001A patent/CA2687001C/en active Active
- 2008-05-12 BR BR122019000505-2A patent/BR122019000505B1/pt active Search and Examination
- 2008-05-12 WO PCT/CA2008/000923 patent/WO2008138131A1/en not_active Ceased
- 2008-05-12 EP EP11004496.3A patent/EP2368999B1/en active Active
- 2008-05-12 ES ES08757088T patent/ES2380546T3/es active Active
- 2008-05-12 ES ES11004496.3T patent/ES2471915T3/es active Active
- 2008-05-12 PT PT110044963T patent/PT2368999E/pt unknown
- 2008-05-12 ME MEP-2014-48A patent/ME01828B/me unknown
- 2008-05-12 EP EP08757088A patent/EP2158319B1/en active Active
- 2008-05-12 RS RS20140237A patent/RS53302B/sr unknown
- 2008-05-12 ES ES13002327T patent/ES2619332T3/es active Active
- 2008-05-12 PT PT08757088T patent/PT2158319E/pt unknown
- 2008-05-12 PL PL11004496T patent/PL2368999T3/pl unknown
- 2008-05-12 AT AT08757088T patent/ATE536413T1/de active
- 2008-05-12 AU AU2008250945A patent/AU2008250945B2/en active Active
-
2009
- 2009-11-11 IL IL202057A patent/IL202057A0/en unknown
-
2014
- 2014-05-08 HR HRP20140416AT patent/HRP20140416T1/hr unknown
-
2016
- 2016-01-15 HU HUS1600005C patent/HUS1600005I1/hu unknown
- 2016-01-28 LT LTPA2016004C patent/LTC2368999I2/lt unknown
- 2016-02-02 NO NO2016002C patent/NO2016002I2/no not_active IP Right Cessation
- 2016-02-10 LU LU92976C patent/LU92976I2/xx unknown
- 2016-02-19 FR FR16C0007C patent/FR16C0007I2/fr active Active
- 2016-02-23 CY CY2016005C patent/CY2016005I2/el unknown
- 2016-02-26 NL NL300798C patent/NL300798I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2380546T3 (es) | Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma | |
| US11224638B2 (en) | Treating seizure with recombinant alkaline phosphatase | |
| Millán et al. | Alkaline phosphatase and hypophosphatasia | |
| Millán et al. | Enzyme replacement therapy for murine hypophosphatasia | |
| US9988620B2 (en) | Methods, compositions, and kits for the treatment of matrix mineralization disorders | |
| ES2234032T3 (es) | Terapia para la deficiencia de alfa-galactosidasa a. | |
| JP2018168176A (ja) | アクチビン−ＡｃｔＲＩＩアンタゴニスト並びに骨障害及び他の障害の治療に対する使用 | |
| ES2796743T3 (es) | Un polipéptido de receptor de factor de crecimiento de fibroblastos 3 (FGR3) soluble para su uso en la prevención o tratamiento de trastornos de retraso del crecimiento esquelético | |
| HK1141047B (en) | Bone targeted alkaline phosphatase, kits and methods of use thereof | |
| HK1162589B (en) | Bone targeted alkaline phosphatase, kits and methods of use thereof | |
| HK1191372B (en) | Bone targeted alkaline phosphatase, kits and methods of use thereof | |
| AU2013203875A1 (en) | Bone Targeted Alkaline Phosphatase, Kits and Methods of Use Thereof |